Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 16, 2009, Pages 6063-6072

  Gemma, Sandra ^a   Savini, Luisa ^a   Altarelli, Maria ^a   Tripaldi, Pierangela ^a   Chiasserini, Luisa ^a   Coccone, Salvatore Sanna ^a   Kumar, Vinod ^a   Camodeca, Caterina ^a   Campiani, Giuseppe ^a   Novellino, Ettore ^a,b   Clarizio, Sandra ^c   Delogu, Giovanni ^c   Butini, Stefania ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

Hydrazone; Mycobacterium tuberculosis; Quinoline

Indexed keywords

2 BENZYLIDENE 1 (6 METHYL[1,3]DIOXOLO[4,5 G]QUINOLIN 8 YL)HYDRAZINE; 4 QUINOLYLHYDRAZONE DERIVATIVE; HYDRAZONE DERIVATIVE; QUINOLINE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIUM ISOLATE; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTITUBERCULAR AGENTS; CELL LINE; CERCOPITHECUS AETHIOPS; HYDRAZONES; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 68149129505     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.051     Document Type: Article

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