Decreased active, total and altered active to total ghrelin ratio in normal weight women with the more severe form of polycystic ovary syndrome

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 149, Issue 2, 2010, Pages 170-174

  Panidis, Dimitrios ^a   Asteriadis, Chrisostomos ^a   Georgopoulos, Neoklis A ^b   Katsikis, Ilias ^a   Zournatzi, Vassiliki ^a   Karkanaki, Artemis ^a   Saltamavros, Alexandros D ^b   Decavalas, George ^b   Diamanti Kandarakis, Evanthia ^c  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c LAIKO GENERAL HOSPITAL   (Greece)

Author keywords

Active ghrelin; Active to total ghrelin ratio; Hyperandrogenism; Polycystic ovary syndrome; Total ghrelin

Indexed keywords

GHRELIN;

ADULT; ANOVULATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HYPERANDROGENISM; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STATISTICAL SIGNIFICANCE;

EID: 77649189133     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2009.12.019     Document Type: Article

References (24)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
2. Nakazato M., Murakami N., Date Y., et al. A role for ghrelin in the central regulation of feeding. Nature 409 (2001) 194-198
3. Wren A.M., Small C.J., Ward H.L., et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141 (2000) 4325-4328
4. Wren A.M., Seal L.J., Cohen M.A., et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86 (2001) 5992-5995
5. Van Der Lely A.J., Tschop M., Heiman M., and Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25 (2004) 426-457
6. Shiiya T., Nakazato M., Mizuta M., et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87 (2002) 240-244
7. Tschop M., Weyer C., Tataranni P.A., Devanaryan V., Ravussin E., and Heiman M.L. Circulating ghrelin levels are decreased in human obesity. Diabetes 50 (2001) 707-709
8. Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 19 (2004) 41-47
9. Goodarzi M.O., and Korenman S.G. The importance of insulin resistance in polycystic ovary syndrome. Fertil Steril 80 (2003) 255-258
10. Pagotto U., Gambineri A., Vicennati V., Heiman M.L., Tschop M., and Pasquali R. Plasma ghrelin, obesity, and the polycystic ovary syndrome, correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab 87 (2002) 5625-5629
11. Schofl C., Horn R., Schill T., Schlosser H.W., Muller M.J., and Brabant G. Circulating ghrelin levels in patients with polycystic ovary syndrome. J Clin Endocrinol Metab 87 (2002) 4607-4610
12. Moran L.J., Noakes M., Clifton P.M., et al. Ghrelin and measures of satiety are altered in polycystic ovary syndrome but not differentially affected by diet composition. J Clin Endocrinol Metab 89 (2004) 3337-3344
13. Mitkov M., Pehlivanov B., and Orbetzova M. Serum ghrelin level in women with polycystic ovary syndrome and its relationship with endocrine and metabolic parameters. Gynecol Endocrinol 24 (2008) 625-630
14. Glinborg D., Andersen M., Hagen C., et al. Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS) Adiponectin, ghrelin, leptin and body composition in hirsute Women with PCOS and controls. Eur J Endocrinol 155 (2006) 337-345
15. Wasko R., Komarowska H., Warenik-Szymankiewicz A., and Sowinski J. Elevated ghrelin plasma levels in patients with polycystic ovary syndrome. Horm Metab Res 36 (2004) 170-173
16. Panidis D., Farmakiotis D., Koliakos G., et al. Comparative study of plasma ghrelin levels in women with polycystic ovary syndrome, in hyperandrogenic women and in normal controls. Hum Reprod 20 (2005) 2127-2132
17. Zwirska-Korczala K., Sodowski K., Konturek S.J., et al. Postprandial response of ghrelin and PYY and indices of low-grade chronic inflammation in lean young women with polycystic ovary syndrome. J Physiol Pharmacol 59 Suppl. 2 (2008) 161-178
18. Liu J., Prudom C.E., Nass R., et al. Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men. J Clin Endocrinol Metab 93 (2008) 1980-1987
19. In: Zawadski J.K., and Dunaif A. (Eds). Polycystic ovary syndrome (1992), Blackwell Scientific Publications, Boston
20. Norman R.J., Dewailly D., Legro R.S., and Hickey T.E. Polycystic ovary syndrome. Lancet 370 (2007) 685-697
21. Tai M.M. A Mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diabetes Care 17 (1994) 152-154
22. Fernandez-Fernandez R., Tena-Sempere M., Aguilar E., and Pinilla L. Ghrelin effects on gonadotropin secretion in male and female rats. Neurosci Lett 362 (2004) 103-107
23. Vulliemoz N.R., Xiao E., Xia-Zhang L., Germond M., Rivier J., and Ferin M. Decrease in luteinizing hormone pulse frequency during a five hour peripheral ghrelin infusion in the ovariectomized rhesus monkey. J Clin Endocrinol Metab 89 (2004) 5718-5723
24. Barreiro M.L., and Tena-Sempere M. Ghrelin and reproduction: a novel signal linking energy status and infertility?. Mol Cell Endocrinol 29 (2004) 1-9