Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke

Stroke

Volumn 40, Issue 1, 2009, Pages 254-260

  Zacharek, Alex ^a   Chen, Jieli ^a   Cui, Xu ^a   Yang, Yuping ^a   Chopp, Michael ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

Arteriogenesis; Notch signaling; Presenilin 1; Simvastatin; Stroke

Indexed keywords

NOTCH RECEPTOR; PRESENILIN 1; SIMVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NOTCH1 PROTEIN, RAT; NOTCH1 RECEPTOR; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; BRAIN ISCHEMIA; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; STROKE; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ANIMAL; BRAIN; BRAIN ARTERY; BRAIN CIRCULATION; CELL MOTION; CONVALESCENCE; DISEASE MODEL; DRUG EFFECT; METABOLISM; MICROCIRCULATION; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; VASCULARIZATION; WISTAR RAT;

ANIMALS; BRAIN; CELL MOVEMENT; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MICROCIRCULATION; MYOCYTES, SMOOTH MUSCLE; NEOVASCULARIZATION, PHYSIOLOGIC; ORGAN CULTURE TECHNIQUES; PRESENILIN-1; RATS; RATS, WISTAR; RECEPTOR, NOTCH1; RECOVERY OF FUNCTION; SIGNAL TRANSDUCTION; SIMVASTATIN; STROKE; TREATMENT OUTCOME; UP-REGULATION;

EID: 60549087930     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.108.524116     Document Type: Article

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