Caffeine induces sonic hedgehog gene expression in cultured astrocytes and neurons

Journal of Molecular Neuroscience

Volumn 24, Issue 2, 2004, Pages 201-205

  Sahir, Nadia ^a   Evrard, Philippe ^a   Gressens, Pierre ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Primary culture; Protein kinase A; Real time PCR

Indexed keywords

CAFFEINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; SONIC HEDGEHOG PROTEIN; CENTRAL STIMULANT AGENT; PROTEIN SUBUNIT; SHH PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN DEVELOPMENT; CELL CULTURE; CONTROLLED STUDY; DNA MODIFICATION; GENE EXPRESSION; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR MECHANICS; MOUSE; NERVE CELL; NEUROEPITHELIUM; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY; TELENCEPHALON; ANIMAL; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY;

ERINACEIDAE; MURINAE;

ANIMALS; ASTROCYTES; CAFFEINE; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM STIMULANTS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; MICE; NEURONS; PROTEIN SUBUNITS; TRANS-ACTIVATORS;

EID: 25444506576     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:24:2:201     Document Type: Article

References (17)

1. Brenneman D. E., Phillips T. M., Festoff B. W., and Gozes I. (1997) Identity of neurotrophic molecules released from astroglia by vasoactive intestinal peptide. Ann. N. Y. Acad. Sci. 814, 167-173.
2. de Lima A. D., Merten M. D., and Voigt T. (1997) Neuritic differentiation and synaptogenesis in serum-free neuronal cultures of the rat cerebral cortex. J. Comp. Neurol. 382, 230-246.
3. Echelard Y., Epstein D. J., St-Jacques B., Shen L., Mohler J., McMahon J. A., and McMahon A. P. (1993) Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.
4. Epstein D. J., Marti E., Scott M. P., and McMahon A.P. (1996) Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development 122, 2885-2894.
5. Ericson J., Morton S., Kawakami A., Roelink H., and Jessell T. M. (1996) Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.
6. Ho K. S. and Scott M. P. (2002) Sonic hedgehog in the nervous system: functions, modifications and mechanisms. Curr. Opin. Neurobiol. 12, 57-63.
7. Hynes M., Porter J. A., Chiang C., Chang D., Tessier-Lavigne M., Beachy P. A., and Rosenthal A. (1995) Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron 15, 35-44.
8. Kimmel C. A., Kimmel G. L., White C. G., Grafton T. F., Young J. F., and Nelson C .J. (1984) Blood flow changes and conceptal development in pregnant rats in response to caffeine. Fundam. Appl. Toxicol. 4, 240-247.
9. Marret S., Gressens P., Van-Maele-Fabry G., Picard J., and Evrard P. (1997) Caffeine-induced disturbances of early neurogenesis in whole mouse embryo cultures. Brain Res. 773, 213-216.
10. Nehlig A. and Debry G. (1994) Potential teratogenic and neurodevelopmental consequences of coffee and caffeine exposure: a review on human and animal data. Neurotoxicol. Teratol. 16, 531-543.
11. Pfaffl M. W. (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45.
12. Prasad K. N., Hovland A. R., Cole W. C., Prasad K. C., Nahreini P., Edwards-Prasad J., and Andreatta C. P. (2000) Multiple antioxidants in the prevention and treatment of Alzheimer disease: analysis of biologic rationale. Clin. Neuropharmacol. 23, 2-13.
13. Ribeiro J. A., Sebastiao A. M., and de Mendonca A. (2002) Adenosine receptors in the nervous system: pathophysiological implications. Prog. Neurobiol. 68, 377-392.
14. Sahir N., Bahi N., Evrard P., and Gressens P. (2000) Caffeine induces in vivo premature appearance of telencephalic vesicles. Brain Res. Dev. Brain Res. 121, 213-217.
15. Sahir N., Mas C., Bourgeois F., Simonneau M., Evrard P., and Gressens P. (2001) Caffeine-induced telencephalic vesicle evagination in early post-implantation mouse embryos involves cAMP-dependent protein kinase (PKA) inhibition. Cereb. Cortex 11, 343-349.
16. Stewart G. A., Lowrey J. A. Wakelin S. J., Fitch P. M., Lindey S., Dallman M. J., et al. (2002) Sonic hedgehog signaling modulates activation of and cytokine production by human peripheral CD4(+) T cells. J. Immunol. 169, 5451-5457.
17. Watkinson B. and Fried P. A. (1985) Maternal caffeine use before, during and after pregnancy and effects upon offspring. Neurobehav. Toxicol. 7, 9-17.