Expression of transforming growth factor-β1, 2, 3 isoforms and type I and II receptors in acute focal cerebral ischemia: An immunohistochemical study in rat after transient and permanent occlusion of middle cerebral artery

Acta Neuropathologica

Volumn 97, Issue 5, 1999, Pages 447-455

  Ata, Khaled Ahmad ^a   Lennmyr, Fredrik ^a   Funa, Keiko ^b   Olsson, Yngve ^a   Terént, Andreas ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Brain infarct; Middle cerebral artery occlusion; Rat brain; Receptor; Transforming growth factor

Indexed keywords

GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN ABSCESS; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; HUMANS; IMMUNOHISTOCHEMISTRY; ISCHEMIC ATTACK, TRANSIENT; MALE; MIDDLE CEREBRAL ARTERY; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032963643     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010051013     Document Type: Article

References (49)

1. Alevizopoulos A, Mermod N (1997) Transforming growth factor-beta: the breaking open of a black box. Bioessays 19: 581-591
2. Ata AK, Funa K, Olsson Y (1997) Expression of various TGF-β isoforms and type I receptor in necrotizing human brain lesions. Acta Neuropathol 93:326-333
3. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476
4. Bottner M, Unsicker K, Suter CC (1996) Expression of TGF-beta type II receptor mRNA in the CNS. Neuroreport 7:2903-2907
5. Cheifetz S, Bellon T, Cales C, Vera S, Bernabeu C, Massague J, Letarte M (1992) Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem 267:19027-19030
6. Colosetti P, Olsson T, Miyazono K, Funa K (1995) Axotomy of rat facial nerve induces TGF-beta and latent TGF-beta binding protein. Brain Res Bull 37:561-567
7. Eccleston PA, Funa K, Heldin CH (1995) Neurons of the peripheral nervous system express thymidine phosphorylase. Neurosci Lett 192:137-141
8. Flanders KC, Ludecke G, Engels S, Cissel DS, Roberts AB, Kondaiah P, Lafyatis R, Sporn MB, Unsicker K (1991) Localization and actions of transforming growth factor-betas in the embryonic nervous system. Development 113 : 183-191
9. Franzén P, Dijke P ten, Ichijo H, Yamashita H, Schulz P, Heldin CH, Miyazono K (1993) Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell 75:681-692
10. Gross CE, Bednar MM, Howard DB, Sporn MB (1993) Transforming growth factor-beta 1 reduces infarct size after experimental cerebral ischemia in a rabbit model. Stroke 24:558-562
11. Hancock MB (1984) Visualization of peptide-immunoreactive processes of serotonin-immunoreactive cells using two color immunoperoxidase staining. J Histochem Cytochem 32:311-314
12. Itoh K, Konishi A, Nomura S, Mizuno N, Nakamura Y, Sugimoto T (1979) Application of coupled oxidation reaction to electron microscopic demonstration of horseradish peroxidase: cobalt-glucose oxidase method. Brain Res 175:341-346
13. Kalimo H, Kaste M, Haltia M (1997) Vascular diseases. In: Graham DI, Lantos PL (eds) Greenfield's neuropathology, vol 6. Arnold, London, pp 315-396
14. Knuckey NW, Finch P, Palm DE, Primiano MJ, Johanson CE, Flanders KC, Thompson NL (1996) Differential neuronal and astrocytic expression of transforming growth factor beta isoforms in rat hippocampus following transient forebrain ischemia. Brain Res Mol Brain Res 40:1-14
15. Krupinski J, Kumar P, Kumar S, Kaluza J (1996) Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans. Stroke 27:852-857
16. Lehrmann E, Kiefer R, Finsen B, Diemer NH, Zimmer J, Hartung HP (1995) Cytokines in cerebral ischemia: expression of transforming growth factor beta-1 (TGF-beta 1) mRNA in the postischemic adult rat hippocampus. Exp Neurol 131:114-123
17. Lennmyr F, Ata KA, Funa K, Olsson Y, Terent A (1998) VEGF and its receptors Flt-1 and Flk-1 in acte focal cerebral iscemia. J Neuropathol Exp Neurol 57:874-882
18. Li GL, Farooque M, Holtz A, Olsson Y (1995) Microtubule-associated protein 2 as a sensitive marker for dendritic lesion after spinal cord trauma: an immunohistochemical study in the rat. Restor Neurol Neurosci 8:189-197
19. Lindholm D, Castrén E, Kiefer R, Zafra F, Thoenen H (1992) Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation. J Cell Biol 117:395-400
20. Lindholm D, Hengerer B, Zafra F, Thoenen H (1990) Transforming growth factor beta 1 stimulates expression of nerve growth factor in the rat CNS. Neuroreport 1:9-12
21. Liu HM, Yang HB, Chen RM (1994) Expression of basic fibroblast growth factor, nerve growth factor, platelet-derived growth factor and transforming growth factor-beta in human brain abscess. Acta Neuropathol 88:143-150
22. Logan A (1990) CNS growth factors. Br J Hosp Med 43:428-437
23. Logan A, Frautschy SA, Gonzalez AM, Sporn MB, Baird A (1992) Enhanced expression of transforming growth factor beta 1 in the rat brain after a localized cerebral injury. Brain Res 587: 216-225
24. Lopez CF, Wrana JL, Massague J (1993) Beta-glycan presents ligand to the TGF-beta signaling receptor. Cell 73: 1435-1444
25. McNeill H, Williams C, Guan J, Dragunow M, Lawlor P, Sirimanne E, Nikolics K, Gluckman P (1994) Neuronal rescue with transforming growth factor-beta 1 after hypoxic-ischaemic brain injury. Neuroreport 5:901-904
26. Merrill JE, Zimmermann RP (1991) Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibited by TGF-beta. Glia 4: 327-332
27. Miyazono K (1997) TGF-beta receptors and signal transduction. Int J Hematol 65:97-104
28. Morganti KM, Kossmann T, Brandes ME, Mergenhagen SE, Wahl SM (1992) Autocrine and paracrine regulation of astrocyte function by transforming growth factor-beta. J Neuroimmunol 39: 163-173
29. Morita N, Takumi T, Kiyama H (1996) Distinct localization of two serine-threonine kinase receptors for activin and TGF-beta in the rat brain and down-regulation of type I activin receptor during peripheral nerve regeneration. Brain Res Mol Brain Res 42: 263-271
30. Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deuel TF (1987) Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science 237: 1333-1336
31. Peress NS, Perillo E (1995) Differential expression of TGF-ß1, 2 and 3 isotypes in Alzheimer's disease: a comparative immunohistochemical study with cerebral infarction, aged human and mouse control brains. J Neuropathol Exp Neurol 54:802-811
32. Plate KH, Breier G, Weich HA, Risau W (1992) Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359:845-848
33. Plate KH, Breier G, Risau W (1994) Molecular mechanisms of developmental and tumor angiogenesis. Brain Pathol 4:207-218
34. Risau W (1991) Embryonic angiogenesis factors. Pharmacol Ther 51:371-376
35. Risau W, Drexler H, Mironov V, Smits A, Siegbahn A, Funa K, Heldin CH (1992) Platelet-derived growth factor is angiogenic in vivo. Growth Factors 7: 261-266
36. Roberts AB, Sporn MB (1985) Transforming growth factors. Cancer Surv 4:683-707
37. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, L i L, Falanga V, Kehrl JH (1986) Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 83:4167-4171
38. Sakai Y, Rawson C, Lindburg K, Barnes D (1990) Serum and transforming growth factor beta regulate glial fibrillary acidic protein in serum-free derived mouse embryo cells. Proc Natl Acad Sci USA 87:8378-8382
39. Shu S, Ju G, Fan L (1988) The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci Lett 85:169-171
40. 14C) iodoantipyrine autoradiography following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1 : 61-69
41. Tamura A, McCulloch J, Graham DI, Teasdale GM (1981) Focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 1 : 53-69
42. Unsicker K, Flanders KC, Cissel DS, Lafyatis R, Sporn MB (1991) Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system. Neuroscience 44: 613-625
43. Unsicker K, Prehn JHM, Backhaus C, Kriglstein K, Otto D, Krieglstein J (1992) Growth factors and their implications for the injured brain: regulation and neuroprotective effects of FGFs and TGF-betas in ischemic and other lesion paradigms. Pharmacol Cereb Ischemia 1:229-238
44. Wiessner C, Gehrmann J, Lindholm D, Töpper R, Kreutzberg GW, Hossmann KA (1993) Expression of transforming growth factor-beta 1 and interleukin-1 beta mRNA in rat brain following transient forebrain ischemia. Acta Neuropathol 86:439-446
45. Wrana JL, Attisano L, Carcamo J, Zentella A, Doody J, Laiho M, Wang XF, Massague J (1992) TGF beta signals through a heteromeric protein kinase receptor complex. Cell 71:1003-1014
46. Wyss-Coray T, Borrow P, Brooker MJ, Mucke L (1997) Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice. J Neuroimmunol 77:45-50
47. Yamada N, Kato M, Yamashita H, Nister M, Miyazono K, Heldin CH, Funa K (1995) Enhanced expression of transforming growth factor-beta and its type-I and type-II receptors in human glioblastoma. Int J Cancer 62: 386-392
48. Zagzag D (1995) Angiogenic growth factors in neural embryogenesis and neoplasia. Am J Pathol 146:293-309
49. Zea-Longa E, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle artery occlusion without craniotomy in rats. Stroke 20:84-91