Characteristics of Polycystic Ovarian Syndrome and Relationship with Ghrelin in Adolescents

Journal of Pediatric and Adolescent Gynecology

Volumn 23, Issue 5, 2010, Pages 285-289

  Ozgen, I T ^a   Aydin, M ^a   Guven, A ^a   Aliyazicioglu, Y ^a  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

Author keywords

Adolescence; Ghrelin; Insulin resistance; Polycystic ovarian syndrome

Indexed keywords

ANDROGEN; GHRELIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HYDROXYPROGESTERONE; INSULIN; LOW DENSITY LIPOPROTEIN; PRASTERONE SULFATE; TESTOSTERONE; THYROTROPIN; TRIACYLGLYCEROL;

ADOLESCENCE; ADOLESCENT; AMENORRHEA; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HYPERANDROGENISM; HYPERINSULINISM; INSULIN RESISTANCE; LEAN BODY WEIGHT; OBESITY; OLIGOMENORRHEA; ORAL GLUCOSE TOLERANCE TEST; OVARY CYST; OVARY POLYCYSTIC DISEASE; PATHOGENESIS; PEDIATRIC HOSPITAL; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN FUNCTION; TESTOSTERONE BLOOD LEVEL; UNIVERSITY HOSPITAL;

ADOLESCENT; CASE-CONTROL STUDIES; FEMALE; GHRELIN; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; OBESITY; POLYCYSTIC OVARY SYNDROME; PROSPECTIVE STUDIES; THINNESS;

EID: 77956185133     PISSN: 10833188     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpag.2010.02.011     Document Type: Article

References (34)

1. Sheehan M.T. Polycystic ovarian syndrome: diagnosis and management. Clin Med Res 2004, 2:13.
2. Ten S., Maclaren N. Insulin resistance syndrome in children. J Clin Endocrinol Metab 2004, 89:2526.
3. Barnes R.B., Rosenfield R.L., Burstein S., et al. Pituitary-ovarian responses to nafarelin testing in the polycystic ovary syndrome. N Engl J Med 1989, 320:559.
4. Yen S.S., Vela P., Rankin J. Inappropriate secretion of follicle stimulating hormone and luteinizing hormone in polycystic ovarian disease. J Clin Endocrinol Metab 1970, 30:435.
5. Dunaif A. Insulin resistance and polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1996, 18:774.
6. Pagotto U., Gambineri A., Vicennati V., et al. Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 2002, 87:5625.
7. Gaytan F., Barreiro M.L., Chopin L.K., et al. Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. J Clin Endocrinol Metab 2003, 88:879.
8. Muccioli G., Tschöp M., Papotti M., et al. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 2002, 440:235.
9. Miller D.W., Harrison J.L., Brown Y.A., et al. Immunohistochemical evidence for an endocrine/paracrine role for ghrelin in the reproductive tissues of sheep. Reprod Biol Endocrinol 2005, 3:60.
10. Fernández-Fernández R., Tena-Sempere M., Navarro V.M., et al. Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: in vivo and in vitro studies. Neuroendocrinology 2006, 82:245.
11. Sultan C., Paris F. Clinical expression of polycystic ovary syndrome in adolescent girls Fertil Steril 2006, 86(Suppl 1):S6.
12. Kuczmarski R.J., Ogden C.L., Grummer-Strawn L.M., et al. CDC growth charts: United States. Adv Data 2000, 314:1.
13. Matthews D.R., Hosker J.P., Rudenski A.S., et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412.
14. Valerio G., Licenziati M.R., Iannuzzi A., et al. Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy. Nutr Metab Cardiovasc Dis 2006, 16:279.
15. Ferriman D., Gallwey J.D. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961, 21:1440.
16. Nardo L.G., Buckett W.M., Khullar V. Determination of the best-fitting ultrasound formulaic method for ovarian volume measurement in women with polycystic ovary syndrome. Fertil Steril 2003, 79:632.
17. Diamanti-Kandarakis E. PCOS in adolescents. Best Pract Res Clin Obstet Gynaecol 2010, 24:173.
18. Buyalos R.P., Geffner M.E., Watanabe R.M., et al. The influence of luteinizing hormone and insulin on sex steroids and sex hormone-binding globulin in the polycystic ovarian syndrome. Fertil Steril 1993, 60:626.
19. Cara J.F., Mirmira R.G., Nakagawa S.H., et al. An insulin-like growth factor I/insulin hybrid exhibiting high potency for interaction with the type I insulin-like growth factor and insulin receptors of placental plasma membranes. J Biol Chem 1990, 265:17820.
20. Berker B., Emral R., Demirel C., et al. Increased insulin-like growth factor-I levels in women with polycystic ovary syndrome, and beneficial effects of metformin therapy. Gynecol Endocrinol 2004, 19:125.
21. Nestler J.E. Insulin regulation of human ovarian androgens. Hum Reprod 1997, 12(Suppl 1):53.
22. Zhang G., Veldhuis J.D. Insulin drives transcriptional activity of the CYP17 gene in primary cultures of swine theca cells. Biol Reprod 2004, 70:1600.
23. Fendri S., Arlot S., Marcelli J.M., et al. Relationship between insulin sensitivity and circulating sex hormone-binding globulin levels in hyperandrogenic obese women. Int J Obes Relat Metab Disord 1994, 18:755.
24. Dunaif A. Insulin resistance in women with polycystic ovary syndrome. Fertil Steril 2006, 86(Suppl 1):S13.
25. Dunaif A., Segal K.R., Futterweit W., et al. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989, 38:1165.
26. Chang R.J., Nakamura R.M., Judd H.L., et al. Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab 1983, 57:356.
27. Dale P.O., Tanbo T., Vaaler S., et al. Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations. Fertil Steril 1992, 58:487.
28. Herbert C.M., Hill G.A., Diamond M.P. The use of the intravenous glucose tolerance test to evaluate nonobese hyperandrogenemic women. Fertil Steril 1990, 53:647.
29. Bhattacharya S.M., Ghosh M. Insulin resistance and adolescent girls with polycystic ovary syndrome. J Pediatr Adolesc Gynecol 2010, 23:158.
30. Schofl C., Horn R., Schill T., et al. Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 2002, 87:4607.
31. Panidis D., Farmakiotis D., Koliakos G., et al. Comparative study of plasma ghrelin levels in women with polycystic ovary syndrome, in hyperandrogenic women and in normal controls. Hum Reprod 2005, 20:2127.
32. Bideci A., Camurdan M.O., Yeşilkaya E., et al. Serum ghrelin, leptin and resistin levels in adolescent girls with polycystic ovary syndrome. J Obstet Gynaecol Res 2008, 34:578.
33. Moran L.J., Noakes M., Clifton P.M., et al. Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. J Clin Endocrinol Metab 2004, 89:3337.
34. Barber T.M., Casanueva F.F., Karpe F., et al. Ghrelin levels are suppressed and show a blunted response to oral glucose in women with polycystic ovary syndrome. Eur J Endocrinol 2008, 158:511.