Ctf19p: A novel kinetochore protein in Saccharomyces cerevisiae and a potential link between the kinetochore and mitotic spindle

Journal of Cell Biology

Volumn 145, Issue 1, 1999, Pages 15-28

  Hyland, Katherine M ^a,b   Kingsbury, Jeffrey ^c   Koshland, Doug ^c   Hieter, Philip ^b,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c GEOPHYSICAL LABORATORY   (United States)

^d Centre for Molecular Medicine and Therapeutics   (Canada)

Author keywords

Centromere; Chromosome segregation; Kinetochores; Mitotic spindle apparatus; Saccharomyces cerevisiae

Indexed keywords

BENOMYL; FUNGAL DNA; FUNGAL PROTEIN; NUCLEAR PROTEIN; PROTEIN CTF19P; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G2 PHASE; CENTROMERE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; FUNGAL GENETICS; FUNGUS MUTANT; GENE FUNCTION; GENE ISOLATION; GENE SEQUENCE; MICROTUBULE; MITOSIS SPINDLE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; STRAIN DIFFERENCE;

ANAPHASE; CLONING, MOLECULAR; DNA, FUNGAL; FUNGAL PROTEINS; GENES, FUNGAL; KINETOCHORES; MACROMOLECULAR SUBSTANCES; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; PHENOTYPE; SACCHAROMYCES CEREVISIAE;

FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0033526004     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.145.1.15     Document Type: Article

References (61)

1. Baker, R.E., and D.C. Masison. 1990. Isolation of the gene encoding the Saccharomyces cerevisiae centromere-binding protein CP1. Mol. Cell. Biol. 10: 2458-2467.
2. Bloom, K., A. Hill, M. Kenna, and M. Saunders. 1989. The structure of a primitive kinelochore. Trends Biochem. Sci. 14:223-227.
3. Bloom, K.S., and J. Carbon. 1982. Yeast centromere DNA is in a unique and highly ordered structure in chromosomes and small circular minichromosomes. Cell. 29:305-317.
4. Boeke, J.D., J. Trueheart, G. Natsoulis, and G.R. Fink. 1987. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol. 154: 164-175.
5. Cai, M., and R.W. Davis. 1990. Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy. Cell. 61:437-446.
6. Connelly, C., and P. Hieter. 1996. Budding yeast SKPI encodes an evolutionarily conserved kinetochore protein required for cell cycle progression. Cell. 86:275-285.
7. Doheny, K.F., P.K. Sorger, A.A. Hyman, S. Tugendreich, F. Spencer, and P. Hieter. 1993. Identification of essential components of the S. cerevisiae kinetochore. Cell. 73:761-774.
8. Espelin, C.W., K.B. Kaplan, and P.K. Sorger. 1997. Probing the architecture of a simple kinetochore using DNA-protein cross-linking. J. Cell Biol. 139: 1383-1396.
9. Ferguson, M., and D.C. Ward. 1992. Cell cycle dependent chromosomal movement in pre-mitotic human T-lymphocyte nuclei. Chromosoma. 101:557-565.
10. Field, J., J. Nikawa, D. Broek, B. MacDonald, L. Rodgers, I.A. Wilson, R.A. Lerner, and M. Wigler. 1988. Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell. Biol. 8:2159-2165.
11. Funabiki, H., I. Hagan, S. Uzawa, and M. Yanagida. 1993. Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast. J. Cell Biol. 121:961-976.
12. Funk, M., J.H. Hegemann, and P. Philippsen. 1989. Chromalin digestion with restriction endonucleases reveals 150-160 bp of protected DNA in the centromere of chromosome XIV in Saccharomyces cerevisiae. Mol. Gen. Genet. 219:153-160.
13. Geissler, S., G. Pereira, A. Spang, M. Knop, S. Soues, J. Kilmartin, and E. Schiebel. 1996. The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment [published erratum appears in EMBO (Eur. Mol. Biol. Organ.) J. 1996. 15:5124]. EMBO (Eur. Mol. Biol. Organ.) J. 15:3899-3911.
14. Geissler, S., G. Pereira, A. Spang, M. Knop, S. Soues, J. Kilmartin, and E. Schiebel. 1996. The spindle pole body component Spc98p interacts with the gamma-tubulin-like Tub4p of Saccharomyces cerevisiae at the sites of microtubule attachment [published erratum appears in EMBO (Eur. Mol. Biol. Organ.) J. 1996. 15:5124]. EMBO (Eur. Mol. Biol. Organ.) J. 15:3899-3911.
15. Gerring, S.L., F. Spencer, and P. Hieter. 1990. The CHL 1 (CTF 1) gene product of Saccharomyces cerevisiae is important for chromosome transmission and normal cell cycle progression in G2/M. EMBO (Eur. Mol. Biol. Organ.) J. 9:4347-4358.
16. Goffeau, A., B.G. Barrell, H. Bussey, R.W. Davis, B. Dujon, H. Feldmann, F. Galibert, J.D. Hoheisel, C. Jacq, M. Johnston, et al. 1996. Life with 6000 genes. Science. 274:546, 563-567.
17. Goh, P.Y., and J.V. Kilmartin. 1993. NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 121:503-512.
18. Gorbsky, G.J. 1995. Kinetochores, microtubules and the metaphase checkpoint. Trends Cell. Biol. 5:143-148.
19. Guacci, V., E. Hogan, and D. Koshland. 1997. Centromere position in budding yeast: evidence for anaphase A. Mol. Biol. Cell. 8:957-972.
20. Hardwick, K.G., and A.W. Murray. 1995. Madlp, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131:709-720.
21. Hoyt, M.A., L. Totis, and B.T. Roberts. 1991. S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function. Cell. 66:507-517.
22. Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 153:163-168.
23. Jacobs, C.W., A.E.M. Adams, P.J. Szaniszlo, and J.R. Pringle. 1988. Functions of microtubules in the Saccharomyces cerevisiae cell cycle. J. Cell Biol. 107: 1409-1426.
24. Jiang, W., J. Lechner, and J. Carbon. 1993. Isolation and characterization of a gene (CBF2) specifying a protein component of the budding yeast kinetochore. J. Cell Biol. 121:513-519.
25. Kingsbury, J., and D. Koshland. 1991. Centromere-dependent binding of yeast minichromosomcs to microtubules in vitro. Cell. 66:483-495.
26. Knop, M., G. Pereira, S. Geissler, K. Grein, and E. Schiebel. 1997. The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication. EMBO (Eur. Mol. Biol. Organ.) J. 16:1550-1564.
27. Koshland, D. 1994. Mitosis: back to the basics. Cell. 77:951-954.
28. Koshland, D., and P. Hieter. 1987. Visual assay for chromosome ploidy. Methods Enzymol. 155:351-372.
29. Kroll, E.S., K.M. Hyland, P. Hieter, and J.J. Li. 1996. Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics. 143:95-102.
30. Lechner, J. 1994. A zinc finger protein, essential for chromosome segregation, constitutes a putative DNA binding subunit of the Saccharomyces cerevisiae kinetochore complex, Cbf3. EMBO (Eur. Mol. Biol. Organ.) J. 13:5203-5211.
31. Lechner, J., and J. Carbon. 1991. A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell. 64:717-725.
32. Li, R., and A.W. Murray. 1991. Feedback control of mitosis in budding yeast [published erratum appears in Cell. 1994, 79:388]. Cell. 66:519-531.
33. Li, R., and A.W. Murray. 1991. Feedback control of mitosis in budding yeast [published erratum appears in Cell. 1994, 79:388]. Cell. 66:519-531.
34. Link, A.J., and M.V. Olson. 1991. Physical map of the Saccharomyces cerevisiae genome at 110-kb resolution. Genetics. 127:681-698.
35. Lorenz, M.C., R.S. Muir, E. Lim, J. McElver, S.C. Weber, and J. Heitman, 1995. Gene disruption with PCR products in Saccharomyces cerevisiae. Gene. 158: 113-117.
36. Lydall, D., and T. Weinert. 1995. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science. 270:1488-1491.
37. Marschall, L.G., R.L. Jeng, J. Mulholland, and T. Stearns. 1996. Analysis of Tub4p, a yeast gamma-tubulin-like protein: implications for microtubule-organizing center function. J. Cell Biol. 134:443-454.
38. Mellor, J., W. Jiang, M. Funk, J. Rathjen, C.A. Barnes, T. Hinz, J.H. Hegemann, and P. Philippsen. 1990. CPF1. a yeast protein which functions in centromeres and promoters. EMBO (Eur. Mol. Biol. Organ.) J. 9:4017-4026.
39. Meluh, P.B., and D. Koshland. 1995. Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Mol. Biol. Cell. 6:793-807.
40. Meluh, P.B., and D. Koshland. 1997. Budding yeast centromere composition and assembly as revealed by in vivo cross-linking. Genes Dev. 11:3401-3412.
41. Meluh, P.B., P. Yang, L. Glowczewski, D. Koshland, and M.M. Smith. 1998. Cse4p is a component of the core centromere of Saccharomyces cerevisiae. Cell. 94:607-613.
42. Pangilinan, F., and F. Spencer. 1996. Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast. Mol. Biol. Cell. 7:1195-1208.
43. Pluta, A.F., C.A. Cooke, and W.C. Earnshaw. 1990. Structure of the human centromere at metaphase. Trends Biochem. Sci. 15:181-185.
44. Pringle, J.R., R.A. Preston, A.E. Adams, T. Stearns, D.G. Drubin, B.K. Haarer, and E.W. Jones. 1989. Fluorescence microscopy methods for yeast. Methods Cell Biol. 31:357-435.
45. Rieder, C.L. 1982. The formation, structure, and composition of the mammalian kinetochore and kinetochore fiber. Int. Rev. Cytol. 79:1-58.
46. Rose, M.D., F. Winston, and P. Hieter. 1990. Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 198 pp.
47. Rudner, A.D., and A.W. Murray. 1996. The spindle assembly checkpoint. Curr. Opin. Cell Biol. 8:773-780.
48. Sikorski, R.S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics. 122:19-27.
49. Sobel, S.G., and M. Snyder. 1995. A highly divergent gamma-tubulin gene is essential for cell growth and proper microtubule organization in Saccharomyces cerevisiae. J. Cell Biol. 131:1775-1788.
50. Sorger, P.K., F.F. Severin, and A.A. Hyman. 1994. Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro. J. Cell Biol. 127:995-1008.
51. Spang, A., S. Geissler, K. Grein, and E. Schiebel. 1996. γ-Tubulin-like Tub4p of Saccharomvces cerevisiae is associated with the spindle pole body substructures that organize microtubules and is required for mitotic spindle formation. J. Cell Biol. 134:429-441.
52. Spencer, F., S.L. Gerring, C. Connelly, and P. Hieter. 1990. Mitotic chromosome transmission fidelity mutants in Saccharomvces cerevisiae. Genetics. 124:237-249.
53. Stemmann, O., and J. Lechner. 1996. The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution. EMBO (Eur. Mol. Biol Organ.) J. 15:3611-3620.
54. Stemmann, O., J. Ortiz, S. Rank, and J. Lechner. 1999. A putative complex consisting of Ctf19, Mcm21 and Okp1 represents a missing link in the budding yeast kinetochore. Genes Dev. In press.
55. Straight, A.F., W.F. Marshall, J.W. Sedat, and A.W. Murray. 1997. Mitosis in living budding yeast: anaphase A but no metaphase plate. Science. 277:574-578.
56. Strunnikov, A.V., J. Kingsbury, and D. Koshland. 1995. CEP3 encodes a centromere protein of Saccharomvces cerevisiae. J. Cell Biol. 128:749-760.
57. Vourc'h, C., D. Taruscio, A.L. Boyle, and D.C. Ward. 1993. Cell cycle-dependent distribution of telomeres, centromeres, and chromosome-specific subsatellite domains in the interphase nucleus of mouse lymphocytes. Exp. Cell Res. 205:142-151.
58. Wang, Y., and D.J. Burke. 1995. Checkpoint genes required to delay cell division in response to nocodazole respond to impaired kinetochore function in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 15:6838-6844.
59. Weinert, T.A., and L.H. Hartwell. 1988. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science. 241:317-322.
60. Wells, W.A., and A.W. Murray. 1996. Aberrantly segregating centromeres activate the spindle assembly checkpoint in budding yeast. J. Cell Biol. 133:75-84.
61. Wigge, P.A., O.N. Jensen, S. Holmes, S. Soues, M. Mann, and J.V. Kilmartin. 1998. Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J. Cell Biol. 141:967-977.