Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases

Journal of Biological Chemistry

Volumn 284, Issue 33, 2009, Pages 22048-22058

  Sacco, Francesca ^a   Tinti, Michele ^a   Palma, Anita ^a   Ferrari, Emanuela ^a   Nardozza, Aurelio P ^a   van Huijsduijnen, Rob Hooft ^b   Takahashi, Takamune ^c   Castagnoli, Luisa ^a   Cesareni, Gianni ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b MERCK SERONO S A   (Switzerland)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; ANTI-PROLIFERATIVE; CONCENTRATION OF; DENSITY-DEPENDENT; DEPHOSPHORYLATIONS; DOCKING MECHANISMS; EPIDERMAL GROWTH FACTORS; GROWTH INHIBITION; HIGH DENSITY; IN-VITRO; IN-VIVO; MEMBRANE RECEPTORS; NEW MECHANISMS; PEPTIDE ARRAYS; PHOSPHORYLATED TYROSINE; PHYSIOLOGICAL SUBSTRATE; TUMOR SUPPRESSORS;

AMINES; AMINO ACIDS; BIOINFORMATICS; DOCKING; PEPTIDES; PHOSPHORYLATION; SUBSTRATES; TUMORS;

DIELECTRIC DEVICES;

DENSITY ENHANCED PHOSPHATASE 1; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; RAS PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME SPECIFICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; EPIDERMAL GROWTH FACTOR; ESCHERICHIA COLI; HUMANS; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN ARRAY ANALYSIS; RAS PROTEINS; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 3; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 69249142851     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.002758     Document Type: Article

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