Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans

Journal of Endocrinological Investigation

Volumn 26, Issue 3, 2003, Pages 192-196

  Broglio, F ^a   Benso, A ^a   Gottero, C ^a   Prodam, F ^a   Gauna, C ^a   Filtri, L ^a   Arvat, E ^a   Van Der Lely, A J ^b   Deghengi, R ^c   Ghigo, Ezio ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c Ardana   (France)

Author keywords

ACTH; Acylation; GH; GH Secretagogues; Ghrelin; Glucose; Insulin; PRL

Indexed keywords

CORTICOTROPIN; GHRELIN; GLUCOSE; GROWTH HORMONE; GROWTH HORMONE SECRETAGOGUE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; HYDROCORTISONE; INSULIN; PLACEBO; PROLACTIN; SERINE;

ACYLATION; ADULT; AREA UNDER THE CURVE; ARTICLE; BODY MASS; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DRUG EFFECT; ENDOCRINE FUNCTION; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; HYDROCORTISONE BLOOD LEVEL; HYPERGLYCEMIA; HYPOPHYSIS FUNCTION; INSULIN BLOOD LEVEL; MALE; NORMAL HUMAN; PANCREAS FUNCTION; PROLACTIN BLOOD LEVEL; VOLUNTEER;

EID: 12444333167     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03345156     Document Type: Article

References (26)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999, 402: 656-660.
2. Kojima M., Hosoda H., Matsuo H., Kangawa K. Ghrelin: Discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol. Metabol. 2001, 12: 118-122.
3. Inui A. Ghrelin: An orexigenic and somatotrophic signal from the stomach. Nat. Rev. Neurosci. 2001, 2: 551-560.
4. Takaya K., Ariyasu H., Kanamoto N. et al. Ghrelin strongly stimulates growth hormone release in humans. J. Clin. Endocrinol. Metab. 2000, 85: 4908-4011.
5. Ghigo E., Arvat E., Giordano R. et al. Biologic activities of growth hormone secretagogues in humans. Endocrine 2001, 14: 87-93.
6. Smith R.G., Van Der Ploeg L.H., Howard A.D. et al. Peptidomimetric regulation of growth hormone secretion. Endocr. Rev. 1997, 18: 621-645.
7. Papotti M., Ghè C., Cassoni P. et al. Growth hormone secretagogue binding sites in peripheral human tissues. J. Clin. Endocrinol. Metab. 2000, 85: 3803-3807.
8. Volante M., Allia E., Gugliotta P. et al. Expression of ghrelin and of GHS receptor by pancreatic islet cells and related endocrine tumors. J. Clin. Endocrinol. Metab. 2002, 87: 1300-1308.
9. Date Y., Nakazato M., Hashiguchi S. et al. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 2002, 51: 124-129.
10. Arvat E., Maccario M., Di Vito L. et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: Comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J. Clin. Endocrinol. Metab. 2001, 86: 1169-1174.
11. Horvath T.L., Diano S., Sotonyi P., Heiman M.L., Tschop M. Ghrelin and the regulation of energy homeostasis: A hypothalamic perspective. Endocrinology 2001, 142: 4163-4169.
12. Zhang W., Chen M., Chen X., Segura B.J., Mulholland M.W. Inhibition of pancreatic protein secretion by ghrelin in the rat. J. Physiol. 2001, 537: 231-236.
13. Broglio F., Arvat E., Benso A. et al. Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J. Clin. Endocrinol. Metab. 2001, 86: 5083-5086.
14. Nagaya N., Kojima M., Uematsu M. et al. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am. J. Physiol. Regul. Intergr. Comp. Physiol. 2001, 280: R1483-R1487.
15. Nagaya N., Uematsu M., Kojima M. et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 2001, 104: 1430-1435.
16. Cassoni P., Papotti M., Catapano F. et al. Specific binding sites for synthetic growth hormone secretagogues in non-tumoral and neoplastic human thyroid tissue. J. Endocrinol. 2000, 165: 139-146.
17. Cassoni P., Papotti M., Ghè C. et al. Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. J. Clin. Endocrinol. Metab. 2001, 86: 1738-1745.
18. Ghè C., Cassoni P., Catalano F. et al. The antiproliferative effect of synthetic peptidyl growth hormone secretagogues (GHS) in CALU-1 lung carcinoma cells. Endocrinology 2002, 143: 484-491.
19. Date Y., Kojima M., Hosoda H. et al. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000, 141: 4255-4261.
20. Hewson A.K., Dickson S.L. Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J. Neuroendocrinol. 2000, 12: 1047-1049.
21. Bednarek M.A., Feighner S.D., Pong S.S. et al. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J. Med. Chem. 2000, 43: 4370-4376.
22. Matsumoto M., Hosoda H., Kitajima Y. et al. Structure-activity relationship of ghrelin: Pharmacological study of Ghrelin peptides. Biochem. Biophys. Res. Commun. 2001, 287: 142-146.
23. Arvat E., Di Vito L., Broglio F. et al. Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. J. Endocrinol. Invest. 2000, 23: 493-495.
24. Date Y., Nakazato M., Murakami N., Kojima M., Kangawa K., Matsukura S. Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem. Biophys. Res. Commun. 2001, 280: 904-907.
25. Muccioli G., Papotti M., Locatelli V. et al. Binding of 125 I-labeled ghrelin to membranes from human hypothalamus and pituitary gland. J. Endocrinol. Invest. 2001, 24: RC7-RC9.
26. Muccioli G., Tschop M., Papotti M., Deghenghi R., Heiman M., Ghigo E. Neuroendocrine and peripheral activities of ghrelin: Implications in metabolism and obesity. Eur. J. Pharmacol. 2002, 440: 235-254.