Chemoenzymatic synthesis of amaryllidaceae constituents and biological evaluation of their C-1 analogues. the next generation synthesis of 7-deoxypancratistatin and trans -dihydrolycoricidine

Journal of Organic Chemistry

Volumn 75, Issue 9, 2010, Pages 3069-3084

  Collins, Jonathan ^a   Rinner, Uwe ^a   Moser, Michael ^a   Hudlicky, Tomas ^a   Ghiviriga, Ion ^b   Romero, Anntherese E ^c   Kornienko, Alexander ^c   Ma, Dennis ^d   Griffin, Carly ^d   Pandey, Siyaram ^d  

^a BROCK UNIVERSITY   (Canada)

^b UNIVERSITY OF FLORIDA   (United States)

^c NEW MEXICO INSTITUTE OF MINING AND TECHNOLOGY   (United States)

^d UNIVERSITY OF WINDSOR   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLIDES; AMARYLLIDACEAE; APOPTOSIS; AZIRIDINES; BIOLOGICAL ACTIVITIES; BIOLOGICAL EVALUATION; CANCER CELL LINES; CHEMO-ENZYMATIC SYNTHESIS; EFFICIENT SYNTHESIS; NATURAL PRODUCTS; OXIDATIVE CLEAVAGES; SPECTRAL DATA; TOTAL SYNTHESIS;

ALDEHYDES; CELL CULTURE; CELL DEATH; GELS; METHANOL; SILICA; SYNTHESIS (CHEMICAL);

IONIC LIQUIDS;

((1,2,3,4,4A,11B) 2,3,4 TRIHYDROXY 6 OXO 1,2,3,4,4A,5,6,11B OCTAHYDRO [1,3]DIOXOLO[4,5 J]PHENANTHRIDIN 1 YL)METHYL ACETATE; (1,2,3,4,4A,11B) 2,3,4 TRIHYDROXY 1 (HYDROXYMETHYL) 1,2,3,4,4A,5 HEXAHYDRO [1,3]DIOXOLO[4,5 J]PHENANTHRIDIN 6(11BH) ONE; 7 DEOXYPANCRATISTATIN; ALDEHYDE; AMARYLLIDACEAE ALKALOID; AZIRIDINE; EPOXIDE; PHENANTHRENE; SILICA GEL; TRANS DIHYDROLYCORICIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CATALYSIS; CONTROLLED STUDY; CYCLIZATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXIDATION; PHARMACOPHORE; SOLID STATE;

ALDEHYDES; AMARYLLIDACEAE ALKALOIDS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AZIRIDINES; CATALYSIS; CELL LINE, TUMOR; CYCLIZATION; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; HUMANS; ISOQUINOLINES; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PHENANTHRENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77951783308     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo1003136     Document Type: Article

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