-
1
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu PP, Sabatini DM, ((2008)) Cancer cell metabolism: Warburg and beyond. Cell 134:: 703--707.
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
2
-
-
37549013776
-
A microenvironmental model of carcinogenesis
-
Gatenby RA, Gillies RJ, ((2008)) A microenvironmental model of carcinogenesis. Nat Rev Cancer 8:: 56--61.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 56-61
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
3
-
-
77951803596
-
Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited
-
Vazquez A, Liu J, Zhou Y, Oltvai ZN, ((2010)) Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited. BMC Syst Biol 4:: 58.
-
(2010)
BMC Syst Biol
, vol.4
, pp. 58
-
-
Vazquez, A.1
Liu, J.2
Zhou, Y.3
Oltvai, Z.N.4
-
4
-
-
46749121459
-
Causes and consequences of increased glucose metabolism of cancers
-
Gillies RJ, Robey I, Gatenby RA, ((2008)) Causes and consequences of increased glucose metabolism of cancers. J Nucl Med 49 Suppl 2: 24S--42S.
-
(2008)
J Nucl Med
, vol.49
-
-
Gillies, R.J.1
Robey, I.2
Gatenby, R.A.3
-
5
-
-
56049122457
-
Clinical and molecular progress in hereditary paraganglioma
-
Baysal BE, ((2008)) Clinical and molecular progress in hereditary paraganglioma. J Med Genet 45:: 689--694.
-
(2008)
J Med Genet
, vol.45
, pp. 689-694
-
-
Baysal, B.E.1
-
6
-
-
67651204610
-
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species
-
Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, et al. ((2009)) Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol 29:: 4080--4090.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4080-4090
-
-
Sudarshan, S.1
Sourbier, C.2
Kong, H.S.3
Block, K.4
Valera Romero, V.A.5
-
7
-
-
77951432631
-
The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy
-
Ralph SJ, Rodriguez-Enriquez S, Neuzil J, Saavedra E, Moreno-Sanchez R, ((2010)) The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation- why mitochondria are targets for cancer therapy. Mol Aspects Med 31:: 145--170.
-
(2010)
Mol Aspects Med
, vol.31
, pp. 145-170
-
-
Ralph, S.J.1
Rodriguez-Enriquez, S.2
Neuzil, J.3
Saavedra, E.4
Moreno-Sanchez, R.5
-
8
-
-
41849094797
-
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells
-
Jung SN, Yang WK, Kim J, Kim HS, Kim EJ, et al. ((2008)) Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis 29:: 713--721.
-
(2008)
Carcinogenesis
, vol.29
, pp. 713-721
-
-
Jung, S.N.1
Yang, W.K.2
Kim, J.3
Kim, H.S.4
Kim, E.J.5
-
9
-
-
33644551073
-
Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers
-
Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, et al. ((2006)) Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med 3:: e47.
-
(2006)
PLoS Med
, vol.3
-
-
Chi, J.T.1
Wang, Z.2
Nuyten, D.S.3
Rodriguez, E.H.4
Schaner, M.E.5
-
10
-
-
60949102817
-
Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes
-
Qing G, Simon MC, ((2009)) Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes. Curr Opin Genet Dev 19:: 60--66.
-
(2009)
Curr Opin Genet Dev
, vol.19
, pp. 60-66
-
-
Qing, G.1
Simon, M.C.2
-
11
-
-
0034602950
-
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
-
Baysal BE, Ferrell RE, Willett-Brozick JE, Lawrence EC, Myssiorek D, et al. ((2000)) Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 287:: 848--851.
-
(2000)
Science
, vol.287
, pp. 848-851
-
-
Baysal, B.E.1
Ferrell, R.E.2
Willett-Brozick, J.E.3
Lawrence, E.C.4
Myssiorek, D.5
-
12
-
-
0033767445
-
Mutations in SDHC cause autosomal dominant paraganglioma, type 3
-
Niemann S, Muller U, ((2000)) Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nat Genet 26:: 268--270.
-
(2000)
Nat Genet
, vol.26
, pp. 268-270
-
-
Niemann, S.1
Muller, U.2
-
13
-
-
0034964421
-
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
-
Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, et al. ((2001)) Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet 69:: 49--54.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 49-54
-
-
Astuti, D.1
Latif, F.2
Dallol, A.3
Dahia, P.L.4
Douglas, F.5
-
14
-
-
77958164441
-
SDHA is a tumor suppressor gene causing paraganglioma
-
Burnichon N, Briere JJ, Libe R, Vescovo L, Riviere J, et al. ((2010)) SDHA is a tumor suppressor gene causing paraganglioma. Hum Mol Genet 19:: 3011--3020.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3011-3020
-
-
Burnichon, N.1
Briere, J.J.2
Libe, R.3
Vescovo, L.4
Riviere, J.5
-
15
-
-
0036774422
-
Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma
-
Gimenez-Roqueplo AP, Favier J, Rustin P, Rieubland C, Kerlan V, et al. ((2002)) Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma. J Clin Endocrinol Metab 87:: 4771--4774.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 4771-4774
-
-
Gimenez-Roqueplo, A.P.1
Favier, J.2
Rustin, P.3
Rieubland, C.4
Kerlan, V.5
-
16
-
-
70349472696
-
The Warburg effect is genetically determined in inherited pheochromocytomas
-
Favier J, Briere JJ, Burnichon N, Riviere J, Vescovo L, et al. ((2009)) The Warburg effect is genetically determined in inherited pheochromocytomas. PLoS One 4:: e7094.
-
(2009)
PLoS One
, vol.4
-
-
Favier, J.1
Briere, J.J.2
Burnichon, N.3
Riviere, J.4
Vescovo, L.5
-
17
-
-
0035213138
-
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway
-
Gimenez-Roqueplo AP, Favier J, Rustin P, Mourad JJ, Plouin PF, et al. ((2001)) The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am J Hum Genet 69:: 1186--1197.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 1186-1197
-
-
Gimenez-Roqueplo, A.P.1
Favier, J.2
Rustin, P.3
Mourad, J.J.4
Plouin, P.F.5
-
18
-
-
0242391866
-
SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology
-
Douwes Dekker P, Hogendoorn P, Kuipers-Dijkshoorn N, Prins F, van Duinen S, et al. ((2003)) SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology. The Journal of Pathology 201:: 480--486.
-
(2003)
The Journal of Pathology
, vol.201
, pp. 480-486
-
-
Douwes Dekker, P.1
Hogendoorn, P.2
Kuipers-Dijkshoorn, N.3
Prins, F.4
van Duinen, S.5
-
19
-
-
26444570010
-
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
-
Pollard PJ, Briere JJ, Alam NA, Barwell J, Barclay E, et al. ((2005)) Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 14:: 2231--2239.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2231-2239
-
-
Pollard, P.J.1
Briere, J.J.2
Alam, N.A.3
Barwell, J.4
Barclay, E.5
-
20
-
-
37849022071
-
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis
-
Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT, ((2008)) Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol 28:: 718--731.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 718-731
-
-
Guzy, R.D.1
Sharma, B.2
Bell, E.3
Chandel, N.S.4
Schumacker, P.T.5
-
21
-
-
33845510751
-
Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas
-
Dahia PL, ((2006)) Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas. Ann N Y Acad Sci 1073:: 208--220.
-
(2006)
Ann N Y Acad Sci
, vol.1073
, pp. 208-220
-
-
Dahia, P.L.1
-
22
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, et al. ((1999)) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399:: 271--275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
-
23
-
-
0036718539
-
Molecular basis of the VHL hereditary cancer syndrome
-
Kaelin WG Jr, ((2002)) Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2:: 673--682.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 673-682
-
-
Kaelin Jr., W.G.1
-
24
-
-
0141704510
-
Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas
-
Gimenez-Roqueplo AP, Favier J, Rustin P, Rieubland C, Crespin M, et al. ((2003)) Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas. Cancer Res 63:: 5615--5621.
-
(2003)
Cancer Res
, vol.63
, pp. 5615-5621
-
-
Gimenez-Roqueplo, A.P.1
Favier, J.2
Rustin, P.3
Rieubland, C.4
Crespin, M.5
-
25
-
-
4143105824
-
Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations
-
Neumann HP, Pawlu C, Peczkowska M, Bausch B, McWhinney SR, et al. ((2004)) Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. Jama 292:: 943--951.
-
(2004)
Jama
, vol.292
, pp. 943-951
-
-
Neumann, H.P.1
Pawlu, C.2
Peczkowska, M.3
Bausch, B.4
McWhinney, S.R.5
-
26
-
-
33644834491
-
Genetic testing in pheochromocytoma or functional paraganglioma
-
Amar L, Bertherat J, Baudin E, Ajzenberg C, Bressac-de Paillerets B, et al. ((2005)) Genetic testing in pheochromocytoma or functional paraganglioma. J Clin Oncol 23:: 8812--8818.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8812-8818
-
-
Amar, L.1
Bertherat, J.2
Baudin, E.3
Ajzenberg, C.4
Bressac-de Paillerets, B.5
-
27
-
-
33947530604
-
Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas
-
Timmers HJ, Kozupa A, Eisenhofer G, Raygada M, Adams KT, et al. ((2007)) Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas. J Clin Endocrinol Metab 92:: 779--786.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 779-786
-
-
Timmers, H.J.1
Kozupa, A.2
Eisenhofer, G.3
Raygada, M.4
Adams, K.T.5
-
28
-
-
67650492401
-
Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours
-
Srirangalingam U, Khoo B, Walker L, MacDonald F, Skelly RH, et al. ((2009)) Contrasting clinical manifestations of SDHB and VHL associated chromaffin tumours. Endocr Relat Cancer 16:: 515--525.
-
(2009)
Endocr Relat Cancer
, vol.16
, pp. 515-525
-
-
Srirangalingam, U.1
Khoo, B.2
Walker, L.3
MacDonald, F.4
Skelly, R.H.5
-
29
-
-
34547106041
-
Pheochromocytomas in Nf1 knockout mice express a neural progenitor gene expression profile
-
Powers JF, Evinger MJ, Zhi J, Picard KL, Tischler AS, ((2007)) Pheochromocytomas in Nf1 knockout mice express a neural progenitor gene expression profile. Neuroscience 147:: 928--937.
-
(2007)
Neuroscience
, vol.147
, pp. 928-937
-
-
Powers, J.F.1
Evinger, M.J.2
Zhi, J.3
Picard, K.L.4
Tischler, A.S.5
-
30
-
-
68549130515
-
Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy
-
Lai EW, Joshi BH, Martiniova L, Dogra R, Fujisawa T, et al. ((2009)) Overexpression of interleukin-13 receptor-alpha2 in neuroendocrine malignant pheochromocytoma: a novel target for receptor directed anti-cancer therapy. J Clin Endocrinol Metab 94:: 2952--2957.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 2952-2957
-
-
Lai, E.W.1
Joshi, B.H.2
Martiniova, L.3
Dogra, R.4
Fujisawa, T.5
-
31
-
-
61449213031
-
Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature
-
Martiniova L, Lai EW, Elkahloun AG, Abu-Asab M, Wickremasinghe A, et al. ((2009)) Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature. Clin Exp Metastasis 26:: 239--250.
-
(2009)
Clin Exp Metastasis
, vol.26
, pp. 239-250
-
-
Martiniova, L.1
Lai, E.W.2
Elkahloun, A.G.3
Abu-Asab, M.4
Wickremasinghe, A.5
-
32
-
-
36249005491
-
Succinate inhibition of {alpha}-ketoglutarate-dependent enzymes in a yeast model of paraganglioma
-
Smith EH, Janknecht R, Maher LJ III, ((2007)) Succinate inhibition of {alpha}-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. Hum Mol Genet 16:: 3136--3148.
-
(2007)
Hum Mol Genet
, vol.16
, pp. 3136-3148
-
-
Smith, E.H.1
Janknecht, R.2
Maher III, L.J.3
-
33
-
-
65449185779
-
Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor
-
Goffrini P, Ercolino T, Panizza E, Giache V, Cavone L, et al. ((2009)) Functional study in a yeast model of a novel succinate dehydrogenase subunit B gene germline missense mutation (C191Y) diagnosed in a patient affected by a glomus tumor. Hum Mol Genet 18:: 1860--1868.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 1860-1868
-
-
Goffrini, P.1
Ercolino, T.2
Panizza, E.3
Giache, V.4
Cavone, L.5
-
34
-
-
62049086087
-
Mutations in the C. elegans succinate dehydrogenase iron-sulfur subunit promote superoxide generation and premature aging
-
Huang J, Lemire BD, ((2009)) Mutations in the C. elegans succinate dehydrogenase iron-sulfur subunit promote superoxide generation and premature aging. J Mol Biol 387:: 559--569.
-
(2009)
J Mol Biol
, vol.387
, pp. 559-569
-
-
Huang, J.1
Lemire, B.D.2
-
35
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ, ((2004)) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:: 891--899.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
36
-
-
77950643062
-
Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials
-
Granchi C, Bertini S, Macchia M, Minutolo F, ((2010)) Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials. Curr Med Chem 17:: 672--697.
-
(2010)
Curr Med Chem
, vol.17
, pp. 672-697
-
-
Granchi, C.1
Bertini, S.2
Macchia, M.3
Minutolo, F.4
-
37
-
-
77957979206
-
Manipulating tumor acidification as a cancer treatment strategy
-
McCarty MF, Whitaker J, ((2010)) Manipulating tumor acidification as a cancer treatment strategy. Altern Med Rev 15:: 264--272.
-
(2010)
Altern Med Rev
, vol.15
, pp. 264-272
-
-
McCarty, M.F.1
Whitaker, J.2
-
38
-
-
0031029634
-
Correlation of high lactate levels in head and neck tumors with incidence of metastasis
-
Walenta S, Salameh A, Lyng H, Evensen JF, Mitze M, et al. ((1997)) Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Am J Pathol 150:: 409--415.
-
(1997)
Am J Pathol
, vol.150
, pp. 409-415
-
-
Walenta, S.1
Salameh, A.2
Lyng, H.3
Evensen, J.F.4
Mitze, M.5
-
39
-
-
0035479076
-
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer
-
Brizel DM, Schroeder T, Scher RL, Walenta S, Clough RW, et al. ((2001)) Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys 51:: 349--353.
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.51
, pp. 349-353
-
-
Brizel, D.M.1
Schroeder, T.2
Scher, R.L.3
Walenta, S.4
Clough, R.W.5
-
40
-
-
0034652620
-
High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
-
Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, et al. ((2000)) High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 60:: 916--921.
-
(2000)
Cancer Res
, vol.60
, pp. 916-921
-
-
Walenta, S.1
Wetterling, M.2
Lehrke, M.3
Schwickert, G.4
Sundfor, K.5
-
41
-
-
61649098857
-
Laser microdissection expression profiling of marginal edges of colorectal tumours reveals evidence of increased lactate metabolism in the aggressive phenotype
-
Thorn CC, Freeman TC, Scott N, Guillou PJ, Jayne DG, ((2009)) Laser microdissection expression profiling of marginal edges of colorectal tumours reveals evidence of increased lactate metabolism in the aggressive phenotype. Gut 58:: 404--412.
-
(2009)
Gut
, vol.58
, pp. 404-412
-
-
Thorn, C.C.1
Freeman, T.C.2
Scott, N.3
Guillou, P.J.4
Jayne, D.G.5
-
42
-
-
33744783432
-
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
-
Fantin VR, St-Pierre J, Leder P, ((2006)) Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9:: 425--434.
-
(2006)
Cancer Cell
, vol.9
, pp. 425-434
-
-
Fantin, V.R.1
St-Pierre, J.2
Leder, P.3
-
43
-
-
76649126249
-
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
-
Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, et al. ((2010)) Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression. Proc Natl Acad Sci U S A 107:: 2037--2042.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 2037-2042
-
-
Le, A.1
Cooper, C.R.2
Gouw, A.M.3
Dinavahi, R.4
Maitra, A.5
-
44
-
-
66449103009
-
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
-
Xie H, Valera VA, Merino MJ, Amato AM, Signoretti S, et al. ((2009)) LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther 8:: 626--635.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 626-635
-
-
Xie, H.1
Valera, V.A.2
Merino, M.J.3
Amato, A.M.4
Signoretti, S.5
-
45
-
-
33747893489
-
Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability
-
Slane BG, Aykin-Burns N, Smith BJ, Kalen AL, Goswami PC, et al. ((2006)) Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Res 66:: 7615--7620.
-
(2006)
Cancer Res
, vol.66
, pp. 7615-7620
-
-
Slane, B.G.1
Aykin-Burns, N.2
Smith, B.J.3
Kalen, A.L.4
Goswami, P.C.5
-
46
-
-
44849141175
-
Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells
-
Piantadosi CA, Suliman HB, ((2008)) Transcriptional Regulation of SDHa flavoprotein by nuclear respiratory factor-1 prevents pseudo-hypoxia in aerobic cardiac cells. J Biol Chem 283:: 10967--10977.
-
(2008)
J Biol Chem
, vol.283
, pp. 10967-10977
-
-
Piantadosi, C.A.1
Suliman, H.B.2
-
47
-
-
34848866025
-
Ubiquinone-binding Site Mutations in the Saccharomyces cerevisiae Succinate Dehydrogenase Generate Superoxide and Lead to the Accumulation of Succinate
-
Szeto SSW, Reinke SN, Sykes BD, Lemire BD, ((2007)) Ubiquinone-binding Site Mutations in the Saccharomyces cerevisiae Succinate Dehydrogenase Generate Superoxide and Lead to the Accumulation of Succinate. J Biol Chem 282:: 27518--27526.
-
(2007)
J Biol Chem
, vol.282
, pp. 27518-27526
-
-
Szeto, S.S.W.1
Reinke, S.N.2
Sykes, B.D.3
Lemire, B.D.4
-
48
-
-
33947358279
-
Effects of site-directed mutations in Escherichia coli succinate dehydrogenase on the enzyme activity and production of superoxide radicals
-
Zhao Z, Rothery RA, Weiner JH, ((2006)) Effects of site-directed mutations in Escherichia coli succinate dehydrogenase on the enzyme activity and production of superoxide radicals. Biochem Cell Biol 84:: 1013--1021.
-
(2006)
Biochem Cell Biol
, vol.84
, pp. 1013-1021
-
-
Zhao, Z.1
Rothery, R.A.2
Weiner, J.H.3
-
49
-
-
33749998916
-
Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells
-
Bacsi A, Woodberry M, Widger W, Papaconstantinou J, Mitra S, et al. ((2006)) Localization of superoxide anion production to mitochondrial electron transport chain in 3-NPA-treated cells. Mitochondrion 6:: 235--244.
-
(2006)
Mitochondrion
, vol.6
, pp. 235-244
-
-
Bacsi, A.1
Woodberry, M.2
Widger, W.3
Papaconstantinou, J.4
Mitra, S.5
-
50
-
-
0346850862
-
The ubiquinone-binding site of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase is a source of superoxide
-
Guo J, Lemire BD, ((2003)) The ubiquinone-binding site of the Saccharomyces cerevisiae succinate-ubiquinone oxidoreductase is a source of superoxide. J Biol Chem 278:: 47629--47635.
-
(2003)
J Biol Chem
, vol.278
, pp. 47629-47635
-
-
Guo, J.1
Lemire, B.D.2
-
51
-
-
49249127688
-
Cells silenced for SDHB expression display characteristic features of the tumor phenotype
-
Cervera AM, Apostolova N, Crespo FL, Mata M, McCreath KJ, ((2008)) Cells silenced for SDHB expression display characteristic features of the tumor phenotype. Cancer Res 68:: 4058--4067.
-
(2008)
Cancer Res
, vol.68
, pp. 4058-4067
-
-
Cervera, A.M.1
Apostolova, N.2
Crespo, F.L.3
Mata, M.4
McCreath, K.J.5
-
52
-
-
33847100058
-
The role of Sdh4p Tyr-89 in ubiquinone reduction by the Saccharomyces cerevisiae succinate dehydrogenase
-
Silkin Y, Oyedotun KS, Lemire BD, ((2007)) The role of Sdh4p Tyr-89 in ubiquinone reduction by the Saccharomyces cerevisiae succinate dehydrogenase. Biochim Biophys Acta 1767:: 143--150.
-
(2007)
Biochim Biophys Acta
, vol.1767
, pp. 143-150
-
-
Silkin, Y.1
Oyedotun, K.S.2
Lemire, B.D.3
-
53
-
-
33745591371
-
Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells
-
Selak MA, Duran RV, Gottlieb E, ((2006)) Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells. Biochim Biophys Acta 1757:: 567--572.
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 567-572
-
-
Selak, M.A.1
Duran, R.V.2
Gottlieb, E.3
-
54
-
-
84655167253
-
Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-*) and H2O2
-
Owens KM, Aykin-Burns N, Dayal D, Coleman MC, Domann FE, et al. ((2012)) Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-*) and H2O2. Free Radic Biol Med 52:: 160--166.
-
(2012)
Free Radic Biol Med
, vol.52
, pp. 160-166
-
-
Owens, K.M.1
Aykin-Burns, N.2
Dayal, D.3
Coleman, M.C.4
Domann, F.E.5
-
55
-
-
77954562833
-
Metastasis: cancer cell's escape from oxidative stress
-
Pani G, Galeotti T, Chiarugi P, ((2010)) Metastasis: cancer cell's escape from oxidative stress. Cancer Metastasis Rev 29:: 351--378.
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 351-378
-
-
Pani, G.1
Galeotti, T.2
Chiarugi, P.3
-
56
-
-
35948936350
-
Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells
-
Connor KM, Hempel N, Nelson KK, Dabiri G, Gamarra A, et al. ((2007)) Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Cancer Res 67:: 10260--10267.
-
(2007)
Cancer Res
, vol.67
, pp. 10260-10267
-
-
Connor, K.M.1
Hempel, N.2
Nelson, K.K.3
Dabiri, G.4
Gamarra, A.5
-
57
-
-
79953793364
-
Manganese superoxide dismutase (Sod2) and redox-control of signaling events that drive metastasis
-
Hempel N, Carrico PM, Melendez JA, ((2011)) Manganese superoxide dismutase (Sod2) and redox-control of signaling events that drive metastasis. Anticancer Agents Med Chem 11:: 191--201.
-
(2011)
Anticancer Agents Med Chem
, vol.11
, pp. 191-201
-
-
Hempel, N.1
Carrico, P.M.2
Melendez, J.A.3
-
58
-
-
2342455198
-
Mitochondrial superoxide dismutase: a promising target for new anticancer therapies
-
Pani G, Colavitti R, Bedogni B, Fusco S, Ferraro D, et al. ((2004)) Mitochondrial superoxide dismutase: a promising target for new anticancer therapies. Curr Med Chem 11:: 1299--1308.
-
(2004)
Curr Med Chem
, vol.11
, pp. 1299-1308
-
-
Pani, G.1
Colavitti, R.2
Bedogni, B.3
Fusco, S.4
Ferraro, D.5
-
59
-
-
79951699777
-
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
-
Wolf A, Agnihotri S, Micallef J, Mukherjee J, Sabha N, et al. ((2011)) Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 208:: 313--326.
-
(2011)
J Exp Med
, vol.208
, pp. 313-326
-
-
Wolf, A.1
Agnihotri, S.2
Micallef, J.3
Mukherjee, J.4
Sabha, N.5
-
60
-
-
35448961940
-
HIF-1 mediates the Warburg effect in clear cell renal carcinoma
-
Semenza GL, ((2007)) HIF-1 mediates the Warburg effect in clear cell renal carcinoma. J Bioenerg Biomembr 39:: 231--234.
-
(2007)
J Bioenerg Biomembr
, vol.39
, pp. 231-234
-
-
Semenza, G.L.1
-
61
-
-
70350217774
-
Clinical predictors and algorithm for the genetic diagnosis of pheochromocytoma patients
-
Erlic Z, Rybicki L, Peczkowska M, Golcher H, Kann PH, et al. ((2009)) Clinical predictors and algorithm for the genetic diagnosis of pheochromocytoma patients. Clin Cancer Res 15:: 6378--6385.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6378-6385
-
-
Erlic, Z.1
Rybicki, L.2
Peczkowska, M.3
Golcher, H.4
Kann, P.H.5
-
62
-
-
77955172890
-
Tyrosine hydroxylase, chromogranin A, and steroidogenic acute regulator as markers for successful separation of human adrenal medulla
-
Fliedner SM, Breza J, Kvetnansky R, Powers JF, Tischler AS, et al. ((2010)) Tyrosine hydroxylase, chromogranin A, and steroidogenic acute regulator as markers for successful separation of human adrenal medulla. Cell Tissue Res 340:: 607--612.
-
(2010)
Cell Tissue Res
, vol.340
, pp. 607-612
-
-
Fliedner, S.M.1
Breza, J.2
Kvetnansky, R.3
Powers, J.F.4
Tischler, A.S.5
-
63
-
-
29244432748
-
Two-dimensional gel electrophoresis maps of the proteome and phosphoproteome of primitively cultured rat mesangial cells
-
Jiang X-S, Tang L-Y, Cao X-J, Zhou H, Xia Q-C, et al. ((2005)) Two-dimensional gel electrophoresis maps of the proteome and phosphoproteome of primitively cultured rat mesangial cells. Electrophoresis 26:: 4540--4562.
-
(2005)
Electrophoresis
, vol.26
, pp. 4540-4562
-
-
Jiang, X.-S.1
Tang, L.-Y.2
Cao, X.-J.3
Zhou, H.4
Xia, Q.-C.5
-
64
-
-
0033434080
-
Probability-based protein identification by searching sequence databases using mass spectrometry data
-
Perkins DN, Pappin DJ, Creasy DM, Cottrell JS, ((1999)) Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20:: 3551--3567.
-
(1999)
Electrophoresis
, vol.20
, pp. 3551-3567
-
-
Perkins, D.N.1
Pappin, D.J.2
Creasy, D.M.3
Cottrell, J.S.4
-
65
-
-
0036491512
-
Isolation of protein subpopulations undergoing protein-protein interactions
-
Nelson TJ, Backlund PSJ, Yergey AL, Alkon DL, ((2002)) Isolation of protein subpopulations undergoing protein-protein interactions. Mol Cell Proteomics 1:: 253--259.
-
(2002)
Mol Cell Proteomics
, vol.1
, pp. 253-259
-
-
Nelson, T.J.1
Backlund, P.S.J.2
Yergey, A.L.3
Alkon, D.L.4
-
66
-
-
0037108887
-
Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
-
Keller A, Nesvizhskii AI, Kolker E, Aebersold R, ((2002)) Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. Anal Chem 74:: 5383--5392.
-
(2002)
Anal Chem
, vol.74
, pp. 5383-5392
-
-
Keller, A.1
Nesvizhskii, A.I.2
Kolker, E.3
Aebersold, R.4
-
67
-
-
0042338362
-
A statistical model for identifying proteins by tandem mass spectrometry
-
Nesvizhskii AI, Keller A, Kolker E, Aebersold R, ((2003)) A statistical model for identifying proteins by tandem mass spectrometry. Anal Chem 75:: 4646--4658.
-
(2003)
Anal Chem
, vol.75
, pp. 4646-4658
-
-
Nesvizhskii, A.I.1
Keller, A.2
Kolker, E.3
Aebersold, R.4
-
68
-
-
0001883657
-
Isolation and characteristics of intact mitochondria
-
Rickwood D, Wilson M, Darley-Usmar V, ((1987)) Isolation and characteristics of intact mitochondria. In: Darley-Usmar V, Rickwood D, Wilson M, editors. Mitochondria: A Practical Approach Oxford, U.K.: IRL Press pp. pp. 1--16.
-
(1987)
, pp. 1-16
-
-
Rickwood, D.1
Wilson, M.2
Darley-Usmar, V.3
Darley-Usmar, V.4
Rickwood, D.5
Wilson, M.6
-
69
-
-
0027931039
-
Biochemical and molecular investigations in respiratory chain deficiencies
-
Rustin P, Chretien D, Bourgeron T, Gerard B, Rotig A, et al. ((1994)) Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta 228:: 35--51.
-
(1994)
Clin Chim Acta
, vol.228
, pp. 35-51
-
-
Rustin, P.1
Chretien, D.2
Bourgeron, T.3
Gerard, B.4
Rotig, A.5
-
70
-
-
67649243697
-
The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury
-
Carpi A, Menabo R, Kaludercic N, Pelicci P, Di Lisa F, et al. ((2009)) The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury. Biochim Biophys Acta 1787:: 774--780.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 774-780
-
-
Carpi, A.1
Menabo, R.2
Kaludercic, N.3
Pelicci, P.4
Di Lisa, F.5
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