Creatine supplementation with specific view to exercise/sports performance: An update

Journal of the International Society of Sports Nutrition

Volumn 9, Issue , 2012, Pages

  Cooper, Robert ^a   Naclerio, Fernando ^a   Allgrove, Judith ^a   Jimenez, Alfonso ^a,b  

^a UNIVERSITY OF GREENWICH   (United Kingdom)

^b VICTORIA UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84864390824     PISSN: None     EISSN: 15502783     Source Type: Journal    
DOI: 10.1186/1550-2783-9-33     Document Type: Review

References (85)

1. Persky A, Brazeau G. Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacol Rev 2001, 53:161-176.
2. Burke DG, Candow DG, Chilibeck PD, MacNeil LG, Roy BD, Tarnopolsky MA, Ziegenfuss T. Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults. Int J Sport Nutr Exerc Metab 2008, 18:389-398.
3. Gualano B, Artioli GG, Poortmans JR, Lancha Junior AH. Exploring the therapeutic role of creatine supplementation. Amino Acids 2010, 38:31-44. 10.1007/s00726-009-0263-6, 19253023.
4. Tarnopolsky MA. Creatine as a therapeutic strategy for myopathies. Amino Acids 2011, 40:1397-1407. 10.1007/s00726-011-0876-4, 21399918.
5. Buford T, Kreider R, Stout J, Greenwood M, Campbell B, Spano M, Ziegenfuss T, Lopez H, Landis J, Antonio J. International Society of Sports Nutrition position stand: creatine supplementation and exercise. J Int Soc Sports Nutr 2007, 4:6. 10.1186/1550-2783-4-6, 2048496, 17908288.
6. American College of Sport Medicine Round Table, the physiological and health effects of oral creatine supplementation. Med Sci Sports Exc 2000, 32:706-717. American College of Sport Medicine.
7. Branch JD. Effects of creatine supplementation on body composition and performace: a meta análisis. Int J Sports Nutr Exerc Metabol 2003, 13:I198-122.
8. Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res 2003, 17:822-831.
9. Volek JS, Kraemer WJ. Creatine suplemetation: its effects on human muscular performance and body composition. J Strength Cond Res 1996, 10:200-210.
10. Bemben M, Lamont H. Creatine supplementation and exercise performance: recent findings. Sports Med 2005, 35:107-125. 10.2165/00007256-200535020-00002, 15707376.
11. Brosnan JT, da Silva RP, Brosnan ME. The metabolic burden of creatine synthesis. Amino Acids 2011, 40:1325-1331. 10.1007/s00726-011-0853-y, 21387089.
12. Snow RJ, Murphy RM. Creatine and the creatine transporter: a review. Mol Cell Biochem 2001, 224:169-181. 10.1023/A:1011908606819, 11693194.
13. Snow RJ, Murphy RM. Factors influencing creatine loading into human skeletal muscle. Exerc Sport Sci Rev 2003, 31:154-158. 10.1097/00003677-200307000-00010, 12882483.
14. Schoch RD, Willoughby D, Greenwood M. The regulation and expression of the creatine transporter: a brief review of creatine supplementation in humans and animals. J Int Soc Sports Nutr 2006, 3:60-66. 10.1186/1550-2783-3-1-60, 2129152, 18500965.
15. Hickner R, Dyck D, Sklar J, Hatley H, Byrd P. Effect of 28 days of creatine ingestion on muscle metabolism and performance of a simulated cycling road race. J Int Soc Sports Nutr 2010, 7:26. 10.1186/1550-2783-7-26, 2909923, 20609257.
16. Hespel P, Derave W. Ergogenic effects of creatine in sports and rehabilitation. Subcell Biochem 2007, 46:245-259. 10.1021/bi061646s, 18652080.
17. Casey A, Greenhaff P. Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance?. Am J Clin Nutr 2000, 72:607S-617S.
18. Volek J, Duncan N, Mazzetti S, Staron R, Putukian M, Gómez A, Pearson D, Fink W, Kraemer W. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sports Exerc 1999, 31:1147-1156. 10.1097/00005768-199908000-00011, 10449017.
19. Dempsey R, Mazzone M, Meurer L. Does oral creatine supplementation improve strength? A meta-analysis. J Fam Pract 2002, 51:945-951.
20. Kreider RB. Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem 2003, 244:89-94. 10.1023/A:1022465203458, 12701815.
21. van Loon L, Oosterlaar A, Hartgens F, Hesselink M, Snow R, Wagenmakers A. Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans. Clin Sci (Lond) 2003, 104:153-162.
22. Volek J, Rawson E. Scientific basis and practical aspects of creatine supplementation for athletes. Nutrition 2004, 20:609-614. 10.1016/j.nut.2004.04.014, 15212742.
23. Jakobi J, Rice C, Curtin S, Marsh G. Contractile properties, fatigue and recovery are not influenced by short-term creatine supplementation in human muscle. Exp Physiol 2000, 85:451-460. 10.1017/S0958067000020212, 10918084.
24. Bemben MG, Witten MS, Carter JM, Eliot KA, Knehans AW, Bemben DA. The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men. J Nutr Health Aging 2010, 14:155-159. 10.1007/s12603-009-0124-8, 20126965.
25. Safdar A, Yardley N, Snow R, Melov S, Tarnopolsky M. Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation. Physiol Genomics 2008, 32:219-228.
26. Saremi A, Gharakhanloo R, Sharghi S, Gharaati M, Larijani B, Omidfar K. Effects of oral creatine and resistance training on serum myostatin and GASP-1. Mol Cell Endocrinol 2010, 317:25-30. 10.1016/j.mce.2009.12.019, 20026378.
27. Bazzucchi I, Felici F, Sacchetti M. Effect of short-term creatine supplementation on neuromuscular function. Med Sci Sports Exerc 2009, 41:1934-41. 10.1249/MSS.0b013e3181a2c05c, 19727018.
28. Branch J. Effect of creatine supplementation on body composition and performance: a meta-analysis. Int J Sport Nutr Exerc Metab 2003, 13:198-226.
29. Cribb PJ, Williams AD, Hayes A. A creatine-protein-carbohydrate supplement enhances responses to resistance training. Med Sci Sports Exerc 2007, 39:1960-1968. 10.1249/mss.0b013e31814fb52a, 17986903.
30. Parise G, Mihic S, MacLennan D, Yarasheski KE, Tarnopolsky MA. Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis. J Appl Physiol 2001, 91:1041-1047.
31. Louis M, Poortmans JR, Francaux M, Hultman E, Berre J, Boisseau N, Young VR, Smith K, Meier-Augenstein W, Babraj JA, et al. Creatine supplementation has no effect on human muscle protein turnover at rest in the postabsorptive or fed states. Am J Physiol Endocrinol Metab 2003, 284:E764-E770.
32. Deldicque L, Atherton P, Patel R, Theisen D, Nielens H, Rennie M, Francaux M. Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle. J Appl Physiol 2008, 104:371-378.
33. Harp JB, Goldstein S, Phillips LS. Nutrition and somatomedin. XXIII. Molecular regulation of IGF-I by amino acid availability in cultured hepatocytes. Diabetes 1991, 40:95-101. 10.2337/diabetes.40.1.95, 1901809.
34. Chwalbiñska-Moneta J. Effect of creatine supplementation on aerobic performance and anaerobic capacity in elite rowers in the course of endurance training. Int J Sport Nutr Exerc Metab 2003, 13:173-183.
35. Graef J, Smith A, Kendall K, Fukuda D, Moon J, Beck T, Cramer J, Stout J. The effects of four weeks of creatine supplementation and high-intensity interval training on cardiorespiratory fitness: a randomized controlled trial. J Int Soc Sports Nutr 2009, 6:18. 10.1186/1550-2783-6-18, 2780977, 19909536.
36. Thompson C, Kemp G, Sanderson A, Dixon R, Styles P, Taylor D, Radda G. Effect of creatine on aerobic and anaerobic metabolism in skeletal muscle in swimmers. Br J Sports Med 1996, 30:222-225. 10.1136/bjsm.30.3.222, 1332335, 8889115.
37. Nelson A, Arnall D, Kokkonen J, Day R, Evans J. Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Med Sci Sports Exerc 2001, 33:1096-1100.
38. Sewell D, Robinson T, Greenhaff P. Creatine supplementation does not affect human skeletal muscle glycogen content in the absence of prior exercise. J Appl Physiol 2008, 104:508-512.
39. Op 't Eijnde B, Urso B, Richter EA, Greenhaff PL, Hespel P. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes 2001, 50:18-23. 10.2337/diabetes.50.1.18, 11147785.
40. Bassit RA, Pinheiro CH, Vitzel KF, Sproesser AJ, Silveira LR, Curi R. Effect of short-term creatine supplementation on markers of skeletal muscle damage after strenuous contractile activity. Eur J Appl Physiol 2010, 108:945-955. 10.1007/s00421-009-1305-1, 19956970.
41. Cooke MB, Rybalka E, Williams AD, Cribb PJ, Hayes A. Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals. J Int Soc Sports Nutr 2009, 6:13. 10.1186/1550-2783-6-13, 2697134, 19490606.
42. Lawler JM, Barnes WS, Wu G, Song W, Demaree S. Direct antioxidant properties of creatine. Biochem Biophys Res Commun 2002, 290:47-52. 10.1006/bbrc.2001.6164, 11779131.
43. Sestili P, Martinelli C, Bravi G, Piccoli G, Curci R, Battistelli M, Falcieri E, Agostini D, Gioacchini AM, Stocchi V. Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian cells via direct antioxidant activity. Free Radic Biol Med 2006, 40:837-849. 10.1016/j.freeradbiomed.2005.10.035, 16520236.
44. Rahimi R. Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise. J Strength Cond Res 2011, 25:3448-3455. 10.1519/JSC.0b013e3182162f2b, 22080314.
45. Sculthorpe N, Grace F, Jones P, Fletcher I. The effect of short-term creatine loading on active range of movement. Appl Physiol Nutr Metab 2010, 35:507-511. 10.1139/H10-036, 20725117.
46. Hile A, Anderson J, Fiala K, Stevenson J, Casa D, Maresh C. Creatine supplementation and anterior compartment pressure during exercise in the heat in dehydrated men. J Athl Train 2006, 41:30-35. 1421498, 16619092.
47. Hammett S, Wall M, Edwards T, Smith A. Dietary supplementation of creatine monohydrate reduces the human fMRI BOLD signal. Neurosci Lett 2010, 479:201-205. 10.1016/j.neulet.2010.05.054, 20570601.
48. D'Anci KE, Allen PJ, Kanarek RB. A potential role for creatine in drug abuse?. Mol Neurobiol 2011, 44:136-41. 10.1007/s12035-011-8176-2, 21399936.
49. Rawson ES, Venezia AC. Use of creatine in the elderly and evidence for effects on cognitive function in young and old. Amino Acids 2011, 40:1349-1362. 10.1007/s00726-011-0855-9, 21394604.
50. Beal MF. Neuroprotective effects of creatine. Amino Acids 2011, 40:1305-1313. 10.1007/s00726-011-0851-0, 21448659.
51. Braissant O, Henry H, Béard E, Uldry J. Creatine deficiency syndromes and the importance of creatine synthesis in the brain. Amino Acids 2011, 40:1315-1324. 10.1007/s00726-011-0852-z, 21390529.
52. Metzl JD, Small E, Levine SR, Gershel JC. Creatine use among young athletes. Pediatrics 2001, 108:421-425. 10.1542/peds.108.2.421, 11483809.
53. Evans MW, Ndetan H, Perko M, Williams R, Walker C. Dietary supplement use by children and adolescents in the United States to Enhance sport performance: results of the national health interview survey. J Prim Prev 2012, 33:3-12. 10.1007/s10935-012-0261-4, 22297456.
54. Unnithan VB, Veehof SH, Vella CA, Kern M. Is there a physiologic basis for creatine use in children and adolescents?. J Strength Cond Res 2001, 15:524-528.
55. Willoughby DS, Rosene J. Effects of oral creatine and resistance training on myosin heavy chain expression. Med Sci Sports Exerc 2001, 33:1674-1681. 10.1097/00005768-200110000-00010, 11581551.
56. Sale C, Harris RC, Florance J, Kumps A, Sanvura R, Poortmans JR. Urinary creatine and methylamine excretion following 4 x 5 g x day(-1) or 20 x 1 g x day(-1) of creatine monohydrate for 5 days. J Sports Sci 2009, 27:759-766. 10.1080/02640410902838237, 19437189.
57. Syrotuik DG, Bell GJ. Acute creatine monohydrate supplementation: a descriptive physiological profile of responders vs. nonresponders. J Strength Cond Res 2004, 18:610-617.
58. Greenhaff PL, Bodin K, Soderlund K, Hultman E. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol 1994, 266:E725-E730.
59. Ganguly S, Jayappa S, Dash AK. Evaluation of the stability of creatine in solution prepared from effervescent creatine formulations. AAPS PharmSciTech 2003, 4:E25. 2750587, 12916907.
60. Jäger R, Harris RC, Purpura M, Francaux M. Comparison of new forms of creatine in raising plasma creatine levels. J Int Soc Sports Nutr 2007, 4:17. 10.1186/1550-2783-4-17, 2206055, 17997838.
61. Jäger R, Metzger J, Lautmann K, Shushakov V, Purpura M, Geiss K, Maassen N. The effects of creatine pyruvate and creatine citrate on performance during high intensity exercise. J Int Soc Sports Nutr 2008, 5:4. 10.1186/1550-2783-5-4, 2276184, 18269769.
62. Jäger R, Purpura M, Shao A, Inoue T, Kreider RB. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Amino Acids 2011, 40:1369-83. 10.1007/s00726-011-0874-6, 3080578, 21424716.
63. Gufford BT, Sriraghavan K, Miller N, Miller D, Gu X, Vennerstrom J, Robinson D. Physicochemical characterization of creatine N-methylguanidinium salts. Journal of Dietary Supplements 2010, 7:240-252. 10.3109/19390211.2010.491507, 22432515.
64. Persky AM, Brazeau GA, Hochhaus G. Pharmacokinetics of the dietary supplement creatine. Clin Pharmacokinet 2003, 42:557-574. 10.2165/00003088-200342060-00005, 12793840.
65. Spillane M, Schoch R, Cooke M, Harvey T, Greenwood M, Kreider R, Willoughby DS. The effects of creatine ethyl ester supplementation combined with heavy resistance training on body composition, muscle performance, and serum and muscle creatine levels. J Int Soc Sports Nutr 2009, 6:6. 10.1186/1550-2783-6-6, 2649889, 19228401.
66. Knop K, Hoogenboom R, Fischer D, Schubert US. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem Int Ed Engl 2010, 49:6288-6308. 10.1002/anie.200902672, 20648499.
67. Camic CL, Hendrix CR, Housh TJ, Zuniga JM, Mielke M, Johnson GO, Schmidt RJ, Housh DJ. The effects of polyethylene glycosylated creatine supplementation on muscular strength and power. J Strength Cond Res 2010, 24:3343-3351. 10.1519/JSC.0b013e3181fc5c5c, 21068676.
68. Herda TJ, Beck TW, Ryan ED, Smith AE, Walter AA, Hartman MJ, Stout JR, Cramer JT. Effects of creatine monohydrate and polyethylene glycosylated creatine supplementation on muscular strength, endurance, and power output. J Strength Cond Res 2009, 23:818-826. 10.1519/JSC.0b013e3181a2ed11, 19387397.
69. Steenge GR, Lambourne J, Casey A, Macdonald IA, Greenhaff PL. Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. Am J Physiol 1998, 275:E974-E979.
70. Steenge G, Simpson E, Greenhaff P. Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. J Appl Physiol 2000, 89:1165-1171.
71. Olsen S, Aagaard P, Kadi F, Tufekovic G, Verney J, Olesen JL, Suetta C, Kjaer M. Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training. J Physiol 2006, 573:525-534. 10.1113/jphysiol.2006.107359, 1779717, 16581862.
72. Walsh AL, Gonzalez AM, Ratamess NA, Kang J, Hoffman JR. Improved time to exhaustion following ingestion of the energy drink Amino Impact. J Int Soc Sports Nutr 2010, 7:14. 10.1186/1550-2783-7-14, 2861014, 20398312.
73. Yoshizumi W, Tsourounis C. Effects of creatine supplementation on renal function. J Herb Pharmacother 2004, 4:1-7.
74. Thorsteinsdottir B, Grande J, Garovic V. Acute renal failure in a young weight lifter taking multiple food supplements, including creatine monohydrate. J Ren Nutr 2006, 16:341-345. 10.1053/j.jrn.2006.04.025, 17046619.
75. Pline K, Smith C. The effect of creatine intake on renal function. Ann Pharmacother 2005, 39:1093-1096. 10.1345/aph.1E628, 15886291.
76. Poortmans J, Francaux M. Adverse effects of creatine supplementation: fact or fiction?. Sports Med 2000, 30:155-170. 10.2165/00007256-200030030-00002, 10999421.
77. Bizzarini E, De Angelis L. Is the use of oral creatine supplementation safe?. J Sports Med Phys Fitness 2004, 44:411-416.
78. Kim HJ, Kim CK, Carpentier A, Poortmans JR. Studies on the safety of creatine supplementation. Amino Acids 2011, 40:1409-1418. 10.1007/s00726-011-0878-2, 21399917.
79. Tarnopolsky M, Zimmer A, Paikin J, Safdar A, Aboud A, Pearce E, Roy B, Doherty T. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. PLoS One 2007, 2:e991. 10.1371/journal.pone.0000991, 1994592, 17912368.
80. Cornelissen VA, Defoor JG, Stevens A, Schepers D, Hespel P, Decramer M, Mortelmans L, Dobbels F, Vanhaecke J, Fagard RH, Vanhees L. Effect of creatine supplementation as a potential adjuvant therapy to exercise training in cardiac patients: a randomized controlled trial. Clin Rehabil 2010, 24:988-999. 10.1177/0269215510367995, 20576665.
81. Schilling B, Stone M, Utter A, Kearney J, Johnson M, Coglianese R, Smith L, O'Bryant H, Fry A, Starks M, et al. Creatine supplementation and health variables: a retrospective study. Med Sci Sports Exerc 2001, 33:183-188.
82. Dalbo V, Roberts M, Stout J, Kerksick C. Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration. Br J Sports Med 2008, 42:567-573. 10.1136/bjsm.2007.042473, 18184753.
83. Watson G, Casa D, Fiala K, Hile A, Roti M, Healey J, Armstrong L, Maresh C. Creatine use and exercise heat tolerance in dehydrated men. J Athl Train 2006, 41:18-29. 1421496, 16619091.
84. Lopez R, Casa D, McDermott B, Ganio M, Armstrong L, Maresh C. Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses. J Athl Train 2009, 44:215-223. 10.4085/1062-6050-44.2.215, 2657025, 19295968.
85. Hadjicharalambous M, Kilduff L, Pitsiladis Y. Brain serotonin and dopamine modulators, perceptual responses and endurance performance during exercise in the heat following creatine supplementation. J Int Soc Sports Nutr 2008, 5:14. 10.1186/1550-2783-5-14, 2570654, 18826587.