The S. cerevisiae Mag1 3-methyladenine DNA glycosylase modulates susceptibility to homologous recombination

DNA Repair

Volumn 1, Issue 8, 2002, Pages 645-659

  Hendricks, C A ^a   Razlog, M ^a   Matsuguchi, T ^a   Goyal, A ^a   Brock, A L ^a   Engelward, B P ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

3 Methyladenine; Base excision repair; Glycosylase; Homologous recombination; Mag1; Methylation damage

Indexed keywords

APURINIC ACID; DNA DIRECTED DNA POLYMERASE; DNA GLYCOSYLTRANSFERASE; DNA POLYMERASE ZETA; FUNGAL DNA; GLYCOSIDASE; MAG1 PROTEIN, S CEREVISIAE; PYRIMIDINE DERIVATIVE; REV3 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; MAG1 3 METHYLADENINE DNA GLYCOSYLASE; NUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; CELL SURVIVAL; CHEMISTRY; DNA DAMAGE; DNA METHYLATION; DNA REPAIR; ENZYMOLOGY; ESCHERICHIA COLI; GENETIC RECOMBINATION; GENETICS; METABOLISM; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE; CELL ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; ENZYME ASSAY; EXCISION REPAIR; FUNGAL STRAIN; GENE EXPRESSION; GENE REPLICATION; GENETIC DAMAGE; HOMOLOGOUS RECOMBINATION; METHYLATION; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL;

APURINIC ACID; CELL SURVIVAL; DNA DAMAGE; DNA GLYCOSYLASES; DNA METHYLATION; DNA REPAIR; DNA, FUNGAL; DNA-DIRECTED DNA POLYMERASE; ESCHERICHIA COLI; N-GLYCOSYL HYDROLASES; PYRIMIDINES; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

ESCHERICHIA COLI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; ZIZIPHUS MAURITIANA;

EID: 0037031214     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-7864(02)00072-1     Document Type: Article

References (70)

1. Base excision repair in yeast and mammals
2. Nucleotide excision repair in yeast
3. Base excision repair in a network of defense and tolerance
4. Multiple pathways of recombination induced by double-strand breaks in S. cerevisiae
5. DNA replication meets genetic exchange: Chromosomal damage and its repair by homologous recombination
6. Rescue of arrested replication forks by homologous recombination
7. DNA recombination: The replication connection
8. Break-induced replication: A review and an example in budding yeast
9. Mitotic recombination in yeast: Elements controlling its incidence
10. Transgenic systems in studies on genotoxicity of alkylating agents: Critical lesions, thresholds and defense mechanisms
11. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating agents
12. In vivo repair of methylation damage in Aag 3-methyladenine DNA glycosylase null mouse cells
13. A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome
14. 6-methylguanine induces intrachromosomal homologous recombination in human cells
15. 6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: The role of MGMT in protection against the genotoxic effects of alkylating agents
16. 6-methylguanine residues in genomic DNA and production of sister-chromatid exchanges, mutations and lethal events in a Mer-human tumor cell line
17. Methylation-induced blocks to in vitro DNA replication
18. Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in E. coli
19. The yeast structural gene (APN1) for the major apurinic AP endonuclease: Homology to E. coli endonuclease IV
20. DNA polymerase delta is required for base excision repair of DNA methylation damage in S. cerevisiae
21. DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in S. cerevisiae
22. Relationships between yeast Rad27 and Apn1 in response to apurinic/apyrimidinic (AP) sites in DNA
23. DNA excision repair pathways
24. The repair of DNA methylation damage in S. cerevisiae
25. Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damage
26. Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe
27. Reconstitution of yeast nucleotide excision repair with purified Rad proteins, replication protein A, and transcription factor TFIIH
28. Affinity of yeast nucleotide excision repair factor 2, consisting of the Rad4 and Rad23 proteins, for ultraviolet damaged DNA
29. Incision and postincision steps of pyrimidine dimer removal in excision-defective mutants of S. cerevisiae
30. Generation of a strong mutator phenotype in yeast by imbalanced base excision repair
31. Overexpression of N-methylpurine-DNA glycosylase in Chinese hamster ovary cells renders them more sensitive to the production of chromosomal aberrations by methylating agents - A case of imbalanced DNA repair
32. Thymine-thymine dimer bypass by yeast DNA polymerase zeta
33. Deoxycytidyl transferase activity of yeast Rev1 protein
34. Identification of APN2, the S. cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites
35. Mutants of yeast defective in mutation induced by ultraviolet light
36. Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene
37. Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in S. cerevisiae
38. Getting started with yeast
39. Analysis of the mechanism for reversion of a disrupted gene
40. A new efficient gene disruption cassette for repeated use in budding yeast
41. PMPY-ZAP: A reusable polymerase chain reaction-directed gene disruption cassette for S. cerevisiae
42. A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains
43. 5-Fluoroorotic acid as a selective agent in yeast molecular genetics
44. Endonuclease IV (nfo) mutant of E. coli
45. Carcinogens induce intrachromosomal recombination in yeast
46. Depurination causes mutations in SOS-induced cells
47. Purification and properties of the alkylation repair DNA glycosylase encoded by the MAG gene from S. cerevisiae
48. Cloning and expression in Escherichia Coli of a gene for an alkylase DNA glycosylase from Saccharomyces Cerevisiae a homolog to the bacterial alka gene
49. Release of normal bases from intact DNA by a native DNA repair enzyme
50. Purification and characterization of 3-methyladenine DNA glycosylase I from E. coli
51. Replication-dependent sister chromatid recombination in rad1 mutants of S. cerevisiae
52. Repair deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation induced chromosome damage and cell killing
53. Spontaneous mitotic recombination in yeast: The hyper-recombinational rem1 mutations are alleles of the Rad3 gene
54. In vivo biochemistry: Physical monitoring of recombination induced by site-specific endonucleases
55. Genetic manipulation of genomes with rare-cutting endonucleases
56. Enhanced mitotic recombination in a ligase-defective mutant of the yeast S. cerevisiae
57. Effects of DNA double-strand and single-strand breaks on intrachromosomal recombination events in cell-cycle-arrested yeast cells
58. Managing DNA polymerases: Coordinating DNA replication, DNA repair, and DNA recombination
59. The expanding polymerase universe
60. A plethora of lesion-replicating DNA polymerases
61. Efficient bypass of a thymine-thymine dimer by yeast DNA plymerase, Pol η
62. Cell division transforms mutagenic lesions into deletion - Recombinagenic lesions in yeast cells
63. RuvAB acts at arrested replication forks
64. Collapse and repair of replication forks in E. coli
65. Initiation of genetic recombination and recombination-dependent replication
66. A sister-strand exchange mechanism for recA-independent deletion of repeated DNA sequences in E. coli
67. Slipped misalignment mechanisms of deletion formation: In vivo susceptibility to nucleases