-
2
-
-
0041330433
-
Receptor-mediated choreography of life and death
-
Bhardwaj, A.; Aggarwal, B.B. Receptor-mediated choreography of life and death. J. Clin. Immun., 2003, 23, 317-332.
-
(2003)
J. Clin. Immun.
, vol.23
, pp. 317-332
-
-
Bhardwaj, A.1
Aggarwal, B.B.2
-
4
-
-
0036162436
-
The molecular architecture of the TNF superfamily
-
Bodmer, J.L.; Schneider, P.; Tschopp, J. The molecular architecture of the TNF superfamily. Trends in Biochem.Sci., 2002, 27, 19-26.
-
(2002)
Trends in Biochem.Sci.
, vol.27
, pp. 19-26
-
-
Bodmer, J.L.1
Schneider, P.2
Tschopp, J.3
-
5
-
-
9944222054
-
Exploiting death receptor signaling pathways for tumor therapy
-
Fulda, S.; Debatin, K.M. Exploiting death receptor signaling pathways for tumor therapy. Biochimica et Biophysica Acta, 2004, 1705, 27-41.
-
(2004)
Biochimica Et Biophysica Acta
, vol.1705
, pp. 27-41
-
-
Fulda, S.1
Debatin, K.M.2
-
6
-
-
0032575714
-
Death receptors: Signaling and modulation
-
Ashkenazi, A.; Dixit, V.M. Death receptors: signaling and modulation. Science, 1998, 281, 1305-1308.
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
7
-
-
14044278251
-
Death receptor signaling
-
Lavrik, I.; Golks, A.; Krammer, P.H. Death receptor signaling. Journal of Cell Science, 2005, 118, 265-267.
-
(2005)
Journal of Cell Science
, vol.118
, pp. 265-267
-
-
Lavrik, I.1
Golks, A.2
Krammer, P.H.3
-
8
-
-
0037276437
-
The CD95(APO-1/Fas) DISC and beyond
-
Peter, M.E.; Krammer, P.H. The CD95(APO-1/Fas) DISC and beyond. Cell Death Diff., 2003, 10, 26-35.
-
(2003)
Cell Death Diff.
, vol.10
, pp. 26-35
-
-
Peter, M.E.1
Krammer, P.H.2
-
9
-
-
35948933964
-
Death receptor-mediated liver injury
-
Akazawa, Y.; Gores, G.J. Death receptor-mediated liver injury. Semin. Liver Dis., 2007, 27, 327-338.
-
(2007)
Semin. Liver Dis.
, vol.27
, pp. 327-338
-
-
Akazawa, Y.1
Gores, G.J.2
-
10
-
-
14944385553
-
Global cancer statistics
-
2002. CA
-
Parkin, D.M.; Bray, F.; Ferlay, J.; Pisani, P. Global cancer statistics, 2002. CA Cancer J. Clin., 2005, 55, 74-108.
-
(2005)
Cancer J. Clin.
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
11
-
-
0035888074
-
Estimating the world cancer burden: Globocan 2000
-
Parkin, D.M.; Bray, F.; Ferlay, J.; Pisani, P. Estimating the world cancer burden: Globocan 2000. Int. J. Cancer, 2001, 94, 153-156.
-
(2001)
Int. J. Cancer
, vol.94
, pp. 153-156
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
12
-
-
34250020201
-
Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
-
El-Serag, H.B.; Rudolph, K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 2007, 132, 2557-2576.
-
(2007)
Gastroenterology
, vol.132
, pp. 2557-2576
-
-
El-Serag, H.B.1
Rudolph, K.L.2
-
13
-
-
0027291205
-
Lethal effect of the anti-Fas antibody in mice
-
Ogasawara, J.; Watanabe-Fukunaga, R.; Adachi, M.; Matsuzawa, A.; Kasugai, T.; Kitamura, Y.; Itoh, N.; Suda, T.; Nagata, S. Lethal effect of the anti-Fas antibody in mice. Nature, 1993, 364, 806-809.
-
(1993)
Nature
, vol.364
, pp. 806-809
-
-
Ogasawara, J.1
Watanabe-Fukunaga, R.2
Adachi, M.3
Matsuzawa, A.4
Kasugai, T.5
Kitamura, Y.6
Itoh, N.7
Suda, T.8
Nagata, S.9
-
14
-
-
0028783367
-
Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage
-
Galle, P.R.; Hofmann, W.J.; Walczak, H.; Schaller, H.; Otto, G.; Stremmel, W.; Krammer, P.H.; Runkel, L. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J. Exp. Med., 1995, 182, 1223-1230.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1223-1230
-
-
Galle, P.R.1
Hofmann, W.J.2
Walczak, H.3
Schaller, H.4
Otto, G.5
Stremmel, W.6
Krammer, P.H.7
Runkel, L.8
-
15
-
-
0030035921
-
Fas antigen expression and its relationship with apoptosis in human hepatocellular carcinoma and noncancerous tissues
-
Higaki, K.; Yano, H.; Kojiro, M. Fas antigen expression and its relationship with apoptosis in human hepatocellular carcinoma and noncancerous tissues. Am. J. Path., 1996, 149, 429-437.
-
(1996)
Am. J. Path.
, vol.149
, pp. 429-437
-
-
Higaki, K.1
Yano, H.2
Kojiro, M.3
-
16
-
-
0031985504
-
Fas antigen expression in hepatocellular carcinoma tissues
-
Ito, Y.; Takeda, T.; Umeshita, K.; Sakon, M.; Wakasa, K.; Matsuura, N.; Monden, M. Fas antigen expression in hepatocellular carcinoma tissues. Oncol. Reports, 1998, 5, 41-44.
-
(1998)
Oncol. Reports
, vol.5
, pp. 41-44
-
-
Ito, Y.1
Takeda, T.2
Umeshita, K.3
Sakon, M.4
Wakasa, K.5
Matsuura, N.6
Monden, M.7
-
17
-
-
0027584709
-
Hepatocellular carcinoma with portal tumor thrombus: Analysis of factors determining prognosis
-
Fujii, T.; Takayasu, K.; Muramatsu, Y.; Moriyama, N.; Wakao, F.; Kosuge, T.; Takayama, T.; Makuuchi, M.; Yamasaki, S.; Okazaki, N.; et al. Hepatocellular carcinoma with portal tumor thrombus: analysis of factors determining prognosis. Jpn. J. Clin. Oncol., 1993, 23, 105-109.
-
(1993)
Jpn. J. Clin. Oncol.
, vol.23
, pp. 105-109
-
-
Fujii, T.1
Takayasu, K.2
Muramatsu, Y.3
Moriyama, N.4
Wakao, F.5
Kosuge, T.6
Takayama, T.7
Makuuchi, M.8
Yamasaki, S.9
Okazaki, N.10
-
18
-
-
0031911767
-
Surgical intervention for patients with stage IV-A hepatocellular carcinoma without lymph node metastasis: Proposal as a standard therapy
-
Ikai, I.; Yamaoka, Y.; Yamamoto, Y.; Ozaki, N.; Sakai, Y.; Satoh, S.; Shinkura, N.; Yamamoto, M. Surgical intervention for patients with stage IV-A hepatocellular carcinoma without lymph node metastasis: proposal as a standard therapy. Ann. Surg., 1998, 227, 433-439.
-
(1998)
Ann. Surg.
, vol.227
, pp. 433-439
-
-
Ikai, I.1
Yamaoka, Y.2
Yamamoto, Y.3
Ozaki, N.4
Sakai, Y.5
Satoh, S.6
Shinkura, N.7
Yamamoto, M.8
-
19
-
-
0035119043
-
Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein
-
Fan, J.; Wu, Z.Q.; Tang, Z.Y.; Zhou, J.; Qiu, S.J.; Ma, Z.C.; Zhou, X.D.; Ye, S.L. Multimodality treatment in hepatocellular carcinoma patients with tumor thrombi in portal vein. World J. Gastroenterol., 2001, 7, 28-32.
-
(2001)
World J. Gastroenterol.
, vol.7
, pp. 28-32
-
-
Fan, J.1
Wu, Z.Q.2
Tang, Z.Y.3
Zhou, J.4
Qiu, S.J.5
Ma, Z.C.6
Zhou, X.D.7
Ye, S.L.8
-
20
-
-
0141491273
-
Hepatocellular carcinoma
-
Llovet, J.M.; Burroughs, A.; Bruix, J. Hepatocellular carcinoma. Lancet, 2003, 362, 1907-1917.
-
(2003)
Lancet
, vol.362
, pp. 1907-1917
-
-
Llovet, J.M.1
Burroughs, A.2
Bruix, J.3
-
21
-
-
0026071402
-
Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression
-
Shen, D.W.; Lu, Y.G.; Chin, K.V.; Pastan, I.; Gottesman, M.M. Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression. J. Cell Sci., 1991, 98 (Pt 3), 317-322.
-
(1991)
J. Cell Sci.
, vol.98
, Issue.PART 3
, pp. 317-322
-
-
Shen, D.W.1
Lu, Y.G.2
Chin, K.V.3
Pastan, I.4
Gottesman, M.M.5
-
22
-
-
0023878653
-
Intrahepatic chemotherapy for unresectable hepatocellular carcinoma
-
Doci, R.; Bignami, P.; Bozzetti, F.; Bonfanti, G.; Audisio, R.; Colombo, M.; Gennari, L. Intrahepatic chemotherapy for unresectable hepatocellular carcinoma. Cancer, 1988, 61, 1983-1987.
-
(1988)
Cancer
, vol.61
, pp. 1983-1987
-
-
Doci, R.1
Bignami, P.2
Bozzetti, F.3
Bonfanti, G.4
Audisio, R.5
Colombo, M.6
Gennari, L.7
-
23
-
-
0036096420
-
Hepatocellular carcinoma: Diagnosis and treatment
-
Befeler, A.S.; Di Bisceglie, A.M. Hepatocellular carcinoma: diagnosis and treatment. Gastroenterology, 2002, 122, 1609-1619.
-
(2002)
Gastroenterology
, vol.122
, pp. 1609-1619
-
-
Befeler, A.S.1
Di Bisceglie, A.M.2
-
24
-
-
0034786583
-
Ablative techniques for hepatocellular carcinoma. Semin
-
Barnett, C.C., Jr.; Curley, S.A. Ablative techniques for hepatocellular carcinoma. Semin. Oncol., 2001, 28, 487-496.
-
(2001)
Oncol
, vol.28
, pp. 487-496
-
-
Barnett Jr., C.C.1
Curley, S.A.2
-
25
-
-
0035936797
-
The TNF and TNF receptor superfamilies: Integrating mammalian biology
-
Locksley, R.M.; Killeen, N.; Lenardo, M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell, 2001, 104, 487-501.
-
(2001)
Cell
, vol.104
, pp. 487-501
-
-
Locksley, R.M.1
Killeen, N.2
Lenardo, M.J.3
-
26
-
-
0027251830
-
Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation
-
Komori, A.; Yatsunami, J.; Suganuma, M.; Okabe, S.; Abe, S.; Sakai, A.; Sasaki, K.; Fujiki, H. Tumor necrosis factor acts as a tumor promoter in BALB/3T3 cell transformation. Cancer Res., 1993, 53, 1982-1985.
-
(1993)
Cancer Res
, vol.53
, pp. 1982-1985
-
-
Komori, A.1
Yatsunami, J.2
Suganuma, M.3
Okabe, S.4
Abe, S.5
Sakai, A.6
Sasaki, K.7
Fujiki, H.8
-
27
-
-
33646525667
-
Cytokine patterns correlate with liver damage in patients with chronic hepatitis B and C
-
Falasca, K.; Ucciferri, C.; Dalessandro, M.; Zingariello, P.; Mancino, P.; Petrarca, C.; Pizzigallo, E.; Conti, P.; Vecchiet, J. Cytokine patterns correlate with liver damage in patients with chronic hepatitis B and C. Ann. Clin. Lab. Sci., 2006, 36, 144-150.
-
(2006)
Ann. Clin. Lab. Sci
, vol.36
, pp. 144-150
-
-
Falasca, K.1
Ucciferri, C.2
Dalessandro, M.3
Zingariello, P.4
Mancino, P.5
Petrarca, C.6
Pizzigallo, E.7
Conti, P.8
Vecchiet, J.9
-
28
-
-
14744291990
-
Molecular mechanisms in hepatocellular carcinoma development. Best Pract
-
Cha, C.; Dematteo, R.P. Molecular mechanisms in hepatocellular carcinoma development. Best Pract. Res. Clin. Gastroenterol., 2005, 19, 25-37.
-
(2005)
Res. Clin. Gastroenterol
, vol.19
, pp. 25-37
-
-
Cha, C.1
Dematteo, R.P.2
-
29
-
-
1542602172
-
Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia
-
Catalano, M.G.; Fortunati, N.; Arena, K.; Costelli, P.; Aragno, M.; Danni, O.; Boccuzzi, G. Selective up-regulation of tumor necrosis factor receptor I in tumor-bearing rats with cancer-related cachexia. Int. J. Oncol., 2003, 23, 429-436.
-
(2003)
Int. J. Oncol
, vol.23
, pp. 429-436
-
-
Catalano, M.G.1
Fortunati, N.2
Arena, K.3
Costelli, P.4
Aragno, M.5
Danni, O.6
Boccuzzi, G.7
-
30
-
-
36049033413
-
Tumor necrosis factor-alpha 308.2 polymorphism is associated with advanced hepatic fibrosis and higher risk for hepatocellular carcinoma
-
Jeng, J.E.; Tsai, J.F.; Chuang, L.Y.; Ho, M.S.; Lin, Z.Y.; Hsieh, M.Y.; Chen, S.C.; Chuang, W.L.; Wang, L.Y.; Yu, M.L.; Dai, C.Y.; Chang, J.G. Tumor necrosis factor-alpha 308.2 polymorphism is associated with advanced hepatic fibrosis and higher risk for hepatocellular carcinoma. Neoplasia, 2007, 9, 987-992.
-
(2007)
Neoplasia
, vol.9
, pp. 987-992
-
-
Jeng, J.E.1
Tsai, J.F.2
Chuang, L.Y.3
Ho, M.S.4
Lin, Z.Y.5
Hsieh, M.Y.6
Chen, S.C.7
Chuang, W.L.8
Wang, L.Y.9
Yu, M.L.10
Dai, C.Y.11
Chang, J.G.12
-
31
-
-
0037204948
-
TNF-R1 signaling: A beautiful pathway
-
Chen, G.; Goeddel, D.V. TNF-R1 signaling: a beautiful pathway. Science, 2002, 296, 1634-1635.
-
(2002)
Science
, vol.296
, pp. 1634-1635
-
-
Chen, G.1
Goeddel, D.V.2
-
32
-
-
0041853690
-
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
-
Micheau, O.; Tschopp, J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell, 2003, 114, 181-190.
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
33
-
-
0032508414
-
NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang, C.Y.; Mayo, M.W.; Korneluk, R.G.; Goeddel, D.V.; Baldwin, A.S., Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science, 1998, 281, 1680-1683.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
Goeddel, D.V.4
Baldwin Jr., A.S.5
-
34
-
-
0034743199
-
NF-kappaB signals induce the expression of c-FLIP
-
Micheau, O.; Lens, S.; Gaide, O.; Alevizopoulos, K.; Tschopp, J. NF-kappaB signals induce the expression of c-FLIP. Mol. Cell. Biol., 2001, 21, 5299-5305.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 5299-5305
-
-
Micheau, O.1
Lens, S.2
Gaide, O.3
Alevizopoulos, K.4
Tschopp, J.5
-
35
-
-
0034719680
-
The transcription factor NF-kappaB: Control of oncogenesis and cancer therapy resistance
-
Mayo, M.W.; Baldwin, A.S. The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance. Biochimica et Biophysica Acta, 2000, 1470, M55-62.
-
(2000)
Biochimica Et Biophysica Acta
, vol.1470
-
-
Mayo, M.W.1
Baldwin, A.S.2
-
36
-
-
0038320263
-
The signaling adaptors and pathways activated by TNF superfamily
-
Dempsey, P.W.; Doyle, S.E.; He, J.Q.; Cheng, G. The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev., 2003, 14, 193-209.
-
(2003)
Cytokine Growth Factor Rev
, vol.14
, pp. 193-209
-
-
Dempsey, P.W.1
Doyle, S.E.2
He, J.Q.3
Cheng, G.4
-
37
-
-
70349568358
-
A lymphotoxindriven pathway to hepatocellular carcinoma
-
Haybaeck, J.; Zeller, N.; Wolf, M.J.; Weber, A.; Wagner, U.; Kurrer, M.O.; Bremer, J.; Iezzi, G.; Graf, R.; Clavien, P.A.; Thimme, R.; Blum, H.; Nedospasov, S.A.; Zatloukal, K.; Ramzan, M.; Ciesek, S.; Pietschmann, T.; Marche, P.N.; Karin, M.; Kopf, M.; Browning, J.L.; Aguzzi, A.; Heikenwalder, M. A lymphotoxindriven pathway to hepatocellular carcinoma. Cancer Cell, 2009, 16, 295-308.
-
(2009)
Cancer Cell
, vol.16
, pp. 295-308
-
-
Haybaeck, J.1
Zeller, N.2
Wolf, M.J.3
Weber, A.4
Wagner, U.5
Kurrer, M.O.6
Bremer, J.7
Iezzi, G.8
Graf, R.9
Clavien, P.A.10
Thimme, R.11
Blum, H.12
Nedospasov, S.A.13
Zatloukal, K.14
Ramzan, M.15
Ciesek, S.16
Pietschmann, T.17
Marche, P.N.18
Karin, M.19
Kopf, M.20
Browning, J.L.21
Aguzzi, A.22
Heikenwalder, M.23
more..
-
38
-
-
78650794472
-
Cell death and hepatocarcinogenesis: Dysregulation of apoptosis signaling pathways
-
Schattenberg, J.M.; Schuchmann, M.; Galle, P.R. Cell death and hepatocarcinogenesis: Dysregulation of apoptosis signaling pathways. Journal of Gastroenterology and Hepatology, 2011, 26(Suppl 1), 213-219.
-
(2011)
Journal of Gastroenterology and Hepatology
, vol.26
, Issue.SUPPL. 1
, pp. 213-219
-
-
Schattenberg, J.M.1
Schuchmann, M.2
Galle, P.R.3
-
39
-
-
77953692968
-
Targeting TNF for Treatment of Cancer and Autoimmunity
-
Sethi, G.; Sung, B.; Kunnumakkara, A.B.; Aggarwal, B.B. Targeting TNF for Treatment of Cancer and Autoimmunity. Adv. Exp. Med. Biol., 2009, 647, 37-51.
-
(2009)
Adv. Exp. Med. Biol
, vol.647
, pp. 37-51
-
-
Sethi, G.1
Sung, B.2
Kunnumakkara, A.B.3
Aggarwal, B.B.4
-
40
-
-
77954216210
-
Exploring death receptor pathways as selective targets in cancer therapy
-
Russo, M.; Mupo, A.; Spagnuolo, C.; Russo, G.L. Exploring death receptor pathways as selective targets in cancer therapy. Biochem. Pharmacol., 2010, 80, 674-682.
-
(2010)
Biochem. Pharmacol
, vol.80
, pp. 674-682
-
-
Russo, M.1
Mupo, A.2
Spagnuolo, C.3
Russo, G.L.4
-
41
-
-
14044278635
-
Tumor therapeutics by design: Targeting and activation of death receptors
-
Wajant, H.; Gerspach, J.; Pfizenmaier, K. Tumor therapeutics by design: targeting and activation of death receptors. Cytokine Growth Factor Rev., 2005, 16, 55-76.
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 55-76
-
-
Wajant, H.1
Gerspach, J.2
Pfizenmaier, K.3
-
42
-
-
78049447099
-
Tumstatin45-132-TNFalpha suppresses tumour growth through antiangiogenic effects and cytotoxicity
-
Yan, Y.; Xu, W.; Qian, H.; Zhu, W.; Mao, F.; Zhang, X. Tumstatin45-132-TNFalpha suppresses tumour growth through antiangiogenic effects and cytotoxicity. Biotechnol. App. Biochem., 2010, 56, 119-127.
-
(2010)
Biotechnol. App. Biochem
, vol.56
, pp. 119-127
-
-
Yan, Y.1
Xu, W.2
Qian, H.3
Zhu, W.4
Mao, F.5
Zhang, X.6
-
43
-
-
19944430018
-
Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window
-
Shibata, H.; Yoshioka, Y.; Ikemizu, S.; Kobayashi, K.; Yamamoto, Y.; Mukai, Y.; Okamoto, T.; Taniai, M.; Kawamura, M.; Abe, Y.; Nakagawa, S.; Hayakawa, T.; Nagata, S.; Yamagata, Y.; Mayumi, T.; Kamada, H.; Tsutsumi, Y. Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window. Clin. Cancer Res., 2004, 10, 8293-8300.
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 8293-8300
-
-
Shibata, H.1
Yoshioka, Y.2
Ikemizu, S.3
Kobayashi, K.4
Yamamoto, Y.5
Mukai, Y.6
Okamoto, T.7
Taniai, M.8
Kawamura, M.9
Abe, Y.10
Nakagawa, S.11
Hayakawa, T.12
Nagata, S.13
Yamagata, Y.14
Mayumi, T.15
Kamada, H.16
Tsutsumi, Y.17
-
44
-
-
70449707487
-
Improving TNF as a cancer therapeutic: Tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects
-
Gerspach, J.; Pfizenmaier, K.; Wajant, H. Improving TNF as a cancer therapeutic: tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects. Biofactors, 2009, 35, 364-372.
-
(2009)
Biofactors
, vol.35
, pp. 364-372
-
-
Gerspach, J.1
Pfizenmaier, K.2
Wajant, H.3
-
45
-
-
67651115664
-
Translation of the radio- and chemo-inducible TNFerade vector to the treatment of human cancers
-
Weichselbaum, R.R.; Kufe, D. Translation of the radio- and chemo-inducible TNFerade vector to the treatment of human cancers. Cancer Gene Ther., 2009, 16, 609-619.
-
(2009)
Cancer Gene Ther
, vol.16
, pp. 609-619
-
-
Weichselbaum, R.R.1
Kufe, D.2
-
46
-
-
0030747592
-
The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma
-
Amirkhosravi, A.; Warnes, G.; Biggerstaff, J.; Malik, Z.; May, K.; Francis, J.L. The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse Neuro2a neuroblastoma. Clin. Exp. Metastasis, 1997, 15, 453-461.
-
(1997)
Clin. Exp. Metastasis
, vol.15
, pp. 453-461
-
-
Amirkhosravi, A.1
Warnes, G.2
Biggerstaff, J.3
Malik, Z.4
May, K.5
Francis, J.L.6
-
47
-
-
0344305652
-
Low-dose thalidomide treatment for advanced hepatocellular carcinoma
-
Hsu, C.; Chen, C.N.; Chen, L.T.; Wu, C.Y.; Yang, P.M.; Lai, M.Y.; Lee, P.H.; Cheng, A.L. Low-dose thalidomide treatment for advanced hepatocellular carcinoma. Oncology, 2003, 65, 242-249.
-
(2003)
Oncology
, vol.65
, pp. 242-249
-
-
Hsu, C.1
Chen, C.N.2
Chen, L.T.3
Wu, C.Y.4
Yang, P.M.5
Lai, M.Y.6
Lee, P.H.7
Cheng, A.L.8
-
48
-
-
38549176118
-
Tumor necrosis factor antagonist mechanisms of action: A comprehensive review
-
Tracey, D.; Klareskog, L.; Sasso, E.H.; Salfeld, J.G.; Tak, P.P. Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. Pharmacol. Ther., 2008, 117, 244-279.
-
(2008)
Pharmacol. Ther
, vol.117
, pp. 244-279
-
-
Tracey, D.1
Klareskog, L.2
Sasso, E.H.3
Salfeld, J.G.4
Tak, P.P.5
-
49
-
-
43949126520
-
Mechanisms for cytotoxic effects of anti-tumor necrosis factor agents on transmembrane tumor necrosis factor alpha-expressing cells: Comparison among infliximab, etanercept, and adalimumab
-
Mitoma, H.; Horiuchi, T.; Tsukamoto, H.; Tamimoto, Y.; Kimoto, Y.; Uchino, A.; To, K.; Harashima, S.; Hatta, N.; Harada, M. Mechanisms for cytotoxic effects of anti-tumor necrosis factor agents on transmembrane tumor necrosis factor alpha-expressing cells: comparison among infliximab, etanercept, and adalimumab. Arth. Rheum., 2008, 58, 1248-1257.
-
(2008)
Arth. Rheum
, vol.58
, pp. 1248-1257
-
-
Mitoma, H.1
Horiuchi, T.2
Tsukamoto, H.3
Tamimoto, Y.4
Kimoto, Y.5
Uchino, A.6
To, K.7
Harashima, S.8
Hatta, N.9
Harada, M.10
-
50
-
-
29744441553
-
Caspase activation and apoptosis induction by adalimumab: Demonstration in vitro and in vivo in a chimeric mouse model
-
Shen, C.; Van Assche, G.; Rutgeerts, P.; Ceuppens, J.L. Caspase activation and apoptosis induction by adalimumab: demonstration in vitro and in vivo in a chimeric mouse model. Inflamm. Bowel Dis., 2006, 12, 22-28.
-
(2006)
Inflamm. Bowel Dis
, vol.12
, pp. 22-28
-
-
Shen, C.1
van Assche, G.2
Rutgeerts, P.3
Ceuppens, J.L.4
-
51
-
-
77949879162
-
Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway
-
Seitz, S.J.; Schleithoff, E.S.; Koch, A.; Schuster, A.; Teufel, A.; Staib, F.; Stremmel, W.; Melino, G.; Krammer, P.H.; Schilling, T.; Muller, M. Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Inter. J. Cancer, 2010, 126, 2049-2066.
-
(2010)
Inter. J. Cancer
, vol.126
, pp. 2049-2066
-
-
Seitz, S.J.1
Schleithoff, E.S.2
Koch, A.3
Schuster, A.4
Teufel, A.5
Staib, F.6
Stremmel, W.7
Melino, G.8
Krammer, P.H.9
Schilling, T.10
Muller, M.11
-
52
-
-
22744459472
-
TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria
-
Gressner, O.; Schilling, T.; Lorenz, K.; Schulze Schleithoff, E.; Koch, A.; Schulze-Bergkamen, H.; Lena, A.M.; Candi, E.; Terrinoni, A.; Catani, M.V.; Oren, M.; Melino, G.; Krammer, P.H.; Stremmel, W.; Muller, M. TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. EMBO J., 2005, 24, 2458-2471.
-
(2005)
EMBO J
, vol.24
, pp. 2458-2471
-
-
Gressner, O.1
Schilling, T.2
Lorenz, K.3
Schulze, S.E.4
Koch, A.5
Schulze-Bergkamen, H.6
Lena, A.M.7
Candi, E.8
Terrinoni, A.9
Catani, M.V.10
Oren, M.11
Melino, G.12
Krammer, P.H.13
Stremmel, W.14
Muller, M.15
-
53
-
-
27944476397
-
TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma
-
Muller, M.; Schilling, T.; Sayan, A.E.; Kairat, A.; Lorenz, K.; Schulze-Bergkamen, H.; Oren, M.; Koch, A.; Tannapfel, A.; Stremmel, W.; Melino, G.; Krammer, P.H. TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death Diff., 2005, 12, 1564-1577.
-
(2005)
Cell Death Diff
, vol.12
, pp. 1564-1577
-
-
Muller, M.1
Schilling, T.2
Sayan, A.E.3
Kairat, A.4
Lorenz, K.5
Schulze-Bergkamen, H.6
Oren, M.7
Koch, A.8
Tannapfel, A.9
Stremmel, W.10
Melino, G.11
Krammer, P.H.12
-
54
-
-
0036020941
-
NF-kappaB as a therapeutic target in cancer
-
Orlowski, R.Z.; Baldwin, A.S., Jr. NF-kappaB as a therapeutic target in cancer. Trends Mol. Med., 2002, 8, 385-389.
-
(2002)
Trends Mol. Med
, vol.8
, pp. 385-389
-
-
Orlowski, R.Z.1
Baldwin Jr., A.S.2
-
55
-
-
0032905030
-
Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB
-
Wang, C.Y.; Cusack, J.C., Jr.; Liu, R.; Baldwin, A.S., Jr. Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat. Med., 1999, 5, 412-417.
-
(1999)
Nat. Med
, vol.5
, pp. 412-417
-
-
Wang, C.Y.1
Cusack Jr., J.C.2
Liu, R.3
Baldwin Jr., A.S.4
-
56
-
-
0000597684
-
PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells
-
Lee, K.Y.; Chang, W.; Qiu, D.; Kao, P.N.; Rosen, G.D. PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells. J. Biol. Chem., 1999, 274, 13451-13455.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 13451-13455
-
-
Lee, K.Y.1
Chang, W.2
Qiu, D.3
Kao, P.N.4
Rosen, G.D.5
-
57
-
-
0037441760
-
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
-
Hideshima, T.; Mitsiades, C.; Akiyama, M.; Hayashi, T.; Chauhan, D.; Richardson, P.; Schlossman, R.; Podar, K.; Munshi, N.C.; Mitsiades, N.; Anderson, K.C. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood, 2003, 101, 1530-1534.
-
(2003)
Blood
, vol.101
, pp. 1530-1534
-
-
Hideshima, T.1
Mitsiades, C.2
Akiyama, M.3
Hayashi, T.4
Chauhan, D.5
Richardson, P.6
Schlossman, R.7
Podar, K.8
Munshi, N.C.9
Mitsiades, N.10
Anderson, K.C.11
-
58
-
-
42449130564
-
Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIHmediated repression of hypoxia-inducible factor-1
-
Shin, D.H.; Chun, Y.S.; Lee, D.S.; Huang, L.E.; Park, J.W. Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIHmediated repression of hypoxia-inducible factor-1. Blood, 2008, 111, 3131-3136.
-
(2008)
Blood
, vol.111
, pp. 3131-3136
-
-
Shin, D.H.1
Chun, Y.S.2
Lee, D.S.3
Huang, L.E.4
Park, J.W.5
-
59
-
-
48849096951
-
The differential NF-kB modulation by S-adenosyl-Lmethionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis
-
Garcia-Roman, R.; Salazar-Gonzalez, D.; Rosas, S.; Arellanes-Robledo, J.; Beltran-Ramirez, O.; Fattel-Fazenda, S.; Villa-Trevino, S. The differential NF-kB modulation by S-adenosyl-Lmethionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis. Free Rad. Res., 2008, 42, 331-343.
-
(2008)
Free Rad. Res
, vol.42
, pp. 331-343
-
-
Garcia-Roman, R.1
Salazar-Gonzalez, D.2
Rosas, S.3
Arellanes-Robledo, J.4
Beltran-Ramirez, O.5
Fattel-Fazenda, S.6
Villa-Trevino, S.7
-
60
-
-
0037009370
-
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
-
Sprick, M.R.; Rieser, E.; Stahl, H.; Grosse-Wilde, A.; Weigand, M.A.; Walczak, H. Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. EMBO J., 2002, 21, 4520-4530.
-
(2002)
EMBO J
, vol.21
, pp. 4520-4530
-
-
Sprick, M.R.1
Rieser, E.2
Stahl, H.3
Grosse-Wilde, A.4
Weigand, M.A.5
Walczak, H.6
-
61
-
-
17644378775
-
c- FLIPR, a new regulator of death receptor-induced apoptosis
-
Golks, A.; Brenner, D.; Fritsch, C.; Krammer, P.H.; Lavrik, I.N. c- FLIPR, a new regulator of death receptor-induced apoptosis. J. Biol.Chem., 2005, 280, 14507-14513.
-
(2005)
J. Biol.Chem
, vol.280
, pp. 14507-14513
-
-
Golks, A.1
Brenner, D.2
Fritsch, C.3
Krammer, P.H.4
Lavrik, I.N.5
-
62
-
-
0037279654
-
The active caspase-8 heterotetramer is formed at the CD95 DISC
-
Lavrik, I.; Krueger, A.; Schmitz, I.; Baumann, S.; Weyd, H.; Krammer, P.H.; Kirchhoff, S. The active caspase-8 heterotetramer is formed at the CD95 DISC. Cell Death Diff., 2003, 10, 144-145.
-
(2003)
Cell Death Diff
, vol.10
, pp. 144-145
-
-
Lavrik, I.1
Krueger, A.2
Schmitz, I.3
Baumann, S.4
Weyd, H.5
Krammer, P.H.6
Kirchhoff, S.7
-
63
-
-
0030800070
-
Inhibition of death receptor signals by cellular FLIP
-
Irmler, M.; Thome, M.; Hahne, M.; Schneider, P.; Hofmann, K.; Steiner, V.; Bodmer, J.L.; Schroter, M.; Burns, K.; Mattmann, C.; Rimoldi, D.; French, L.E.; Tschopp, J. Inhibition of death receptor signals by cellular FLIP. Nature, 1997, 388, 190-195.
-
(1997)
Nature
, vol.388
, pp. 190-195
-
-
Irmler, M.1
Thome, M.2
Hahne, M.3
Schneider, P.4
Hofmann, K.5
Steiner, V.6
Bodmer, J.L.7
Schroter, M.8
Burns, K.9
Mattmann, C.10
Rimoldi, D.11
French, L.E.12
Tschopp, J.13
-
64
-
-
3543096349
-
NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
-
Kreuz, S.; Siegmund, D.; Rumpf, J.J.; Samel, D.; Leverkus, M.; Janssen, O.; Hacker, G.; Dittrich-Breiholz, O.; Kracht, M.; Scheurich, P.; Wajant, H. NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP. J. Cell Biol., 2004, 166, 369-380.
-
(2004)
J. Cell Biol
, vol.166
, pp. 369-380
-
-
Kreuz, S.1
Siegmund, D.2
Rumpf, J.J.3
Samel, D.4
Leverkus, M.5
Janssen, O.6
Hacker, G.7
Dittrich-Breiholz, O.8
Kracht, M.9
Scheurich, P.10
Wajant, H.11
-
65
-
-
33645893189
-
Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NFkappaB
-
Okamoto, K.; Fujisawa, J.; Reth, M.; Yonehara, S. Human T-cell leukemia virus type-I oncoprotein Tax inhibits Fas-mediated apoptosis by inducing cellular FLIP through activation of NFkappaB. Genes Cells, 2006, 11, 177-191.
-
(2006)
Genes Cells
, vol.11
, pp. 177-191
-
-
Okamoto, K.1
Fujisawa, J.2
Reth, M.3
Yonehara, S.4
-
66
-
-
0040419494
-
Druginduced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53
-
Muller, M.; Strand, S.; Hug, H.; Heinemann, E.M.; Walczak, H.; Hofmann, W.J.; Stremmel, W.; Krammer, P.H.; Galle, P.R. Druginduced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. J. Clin.Invest., 1997, 99, 403-413.
-
(1997)
J. Clin.Invest
, vol.99
, pp. 403-413
-
-
Muller, M.1
Strand, S.2
Hug, H.3
Heinemann, E.M.4
Walczak, H.5
Hofmann, W.J.6
Stremmel, W.7
Krammer, P.H.8
Galle, P.R.9
-
67
-
-
0034098493
-
The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma
-
Ito, Y.; Monden, M.; Takeda, T.; Eguchi, H.; Umeshita, K.; Nagano, H.; Nakamori, S.; Dono, K.; Sakon, M.; Nakamura, M.; Tsujimoto, M.; Nakahara, M.; Nakao, K.; Yokosaki, Y.; Matsuura, N. The status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma. Br. J. Cancer, 2000, 82, 1211-1217.
-
(2000)
Br. J. Cancer
, vol.82
, pp. 1211-1217
-
-
Ito, Y.1
Monden, M.2
Takeda, T.3
Eguchi, H.4
Umeshita, K.5
Nagano, H.6
Nakamori, S.7
Dono, K.8
Sakon, M.9
Nakamura, M.10
Tsujimoto, M.11
Nakahara, M.12
Nakao, K.13
Yokosaki, Y.14
Matsuura, N.15
-
68
-
-
0034798833
-
Loss of CD95 expression is linked to most but not all p53 mutants in European hepatocellular carcinoma
-
Volkmann, M.; Schiff, J.H.; Hajjar, Y.; Otto, G.; Stilgenbauer, F.; Fiehn, W.; Galle, P.R.; Hofmann, W.J. Loss of CD95 expression is linked to most but not all p53 mutants in European hepatocellular carcinoma. J. Mol. Med., 2001, 79, 594-600.
-
(2001)
J. Mol. Med
, vol.79
, pp. 594-600
-
-
Volkmann, M.1
Schiff, J.H.2
Hajjar, Y.3
Otto, G.4
Stilgenbauer, F.5
Fiehn, W.6
Galle, P.R.7
Hofmann, W.J.8
-
69
-
-
0035079863
-
Expression of Fas and Fas-related molecules in human hepatocellular carcinoma
-
Lee, S.H.; Shin, M.S.; Lee, H.S.; Bae, J.H.; Lee, H.K.; Kim, H.S.; Kim, S.Y.; Jang, J.J.; Joo, M.; Kang, Y.K.; Park, W.S.; Park, J.Y.; Oh, R.R.; Han, S.Y.; Lee, J.H.; Kim, S.H.; Lee, J.Y.; Yoo, N.J. Expression of Fas and Fas-related molecules in human hepatocellular carcinoma. Hum. Pathol., 2001, 32, 250-256.
-
(2001)
Hum. Pathol
, vol.32
, pp. 250-256
-
-
Lee, S.H.1
Shin, M.S.2
Lee, H.S.3
Bae, J.H.4
Lee, H.K.5
Kim, H.S.6
Kim, S.Y.7
Jang, J.J.8
Joo, M.9
Kang, Y.K.10
Park, W.S.11
Park, J.Y.12
Oh, R.R.13
Han, S.Y.14
Lee, J.H.15
Kim, S.H.16
Lee, J.Y.17
Yoo, N.J.18
-
70
-
-
0031044915
-
In vivo analysis of Fas antigen-mediated apoptosis: Effects of agonistic anti-mouse Fas mAb on thymus, spleen and liver
-
Nishimura, Y.; Hirabayashi, Y.; Matsuzaki, Y.; Musette, P.; Ishii, A.; Nakauchi, H.; Inoue, T.; Yonehara, S. In vivo analysis of Fas antigen-mediated apoptosis: effects of agonistic anti-mouse Fas mAb on thymus, spleen and liver. Inter. Immunol., 1997, 9, 307-316.
-
(1997)
Inter. Immunol
, vol.9
, pp. 307-316
-
-
Nishimura, Y.1
Hirabayashi, Y.2
Matsuzaki, Y.3
Musette, P.4
Ishii, A.5
Nakauchi, H.6
Inoue, T.7
Yonehara, S.8
-
71
-
-
0034032332
-
A novel murine antihuman Fas mAb which mitigates lymphadenopathy without hepatotoxicity
-
Ichikawa, K.; Yoshida-Kato, H.; Ohtsuki, M.; Ohsumi, J.; Yamaguchi, J.; Takahashi, S.; Tani, Y.; Watanabe, M.; Shiraishi, A.; Nishioka, K.; Yonehara, S.; Serizawa, N. A novel murine antihuman Fas mAb which mitigates lymphadenopathy without hepatotoxicity. Inter. Immunol., 2000, 12, 555-562.
-
(2000)
Inter. Immunol
, vol.12
, pp. 555-562
-
-
Ichikawa, K.1
Yoshida-Kato, H.2
Ohtsuki, M.3
Ohsumi, J.4
Yamaguchi, J.5
Takahashi, S.6
Tani, Y.7
Watanabe, M.8
Shiraishi, A.9
Nishioka, K.10
Yonehara, S.11
Serizawa, N.12
-
72
-
-
30344439133
-
A humanized anti-human Fas antibody, R-125224, induces apoptosis in type I activated lymphocytes but not in type II cells
-
Nakayama, J.; Ogawa, Y.; Yoshigae, Y.; Onozawa, Y.; Yonemura, A.; Saito, M.; Ichikawa, K.; Yamoto, T.; Komai, T.; Tatsuta, T.; Ohtsuki, M. A humanized anti-human Fas antibody, R-125224, induces apoptosis in type I activated lymphocytes but not in type II cells. Inter. Immunol., 2006, 18, 113-124.
-
(2006)
Inter. Immunol
, vol.18
, pp. 113-124
-
-
Nakayama, J.1
Ogawa, Y.2
Yoshigae, Y.3
Onozawa, Y.4
Yonemura, A.5
Saito, M.6
Ichikawa, K.7
Yamoto, T.8
Komai, T.9
Tatsuta, T.10
Ohtsuki, M.11
-
73
-
-
0029096804
-
Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo
-
Rensing-Ehl, A.; Frei, K.; Flury, R.; Matiba, B.; Mariani, S.M.; Weller, M.; Aebischer, P.; Krammer, P.H.; Fontana, A. Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo. Eur J. Immunol., 1995, 25, 2253-2258.
-
(1995)
Eur J. Immunol
, vol.25
, pp. 2253-2258
-
-
Rensing-Ehl, A.1
Frei, K.2
Flury, R.3
Matiba, B.4
Mariani, S.M.5
Weller, M.6
Aebischer, P.7
Krammer, P.H.8
Fontana, A.9
-
74
-
-
0031452949
-
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing
-
Suda, T.; Hashimoto, H.; Tanaka, M.; Ochi, T.; Nagata, S. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J. Exp. Med., 1997, 186, 2045-2050.
-
(1997)
J. Exp. Med
, vol.186
, pp. 2045-2050
-
-
Suda, T.1
Hashimoto, H.2
Tanaka, M.3
Ochi, T.4
Nagata, S.5
-
75
-
-
0032550366
-
Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
-
Schneider, P.; Holler, N.; Bodmer, J.L.; Hahne, M.; Frei, K.; Fontana, A.; Tschopp, J. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J. Exp. Med., 1998, 187, 1205-1213.
-
(1998)
J. Exp. Med
, vol.187
, pp. 1205-1213
-
-
Schneider, P.1
Holler, N.2
Bodmer, J.L.3
Hahne, M.4
Frei, K.5
Fontana, A.6
Tschopp, J.7
-
76
-
-
0035318305
-
Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity
-
Aoki, K.; Kurooka, M.; Chen, J.J.; Petryniak, J.; Nabel, E.G.; Nabel, G.J. Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity. Nat. Immunol., 2001, 2, 333-337.
-
(2001)
Nat. Immunol
, vol.2
, pp. 333-337
-
-
Aoki, K.1
Kurooka, M.2
Chen, J.J.3
Petryniak, J.4
Nabel, E.G.5
Nabel, G.J.6
-
77
-
-
64249144692
-
Targeted cancer immunotherapy using ligands of the tumor necrosis factor super- family
-
Bremer, E.; de Bruyn, M.; Wajant, H.; Helfrich, W. Targeted cancer immunotherapy using ligands of the tumor necrosis factor super- family. Curr. Drug Tar., 2009, 10, 94-103.
-
(2009)
Curr. Drug Tar
, vol.10
, pp. 94-103
-
-
Bremer, E.1
de Bruyn, M.2
Wajant, H.3
Helfrich, W.4
-
78
-
-
0035191647
-
A complex adenovirus vector that delivers FASL-GFP with combined prostate-specific and tetracycline-regulated expression
-
Rubinchik, S.; Wang, D.; Yu, H.; Fan, F.; Luo, M.; Norris, J.S.; Dong, J.Y. A complex adenovirus vector that delivers FASL-GFP with combined prostate-specific and tetracycline-regulated expression. Mol. Ther., 2001, 4, 416-426.
-
(2001)
Mol. Ther
, vol.4
, pp. 416-426
-
-
Rubinchik, S.1
Wang, D.2
Yu, H.3
Fan, F.4
Luo, M.5
Norris, J.S.6
Dong, J.Y.7
-
79
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson, C.B. Apoptosis in the pathogenesis and treatment of disease. Science, 1995, 267, 1456-1462.
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
80
-
-
68549106174
-
Combination of human Fas (CD95/ Apo-1) ligand with adriamycin significantly enhances the efficacy of antitumor response
-
Liu, Z.; Liu, R.; Qiu, J.; Yin, P.; Luo, F.; Su, J.; Li, W.; Chen, C.; Fan, X.; Zhang, J.; Zhuang, G. Combination of human Fas (CD95/ Apo-1) ligand with adriamycin significantly enhances the efficacy of antitumor response. Cell Mol. Immunol., 2009, 6, 167-174.
-
(2009)
Cell Mol. Immunol
, vol.6
, pp. 167-174
-
-
Liu, Z.1
Liu, R.2
Qiu, J.3
Yin, P.4
Luo, F.5
Su, J.6
Li, W.7
Chen, C.8
Fan, X.9
Zhang, J.10
Zhuang, G.11
-
81
-
-
63549131036
-
Combining radiotherapy with APO010 in cancer treatment
-
Verbrugge, I.; Wissink, E.H.; Rooswinkel, R.W.; Jongsma, J.; Beltraminelli, N.; Dupuis, M.; Borst, J.; Verheij, M. Combining radiotherapy with APO010 in cancer treatment. Clin. Cancer Res., 2009, 15, 2031-2038.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 2031-2038
-
-
Verbrugge, I.1
Wissink, E.H.2
Rooswinkel, R.W.3
Jongsma, J.4
Beltraminelli, N.5
Dupuis, M.6
Borst, J.7
Verheij, M.8
-
82
-
-
0031743648
-
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
-
Muller, M.; Wilder, S.; Bannasch, D.; Israeli, D.; Lehlbach, K.; Li-Weber, M.; Friedman, S.L.; Galle, P.R.; Stremmel, W.; Oren, M.; Krammer, P.H. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J. Exp. Med., 1998, 188, 2033-2045.
-
(1998)
J. Exp. Med
, vol.188
, pp. 2033-2045
-
-
Muller, M.1
Wilder, S.2
Bannasch, D.3
Israeli, D.4
Lehlbach, K.5
Li-Weber, M.6
Friedman, S.L.7
Galle, P.R.8
Stremmel, W.9
Oren, M.10
Krammer, P.H.11
-
83
-
-
0037274017
-
Signaling and transcriptional control of Fas ligand gene expression
-
Kavurma, M.M.; Khachigian, L.M. Signaling and transcriptional control of Fas ligand gene expression. Cell Death Diff., 2003, 10, 36-44.
-
(2003)
Cell Death Diff
, vol.10
, pp. 36-44
-
-
Kavurma, M.M.1
Khachigian, L.M.2
-
84
-
-
0033119428
-
Differential involvement of the CD95 (Fas/APO-1) receptor/ ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells
-
Fukazawa, T.; Fujiwara, T.; Morimoto, Y.; Shao, J.; Nishizaki, M.; Kadowaki, Y.; Hizuta, A.; Owen-Schaub, L.B.; Roth, J.A.; Tanaka, N. Differential involvement of the CD95 (Fas/APO-1) receptor/ ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells. Oncogene, 1999, 18, 2189-2199.
-
(1999)
Oncogene
, vol.18
, pp. 2189-2199
-
-
Fukazawa, T.1
Fujiwara, T.2
Morimoto, Y.3
Shao, J.4
Nishizaki, M.5
Kadowaki, Y.6
Hizuta, A.7
Owen-Schaub, L.B.8
Roth, J.A.9
Tanaka, N.10
-
85
-
-
0035895097
-
The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells
-
Gajate, C.; Mollinedo, F. The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cells. Blood, 2001, 98, 3860-3863.
-
(2001)
Blood
, vol.98
, pp. 3860-3863
-
-
Gajate, C.1
Mollinedo, F.2
-
86
-
-
77951761725
-
Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
-
Jimenez-Lopez, J.M.; Rios-Marco, P.; Marco, C.; Segovia, J.L.; Carrasco, M.P. Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids. Lipids Health Dis., 2010, 9, 33.
-
(2010)
Lipids Health Dis
, vol.9
, pp. 33
-
-
Jimenez-Lopez, J.M.1
Rios-Marco, P.2
Marco, C.3
Segovia, J.L.4
Carrasco, M.P.5
-
87
-
-
0033523670
-
Immune escape of tumors in vivo by expression of cellular FLICEinhibitory protein
-
Medema, J.P.; de Jong, J.; van Hall, T.; Melief, C.J.; Offringa, R. Immune escape of tumors in vivo by expression of cellular FLICEinhibitory protein. J. Exp. Med., 1999, 190,1033-1038.
-
(1999)
J. Exp. Med
, vol.190
, pp. 1033-1038
-
-
Medema, J.P.1
de Jong, J.2
van Hall, T.3
Melief, C.J.4
Offringa, R.5
-
88
-
-
35748985110
-
Role of the Fas/FasL pathway in combination therapy with interferon- alpha and fluorouracil against hepatocellular carcinoma in vitro
-
Nakamura, M.; Nagano, H.; Sakon, M.; Yamamoto, T.; Ota, H.; Wada, H.; Damdinsuren, B.; Noda, T.; Marubashi, S.; Miyamoto, A.; Takeda, Y.; Umeshita, K.; Nakamori, S.; Dono, K.; Monden, M. Role of the Fas/FasL pathway in combination therapy with interferon- alpha and fluorouracil against hepatocellular carcinoma in vitro. J. Hepatol., 2007, 46, 77-88.
-
(2007)
J. Hepatol
, vol.46
, pp. 77-88
-
-
Nakamura, M.1
Nagano, H.2
Sakon, M.3
Yamamoto, T.4
Ota, H.5
Wada, H.6
Damdinsuren, B.7
Noda, T.8
Marubashi, S.9
Miyamoto, A.10
Takeda, Y.11
Umeshita, K.12
Nakamori, S.13
Dono, K.14
Monden, M.15
-
89
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
Minucci, S.; Pelicci, P.G. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat. Rev. Cancer, 2006, 6, 38-51.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
90
-
-
79959296080
-
Differential immunotoxicity of histone deacetylase inhibitors on malignant and naive hepatocytes
-
PMID: 20537879
-
Weiller, M.; Weiland, T.; Dunstl, G.; Sack, U.; Kunstle, G.; Wendel, A. Differential immunotoxicity of histone deacetylase inhibitors on malignant and naive hepatocytes. Exp. Toxicol. Pathol., 2010. PMID: 20537879.
-
(2010)
Exp. Toxicol. Pathol.
-
-
Weiller, M.1
Weiland, T.2
Dunstl, G.3
Sack, U.4
Kunstle, G.5
Wendel, A.6
-
91
-
-
33644876853
-
Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptormediated apoptosis and chemotherapy
-
Schuchmann, M.; Schulze-Bergkamen, H.; Fleischer, B.; Schattenberg, J.M.; Siebler, J.; Weinmann, A.; Teufel, A.; Worns, M.; Fischer, T.; Strand, S.; Lohse, A.W.; Galle, P.R. Histone deacetylase inhibition by valproic acid down-regulates c-FLIP/CASH and sensitizes hepatoma cells towards CD95- and TRAIL receptormediated apoptosis and chemotherapy. Oncol. Reports, 2006, 15, 227-230.
-
(2006)
Oncol. Reports
, vol.15
, pp. 227-230
-
-
Schuchmann, M.1
Schulze-Bergkamen, H.2
Fleischer, B.3
Schattenberg, J.M.4
Siebler, J.5
Weinmann, A.6
Teufel, A.7
Worns, M.8
Fischer, T.9
Strand, S.10
Lohse, A.W.11
Galle, P.R.12
-
92
-
-
0037414790
-
Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis
-
Higuchi, H.; Yoon, J.H.; Grambihler, A.; Werneburg, N.; Bronk, S.F.; Gores, G.J. Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis. J. Biol. Chem., 2003, 278, 454-461.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 454-461
-
-
Higuchi, H.1
Yoon, J.H.2
Grambihler, A.3
Werneburg, N.4
Bronk, S.F.5
Gores, G.J.6
-
93
-
-
13344285339
-
Identification and characterization of a new member of the TNF family that induces apoptosis
-
Wiley, S.R.; Schooley, K.; Smolak, P.J.; Din, W.S.; Huang, C.P.; Nicholl, J.K.; Sutherland, G.R.; Smith, T.D.; Rauch, C.; Smith, C.A.; et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity, 1995, 3, 673-682.
-
(1995)
Immunity
, vol.3
, pp. 673-682
-
-
Wiley, S.R.1
Schooley, K.2
Smolak, P.J.3
Din, W.S.4
Huang, C.P.5
Nicholl, J.K.6
Sutherland, G.R.7
Smith, T.D.8
Rauch, C.9
Smith, C.A.10
-
94
-
-
23944484560
-
Expression of TRAIL and TRAIL receptors in normal and malignant tissues
-
Daniels, R.A.; Turley, H.; Kimberley, F.C.; Liu, X.S.; Mongkolsapaya, J.; Ch'En, P.; Xu, X.N.; Jin, B.Q.; Pezzella, F.; Screaton, G.R. Expression of TRAIL and TRAIL receptors in normal and malignant tissues. Cell Res, 2005, 15, 430-438.
-
(2005)
Cell Res
, vol.15
, pp. 430-438
-
-
Daniels, R.A.1
Turley, H.2
Kimberley, F.C.3
Liu, X.S.4
Mongkolsapaya, J.5
Ch'En, P.6
Xu, X.N.7
Jin, B.Q.8
Pezzella, F.9
Screaton, G.R.10
-
95
-
-
0034022160
-
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
-
Jo, M.; Kim, T.H.; Seol, D.W.; Esplen, J.E.; Dorko, K.; Billiar, T.R.; Strom, S.C. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat. Med., 2000, 6, 564-567.
-
(2000)
Nat. Med.
, vol.6
, pp. 564-567
-
-
Jo, M.1
Kim, T.H.2
Seol, D.W.3
Esplen, J.E.4
Dorko, K.5
Billiar, T.R.6
Strom, S.C.7
-
96
-
-
0035050960
-
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
-
Lawrence, D.; Shahrokh, Z.; Marsters, S.; Achilles, K.; Shih, D.; Mounho, B.; Hillan, K.; Totpal, K.; DeForge, L.; Schow, P.; Hooley, J.; Sherwood, S.; Pai, R.; Leung, S.; Khan, L.; Gliniak, B.; Bussiere, J.; Smith, C.A.; Strom, S.S.; Kelley, S.; Fox, J.A.; Thomas, D.; Ashkenazi, A. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat. Med., 2001, 7, 383-385.
-
(2001)
Nat. Med.
, vol.7
, pp. 383-385
-
-
Lawrence, D.1
Shahrokh, Z.2
Marsters, S.3
Achilles, K.4
Shih, D.5
Mounho, B.6
Hillan, K.7
Totpal, K.8
Deforge, L.9
Schow, P.10
Hooley, J.11
Sherwood, S.12
Pai, R.13
Leung, S.14
Khan, L.15
Gliniak, B.16
Bussiere, J.17
Smith, C.A.18
Strom, S.S.19
Kelley, S.20
Fox, J.A.21
Thomas, D.22
Ashkenazi, A.23
more..
-
97
-
-
2542610615
-
Tissue distribution of the death ligand TRAIL and its receptors
-
Spierings, D.C.; de Vries, E.G.; Vellenga, E.; van den Heuvel, F.A.; Koornstra, J.J.; Wesseling, J.; Hollema, H.; de Jong, S. Tissue distribution of the death ligand TRAIL and its receptors. J. Histochem. Cytochem., 2004, 52, 821-831.
-
(2004)
J. Histochem. Cytochem.
, vol.52
, pp. 821-831
-
-
Spierings, D.C.1
de Vries, E.G.2
Vellenga, E.3
van den Heuvel, F.A.4
Koornstra, J.J.5
Wesseling, J.6
Hollema, H.7
de Jong, S.8
-
98
-
-
75449102003
-
TRAILinduced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies
-
Koehler, B.C.; Urbanik, T.; Vick, B.; Boger, R.J.; Heeger, S.; Galle, P.R.; Schuchmann, M.; Schulze-Bergkamen, H. TRAILinduced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies. World J. Gastroenterol., 2009, 15, 5924-5935.
-
(2009)
World J. Gastroenterol.
, vol.15
, pp. 5924-5935
-
-
Koehler, B.C.1
Urbanik, T.2
Vick, B.3
Boger, R.J.4
Heeger, S.5
Galle, P.R.6
Schuchmann, M.7
Schulze-Bergkamen, H.8
-
99
-
-
14744304730
-
Modulation of apoptosis as a target for liver disease
-
Eichhorst, S.T. Modulation of apoptosis as a target for liver disease. Exp. Opin. Therapeut. Targets, 2005, 9, 83-99.
-
(2005)
Exp. Opin. Therapeut. Targets
, vol.9
, pp. 83-99
-
-
Eichhorst, S.T.1
-
100
-
-
78349233558
-
Expression, cellular distribution, and prognostic relevance of TRAIL receptors in hepatocellular carcinoma
-
Kriegl, L.; Jung, A.; Engel, J.; Jackstadt, R.; Gerbes, A.L.; Gallmeier, E.; Reiche, J.A.; Hermeking, H.; Rizzani, A.; Bruns, C.J.; Kolligs, F.T.; Kirchner, T.; Goke, B.; De Toni, E.N. Expression, cellular distribution, and prognostic relevance of TRAIL receptors in hepatocellular carcinoma. Clin. Cancer Res., 2010, 16, 5529-5538.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 5529-5538
-
-
Kriegl, L.1
Jung, A.2
Engel, J.3
Jackstadt, R.4
Gerbes, A.L.5
Gallmeier, E.6
Reiche, J.A.7
Hermeking, H.8
Rizzani, A.9
Bruns, C.J.10
Kolligs, F.T.11
Kirchner, T.12
Goke, B.13
de Toni, E.N.14
-
101
-
-
0036467427
-
Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
-
Cretney, E.; Takeda, K.; Yagita, H.; Glaccum, M.; Peschon, J.J.; Smyth, M.J. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J. Immunol., 2002, 168, 1356-1361.
-
(2002)
J. Immunol
, vol.168
, pp. 1356-1361
-
-
Cretney, E.1
Takeda, K.2
Yagita, H.3
Glaccum, M.4
Peschon, J.J.5
Smyth, M.J.6
-
102
-
-
0033662433
-
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
-
Kischkel, F.C.; Lawrence, D.A.; Chuntharapai, A.; Schow, P.; Kim, K.J.; Ashkenazi, A. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity, 2000, 12, 611-620.
-
(2000)
Immunity
, vol.12
, pp. 611-620
-
-
Kischkel, F.C.1
Lawrence, D.A.2
Chuntharapai, A.3
Schow, P.4
Kim, K.J.5
Ashkenazi, A.6
-
103
-
-
0033667778
-
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
-
Sprick, M.R.; Weigand, M.A.; Rieser, E.; Rauch, C.T.; Juo, P.; Blenis, J.; Krammer, P.H.; Walczak, H. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2. Immunity, 2000, 12, 599-609.
-
(2000)
Immunity
, vol.12
, pp. 599-609
-
-
Sprick, M.R.1
Weigand, M.A.2
Rieser, E.3
Rauch, C.T.4
Juo, P.5
Blenis, J.6
Krammer, P.H.7
Walczak, H.8
-
104
-
-
43149101515
-
TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor
-
Kavurma, M.M.; Schoppet, M.; Bobryshev, Y.V.; Khachigian, L.M.; Bennett, M.R. TRAIL stimulates proliferation of vascular smooth muscle cells via activation of NF-kappaB and induction of insulin-like growth factor-1 receptor. J. Biol. Chem., 2008, 283, 7754-7762.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 7754-7762
-
-
Kavurma, M.M.1
Schoppet, M.2
Bobryshev, Y.V.3
Khachigian, L.M.4
Bennett, M.R.5
-
105
-
-
34547123570
-
Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells
-
Song, J.H.; Tse, M.C.; Bellail, A.; Phuphanich, S.; Khuri, F.; Kneteman, N.M.; Hao, C. Lipid rafts and nonrafts mediate tumor necrosis factor related apoptosis-inducing ligand induced apoptotic and nonapoptotic signals in non small cell lung carcinoma cells. Cancer Res., 2007, 67, 6946-6955.
-
(2007)
Cancer Res.
, vol.67
, pp. 6946-6955
-
-
Song, J.H.1
Tse, M.C.2
Bellail, A.3
Phuphanich, S.4
Khuri, F.5
Kneteman, N.M.6
Hao, C.7
-
106
-
-
52649109068
-
The TRAIL apoptotic pathway in cancer onset, progression and therapy
-
Johnstone, R.W.; Frew, A.J.; Smyth, M.J. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat. Rev. Cancer, 2008, 8, 782-798.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 782-798
-
-
Johnstone, R.W.1
Frew, A.J.2
Smyth, M.J.3
-
107
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi, A.; Pai, R.C.; Fong, S.; Leung, S.; Lawrence, D.A.; Marsters, S.A.; Blackie, C.; Chang, L.; McMurtrey, A.E.; Hebert, A.; DeForge, L.; Koumenis, I.L.; Lewis, D.; Harris, L.; Bussiere, J.; Koeppen, H.; Shahrokh, Z.; Schwall, R.H. Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest., 1999, 104, 155-162.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
Leung, S.4
Lawrence, D.A.5
Marsters, S.A.6
Blackie, C.7
Chang, L.8
McMurtrey, A.E.9
Hebert, A.10
Deforge, L.11
Koumenis, I.L.12
Lewis, D.13
Harris, L.14
Bussiere, J.15
Koeppen, H.16
Shahrokh, Z.17
Schwall, R.H.18
-
108
-
-
0034812659
-
Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: Characterization of in vivo efficacy, pharmacokinetics, and safety
-
Kelley, S.K.; Harris, L.A.; Xie, D.; Deforge, L.; Totpal, K.; Bussiere, J.; Fox, J.A. Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety. J. Pharmacol. Exp. Ther., 2001, 299, 31-38.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 31-38
-
-
Kelley, S.K.1
Harris, L.A.2
Xie, D.3
Deforge, L.4
Totpal, K.5
Bussiere, J.6
Fox, J.A.7
-
109
-
-
71749102407
-
TNF-related apoptosis-inducing ligand (TRAIL): A new path to anti-cancer therapies
-
Holoch, P.A.; Griffith, T.S. TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies. Eur. J. Pharmacol., 2009, 625, 63-72.
-
(2009)
Eur. J. Pharmacol.
, vol.625
, pp. 63-72
-
-
Holoch, P.A.1
Griffith, T.S.2
-
110
-
-
0034283942
-
Adenoviral-mediated transfer of the TNF-related apoptosis- inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis
-
Griffith, T.S.; Anderson, R.D.; Davidson, B.L.; Williams, R.D.; Ratliff, T.L. Adenoviral-mediated transfer of the TNF-related apoptosis- inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis. J Immunol, 2000, 165, 2886-2894.
-
(2000)
J Immunol.
, vol.165
, pp. 2886-2894
-
-
Griffith, T.S.1
Anderson, R.D.2
Davidson, B.L.3
Williams, R.D.4
Ratliff, T.L.5
-
111
-
-
22044448449
-
Recombinant adeno-associated virus-mediated TRAIL gene therapy suppresses liver metastatic tumors
-
Ma, H.; Liu, Y.; Liu, S.; Kung, H.F.; Sun, X.; Zheng, D.; Xu, R. Recombinant adeno-associated virus-mediated TRAIL gene therapy suppresses liver metastatic tumors. Int. J. Cancer, 2005, 116, 314-321.
-
(2005)
Int. J. Cancer
, vol.116
, pp. 314-321
-
-
Ma, H.1
Liu, Y.2
Liu, S.3
Kung, H.F.4
Sun, X.5
Zheng, D.6
Xu, R.7
-
112
-
-
3442884825
-
p53 upregulates death receptor 4 expression through an intronic p53 binding site
-
Liu, X.; Yue, P.; Khuri, F.R.; Sun, S.Y. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res., 2004, 64, 5078-5083.
-
(2004)
Cancer Res.
, vol.64
, pp. 5078-5083
-
-
Liu, X.1
Yue, P.2
Khuri, F.R.3
Sun, S.Y.4
-
113
-
-
33846476267
-
Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level
-
Roue, G.; Perez-Galan, P.; Lopez-Guerra, M.; Villamor, N.; Campo, E.; Colomer, D. Selective inhibition of IkappaB kinase sensitizes mantle cell lymphoma B cells to TRAIL by decreasing cellular FLIP level. J. Immunol., 2007, 178, 1923-1930.
-
(2007)
J. Immunol.
, vol.178
, pp. 1923-1930
-
-
Roue, G.1
Perez-Galan, P.2
Lopez-Guerra, M.3
Villamor, N.4
Campo, E.5
Colomer, D.6
-
114
-
-
34447294826
-
TRAIL therapy in non-small cell lung cancer cells: Sensitization to death receptor-mediated apoptosis by proteasome inhibitor bortezomib
-
Voortman, J.; Resende, T.P.; Abou El Hassan, M.A.; Giaccone, G.; Kruyt, F.A. TRAIL therapy in non-small cell lung cancer cells: sensitization to death receptor-mediated apoptosis by proteasome inhibitor bortezomib. Mol. Cancer Ther., 2007, 6, 2103-2112.
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2103-2112
-
-
Voortman, J.1
Resende, T.P.2
Abou El Hassan, M.A.3
Giaccone, G.4
Kruyt, F.A.5
-
115
-
-
38949181537
-
Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: A gene expression profiling study with implications for potential combination therapies
-
Zhao, X.; Qiu, W.; Kung, J.; Peng, X.; Yegappan, M.; Yen-Lieberman, B.; Hsi, E.D. Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leukemia Res., 2008, 32, 275-285.
-
(2008)
Leukemia Res.
, vol.32
, pp. 275-285
-
-
Zhao, X.1
Qiu, W.2
Kung, J.3
Peng, X.4
Yegappan, M.5
Yen-Lieberman, B.6
Hsi, E.D.7
-
116
-
-
24144489702
-
Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL
-
Ganten, T.M.; Koschny, R.; Haas, T.L.; Sykora, J.; Li-Weber, M.; Herzer, K.; Walczak, H. Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL. Hepatology, 2005, 42, 588-597.
-
(2005)
Hepatology
, vol.42
, pp. 588-597
-
-
Ganten, T.M.1
Koschny, R.2
Haas, T.L.3
Sykora, J.4
Li-Weber, M.5
Herzer, K.6
Walczak, H.7
-
117
-
-
33947368690
-
TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window
-
Koschny, R.; Ganten, T.M.; Sykora, J.; Haas, T.L.; Sprick, M.R.; Kolb, A.; Stremmel, W.; Walczak, H. TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology, 2007, 45, 649-658.
-
(2007)
Hepatology
, vol.45
, pp. 649-658
-
-
Koschny, R.1
Ganten, T.M.2
Sykora, J.3
Haas, T.L.4
Sprick, M.R.5
Kolb, A.6
Stremmel, W.7
Walczak, H.8
-
118
-
-
60849086467
-
Mapatumumab and lexatumumab induce apoptosis in TRAILR1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib
-
Luster, T.A.; Carrell, J.A.; McCormick, K.; Sun, D.; Humphreys, R. Mapatumumab and lexatumumab induce apoptosis in TRAILR1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib. Mol. Cancer Ther., 2009, 8, 292-302.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 292-302
-
-
Luster, T.A.1
Carrell, J.A.2
McCormick, K.3
Sun, D.4
Humphreys, R.5
-
119
-
-
32244442000
-
The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAIL mediated apoptosis
-
Brooks, A.D.; Ramirez, T.; Toh, U.; Onksen, J.; Elliott, P.J.; Murphy, W.J.; Sayers, T.J. The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAIL mediated apoptosis. Ann. NY Acad. Sci., 2005, 1059, 160-167.
-
(2005)
Ann. NY Acad. Sci.
, vol.1059
, pp. 160-167
-
-
Brooks, A.D.1
Ramirez, T.2
Toh, U.3
Onksen, J.4
Elliott, P.J.5
Murphy, W.J.6
Sayers, T.J.7
-
120
-
-
35148900795
-
The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation
-
Rosato, R.R.; Almenara, J.A.; Coe, S.; Grant, S. The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation. Cancer Res., 2007, 67, 9490-9500.
-
(2007)
Cancer Res.
, vol.67
, pp. 9490-9500
-
-
Rosato, R.R.1
Almenara, J.A.2
Coe, S.3
Grant, S.4
-
121
-
-
27744591014
-
HDAC inhibitors: Double edge sword for TRAIL cancer therapy?
-
Fulda, S.; Debatin, K.M. HDAC inhibitors: double edge sword for TRAIL cancer therapy?, Cancer Biol. Ther., 2005, 4, 1113-1115.
-
(2005)
Cancer Biol. Ther.
, vol.4
, pp. 1113-1115
-
-
Fulda, S.1
Debatin, K.M.2
-
122
-
-
33645239495
-
HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL
-
Pathil, A.; Armeanu, S.; Venturelli, S.; Mascagni, P.; Weiss, T.S.; Gregor, M.; Lauer, U.M.; Bitzer, M. HDAC inhibitor treatment of hepatoma cells induces both TRAIL-independent apoptosis and restoration of sensitivity to TRAIL. Hepatology, 2006, 43, 425-434.
-
(2006)
Hepatology
, vol.43
, pp. 425-434
-
-
Pathil, A.1
Armeanu, S.2
Venturelli, S.3
Mascagni, P.4
Weiss, T.S.5
Gregor, M.6
Lauer, U.M.7
Bitzer, M.8
-
123
-
-
68749089762
-
The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation
-
Carlisi, D.; Lauricella, M.; D'Anneo, A.; Emanuele, S.; Angileri, L.; Di Fazio, P.; Santulli, A.; Vento, R.; Tesoriere, G. The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation. Eur. J. Cancer, 2009, 45, 2425-2438.
-
(2009)
Eur. J. Cancer
, vol.45
, pp. 2425-2438
-
-
Carlisi, D.1
Lauricella, M.2
D'Anneo, A.3
Emanuele, S.4
Angileri, L.5
Di Fazio, P.6
Santulli, A.7
Vento, R.8
Tesoriere, G.9
-
124
-
-
0031561127
-
Increased MAPK expression and activity in primary human hepatocellular carcinoma
-
Schmidt, C.M.; McKillop, I.H.; Cahill, P.A.; Sitzmann, J.V. Increased MAPK expression and activity in primary human hepatocellular carcinoma. Biochem. Biophys. Res. Commun., 1997, 236, 54-58.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.236
, pp. 54-58
-
-
Schmidt, C.M.1
McKillop, I.H.2
Cahill, P.A.3
Sitzmann, J.V.4
-
125
-
-
33746032571
-
Loss of hepatic NFkappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
-
USA
-
Sakurai, T.; Maeda, S.; Chang, L.; Karin, M. Loss of hepatic NFkappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc. Natl. Acad. Sci. USA, 2006, 103, 10544-10551.
-
(2006)
Proc. Natl. Acad. Sci
, vol.103
, pp. 10544-10551
-
-
Sakurai, T.1
Maeda, S.2
Chang, L.3
Karin, M.4
-
126
-
-
0037462454
-
Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53
-
Eferl, R.; Ricci, R.; Kenner, L.; Zenz, R.; David, J.P.; Rath, M.; Wagner, E.F. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell, 2003, 112, 181-192.
-
(2003)
Cell
, vol.112
, pp. 181-192
-
-
Eferl, R.1
Ricci, R.2
Kenner, L.3
Zenz, R.4
David, J.P.5
Rath, M.6
Wagner, E.F.7
-
127
-
-
66349131044
-
JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosisinducing ligand
-
Mucha, S.R.; Rizzani, A.; Gerbes, A.L.; Camaj, P.; Thasler, W.E.; Bruns, C.J.; Eichhorst, S.T.; Gallmeier, E.; Kolligs, F.T.; Goke, B.; De Toni, E.N. JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosisinducing ligand. Gut, 2009, 58, 688-698.
-
(2009)
Gut
, vol.58
, pp. 688-698
-
-
Mucha, S.R.1
Rizzani, A.2
Gerbes, A.L.3
Camaj, P.4
Thasler, W.E.5
Bruns, C.J.6
Eichhorst, S.T.7
Gallmeier, E.8
Kolligs, F.T.9
Goke, B.10
de Toni, E.N.11
-
128
-
-
30944438284
-
Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor
-
Ray, S.; Bucur, O.; Almasan, A. Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor. Apoptosis, 2005, 10, 1411-1418.
-
(2005)
Apoptosis
, vol.10
, pp. 1411-1418
-
-
Ray, S.1
Bucur, O.2
Almasan, A.3
-
129
-
-
77956414973
-
Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer
-
Herbst, R.S.; Eckhardt, S.G.; Kurzrock, R.; Ebbinghaus, S.; O'Dwyer, P.J.; Gordon, M.S.; Novotny, W.; Goldwasser, M.A.; Tohnya, T.M.; Lum, B.L.; Ashkenazi, A.; Jubb, A.M.; Mendelson, D.S. Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J. Clin. Oncol., 2010, 28, 2839-2846.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 2839-2846
-
-
Herbst, R.S.1
Eckhardt, S.G.2
Kurzrock, R.3
Ebbinghaus, S.4
O'Dwyer, P.J.5
Gordon, M.S.6
Novotny, W.7
Goldwasser, M.A.8
Tohnya, T.M.9
Lum, B.L.10
Ashkenazi, A.11
Jubb, A.M.12
Mendelson, D.S.13
-
130
-
-
34248187996
-
Phase I.pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factorrelated apoptosis-inducing ligand receptor-1
-
Tolcher, A.W.; Mita, M.; Meropol, N.J.; von Mehren, M.; Patnaik, A.; Padavic, K.; Hill, M.; Mays, T.; McCoy, T.; Fox, N.L.; Halpern, W.; Corey, A.; Cohen, R.B. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factorrelated apoptosis-inducing ligand receptor-1. J. Clin. Oncol., 2007, 25, 1390-1395.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1390-1395
-
-
Tolcher, A.W.1
Mita, M.2
Meropol, N.J.3
von Mehren, M.4
Patnaik, A.5
Padavic, K.6
Hill, M.7
Mays, T.8
McCoy, T.9
Fox, N.L.10
Halpern, W.11
Corey, A.12
Cohen, R.B.13
-
131
-
-
70349318434
-
Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: Results of a phase I and pharmacokinetic study
-
Leong, S.; Cohen, R.B.; Gustafson, D.L.; Langer, C.J.; Camidge, D.R.; Padavic, K.; Gore, L.; Smith, M.; Chow, L.Q.; von Mehren, M.; O'Bryant, C.; Hariharan, S.; Diab, S.; Fox, N.L.; Miceli, R.; Eckhardt, S.G. Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study. J. Clin. Oncol., 2009, 27, 4413-4421.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 4413-4421
-
-
Leong, S.1
Cohen, R.B.2
Gustafson, D.L.3
Langer, C.J.4
Camidge, D.R.5
Padavic, K.6
Gore, L.7
Smith, M.8
Chow, L.Q.9
von Mehren, M.10
O'Bryant, C.11
Hariharan, S.12
Diab, S.13
Fox, N.L.14
Miceli, R.15
Eckhardt, S.G.16
-
132
-
-
45649084324
-
Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced nonsmall cell lung cancer
-
Greco, F.A.; Bonomi, P.; Crawford, J.; Kelly, K.; Oh, Y.; Halpern, W.; Lo, L.; Gallant, G.; Klein, J. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced nonsmall cell lung cancer. Lung Cancer, 2008, 61, 82-90.
-
(2008)
Lung Cancer
, vol.61
, pp. 82-90
-
-
Greco, F.A.1
Bonomi, P.2
Crawford, J.3
Kelly, K.4
Oh, Y.5
Halpern, W.6
Lo, L.7
Gallant, G.8
Klein, J.9
-
133
-
-
72449141229
-
Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors
-
Wakelee, H.A.; Patnaik, A.; Sikic, B.I.; Mita, M.; Fox, N.L.; Miceli, R.; Ullrich, S.J.; Fisher, G.A.; Tolcher, A.W. Phase I and pharmacokinetic study of lexatumumab (HGS-ETR2) given every 2 weeks in patients with advanced solid tumors. Ann. Oncol., 2010, 21, 376-381.
-
(2010)
Ann. Oncol.
, vol.21
, pp. 376-381
-
-
Wakelee, H.A.1
Patnaik, A.2
Sikic, B.I.3
Mita, M.4
Fox, N.L.5
Miceli, R.6
Ullrich, S.J.7
Fisher, G.A.8
Tolcher, A.W.9
-
134
-
-
47949092316
-
Apomab: An agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors
-
Camidge, D.R. Apomab: an agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors. Exp. Opin. Biol. Ther., 2008, 8, 1167-1176.
-
(2008)
Exp. Opin. Biol. Ther.
, vol.8
, pp. 1167-1176
-
-
Camidge, D.R.1
-
135
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet, J.M.; Ricci, S.; Mazzaferro, V.; Hilgard, P.; Gane, E.; Blanc, J.F.; de Oliveira, A.C.; Santoro, A.; Raoul, J.L.; Forner, A.; Schwartz, M.; Porta, C.; Zeuzem, S.; Bolondi, L.; Greten, T.F.; Galle, P.R.; Seitz, J.F.; Borbath, I.; Haussinger, D.; Giannaris, T.; Shan, M.; Moscovici, M.; Voliotis, D.; Bruix, J. Sorafenib in advanced hepatocellular carcinoma. New England J. Med., 2008, 359, 378-390.
-
(2008)
New England J. Med.
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
de Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Haussinger, D.19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
|