The effect of creatine intake on renal function

Annals of Pharmacotherapy

Volumn 39, Issue 6, 2005, Pages 1093-1096

  Pline, Kurt A ^a,b   Smith, Curtis L ^a,c  

^a FERRIS STATE UNIVERSITY   (United States)

^b Sparrow Hospital ^*

^c Claire Dart Stroke Center Sparrow Hospital   (United States)

Author keywords

Creatine; Creatinine clearance; Renal function

Indexed keywords

CREATINE; CREATININE;

ARTICLE; ATHLETE; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DIET SUPPLEMENTATION; FLANK PAIN; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY DISEASE; KIDNEY FUNCTION; MEDLINE; NAUSEA; NEPHROTOXICITY; PRIORITY JOURNAL; UPREGULATION; VOMITING;

ADULT; CLINICAL TRIALS; CREATINE; DIETARY SUPPLEMENTS; HUMANS; KIDNEY; KIDNEY FUNCTION TESTS;

EID: 18844413316     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1E628     Document Type: Article

References (24)

1. Steeves S. Webmd.com. Creatine use spreads to high school athletes. http://my.webmd.com/content/article/29/1728_67896.htm (accessed 2004 Jun 30).
2. Metzl JD, Small E, Levine SR, Gershel JC. Creatine use among young athletes. Pediatrics 2001;108:421-5.
3. Lehmkuhl M, Malone M, Justice B, Trone G, Pistilli E, Vinci D, et al. The effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measures. J Strength Cond Res 2003;17:425-38.
4. Stone MH, Sanborn K, Smith LL, O'Bryant HS, Hoke T, Utter AC, et al. Effects of in-season (5 weeks) creatine and pyruvate supplementation on anaerobic performance and body composition in American football players. Int J Sport Nutr Exerc Metab 1999;9:146-65.
5. Kreider RB, Ferreira M, Wilson M, Grindstaff P, Plisk S, Reinardy J, et al. Effects of creatine supplementation on body composition, strength, and sprint performance. Med Sci Sports Exerc 1998;30:73-82.
6. Grindstaff PD, Kreider R, Bishop R, Wilson M, Wood L, Alexander C, et al. Effects of creatine supplementation on repetitive sprint performance and body composition in competitive swimmers. Int J Sport Nutr Exerc Metab 1997;7:330-46.
7. Balsom PD, Soderlund K, Ekblom B. Creatine in humans with special reference to creatine supplementation. Sports Med 1994;18:268-80.
8. Casey A, Greenhaff PL. Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? Am J Clin Nutr 2000;72(2 suppl):607S-17S.
9. Persky AM, Brazeau GA. Clinical pharmacology of dietary supplement creatine monohydrate. Pharmacol Rev 2001;53:161-76.
10. Williams MH, Branch JD. Creatine supplementation and exercise performance: an update. J Am Coll Nutr 1998;17:216-34.
11. Hultman E, Soderland K, Timmons JA, Cederblad G, Greenhaff PL. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7.
12. Perrone RD, Madias NE, Levey AS. Serum creatinine as an index of renal function: new insights into old concepts. Clin Chem 1992;38:1933-53.
13. Priest JB, Tjien OO, Moorehead WR. Exercise-induced changes in common laboratory tests. Am J Clin Pathol 1982;77:285-9.
14. Poortmans JR, Auquier H, Renaut V, Durussel A, Saugy M, Brisson GR. Effect of short-term creatine supplementation on renal responses in men. Eur J Appl Physiol Occup Physiol 1997;76:566-7.
15. Schedel JM, Tanaka H, Kiyonaga A, Shindo M, Schutz Y. Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations. Life Sci 1999;65:2463-70.
16. Kamber M, Koster M, Kreis R, Walker G, Boesch C, Hoppeler H. Creatine supplementation - part I: performance, clinical chemistry, and muscle volume. Med Sci Sports Exerc 1999;31:1763-9.
17. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6.
18. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31-41.
19. Robinson TM, Sewell DA, Casey A, Steenge G, Greenhaff PL. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br J Sports Med 2000;34:284-8.
20. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10.
21. Mayhew DL, Mayhew JL, Ware JS. Effects of long-term creatine supplementation on liver and kidney functions in American college football players. Int J Sport Nutr Exerc Metab 2002;12:453-60.
22. Kreider RB, Melton C, Rasmussen CJ, Greenwood M, Lancaster S, Cantler EC, et al. Long-term creatine supplementation does not significantly affect clinical markers of health in athletes. Mol Cell Biochem 2003;244:95-104.
23. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3.
24. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5.