Creatine supplementation does not affect human skeletal muscle glycogen content in the absence of prior exercise

Journal of Applied Physiology

Volumn 104, Issue 2, 2008, Pages 508-512

  Sewell, Dean A ^a   Robinson, Tristan M ^b   Greenhaff, Paul L ^c  

^a HERIOT WATT UNIVERSITY   (United Kingdom)

^b H J Heinz ^*  (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Carbohydrate; Exercise; Phosphocreatine

Indexed keywords

CARBOHYDRATE; CREATINE; GLUCOSE; GLYCOGEN;

ADULT; ARTICLE; DIET SUPPLEMENTATION; EXERCISE; EXHAUSTION; GLYCOGEN MUSCLE LEVEL; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MUSCLE BIOPSY; NORMAL HUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE; VOLUNTEER;

ADENOSINE TRIPHOSPHATE; ADMINISTRATION, ORAL; ADULT; BLOOD GLUCOSE; BODY WEIGHT; CARBONATED BEVERAGES; CREATINE; CROSS-OVER STUDIES; DIETARY CARBOHYDRATES; DIETARY SUPPLEMENTS; EXERCISE; GLYCOGEN; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE, SKELETAL; PHOSPHOCREATINE; REFERENCE VALUES; TIME FACTORS;

EID: 38949135991     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00787.2007     Document Type: Article

References (29)

1. Bergstrom J. Muscle electrolytes in man, determined by neutron activation analysis on needle biopsy specimens. A study on normal subjects, kidney patients and patients with chronic diarrhea. Scand J Clin Lab Invest 14: 1-110, 1962.
2. Bergstrom J, Hultman E. Muscle glycogen synthesis after exercise: an enhancing factor localised to the muscle cells in man. Nature 1210: 218-228, 1966.
3. Casey A, Constantin-Teodosiu D, Howell S, Hultman E, Greenhaff PL. Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am J Physiol Endocrinol Metab 271: E31-E37, 1996.
4. Cribb PJ, Hayes A. Effects of supplement timing and resistance exercise on skeletal muscle hypertophy. Med Sci Sports Exerc 38: 1918-1925, 2006.
5. Derave W, Einde BO, Verbessem P, Ramaekers M, vam Leemputte M, Richter EA, Hespel P. Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT4 content and glucose tolerance in humans. J Appl Physiol 94: 1910-1916, 2003.
6. Fryer LG, Foufelle F, Barnes K, Baldwin SA, Woods A, Carling D. Characterisation of the role of AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. Biochem J 363: 167-174, 2002.
7. +-ATPase concentration with short-term training. Am J Physiol Cell Physiol 264: C1538-C1541, 1993.
8. Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol Endocrinol Metab 271: E821-E826, 1996.
9. Greenhaff PL, Bodin K, Soderlund K, Hultman E. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Am J Physiol Endocrinol Metab 266: E725-E730, 1994.
10. Hardie DG, Hawley SA. AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays 23: 1112-1119, 2001.
11. Harris RC, Hultman E, Nordesjo LO. Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values. Scand J Clin Lab Invest 33: 109-120, 1974.
12. Harris RC, Soderlund K, Hultman E. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Colch) 83: 367-374, 1992.
13. Haugland RB, Chang DT. Insulin effects on creatine transport in skeletal muscle. Proc Soc Exp Biol Med 148: 1-4, 1975.
14. Hayashi T, Hirshman MF, Fujii N, Habinowski SA, Witters LA, Goodyear LJ. Metabolic stress and altered glucose transport activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes 49: 527-531, 2000.
15. +-ATPase from the intracellular compartments to the plasma membrane in mammalian skeletal muscle. J Biol Chem 267: 5040-5045, 1992.
16. 14C by skeletal muscle in normal and X-irradiated rats. Proc Soc Exp Biol Med 139: 1265-1271, 1972.
17. Low SY, Rennie MJ, Taylor DM. Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume. J Physiol 495: 299-303, 1996.
18. +-ATPase α2 subunit in the surface of rat skeletal muscle: morphological evidence. Am J Physiol Cell Physiol 265: C1716-C1722, 1993.
19. McKenna MJ, Harmer AR, Fraser SF, Li JL. Effects of training on potassium, calcium and hydrogen ion regulation in skeletal muscle and blood during exercise. Acta Physiol Scand 156: 335-346, 1996.
20. McKenna MJ, Heigenhauser GJF, McKelvie RS, MacDougall JD, Jones NL. Sprint training enhances ionic regulation during intense exercise in men. J Physiol 501: 687-702, 1997.
21. Nelson AG, Arnall DA, Kokkonen J, Day R, Evans J. Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Med Sci Sports Exerc 33: 1096-1100, 2001.
22. Newman JEN, Hargreaves M, Garnham A, Snow RJ. Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men. Med Sci Sports Exerc 35: 69-74, 2003.
23. Op't Einde B, Urso B, Richter EA, Greenhaff PL, Hespel P. Effect of oral creatine supplementation on human skeletal muscle GLUT4 protein content after immobilization. Diabetes 50: 18-23, 2001.
24. Ponticos M, Long Lu Q, Morgan JE, Hardie DG, Partridge TA, Carling D. Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle. EMBO J 17: 1688-1699, 1998.
25. Robinson TM, Sewell DA, Hultman E, Greenhaff PL. Role of submaximal exercise in promoting creatine and glycogen accumulation in human skeletal muscle. J Appl Physiol 87: 598-604, 1999.
26. Steenge G, Lambourne J, Casey A, Macdonald IA, Greenhaff PL. Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. Am J Physiol Endocrinol Metab 275: E974-E979, 1998.
27. van Loon LJ, Oosterlaar AM, Hartgens F, Hesselink MKC, Snow RJ, Wagenmakers AJ. Effects of creatine loading and prolonged creatine supplementation on body composition, fuel selection, sprint and endurance performance in humans. Clin Sci (Colch) 104: 153-162, 2003.
28. van Loon LJ, Murphy R, Oosterlaar AM, Cameron-Smith D, Hargreaves M, Wagenmakers AJ, Snow R. Creatine supplementation increases glycogen storage but not GLUT-4 expression in human skeletal muscle. Clin Sci (Colch) 106: 99-106, 2004.
29. Vorgerd M, Zange J. Carbohydrate oxidation disorders of skeletal muscle. Curr Opin Clin Nutr Metab Care 5: 611-617, 2000.