Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/Ref-1)

Journal of Medicinal Chemistry

Volumn 53, Issue 3, 2010, Pages 1200-1210

  Nyland II, Rodney L ^a   Luo, Meihua ^b   Kelley, Mark R ^b   Borch, Richard F ^a  

^a PURDUE UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 3 (1,4 NAPHTHOQUINON 2 YL) 2 METHYLPROPENOIC ACID; 3 (3 BROMO 1,4 NAPHTHOQUINON 2 YL) 2 METHOXYETHYLPROPENOIC ACID; 3 (3 BROMO 1,4 NAPHTHOQUINON 2 YL) 2 METHYLPROPENOIC ACID; 3 (3 BROMO 1,4 NAPHTHOQUINON 2 YL) PROPIONIC ACID; 3 (3 CHLORO 1,4 NAPHTHOQUINON 2 YL) 2 METHYLPROPENOIC ACID; 3 (3 CHLORO 5,6 DIMETHOXY 1,4 DIOXOCYCLOHEXA 2,5 DIENYL) 2 METHYLPROPENOIC ACID; 3 (3 FLUORO 1,4 NAPHTHOQUINON 2 YL) 2 METHYLPROPENOIC ACID; 3 (3 METHOXY 1,4 NAPHTHOQUINON 2 YL) 2 METHYLPROPENOIC ACID; 3 (3 METHYL 1,4 NAPHTHOQUINON 2 YL) 2 METHOXYETHYLPROPENOIC ACID; 3 (3 METHYL 1,4 NAPHTHOQUINON 2 YL) 2 METHYLPROPENOIC ACID; 3 (3 METHYLTHIO 1,4 NAPHTHOQUINON 2 YL) 2 METHYLPROPENOIC ACID; 3 (5,6 DIMETHOXY 3 METHYL 1,4 DIOXOCYCLOHEXA 2,5 DIENYL) 2 BUTYLPROPENOIC ACID; 3 (5,6 DIMETHOXY 3 METHYL 1,4 DIOXOCYCLOHEXA 2,5 DIENYL) 2 ETHYLPROPENOIC ACID; 3 (5,6 DIMETHOXY 3 METHYL 1,4 DIOXOCYCLOHEXA 2,5 DIENYL) 2 METHOXYETHYLPROPENOIC ACID; 3 (5,6 DIMETHOXY 3 METHYL 1,4 DIOXOCYCLOHEXA 2,5 DIENYL) 2 METHYLPROPENOIC ACID; 3(5,6 DIMETHOXY 3 METHYL 1,4 DIOXOCYCLOHEXA 2,5 DIENYL)PROPENOIC ACID; APURINIC ACID; BENZOQUINONE DERIVATIVE; DEOXYRIBONUCLEASE I; DNA; N (2 HYDROXYETHYL) 3 (3 CHLORO 1,4 DIOXONAPHTHOQUINON 2 YL) 2 METHYLPROPENAMIDE; N (2 HYDROXYETHYL) 3 (5,6 DIMETHOXY 3 METHYL 1,4 DIOXOCYCLOHEXA 2,5 DIENYL) 2 NONYLPROPENAMIDE; QUINONE DERIVATIVE; REDOX EFFECTOR FACTOR 1; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; DNA REPAIR; DNA TRANSCRIPTION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; IC 50; IN VITRO STUDY; PROTEIN FUNCTION; TUMOR GROWTH;

BENZOQUINONES; CELL LINE, TUMOR; CELL PROLIFERATION; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DRUG DESIGN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INHIBITORS; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; OVARIAN NEOPLASMS; OXIDATION-REDUCTION; PROPIONIC ACIDS;

EID: 77249176627     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9014857     Document Type: Article

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