A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: Enhancement of activity by tamoxifen

Investigational New Drugs

Volumn 30, Issue 3, 2012, Pages 1012-1027

  Ma, Dennis ^a   Tremblay, Phillip ^a   Mahngar, Kevinjeet ^a   Akbari Asl, Pardis ^a   Collins, Jonathan ^b   Hudlicky, Tomas ^b   McNulty, James ^c   Pandey, Siyaram ^a  

^a UNIVERSITY OF WINDSOR   (Canada)

^b BROCK UNIVERSITY   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

Apoptosis; Autophagy; Colorectal cancer; Combination therapy; Tamoxifen

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOCHROME C; JC TH ACETATE 4; REACTIVE OXYGEN METABOLITE; TAMOXIFEN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CELL ISOLATION; CELL VIABILITY; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN SECRETION; TARGET CELL;

AMARYLLIDACEAE ALKALOIDS; AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE INHIBITORS; CASPASES; CELL LINE; COLORECTAL NEOPLASMS; CYSTEINE PROTEINASE INHIBITORS; HCT116 CELLS; HT29 CELLS; HUMANS; ISOQUINOLINES; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84864375481     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-011-9668-7     Document Type: Article

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