The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men

Journal of Nutrition, Health and Aging

Volumn 14, Issue 2, 2010, Pages 155-159

  Bemben, M G ^a   Witten, M S ^b   Carter, J M ^c   Eliot, K A ^d   Knehans, A W ^d   Bemben, D A ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Norman Regional Hospital   (United States)

^d UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Aging; Creatine monohydrate; Strength; Weight training; Whey protein

Indexed keywords

CREATINE; PLACEBO; PROTEIN; MILK PROTEIN; WHEY PROTEIN;

ADULT; AGED; ARTICLE; BICEPS BRACHII MUSCLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; EXERCISE; HUMAN; HUMAN EXPERIMENT; KNEE FUNCTION; LEAN BODY WEIGHT; MALE; MUSCLE STRENGTH; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; TRICEPS BRACHII MUSCLE; WHEY; AGING; BODY COMPOSITION; DRUG EFFECT; DRUG POTENTIATION; MIDDLE AGED; PHYSIOLOGY; PROTEIN INTAKE; SKELETAL MUSCLE; TASK PERFORMANCE;

AGED; AGING; BODY COMPOSITION; CREATINE; DIETARY PROTEINS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG SYNERGISM; HUMANS; MALE; MIDDLE AGED; MILK PROTEINS; MUSCLE STRENGTH; MUSCLE, SKELETAL; RESISTANCE TRAINING; TASK PERFORMANCE AND ANALYSIS;

EID: 77952314982     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-009-0124-8     Document Type: Article

References (40)

1. Roubenoff R, Hughes V. Sarcopenia: Current Concepts. J Gerontol Medical Series A 2000:55 A: M716-M724.
2. Hunter G, McCarthy J, Bamman M. Effects of resistance training on older adults. Sports. Med 2004:34 (5):329-348.
3. Burke D, Chilibeck P, Davison K, Candow D, Farthing J, Smith-Palmer T. The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength. Int J Sport Nutr Exerc Metab 2001:11:349-364.
4. Campbell W, Crim M, Dallal G, Young V, Evans W. Increased protein requirements in the elderly; New data and retrospective reassessments. Am J Clin Nutr 1994:60:501-509.
5. Campbell W, Crim M, Young V, Joseph J, Evans W. Effects of resistance training and dietary protein intake on protein metabolism in older adults. Am J Physiol 1995:268: E1143-E1153.
6. Hartman J, Tang J, Wilkinson S, Tarnopolsky M, Lawrence R, Fullerton A, Phillips S. Consumption of fat-free fluid milk after resistance exercise promotes greater lean mass accretion than does consumption of soy or carbohydrate in young, novice, male weightlifters. Am J Clin Nutr 2007:86 (2):373-381.
7. Kerksick C, Rasmussen C, Lancaster S, Magu B, Smith P, Melton C, Greenwood M, Almada A, Earnest C, Kreider R. The effects of protein and amino acid supplementation on performance and training adaptations during ten weeks of resistance training. J Strength Cond Res 2006:20 (3):643-653.
8. Lemon P, Tarnopolsky M, Macdougall J, Atkinson S. Protein requirements and muscle mass/strength changes during intensive training in novice bodybuilders. J Appl Physiol 1992:73:767-775.
9. Schulte J, Yarasheski K. Effects of resistance training on the rate of muscle protein synthesis in frail elderly people. Int J Sport Nutr Exerc Metab 2001:11: S111-S118.
10. Short K, Nair K. Muscle protein metabolism and the sarcopenia of aging. Int J Sport Nutr Exerc Metab 2001:11: S119-S127.
11. Tarnopolsky M, Parise G, Yardley N, Ballantyne C, Olatunji S, Phillips S. Creatinedextrose and protein-dextrose induce similar strength gains during training. Med Sci Sports Exerc 2001:33 (12):2044-2052.
12. Rawson, E, Wehnert M, Clarkson P. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol 1999:80:139-144.
13. Smith S, Montain S, Matott R, Zientara G, Jolesz F, Fielding, R. Creatine supplementation and age influence muscle metabolism during exercise. J Appl Physiol 1998:85:1349-1356.
14. Greenhaff P. The nutritional biochemistry of creatine. J Nutr Biochem, 11:1997:610-618.
15. Brose A, Parise G, Tarnopolsky M. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol, Series A 2003:58: B11-B19.
16. Cribb P, Williams A, Stathis C, Carey M, Hayes A. Effects of whey isolate, creatine, and resistance training on muscle hypertrophy. Med Sci Sports Exerc 2007:39 (2):298-307.
17. Olsen S, Aagaard P, Kadi F, Tufekovic G, Verney J, Olesen J, Suetta C, Kjaer M. Creatine supplementation augments the increase in satellite cell myonuclei number in human skeletal muscle induced by strength training. J Physiol 2006:573 (2):525-534.
18. Cohen J. Statistical Power Analysis for the Behavioral Sciences, 2nd edition. 1988 Lawrence Erlbaum Associates, Hillsdale NJ.
19. Eliot K, Knehans A, Bemben D, Witten M, Carter J, Bemben M. The effects of creatine and whey protein supplementation on body composition in men aged 48 to 72 years during resistance training. J Nutr Health Aging 2008:12 (3):208-212.
20. Wilder N, Deiuert R, Hagerman F. The effects of low dose creatine supplementation versus creatine loading in collegiate football players. J Athl Train 2001:36 (2):124-129.
21. Wilder N, Gilders R, Haterman F. The effects of a 10 week, periodized, off-season resistance-training program and creatine supplementation among college football players. J Health res 2002:16 (3):343-352.
22. Bemben M, Bemben D, Loftiss D. Creatine supplementation during resistance training in college football athletes. Med Sci Sports Exerc 2001:33 (10):1667-1673.
23. Becque M, Lochmann J, Melrose D. Effects of oral creatine supplementation on muscular strength and body composition. Med Sci Sports Exerc 2000:32:654-658.
24. Stevenson S, Dudley G. Creatine loading, resistance exercise performance, and muscle mechanics. J Strength Cond Res 2002:15 (4):413-419.
25. Esmarck B, Anderson J, Olsen S, Richter E, Mizuno M, Kiaer M. Timing of post exercise protein intake is important for muscle hypertrophy with resistance training in elderly humans. Am J Physiol 2001:535 (1):301-311.
26. American College of Sports Medicine Position Stand - Progression models in resistance training for healthy adults. Med Sci Sports Exerc 2009:41 (3):687-708.
27. Candow D, Little J, Chilibeck P, Abeysekara S, Zello G, Kazachkov M, Cornish S, Yu P. Low-dose creatine combined with protein during resistance training in older men. Med Sci Sports Exerc 2008:40 (9):1645-1652.
28. Earnest C, Snell P, Mitchell T, Rodriguez R, Almada A. Effect of creatine monohydrate ingestion on peak anaerobic power, capacity, and fatigue index. Med Sci Sports Exerc, 1994:26: S39.
29. Kreider R, Ferreira M, Wilson M, Grindstaff P, Plisk S, Reinardy J, Cantler E, Almada A. Effects of creatine supplementation on body composition, strength, and sprint performance. Med Sci. Sports Exerc 1998:30:73-82.
30. Volek J, Kraemer W, Bush J, Boetes M, Incledon T, Clark K, Lynch J. Creatine supplementation enhances muscular performance during high-intensity resistance exercise. J Am Diet Assoc 1997:97:765-770.
31. Volek J, Duncan N, Mazzetti S, Staron R, Putukian M, Gomez A, Pearson D, Fink W, Kraemer W. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci Sports Exerc 1999:31:1147-1156.
32. Syrotuik D, Bell G. Acute creatine monohydrate supplementation: A descriptive physiological profile of responders vs. nonresponders. J Strength Cond Res 2004:18 (3):610-617.
33. Bermon S, Venembre P, Sachet C, Valour S, Dolisi C. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Acta Physiol Scand 1998:164:147-155.
34. Eijnde B, Leemputte M, Goris M, Labarque V, Taes Y, Verbessem P, Vanhees L, Ramaekers M, Eynde B, Van Schuylengergh R, Dom R, Richter E, Hespel P. Effects of creatine supplementation and exercise training on fitness in men 55-75 yr old. J Appl Physiol 2003:95:818-828.
35. Ahmun R, Tong R, Grimshaw P. The effects of acute creatine supplementation on multiple sprint cycling and running performance in rugby players. J Strength Cond Res 2005:19 (1):92-97.
36. Hoffman J, Stout J, Falco M, Kang J, Ratamess N. Effect of low-dose, shortduration creatine supplementation on anaerobic exercise performance. J Strength Cond Res 2005:19 (2):260-264.
37. Deldicque L, Louis M, Theisen D, Nielens H, Dehoux M, Thissen J-P, Rennie M, Francaux M. Increased IGF mRNA in human skeletal muscle after creatine supplementation. Med Sci Sports Exerc 2005:37 (5):731-736.
38. Dorofeyeva E, Dorofeyev A. Biochemical and heart adaptations to physical training and supplementation with amino acids. J Strength Cond Res 2004:18 (4):738-740.
39. Theodrou A, Havenetidis K, Zanker C, O'Hara J, King R, Hood C, Paradisis G, Cooke C. Effects of acute creatine loading with or without carbohydrate on repeated bouts of maximal swimming in high-performance swimmers. J Strength Cond Res 2005:19 (2):265-269.
40. Bemben M, Lamont H. Creatine supplementation and exercise performance: Recent findings. Sports Med 2005:35 (2):107-125.