Counteracting effects operating on Src homology 2 domain-containing protein-tyrosine phosphatase 2 (SHP2) function drive selection of the recurrent Y62D and Y63C substitutions in Noonan syndrome

Journal of Biological Chemistry

Volumn 287, Issue 32, 2012, Pages 27066-27077

  Martinelli, Simone ^a   Nardozza, Aurelio P ^b   Vigne, Silvia Delle ^a   Sabetta, Gilda ^b   Torreri, Paola ^a   Bocchinfuso, Gianfranco ^b   Flex, Elisabetta ^a   Venanzi, Serenella ^a   Palleschi, Antonio ^b,c   Gelb, Bruce D ^d   Cesareni, Gianni ^b,e   Stella, Lorenzo ^b,c   Castagnoli, Luisa ^b   Tartaglia, Marco ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c IRCCS NEUROMED   (Italy)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC CONTROL; AMINO ACID SUBSTITUTION; BINDING PROPERTIES; BIOCHEMICAL DATA; DISRUPTIVE EFFECTS; DRIVING FORCES; MOLECULAR MECHANISM; PHOSPHOPEPTIDES; PROTEIN-TYROSINE PHOSPHATASE; SRC HOMOLOGY 2; STRUCTURAL REARRANGEMENT;

BINDING ENERGY; PHOSPHATASES; PROTEINS;

AMINO ACIDS;

PROTEIN SH2; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CODON; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; NONHUMAN; NOONAN SYNDROME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; NOONAN SYNDROME; PHOSPHORYLATION; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; SRC HOMOLOGY DOMAINS;

EID: 84864550789     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.350231     Document Type: Article

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