Ghrelin: New insights into female reproductive system-associated disorders and pregnancy

Reproductive Sciences

Volumn 19, Issue 9, 2012, Pages 903-910

  Angelidis, George ^a   Dafopoulos, Konstantinos ^a   Messini, Christina I ^a   Valotassiou, Varvara ^a   Georgoulias, Panagiotis ^a   Messinis, Ioannis E ^a  

^a UNIVERSITY OF THESSALY   (Greece)

Author keywords

fertility; ghrelin; gonadotropins; pregnancy

Indexed keywords

DECANOIC ACID; DECENOYLGHRELIN; FOLLITROPIN; GHRELIN; GHRELIN RECEPTOR; GONADORELIN; HORMONE DERIVATIVE; LUTEINIZING HORMONE; OCTANOYLGHRELIN; PROLACTIN; UNCLASSIFIED DRUG;

ARTICLE; EMBRYO DEVELOPMENT; FEMALE FERTILITY; FEMALE GENITAL SYSTEM; FOLLITROPIN RELEASE; GENE PRODUCT; GYNECOLOGIC DISEASE; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LACTATION; LUTEINIZING HORMONE RELEASE; MATERNAL HYPERTENSION; MENSTRUAL CYCLE; NIDATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OVARY DEVELOPMENT; OVARY FUNCTION; OVARY POLYCYSTIC DISEASE; PATHOGENESIS; PERINATAL DEVELOPMENT; PREGNANCY; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROLACTIN RELEASE;

ANIMALS; FEMALE; GHRELIN; HUMANS; INFERTILITY, FEMALE; PREGNANCY; PREGNANCY COMPLICATIONS; RECEPTORS, GHRELIN; REPRODUCTION;

EID: 84865024562     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719112443880     Document Type: Article

References (74)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999 ; 402 (6762). 656-660
2. Howard AD, Feighner SD, Cully DF, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996 ; 273 (5277). 974-977
3. Locatelli V, Torsello A. Growth hormone secretagogues: focus on the growth hormone releasing peptides. Pharmacol Res. 1997 ; 36 (6). 415-423
4. Angelidis G, Valotassiou V, Georgoulias P. Current and potential roles of ghrelin in clinical practice. J Endocrinol Invest. 2010 ; 33 (11). 823-838
5. Broglio F, Benso A, Gottero C, et al. Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans. J Endocrinol Invest. 2003 ; 26 (3). 192-196
6. García MC, López M, Alvarez CV, Casanueva F, Tena-Sempere M, Diéguez C. Role of ghrelin in reproduction. Reproduction. 2007 ; 133 (3). 531-540
7. Kluge M, Schussler P, Uhr M, Yassouridis A, Steiger A. Ghrelin suppresses secretion of luteinizing hormone in humans. J Clin Endocrinol Metab. 2007 ; 92 (8). 3202-3205
8. Furuta M, Funabashi T, Kimura F. Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun. 2001 ; 288 (4). 780-785
9. Fernández-Fernández R, Tena-Sempere M, Navarro VM, et al. Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies. Neuroendocrinology. 2005 ; 82 (5-6). 245-255
10. Ogata R, Matsuzaki T, Iwasa T, et al. Hypothalamic ghrelin suppresses pulsatile secretion of luteinizing hormone via beta-endorphin in ovariectomized rats. Neuroendocrinology. 2009 ; 90 (4). 364-370
11. Martini AC, Fernandez-Fernandez R, Tovar S, et al. Comparative analysis of the effects of ghrelin and unacylated ghrelin on luteinizing hormone secretion in male rats. Endocrinology. 2006 ; 147 (5). 2374-2382
12. Sokołowska-Mikołajczyk M, Socha M, Szczerbik P, Epler P. The effects of ghrelin on the in vitro spontaneous and sGnRH-A stimulated luteinizing hormone (LH) release from the pituitary cells of common carp (Cyprinus carpio L.). Comp Biochem Physiol A Mol Integr Physiol. 2009 ; 153 (4). 386-390
13. Lanfranco F, Bonelli L, Baldi M, Me E, Broglio F, Ghigo E. Acylated ghrelin inhibits spontaneous luteinizing hormone pulsatility and responsiveness to naloxone but not that to gonadotrophin-releasing hormone in young men: evidence for a central inhibitory action of ghrelin on the gonadal axis. J Clin Endocrinol Metab. 2008 ; 93 (9). 3633-3639
14. Kluge M, Uhr M, Bleninger P, Yassouridis A, Steiger A. Ghrelin suppresses secretion of FSH in males. Clin Endocrinol (Oxf). 2009 ; 70 (6). 920-923
15. Messini CI, Dafopoulos K, Chalvatzas N, Georgoulias P, Messinis IE. Effect of ghrelin on gonadotrophin secretion in women during the menstrual cycle. Hum Reprod. 2009 ; 24 (4). 976-981
16. Dafopoulos K, Sourlas D, Kallitsaris A, Pournaras S, Messinis IE. Blood ghrelin, resistin, and adiponectin concentrations during the normal menstrual cycle. Fertil Steril. 2009 ; 92 (4). 1389-1394
17. Dafopoulos K, Chalvatzas N, Kosmas G, Kallitsaris A, Pournaras S, Messinis IE. The effect of estrogens on plasma ghrelin concentrations in women. J Endocrinol Invest. 2010 ; 33 (2). 109-112
18. Du C, Li H, Cao G, Xilingaowa, , Wang C, Li C. Expression of the orexigenic peptide ghrelin and the type 1a growth hormone secretagogue receptor in sheep oocytes and pre-implantation embryos produced in vitro. Reprod Domest Anim. 2010 ; 45 (1). 92-98
19. Sirotkin AV, Grossmann R, María-Peon MT, Roa J, Tena-Sempere M, Klein S. Novel expression and functional role of ghrelin in chicken ovary. Mol Cell Endocrinol. 2006 ; 257-258: 15-25
20. Sirotkin AV, Grossmann R. Effects of ghrelin and its analogues on chicken ovarian granulosa cells. Domest Anim Endocrinol. 2008 ; 34 (2). 125-134
21. Sirotkin AV, Chrenek P, Darlak K, Valenzuela F, Kuklová Z. Some endocrine traits of transgenic rabbits. II. Changes in hormone secretion and response of isolated ovarian tissue to FSH and ghrelin. Physiol Res. 2008 ; 57 (5). 745-751
22. Sirotkin AV, Rafay J, Kotwica J, Darlak K, Valenzuela F. Role of ghrelin in regulating rabbit ovarian function and the response to LH and IGF-I. Domest Anim Endocrinol. 2009 ; 36 (3). 162-172
23. Sirotkin AV, Rafay J, Kotwica J. Leptin controls rabbit ovarian function in vivo and in vitro: possible interrelationships with ghrelin. Theriogenology. 2009 ; 72 (6). 765-772
24. Chrenek P, Grossmann R, Sirotkin AV. The cAMP analogue, dbcAMP affects release of steroid hormones by cultured rabbit ovarian cells and their response to FSH, IGF-I and ghrelin. Eur J Pharmacol. 2010 ; 640 (1-3). 202-205
25. Sirotkin AV, Meszarosová M. Comparison of effects of leptin and ghrelin on porcine ovarian granulosa cells. Domest Anim Endocrinol. 2010 ; 39 (1). 1-9
26. Viani I, Vottero A, Tassi F, et al. Ghrelin inhibits steroid biosynthesis by cultured granulose-lutein cells. J Clin Endocrinol Metab. 2008 ; 93 (4). 1476-1481
27. Mircea CN, Lujan ME, Pierson RA. Metabolic fuel and clinical implications for female reproduction. J Obstet Gynaecol Can.. 2007 ; 29 (11). 887-902
28. Abou Heif HM, Deif MM, Abdel Aziz HK. Effect of food restriction on ghrelin in adult male rats and its relation to male reproductive hormones. Andrologia. 2010 ; 42 (2). 97-105
29. Vulliémoz NR, Xiao E, Xia-Zhang L, Germond M, Rivier J, Ferin M. Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab. 2004 ; 89 (11). 5718-5723
30. Aghajanova L, Rumman A, Altmäe S, Wånggren K, Stavreus-Evers A. Diminished endometrial expression of ghrelin and ghrelin receptor contributes to infertility. Reprod Sci. 2010 ; 17 (9). 823-832
31. Martin JR, Lieber SB, McGrath J, Shanabrough M, Horvath TL, Taylor HS. Maternal ghrelin deficiency compromises reproduction in female progeny through altered uterine developmental programming. Endocrinology. 2011 ; 152 (5). 2060-2066
32. Castellano JM, Bentsen AH, Mikkelsen JD, Tena-Sempere M. Kisspeptins: bridging energy homeostasis and reproduction. Brain Res. 2010 ; 1364: 129-138
33. Tena-Sempere M. KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility. Neuroendocrinology. 2006 ; 83 (5-6). 275-281
34. Budak E, Fernández Sánchez M, Bellver J, Cerveró A, Simón C, Pellicer A. Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system. Fertil Steril. 2006 ; 85 (6). 1563-1581
35. Rak-Mardyła A, Gregoraszczuk E. Effect of ghrelin on proliferation, apoptosis and secretion of progesterone and hCG in the placental JEG-3 cell line. Reprod Biol. 2010 ; 10 (2). 159-165
36. Tanaka K, Minoura H, Isobe T, et al. Ghrelin is involved in the decidualization of human endometrial stromal cells. J Clin Endocrinol Metab. 2003 ; 88 (5). 2335-2340
37. Tawadros N, Salamonsen LA, Dimitriadis E, Chen C. Facilitation of decidualization by locally produced ghrelin in the human endometrium. Mol Hum Reprod. 2007 ; 13 (7). 483-489
38. O'Brien M, Earley P, Morrison JJ, Smith TJ. Ghrelin in the human myometrium. Reprod Biol Endocrinol. 2010 ; 8: 55
39. Fuglsang J, Skjaerbaek C, Espelund U, et al. Ghrelin and its relationship to growth hormones during normal pregnancy. Clin Endocrinol (Oxf). 2005 ; 62 (5). 554-559
40. Palik E, Baranyi E, Melczer Z, et al. Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance. Diabetes Res Clin Pract. 2007 ; 76 (3). 351-357
41. Riedl M, Maier C, Handisurya A, Luger A, Kautzky-Willer A. Insulin resistance has no impact on ghrelin suppression in pregnancy. J Intern Med. 2007 ; 262 (4). 458-465
42. Makino Y, Hosoda H, Shibata K, et al. Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy. Hypertension. 2002 ; 39 (3). 781-784
43. Tham E, Liu J, Innis S, et al. Acylated ghrelin concentrations are markedly decreased during pregnancy in mothers with and without gestational diabetes: relationship with cholinesterase. Am J Physiol Endocrinol Metab. 2009 ; 296 (5). 1093-1100
44. Gibson W, Liu J, Gaylinn B, et al. Effects of glucose and insulin on acyl ghrelin and desacyl ghrelin, leptin, and adiponectin in pregnant women with diabetes. Metabolism. 2010 ; 59 (6). 841-847
45. Telejko B, Kuzmicki M, Zonenberg A, et al. Ghrelin in gestational diabetes: serum level and mRNA expression in fat and placental tissue. Exp Clin Endocrinol Diabetes. 2010 ; 118 (2). 87-92
46. Poston L. Leptin and preeclampsia. Semin Reprod Med. 2002 ; 20 (2). 131-138
47. Aydin S, Guzel SP, Kumru S, et al. Serum leptin and ghrelin concentrations of maternal serum, arterial and venous cord blood in healthy and preeclamptic pregnant women. J Physiol Biochem. 2008 ; 64 (1). 51-59
48. Kawamura K, Sato N, Fukuda J, et al. Ghrelin inhibits the development of mousepreimplantation embryos in vitro. Endocrinology. 2003 ; 144 (6). 2623-2633
49. Fernandez-Fernandez R, Navarro VM, Barreiro ML, et al. Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology. 2005 ; 146 (7). 3018-3025
50. Hayashida T, Nakahara K, Mondal MS, et al. Ghrelin in neonatal rats: distribution in stomach and its possible role. J Endocrinol. 2002 ; 173 (2). 239-245
51. Nakahara K, Nakagawa M, Baba Y, et al. Maternal ghrelin plays an important role in rat fetal development during pregnancy. Endocrinology. 2006 ; 147 (3). 1333-1342
52. Saad A, Abbas OA. Ghrelin as a regulator of gonadal function in adult male offsprings exposed to cigarette smoking in utero. Endocr Regul. 2009 ; 43 (4). 141-148
53. Volante M, Fulcheri E, Allia E, Cerrato M, Pucci A, Papotti M. Ghrelin expression in fetal, infant, and adult human lung. J Histochem Cytochem. 2002 ; 50 (8). 1013-1021
54. Kyriakakou M, Malamitsi-Puchner A, Mastorakos G, et al. The role of IGF-1 and ghrelin in the compensation of intrauterine growth restriction. Reprod Sci. 2009 ; 16 (12). 1193-1200
55. Tena-Sempere M. Exploring the role of ghrelin as novel regulator of gonadal function. Growth Horm IGF Res. 2005 ; 15 (2). 83-88
56. Messini C, Dafopoulos K, Chalvatzas N, Georgoulias P, Messinis IE. Growth hormone and prolactin response to ghrelin during the normal menstrual cycle. Clin Endocrinol (Oxf). 2009 ; 71 (3). 383-387
57. Messini CI, Dafopoulos K, Chalvatzas N, Georgoulias P, Anifandis G, Messinis IE. Effect of ghrelin and thyrotropin-releasing hormone on prolactin secretion in normal women. Horm Metab Res. 2010 ; 42 (3). 204-208
58. Messini CI, Dafopoulos K, Chalvatzas N, Georgoulias P, Anifandis G, Messinis IE. Blockage of ghrelin-induced prolactin secretion in women by bromocriptine. Fertil Steril. 2010 ; 94 (4). 1478-1481
59. Dündar NO, Dündar B, Cesur G, Yilmaz N, Sütçu R, Ozgüner F. Ghrelin and adiponectin levels in colostrum, cord blood and maternal serum. Pediatr Int. 2010 ; 52 (4). 622-625
60. Aydin S. The presence of the peptides apelin, ghrelin and nesfatin-1 in the human breast milk, and the lowering of their levels in patients with gestational diabetes mellitus. Peptides. 2010 ; 31 (12). 2236-2240
61. Larson-Meyer DE, Ravussin E, Heilbronn L, DeJonge L. Ghrelin and peptide YY in postpartum lactating and nonlactating women. Am J Clin Nutr. 2010 ; 91 (2). 366-372
62. Vrbikova J, Hainer V. Obesity and polycystic ovary syndrome. Obes Facts. 2009 ; 2 (1). 26-35
63. Waśko R, Komarowska H, Warenik-Szymankiewicz A, Sowiński J. Elevated ghrelin plasma levels in patients with polycystic ovary syndrome. Horm Metab Res. 2004 ; 36 (3). 170-173
64. Daghestani MH, Daghestani MH, El-Mazny A. Circulating ghrelin levels and the polycystic ovary syndrome: correlation with the clinical, hormonal and metabolic features. Eur J Obstet Gynecol Reprod Biol. 2011 ; 155 (1). 65-68
65. Schöfl C, Horn R, Schill T, Schlösser HW, Müller MJ, Brabant G. Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2002 ; 87 (10). 4607-4610
66. Panidis D, Asteriadis C, Georgopoulos NA, et al. Decreased active, total and altered active to total ghrelin ratio in normal weight women with the more severe form of polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2010 ; 149 (2). 170-174
67. Ozgen IT, Aydin M, Guven A, Aliyazicioglu Y. Characteristics of polycystic ovarian syndrome and relationship with ghrelin in adolescents. J Pediatr Adolesc Gynecol. 2010 ; 23 (5). 285-289
68. Guido M, Romualdi D, De Marinis L, et al. Administration of exogenous ghrelin in obese patients with polycystic ovary syndrome: effects on plasma levels of growth hormone, glucose, and insulin. Fertil Steril. 2007 ; 88 (1). 125-130
69. Fusco A, Bianchi A, Mancini A, et al. Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome. J Endocrinol Invest. 2007 ; 30 (11). 948-956
70. Nishi Y, Yoh J, Hiejima H, Kojima M. Structures and molecular forms of the ghrelin-family peptides. Peptides. 2011 ; 32 (11). 2175-2182
71. Kaiya H, Kojima M, Hosoda H, et al. Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. J Biol Chem. 2001 ; 276 (44). 40441-40448
72. Kaiya H, Kojima M, Hosoda H, et al. Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity. J Endocrinol. 2003 ; 176 (3). 415-423
73. Hiejima H, Nishi Y, Hosoda H, et al. Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents. Regul Pept. 2009 ; 156 (1-3). 47-56
74. Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem. 2003 ; 278 (1). 64-70