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Volumn 44, Issue 11, 2012, Pages 1970-1982

LRP6 mediates Wnt/β-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells

Author keywords

Adipogenesis; LRP5 6; Mesenchymal stem cells; Wnt catenin signaling; Wnt3a

Indexed keywords

BETA CATENIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; WNT PROTEIN; WNT3A PROTEIN;

EID: 84864925509     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.07.025     Document Type: Article
Times cited : (24)

References (42)
  • 1
    • 34250823973 scopus 로고    scopus 로고
    • Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton
    • R. Baron, and G. Rawadi Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton Endocrinology 148 2007 2635 2643
    • (2007) Endocrinology , vol.148 , pp. 2635-2643
    • Baron, R.1    Rawadi, G.2
  • 3
    • 11144296595 scopus 로고    scopus 로고
    • Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells
    • G.M. Boland, G. Perkins, D.J. Hall, and R.S. Tuan Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells Journal of Cellular Biochemistry 93 2004 1210 1230
    • (2004) Journal of Cellular Biochemistry , vol.93 , pp. 1210-1230
    • Boland, G.M.1    Perkins, G.2    Hall, D.J.3    Tuan, R.S.4
  • 4
    • 77950592184 scopus 로고    scopus 로고
    • Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
    • E. Bourhis, C. Tam, Y. Franke, J.F. Bazan, J. Ernst, and J. Hwang Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6 Journal of Biological Chemistry 285 2010 9172 9179
    • (2010) Journal of Biological Chemistry , vol.285 , pp. 9172-9179
    • Bourhis, E.1    Tam, C.2    Franke, Y.3    Bazan, J.F.4    Ernst, J.5    Hwang, J.6
  • 6
    • 0035889146 scopus 로고    scopus 로고
    • Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
    • C. Campagnoli, I.A. Roberts, S. Kumar, P.R. Bennett, I. Bellantuono, and N.M. Fisk Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow Blood 98 2001 2396 2402
    • (2001) Blood , vol.98 , pp. 2396-2402
    • Campagnoli, C.1    Roberts, I.A.2    Kumar, S.3    Bennett, P.R.4    Bellantuono, I.5    Fisk, N.M.6
  • 11
    • 77958599987 scopus 로고    scopus 로고
    • Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies
    • Y. Gong, E. Bourhis, C. Chiu, S. Stawicki, V.I. DeAlmeida, and B.Y. Liu Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies PLoS ONE 5 2010 e12682
    • (2010) PLoS ONE , vol.5 , pp. 12682
    • Gong, Y.1    Bourhis, E.2    Chiu, C.3    Stawicki, S.4    Dealmeida, V.I.5    Liu, B.Y.6
  • 12
    • 2342430345 scopus 로고    scopus 로고
    • LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: Arrows point the way
    • X. He, M. Semenov, K. Tamai, and X. Zeng LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way Development 131 2004 1663 1677
    • (2004) Development , vol.131 , pp. 1663-1677
    • He, X.1    Semenov, M.2    Tamai, K.3    Zeng, X.4
  • 13
    • 0032541395 scopus 로고    scopus 로고
    • Cloning of a novel member of the low-density lipoprotein receptor family
    • P.J. Hey, R.C. Twells, M.S. Phillips, N. Yusuke, S.D. Brown, and Y. Kawaguchi Cloning of a novel member of the low-density lipoprotein receptor family Gene 216 1998 103 111
    • (1998) Gene , vol.216 , pp. 103-111
    • Hey, P.J.1    Twells, R.C.2    Phillips, M.S.3    Yusuke, N.4    Brown, S.D.5    Kawaguchi, Y.6
  • 14
    • 34249678436 scopus 로고    scopus 로고
    • The beauty of asymmetry: Asymmetric divisions and self-renewal in the haematopoietic system
    • A.D. Ho, and W. Wagner The beauty of asymmetry: asymmetric divisions and self-renewal in the haematopoietic system Current Opinion in Hematology 14 2007 330 336
    • (2007) Current Opinion in Hematology , vol.14 , pp. 330-336
    • Ho, A.D.1    Wagner, W.2
  • 15
    • 21044459196 scopus 로고    scopus 로고
    • Nonviral genetic modification mediates effective transgene expression and functional RNA interference in human mesenchymal stem cells
    • J. Hoelters, M. Ciccarella, M. Drechsel, C. Geissler, H. Gulkan, and W. Bocker Nonviral genetic modification mediates effective transgene expression and functional RNA interference in human mesenchymal stem cells Journal of Gene Medicine 7 2005 718 728
    • (2005) Journal of Gene Medicine , vol.7 , pp. 718-728
    • Hoelters, J.1    Ciccarella, M.2    Drechsel, M.3    Geissler, C.4    Gulkan, H.5    Bocker, W.6
  • 16
    • 0037144481 scopus 로고    scopus 로고
    • A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta-catenin-dependent signaling
    • S.L. Holmen, A. Salic, C.R. Zylstra, M.W. Kirschner, and B.O. Williams A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta-catenin-dependent signaling Journal of Biological Chemistry 277 2002 34727 34735
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 34727-34735
    • Holmen, S.L.1    Salic, A.2    Zylstra, C.R.3    Kirschner, M.W.4    Williams, B.O.5
  • 17
    • 0037092049 scopus 로고    scopus 로고
    • Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
    • M. Kato, M.S. Patel, R. Levasseur, I. Lobov, B.H. Chang, and D.A. Glass Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor Journal of Cell Biology 157 2002 303 314
    • (2002) Journal of Cell Biology , vol.157 , pp. 303-314
    • Kato, M.1    Patel, M.S.2    Levasseur, R.3    Lobov, I.4    Chang, B.H.5    Glass, D.A.6
  • 19
    • 2342441840 scopus 로고    scopus 로고
    • The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
    • O.G. Kelly, K.I. Pinson, and W.C. Skarnes The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice Development 131 2004 2803 2815
    • (2004) Development , vol.131 , pp. 2803-2815
    • Kelly, O.G.1    Pinson, K.I.2    Skarnes, W.C.3
  • 20
    • 0032446373 scopus 로고    scopus 로고
    • A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein e
    • D.H. Kim, Y. Inagaki, T. Suzuki, R.X. Ioka, S.Z. Yoshioka, and K. Magoori A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E Journal of Biochemistry 124 1998 1072 1076
    • (1998) Journal of Biochemistry , vol.124 , pp. 1072-1076
    • Kim, D.H.1    Inagaki, Y.2    Suzuki, T.3    Ioka, R.X.4    Yoshioka, S.Z.5    Magoori, K.6
  • 21
    • 33845351956 scopus 로고    scopus 로고
    • Beta-catenin destruction complex: Insights and questions from a structural perspective
    • D. Kimelman, and W. Xu beta-catenin destruction complex: insights and questions from a structural perspective Oncogene 25 2006 7482 7491
    • (2006) Oncogene , vol.25 , pp. 7482-7491
    • Kimelman, D.1    Xu, W.2
  • 22
    • 79953708195 scopus 로고    scopus 로고
    • Role of WNT signalling in the determination of human mesenchymal stem cells into preadipocytes
    • M. Laudes Role of WNT signalling in the determination of human mesenchymal stem cells into preadipocytes Journal of Molecular Endocrinology 46 2011 R65 R72
    • (2011) Journal of Molecular Endocrinology , vol.46
    • Laudes, M.1
  • 23
    • 59649100796 scopus 로고    scopus 로고
    • Wnt signaling controls the fate of mesenchymal stem cells
    • L. Ling, V. Nurcombe, and S.M. Cool Wnt signaling controls the fate of mesenchymal stem cells Gene 433 2009 1 7
    • (2009) Gene , vol.433 , pp. 1-7
    • Ling, L.1    Nurcombe, V.2    Cool, S.M.3
  • 25
    • 80052020053 scopus 로고    scopus 로고
    • Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6
    • B.T. MacDonald, M.V. Semenov, H. Huang, and X. He Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6 PLoS ONE 6 2011 e23537
    • (2011) PLoS ONE , vol.6 , pp. 23537
    • MacDonald, B.T.1    Semenov, M.V.2    Huang, H.3    He, X.4
  • 27
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • W.J. Nelson, and R. Nusse Convergence of Wnt, beta-catenin, and cadherin pathways Science 303 2004 1483 1487
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 28
    • 33749254672 scopus 로고    scopus 로고
    • Wnt signaling regulates the invasion capacity of human mesenchymal stem cells
    • P. Neth, M. Ciccarella, V. Egea, J. Hoelters, M. Jochum, and C. Ries Wnt signaling regulates the invasion capacity of human mesenchymal stem cells Stem Cells 24 2006 1892 1903
    • (2006) Stem Cells , vol.24 , pp. 1892-1903
    • Neth, P.1    Ciccarella, M.2    Egea, V.3    Hoelters, J.4    Jochum, M.5    Ries, C.6
  • 29
    • 1442332442 scopus 로고    scopus 로고
    • Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential
    • A. Peister, J.A. Mellad, B.L. Larson, B.M. Hall, L.F. Gibson, and D.J. Prockop Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential Blood 103 2004 1662 1668
    • (2004) Blood , vol.103 , pp. 1662-1668
    • Peister, A.1    Mellad, J.A.2    Larson, B.L.3    Hall, B.M.4    Gibson, L.F.5    Prockop, D.J.6
  • 30
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signalling in mice
    • K.I. Pinson, J. Brennan, S. Monkley, B.J. Avery, and W.C. Skarnes An LDL-receptor-related protein mediates Wnt signalling in mice Nature 407 2000 535 538
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3    Avery, B.J.4    Skarnes, W.C.5
  • 32
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • T. Reya, A.W. Duncan, L. Ailles, J. Domen, D.C. Scherer, and K. Willert A role for Wnt signalling in self-renewal of haematopoietic stem cells Nature 423 2003 409 414
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1    Duncan, A.W.2    Ailles, L.3    Domen, J.4    Scherer, D.C.5    Willert, K.6
  • 34
    • 34247368028 scopus 로고    scopus 로고
    • MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: Differential regulation by inflammatory cytokines
    • C. Ries, V. Egea, M. Karow, H. Kolb, M. Jochum, and P. Neth MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines Blood 109 2007 4055 4063
    • (2007) Blood , vol.109 , pp. 4055-4063
    • Ries, C.1    Egea, V.2    Karow, M.3    Kolb, H.4    Jochum, M.5    Neth, P.6
  • 36
    • 34147107634 scopus 로고    scopus 로고
    • Concise review: Adipose tissue-derived stromal cells - Basic and clinical implications for novel cell-based therapies
    • A. Schaffler, and C. Buchler Concise review: adipose tissue-derived stromal cells - basic and clinical implications for novel cell-based therapies Stem Cells 25 2007 818 827
    • (2007) Stem Cells , vol.25 , pp. 818-827
    • Schaffler, A.1    Buchler, C.2
  • 37
    • 79959367476 scopus 로고    scopus 로고
    • Inhibition of adipocytogenesis by canonical WNT signaling in human mesenchymal stem cells
    • L. Shen, J. Glowacki, and S. Zhou Inhibition of adipocytogenesis by canonical WNT signaling in human mesenchymal stem cells Experimental Cell Research 317 2011 1796 1803
    • (2011) Experimental Cell Research , vol.317 , pp. 1796-1803
    • Shen, L.1    Glowacki, J.2    Zhou, S.3
  • 40
    • 55749091843 scopus 로고    scopus 로고
    • Parathyroid hormone signaling through low-density lipoprotein-related protein 6
    • M. Wan, C. Yang, J. Li, X. Wu, H. Yuan, and H. Ma Parathyroid hormone signaling through low-density lipoprotein-related protein 6 Genes and Development 22 2008 2968 2979
    • (2008) Genes and Development , vol.22 , pp. 2968-2979
    • Wan, M.1    Yang, C.2    Li, J.3    Wu, X.4    Yuan, H.5    Ma, H.6
  • 42
    • 58649087137 scopus 로고    scopus 로고
    • Where Wnts went: The exploding field of Lrp5 and Lrp6 signaling in bone
    • B.O. Williams, and K.L. Insogna Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone Journal of Bone and Mineral Research 24 2009 171 178
    • (2009) Journal of Bone and Mineral Research , vol.24 , pp. 171-178
    • Williams, B.O.1    Insogna, K.L.2


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