Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6

Structure

Volumn 19, Issue 3, 2011, Pages 313-323

  Chen, Jianglei ^a   Liu, Chia Chen ^b   Li, Qianqian ^a   Nowak, Christian ^b   Bu, Guojun ^b   Wang, Jianjun ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESODERM DEVELOPMENT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE;

AMINO ACID MOTIFS; ANIMALS; CRICETINAE; ENDOPLASMIC RETICULUM; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION; GOLGI APPARATUS; HISTIDINE; HUMANS; LDL-RECEPTOR RELATED PROTEINS; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 79952470911     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2011.01.010     Document Type: Article

References (33)

1. Baker, N.A., Sept, D., Joseph, S., Holst, M.J., and McCammon, J.A. (2001). Electrostatics of nanosystems: application to microtubules and the ribosome. Proc. Natl. Acad. Sci. USA 98, 10037-10041.
2. Baneyx, F., and Mujacic, M. (2004). Recombinant protein folding and misfolding in Escherichia coli. Nat. Biotechnol. 22, 1399-1408.
3. Bu, G. (2001). The roles of receptor-associated protein (RAP) as a molecular chaperone for membersof the LDL receptor family. Int. Rev. Cytol. 209, 79-116.
4. Bu, G., and Rennke, S. (1996). Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. J. Biol. Chem. 271, 22218-22224.
5. Chen, J., Li, Q., Liu, C.C., Zhou, B., Bu, G., and Wang, J. (2010). NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. J. Biomol. NMR 47, 283-288.
6. Cornilescu, G., Delaglio, F., and Bax, A. (1999). Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J. Biomol. NMR 13, 289-302. (Pubitemid 29143535)
7. Culi, J., and Mann, R.S. (2003). Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell 112, 343-354. (Pubitemid 36187420)
8. Culi, J., Springer, T.A., and Mann, R.S. (2004). Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins. EMBO J. 23, 1372-1380. (Pubitemid 38525008)
9. Delaglio, F., Grzesiek, S., Vuister, G.W., Zhu, G., Pfeifer, J., and Bax, A. (1995). NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J. Biomol. NMR 6, 277-293.
10. Demaurex, N. (2002). pHHomeostasis of cellular organelles. News Physiol. Sci. 17, 1-5.
11. Ellgaard, L., Molinari, M., and Helenius, A. (1999). Setting the standards: quality control in the secretory pathway. Science 286, 1882-1888. (Pubitemid 129515888)
12. Fisher, C., Beglova, N., and Blacklow, S.C. (2006). Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. Mol. Cell 22, 277-283.
13. Guntert, P. (2004). Automated NMR structure calculation with CYANA. Methods Mol. Biol. 278, 353-378.
14. Hartl, F.U., and Hayer-Hartl, M. (2002). Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295, 1852-1858. (Pubitemid 34214115)
15. Herz, J., and Bock, H.H. (2002). Lipoprotein receptors in the nervous system. Annu. Rev. Biochem. 71, 405-434.
16. Herz, J., and Marschang, P. (2003). Coaxing the LDL receptor family into the fold. Cell 112, 289-292. (Pubitemid 36183650)
17. Hsieh, J.C., Lee, L., Zhang, L., Wefer, S., Brown, K., DeRossi, C., Wines, M.E., Rosenquist, T., andHoldener, B.C. (2003).MESDencodes anLRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell 112, 355-367.
18. Huang, H., and He, X. (2008). Wnt/beta-catenin signaling: new (and old) players and new insights. Curr. Opin. Cell Biol. 20, 119-125.
19. Jeon, H., Meng, W., Takagi, J., Eck, M.J., Springer, T.A., and Blacklow, S.C. (2001). Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nat. Struct. Biol. 8, 499-504.
20. Johnson, B.A. (2004). Using NMRView to visualize and analyze the NMR spectra of macromolecules. Methods Mol. Biol. 278, 313-352.
21. Koduri, V., and Blacklow, S.C. (2007). Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation. Biochemistry 46, 6570-6577. (Pubitemid 46870122)
22. Kohler, C., Andersen, O.M., Diehl, A., Krause, G., Schmieder, P., and Oschkinat, H. (2006). The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family. J. Struct. Funct. Genomics 7, 131-138.
23. Lambert, C., Leonard, N., De Bolle, X., and Depiereux, E. (2002). ESyPred3D: prediction of proteins 3D structures. Bioinformatics 18, 1250-1256.
24. Lee, D., Walsh, J.D., Mikhailenko, I., Yu, P., Migliorini, M., Wu, Y., Krueger, S., Curtis, J.E., Harris, B., Lockett, S., et al. (2006). RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. Mol. Cell 22, 423-430. (Pubitemid 44308133)
25. Li, Y., Chen, J., Lu, W., McCormick, L.M., Wang, J., and Bu, G. (2005). MESD binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. J. Cell Sci. 118, 5305-5314. (Pubitemid 41819592)
26. Li, Y., Lu, W., He, X., Schwartz, A.L., and Bu, G. (2004). LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution. Oncogene 23, 9129-9135. (Pubitemid 40013080)
27. Liu, C.C., Pearson, C., and Bu, G. (2009).Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains. J. Biol. Chem. 284, 15299-15307.
28. May, P., Herz, J., and Bock, H.H. (2005). Molecular mechanisms of lipoprotein receptor signalling. Cell. Mol. Life Sci. 62, 2325-2338.
29. Noll, G., Avola, M., Lynch, M., and Daub, J. (2007). Comparison of alternant and nonalternant aromatic bridge systems with respect to their ET-properties. J. Phys. Chem. C 111, 3197-3204.
30. Sivashanmugam, A., and Wang, J. (2009). A unified scheme for initiation and conformational adaptation of human apolipoprotein E N-terminal domain upon lipoprotein binding and for receptor binding activity. J. Biol. Chem. 284, 14657-14666.
31. Stevens, F.J., and Argon, Y. (1999). Protein folding in the ER. Semin. Cell Dev. Biol. 10, 443-454.
32. Strickland, D.K., Gonias, S.L., and Argraves, W.S. (2002). Diverse roles for the LDL receptor family. Trends Endocrinol. Metab. 13, 66-74.
33. Zhang, Y., Wang, Y., Li, X., Zhang, J., Mao, J., Li, Z., Zheng, J., Li, L., Harris, S., and Wu, D. (2004). The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with MESD. Mol. Cell. Biol. 24, 4677-4684.