Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft

BMC Structural Biology

Volumn 7, Issue , 2007, Pages

  Guvench, Olgun ^a   Qu, Cheng Kui ^b   MacKerell Jr , Alexander D ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOTYROSINE; PROTEIN TYROSINE PHOSPHATASE SHP 2; TYROSINE; PEPTIDE; PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; PEPTIDES; PROTEIN CONFORMATION; PROTEIN-TYROSINE-PHOSPHATASE; THERMODYNAMICS; TYROSINE;

EID: 34047192313     PISSN: None     EISSN: 14726807     Source Type: Journal    
DOI: 10.1186/1472-6807-7-14     Document Type: Article

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