Mutability and mutational spectrum of chromosome transmission fidelity genes

Chromosoma

Volumn 121, Issue 3, 2012, Pages 263-275

  Stirling, Peter C ^a   Crisp, Matthew J ^b   Basrai, Munira A ^b   Tucker, Cheryl M ^c   Dunham, Maitreya J ^d   Spencer, Forrest A ^e   Hieter, Philip ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b NATIONAL CANCER INSTITUTE   (United States)

^c PRINCETON UNIVERSITY   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASOME;

ALLELE; ARTICLE; CENTROMERE; CHROMATID; CHROMOSOMAL INSTABILITY; CHROMOSOME ANALYSIS; CHROMOSOME SEGREGATION; CHROMOSOME TRANSMISSION FIDELITY 1 GENE; CHROMOSOME TRANSMISSION FIDELITY 10 GENE; CHROMOSOME TRANSMISSION FIDELITY 11 GENE; CHROMOSOME TRANSMISSION FIDELITY 12 GENE; CHROMOSOME TRANSMISSION FIDELITY 13 GENE; CHROMOSOME TRANSMISSION FIDELITY 14 GENE; CHROMOSOME TRANSMISSION FIDELITY 15 GENE; CHROMOSOME TRANSMISSION FIDELITY 16 GENE; CHROMOSOME TRANSMISSION FIDELITY 17 GENE; CHROMOSOME TRANSMISSION FIDELITY 18 GENE; CHROMOSOME TRANSMISSION FIDELITY 19 GENE; CHROMOSOME TRANSMISSION FIDELITY 2 GENE; CHROMOSOME TRANSMISSION FIDELITY 3 GENE; CHROMOSOME TRANSMISSION FIDELITY 4 GENE; CHROMOSOME TRANSMISSION FIDELITY 5 GENE; CHROMOSOME TRANSMISSION FIDELITY 6 GENE; CHROMOSOME TRANSMISSION FIDELITY 8 GENE; CHROMOSOME TRANSMISSION FIDELITY 9 GENE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC COMPLEMENTATION; MOLECULAR CLONING; MUTATIONAL ANALYSIS; MUTATOR GENE; PHENOTYPE; RNA PROCESSING;

ANIMALS; CHROMOSOMAL INSTABILITY; CHROMOSOME SEGREGATION; CHROMOSOMES, FUNGAL; CLONING, MOLECULAR; DNA-BINDING PROTEINS; GENES, FUNGAL; HUMANS; KINETOCHORES; MUTATION; NEOPLASMS; PHENOTYPE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 84864877056     PISSN: 00095915     EISSN: 14320886     Source Type: Journal    
DOI: 10.1007/s00412-011-0356-3     Document Type: Article

References (79)

1. Andersen MP, Nelson ZW, Hetrick ED et al (2008) A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae. Genetics 179:1179-1195
2. Anderson K, Lutz C, van Delft FW et al (2011) Genetic variegation of clonal architecture and propagating cells in leukaemia. Nature 469:356-361
3. Barber TD, McManus K, Yuen KW et al (2008) Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci USA 105:3443-3448
4. Basrai MA, Kingsbury J, Koshland D et al (1996) Faithful chromosome transmission requires Spt4p, a putative regulator of chromatin structure in Saccharomyces cerevisiae. Mol Cell Biol 16:2838-2847
5. Ben-Aroya S, Coombes C, Kwok T et al (2008) Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30:248-258
6. Ben-Aroya S, Agmon N, Yuen K et al (2010) Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair. PLoS Genet 6: E1000852
7. Biggins S, Bhalla N, Chang A et al (2001) Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. Genetics 159:453-470
8. Breslow DK, Cameron DM, Collins SR et al (2008) A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nat Methods 5:711-718
9. Brough R, Frankum JR, Costa-Cabral S et al (2011) Searching for synthetic lethality in cancer. Curr Opin Genet Dev 21:34-41
10. Burns CG, Ohi R, Mehta S et al (2002) Removal of a single alphatubulin gene intron suppresses cell cycle arrest phenotypes of splicing factor mutations in Saccharomyces cerevisiae. Mol Cell Biol 22:801-815
11. Cahill DP, Kinzler KW, Vogelstein B et al (1999) Genetic instability and Darwinian selection in tumours. Trends Cell Biol9:M57-60
12. Chan CS, Tye BK (1980) Autonomously replicating sequences in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 77:6329-6333
13. Clarke L, Carbon J (1980) Isolation of a yeast centromere and construction of functional small circular chromosomes. Nature 287:504-509
14. Costanzo M, Baryshnikova A, Bellay J et al (2010) The genetic landscape of a cell. Science 327:425-431
15. Doheny KF, Sorger PK, Hyman AA et al (1993) Identification of essential components of the S. cerevisiae kinetochore. Cell 73:761-774
16. Forbes SA, Tang G, Bindal N et al (2010) COSMIC (the Catalogue of Somatic Mutations in Cancer): A resource to investigate acquired mutations in human cancer. Nucleic Acids Res 38:D652-7
17. Futreal PA, Coin L, Marshall M et al (2004) A census of human cancer genes. Nat Rev Cancer 4:177-183
18. Gammie AE, Erdeniz N, Beaver J et al (2007) Functional characterization of pathogenic human MSH2 missense mutations in Saccharomyces cerevisiae. Genetics 177:707-721
19. Gomez-Gonzalez B, Felipe-Abrio I, Aguilera A (2009) The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants. Mol Cell Biol 29:5203-5213
20. Gresham D, Ruderfer DM, Pratt SC et al (2006) Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science 311:1932-1936
21. Haber JE (1974) Bisexual mating behavior in a diploid of Saccharomyces cerevisiae: Evidence for genetically controlled non-random chromosome loss during vegetative growth. Genetics 78:843-858
22. Haering CH, Lowe J, Hochwagen A et al (2002) Molecular architecture of SMC proteins and the yeast cohesin complex. Mol Cell 9:773-788
23. Hanawalt PC, Spivak G (2008) Transcription-coupled DNA repair: Two decades of progress and surprises. Nat Rev Mol Cell Biol 9:958-970
24. Hartwell LH, Culotti J, Reid B (1970) Genetic control of the celldivision cycle in yeast. I. Detection of mutants. Proc Natl Acad Sci USA 66:352-359
25. Hartwell LH, Mortimer RK, Culotti J et al (1973) Genetic control of the cell division cycle in yeast: V. Genetic analysis of cdc mutants. Genetics 74:267-286
26. Hartwell LH, Szankasi P, Roberts CJ et al (1997) Integrating genetic approaches into the discovery of anticancer drugs. Science 278:1064-1068
27. Heinicke S, Livstone MS, Lu C et al (2007) The Princeton Protein Orthology Database (P-POD): A comparative genomics analysis tool for biologists. PLoS One 2:e766
28. Hoyt MA, Stearns T, Botstein D (1990) Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Mol Cell Biol 10:223-234
29. Huffaker TC, Thomas JH, Botstein D (1988) Diverse effects of betatubulin mutations on microtubule formation and function. J Cell Biol 106:1997-2010
30. Hurov KE, Cotta-Ramusino C, Elledge SJ (2010) A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability. Genes Dev 24:1939-1950
31. Hutchins JR, Toyoda Y, Hegemann B et al (2010) Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science 328:593-599
32. Hyland KM, Kingsbury J, Koshland D et al (1999) Ctf19p: A novel kinetochore protein in Saccharomyces cerevisiae and a potential link between the kinetochore and mitotic spindle. J Cell Biol 145:15-28
33. Iouk T, Kerscher O, Scott RJ et al (2002) The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J Cell Biol 159:807-819
34. Jeong H, Herskowitz I, Kroetz DL et al (2007) Function-altering SNPs in the human multidrug transporter gene ABCB1 identified using a Saccharomyces-based assay. PLoS Genet 3:e39
35. Kanellis P, Gagliardi M, Banath JP et al (2007) A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. PLoS Genet 3:e134
36. Katou Y, Kanoh Y, Bando M et al (2003) S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex. Nature 424:1078-1083
37. Kerscher O, Hieter P, Winey M et al (2001) Novel role for a Saccharomyces cerevisiae nucleoporin, Nup170p, in chromosome segregation. Genetics 157:1543-1553
38. Kroll ES, Hyland KM, Hieter P et al (1996) Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics 143:95-102
39. Lang GI, Murray AW (2008) Estimating the per-base-pair mutation rate in the yeast Saccharomyces cerevisiae. Genetics 178:67-82
40. Lange SS, Takata K, Wood RD (2011) DNA polymerases and cancer. Nat Rev Cancer 11:96-110
41. Lejeune J, Gautier M, Turpin R (1959) Study of somatic chromosomes from 9 Mongoloid children. C R Hebd Seances Acad Sci 248:1721-1722
42. Lengauer C, Kinzler KW, Vogelstein B (1997) Genetic instability in colorectal cancers. Nature 386:623-627
43. Li Z, Vizeacoumar FJ, Bahr S et al (2011) Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol 29:361-367
44. Loeb LA (2011) Human cancers express mutator phenotypes: Origin, consequences and targeting. Nat Rev Cancer 11:450-457
45. Luo J, Emanuele MJ, Li D et al (2009) A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137:835-848
46. Maine GT, Sinha P, Tye BK (1984) Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 106:365-385
47. Marini NJ, Gin J, Ziegle J et al (2008) The prevalence of folateremedial MTHFR enzyme variants in humans. Proc Natl Acad Sci USA 105:8055-8060
48. Mayer ML, Pot I, Chang M et al (2004) Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell 15:1736-1745
49. McManus KJ, Barrett IJ, Nouhi Y et al (2009) Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing. Proc Natl Acad Sci USA 106:3276-3281
50. Measday V, Hailey DW, Pot I et al (2002) Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore. Genes Dev 16:101-113
51. Measday V, Baetz K, Guzzo J et al (2005) Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation. Proc Natl Acad Sci USA 102:13956-13961
52. Michaelis C, Ciosk R, Nasmyth K (1997) Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids. Cell 91:35-45
53. Mischo HE, Gomez-Gonzalez B, Grzechnik P et al (2011) Yeast Sen1 helicase protects the genome from transcription-associated instability. Mol Cell 41:21-32
54. Nagai S, Dubrana K, Tsai-Pflugfelder M et al (2008) Functional targeting of DNA damage to a nuclear pore-associated SUMOdependent ubiquitin ligase. Science 322:597-602
55. Neumann B, Walter T, Heriche JK et al (2010) Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 464:721-727
56. Oikawa K, Ohbayashi T,Kiyono Tet al (2004) Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res 64:3545-3549
57. Paulsen RD, Soni DV, Wollman R et al (2009) A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. Mol Cell 35:228-239
58. Pavelka N, Rancati G, Li R (2010) Dr Jekyll and Mr Hyde: Role of aneuploidy in cellular adaptation and cancer. Curr Opin Cell Biol 22:809-815
59. Prado F, Aguilera A (2005) Impairment of replication fork progression mediates RNA polII transcription-associated recombination. EMBO J 24:1267-1276
60. Rowland BD, Roig MB, Nishino T et al (2009) Building sister chromatid cohesion: Smc3 acetylation counteracts an antiestablishment activity. Mol Cell 33:763-774
61. Schvartzman JM, Sotillo R, Benezra R (2010) Mitotic chromosomal instability and cancer: Mouse modelling of the human disease. Nat Rev Cancer 10:102-115
62. Sheltzer JM, Blank HM, Pfau SJ et al (2011) Aneuploidy drives genomic instability in yeast. Science 333:1026-1030
63. Sikdar N, Banerjee S, Zhang H et al (2008) Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway. PLoS Genet 4:e1000290
64. Smith S, Hwang JY, Banerjee S et al (2004) Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 101:9039-9044
65. Solomon DA, Kim T, Diaz-Martinez LA et al (2011) Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science 333:1039-1043
66. Spencer F, Gerring SL, Connelly C et al (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124:237-249
67. Stirling PC, Bloom MS, Solanki-Patil T et al (2011) The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet 7:e1002057
68. Stratton MR, Campbell PJ, Futreal PA (2009) The cancer genome. Nature 458:719-724
69. Szostak JW, Blackburn EH (1982) Cloning yeast telomeres on linear plasmid vectors. Cell 29:245-255
70. Takai H, Xie Y, de Lange T et al (2010) Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev 24:2019-2030
71. Takeuchi Y, Horiuchi T, Kobayashi T (2003) Transcription-dependent recombination and the role of fork collision in yeast rDNA. Genes Dev 17:1497-1506
72. The 1000 Genomes Project, Conrad DF, Keebler JE et al (2011) Variation in genome-wide mutation rates within and between human families. Nat Genet 43: 712-714
73. Thompson SL, Bakhoum SF, Compton DA (2010) Mechanisms of chromosomal instability. Curr Biol 20:R285-95
74. Tong AH, Evangelista M, Parsons AB et al (2001) Systematic genetic analysis with ordered arrays of yeast deletion mutants. Science 294:2364-2368
75. Upton DC, Gregory BL, Arya R et al (2011) AID: A riddle wrapped in a mystery inside an enigma. Immunol Res 49:14-24
76. Wang Z, Cummins JM, Shen D et al (2004) Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res 64:2998-3001
77. Winzeler EA, Shoemaker DD, Astromoff A et al (1999) Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285:901-906
78. Xu H, Tomaszewski JM, McKay MJ (2011) Can corruption of chromosome cohesion create a conduit to cancer? Nat Rev Cancer 11:199-210
79. Yuen KW, Warren CD, Chen O et al (2007) Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci U S A 104:3925-3930