Hypothalamic ghrelin suppresses pulsatile secretion of luteinizing hormone via β-endorphin in ovariectomized rats

Neuroendocrinology

Volumn 90, Issue 4, 2009, Pages 364-370

  Ogata, Rie ^a   Matsuzaki, Toshiya ^a   Iwasa, Takeshi ^a   Kiyokawa, MacHiko ^a   Tanaka, Naoko ^a   Kuwahara, Akira ^a   Yasui, Toshiyuki ^a   Irahara, Minoru ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Endorphin; Ghrelin; Gonadotropin releasing hormone; Luteinizing hormone; Naloxone

Indexed keywords

BETA ENDORPHIN; GHRELIN; LUTEINIZING HORMONE; NALOXONE;

ANIMAL EXPERIMENT; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HYPOTHALAMUS; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE; RADIOIMMUNOASSAY; RAT;

ANIMALS; BETA-ENDORPHIN; BODY WEIGHT; CATHETERIZATION; FEMALE; GHRELIN; HYPOTHALAMUS; LUTEINIZING HORMONE; NALOXONE; NARCOTIC ANTAGONISTS; OVARIECTOMY; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; TIME FACTORS;

EID: 71849093763     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000257421     Document Type: Article

References (35)

1. Loucks AB, Heath EM: Dietary restriction reduces luteinizing hormone (LH) pulse frequency during waking hours and increases LH pulse amplitude during sleep in young menstruating women. J Clin Endocrinol Metab 1994; 78: 910-915.
2. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growthhormone releasing acylated peptide from stomach. Nature 1999; 402: 656-659.
3. Lu S, Guan JL, Wang QP, Uehara K, Yamada S, Goto N, Date Y, Nakazato M, Kojima M, Kangawa K, Shioda S: Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus. Neurosci Lett 2002; 321: 157-160.
4. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S: A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-198.
5. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K, Nakazato M: The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002; 123: 1120-1128.
6. Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T, Guan JL, Wang QP, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M: Ghrelininduced food intake is mediated via the orexin pathway. Endocrinology 2003; 144: 1506-1512.
7. McDonald JK, Lumpkin MD, DePaolo LV: Neuropeptide Y suppresses pulsatile secretion of luteinizing hormone in ovariectomized rats: Possible site of action. Endocrinology 1989; 125: 186-191.
8. Tamura T, Irahara M, Tezuka M, Kiyokawa M, Aono T: Orexins, orexigenic hypothalamic neuropeptides, suppress the pulsatile secretion of luteinizing hormone in ovariectomized female rats. Biochem Biophys Res Commun 1999; 264: 759-762.
9. Furuta M, Funabashi T, Kimura F: Intracerebroventricular administration of ghrelin rapidly suppresses pulsatile luteinizing hormone secretion in ovariectomized rats. Biochem Biophys Res Commun 2001; 288: 780-785.
10. Fernández-Fernández R, Tena-Sempere M, Navarro VM, Barreiro ML, Castellano JM, Aguilar E, Pinilla L: Effects of ghrelin upon gonadotropin-releasing hormone and gonadotropin secretion in adult female rats: In vivo and in vitro studies. Neuroendocrinology 2005; 82: 245-255. (Pubitemid 43800871)
11. Iqbal J, Kurose Y, Canny B, Clarke IJ: Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep. Endocrinology 2006; 147: 510-519.
12. Vulliémoz NR, Xiao E, Xia-Zhang L, Germond M, Rivier J, Ferin M: Decrease in luteinizing hormone pulse frequency during a five-hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab 2004; 89: 5718-5723.
13. Kluge M, Schüssler P, Uhr M, Yassouridis A, Steiger JA: Ghrelin suppresses secretion of luteinizing hormone in humans. J Clin Endocrinol Metab 2007; 92: 3202-3205.
14. Lanfranco F, Bonelli L, Baldi M, Me E, Broglio F, Ghigo E: Acylated ghrelin inhibits spontaneous LH pulsatility and responsiveness to naloxone, but not that to GnRH in young men: Evidence for a central inhibitory action of ghrelin on the gonadal axis. J Clin Endocrin Metab 2008; 93: 3633-3639.
15. Saito S, Shitsukawa K, Irahara M, Matsuzaki T, Aono T: Effects of 2-buten-4-olide, an endogenous feeding suppressant, on the pulsatile secretion of luteinizing hormone in ovariectomized rats. Acta Endocrinol (Copenh) 1993; 129: 467-472.
16. Irahara M, Tamura T, Matuzaki T, Saito S, Yasui T, Yamano S, Kamada M, Aono T: Orexin-A suppresses the pulsatile secretion of luteinizing hormone via - -endorphin. Biochem Biophys Res Commun 2001; 281: 232-236.
17. Kaji H, Saito S, Shitsukawa K, Irahara M, Aono T: The endogenous feeding suppressant, 2-buten-4-olide, impairs the pulsatile secretion of luteinizing hormone through endogenous opioid peptides. Eur J Endocrinol 1998; 138: 198-205.
18. Sibilia V, Lattuada N, Rapetti D, Pagani F, Vincenza D, Bulgarelli I, Locatelli V, Guidobono F, Netti C: Ghrelin inhibits inflammatory pain in rats: Involvement of the opioid system. Neuropharmacology 2006; 51: 497-505.
19. Paxinos G, Watson C: The Rat Brain in Stereotaxic Coordinates. Sydney, Academic Press, 1982.
20. Harms PG, Ojeda SR: A rapid and simple procedure for chronic cannulation of the rat jugular vein. J Appl Physiol 1974; 36: 391-392.
21. Gallo RV: Pulsatile LH release during ovulatory LH surge on proestrus in the rat. Biol Reprod 1981; 24: 100-104.
22. De Paolo LV, King RA, Carrillo AJ: In vivo and in vitro examination of an autoregulatory mechanism for luteinizing hormone-releasing hormone. Endocrinology 1987; 120: 272-279.
23. Culler MD: Role of Leydig cells and endogenous inhibin in regulating pulsatile gonadotropin secretion in the adult male rat. Endocrinology 1990; 127: 2540-2550.
24. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E: Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 2003; 100: 10972-10976.
25. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno Jr JS, Shagoury JK, Bo- Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley Jr WF, Aparicio SA, Colledge WH: The GPR54 gene as a regulator of puberty. N Engl J Med 2003; 349: 1614-1627.
26. Smith JT, Acohido BV, Clifton DK, Steiner RA: KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J Neuroendocrinol 2006; 18: 298-303.
27. Messager S, Chatzidaki EE, Ma D, Hendrick AG, Zahn D, Dixon J, Thresher RR, Malinge I, Lomet D, Carlton MB, Colledge WH, Caraty A, Aparicio SA: Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci USA 2005; 102: 1761-1766.
28. Guan XM, Yu H, Palyha OC, Mckee KK, Feighner SD, Sirinathsinghji DJ, Smith RG, Van der Ploeg LH, Howard AD: Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Mol Brain Res 1997; 48: 23-29. (Pubitemid 27298124)
29. Kimura F, Funabashi T: Two subgroups of gonadotropin-releasing hormone (GnRH) neurons control gonadotropin secretion in rats. News Physiol Sci 1998; 13: 225-231.
30. Guan JL, Okuda H, Takenoya F, Kintaka Y, Yagi M, Wang L, Seki M, Hori Y, Kageyama H, Shioda S: Synaptic relationships between proopiomelanocortin- and ghrelin-containing neurons in the rat arcuate nucleus. Regul Pept 2008; 145: 128-132. (Pubitemid 350296371)
31. Willesen MG, Kristensen P, Romer J: Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 1999; 70: 306-316.
32. Funabashi T, Kato A, Kimura F: Naloxone affects the luteinizing hormone secretory pattern in the short- and long-term ovariectomized rat. Neuroendocrinology 1990; 52: 35-41.
33. Kimura F, Nishihara M, Hiruma H, Funabashi T: Naloxone increases the frequency of the electrical activity of luteinizing hormone-releasing hormone pulse generator in long-term ovariectomized rats. Neuroendocrinology 1991; 53: 97-102.
34. Vulliémoz NR, Xiao E, Xia-Zhang L, Rivier J, Ferin M: Astressin B, a nonselective corticotropin- releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey. Endocrinology 2008; 149: 869-874.
35. Iwasa T, Matsuzaki T, Kiyokawa M, Shimizu F, Minakuchi M, Kuwahara A, Maegawa M, Yasui T, Irahara M: The type 2 corticotrophin- releasing hormone receptor mediates orexin A-induced luteinising hormone suppression in ovariectomised rats. J Neuroendocrinol 2007; 19: 732-738.