Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors

Biochemistry

Volumn 51, Issue 31, 2012, Pages 6246-6259

  Srinivasan, Ajay ^a   Wang, Lirong ^a   Cline, Cari J ^a   Xie, Zhaojun ^a   Sobol, Robert W ^b,c   Xie, Xiang Qun ^a   Gold, Barry ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE MOLECULES; ACTIVE SITE; ANTICANCER DRUG; BASE EXCISION REPAIRS; CELL SURVIVAL; DEPURINATION; DIRECT INTERACTIONS; ENDONUCLEASES; INHIBITOR MOLECULES; MECHANISM OF ACTION; NANOMOLAR INHIBITORS; POTENTIAL INHIBITORS; REPAIR FUNCTIONS; TIME-DEPENDENT; TUMOR CELLS;

CELLS; CYTOLOGY; MOLECULES; PROTEINS; REPAIR;

DNA;

DEOXYRIBONUCLEASE I; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE INHIBITOR; LYASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOACCUMULATION; CANCER CELL; CELL PROLIFERATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; CYTOTOXICITY; DNA DAMAGE; DNA METHYLATION; ENZYME ACTIVE SITE; EXCISION REPAIR; FLUORESCENCE ANALYSIS; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MODIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; CATALYTIC DOMAIN; CELL LINE, TUMOR; DNA; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; MOLECULAR DOCKING SIMULATION; OXIDATION-REDUCTION; SMALL MOLECULE LIBRARIES;

ANIMALIA;

EID: 84864658339     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300490r     Document Type: Article

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