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Volumn 6, Issue 6, 2001, Pages 469-477

Mechanisms of tamoxifen-induced apoptosis

Author keywords

Apoptosis; Breast cancer; Caspases; Signal transduction; Tamoxifen

Indexed keywords

CALCIUM ION; CALMODULIN; CERAMIDE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN CDC42; PROTEIN KINASE C; RAC PROTEIN; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TAMOXIFEN; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035181465     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012437607881     Document Type: Article
Times cited : (364)

References (112)
  • 2
    • 0024312674 scopus 로고
    • Tamoxifen therapy in primary breast cancer: Biology, efficacy, and side effects
    • (1989) J Clin Oncol , vol.7 , pp. 803-815
    • Love, R.R.1
  • 3
    • 0032502451 scopus 로고    scopus 로고
    • Tamoxifen. 'A big deal,' but a complex hand to play
    • (1998) Science , vol.280 , pp. 196
    • Marshall, E.1
  • 6
    • 0033429147 scopus 로고    scopus 로고
    • Role of proliferation and apoptosis in net growth rates of human breast cancer cells (MCF-7) treated with oestradiol and/or tamoxifen
    • (1999) Cell Prolif , vol.32 , pp. 289-302
    • Budtz, P.E.1
  • 7
    • 0029980356 scopus 로고    scopus 로고
    • Tamoxifen induction of apoptosis in estrogen receptor-negative cancers: New tricks for an old dog?
    • (1996) J Natl Cancer Inst , vol.88 , pp. 224-226
    • Gelmann, E.P.1
  • 12
    • 0034544533 scopus 로고    scopus 로고
    • Pharmacodynamics of tamoxifen and its 4-hydroxy and N-desmethyl metabolites: Activation of caspases and induction of apoptosis in rat mammary tumors and in human breast cancer cell lines
    • (2000) Cancer Res , vol.60 , pp. 6601-6606
    • Mandlekar, S.1    Hebbar, V.2    Christov, K.3    Kong, A.N.4
  • 18
    • 0019786905 scopus 로고
    • Comparative binding affinities of tamoxifen, 4-hydroxytamoxifen, and desmethyltamoxifen for estrogen receptors isolated from human breast carcinoma: Correlation with blood levels in patients with metastatic breast cancer
    • (1981) Biopharm Drug Dispos , vol.2 , pp. 381-390
    • Fabian, C.1    Tilzer, L.2    Sternson, L.3
  • 21
    • 0032519653 scopus 로고    scopus 로고
    • Inhibition of the membrane translocation and activation of protein kinase C, and potentiation of doxorubicin-induced apoptosis of hepatocellular carcinoma cells by tamoxifen
    • (1998) Biochem Pharmacol , vol.55 , pp. 523-531
    • Cheng, A.L.1    Chuang, S.E.2    Fine, R.L.3
  • 32
    • 0022828736 scopus 로고
    • Calmodulin antagonism and growth-inhibiting activity of triphenylethylene antiestrogens in MCF-7 human breast cancer cells
    • (1986) CancerRes , vol.46 , pp. 6274-6278
    • Gulino, A.1    Barrera, G.2    Vacca, A.3
  • 37
    • 0034013476 scopus 로고    scopus 로고
    • The role of de novo ceramide synthesis in chemotherapy-induced apoptosis
    • (2000) Ann NY Acad Sci , vol.905 , pp. 91-96
    • Perry, D.K.1
  • 44
    • 0031019309 scopus 로고    scopus 로고
    • Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells
    • (1997) J Biol Chem , vol.272 , pp. 1682-1687
    • Lavie, Y.1    Cao, H.2    Volner, A.3
  • 49
    • 0030843522 scopus 로고    scopus 로고
    • c-Myc plays a role in cellular susceptibility to death receptor-mediated and chemotherapy-induced apoptosis in human monocytic leukemia U937 cells
    • (1997) Oncogene , vol.15 , pp. 639-647
    • Dong, J.1    Naito, M.2    Tsuruo, T.3
  • 53
    • 0032905924 scopus 로고    scopus 로고
    • c-Myc target genes involved in cell growth, apoptosis, and metabolism
    • (1999) Mol Cell Biol , vol.19 , pp. 1-11
    • Dang, C.V.1
  • 64
    • 0001554639 scopus 로고    scopus 로고
    • Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells
    • (1999) Oncogene , vol.18 , pp. 377-384
    • Shtil, A.A.1    Mandlekar, S.2    Yu, R.3
  • 70
    • 0030134173 scopus 로고    scopus 로고
    • The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
    • (1996) Curr Biol , vol.6 , pp. 606-613
    • Zanke, B.W.1    Boudreau, K.2    Rubie, E.3
  • 71
    • 0032575591 scopus 로고    scopus 로고
    • Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase upstream of MKK6 and p38
    • (1998) J Biol Chem , vol.273 , pp. 22681-22692
    • Yuasa, T.1    Ohno, S.2    Kehrl, J.H.3    Kyriakis, J.M.4
  • 73
  • 74
    • 0029938805 scopus 로고    scopus 로고
    • Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD 153) by p38 MAP kinase
    • (1996) Science , vol.272 , pp. 1347-1349
    • Wang, X.Z.1    Ron, D.2
  • 76
    • 0034614615 scopus 로고    scopus 로고
    • Activation of the p38 mitogenactivated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis
    • (2000) J Biol Chem , vol.275 , pp. 479-486
    • Zhang, C.C.1    Shapiro, D.J.2
  • 96
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3
  • 100
    • 0033531954 scopus 로고    scopus 로고
    • Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade
    • (1999) J Biol Chem , vol.274 , pp. 13133-13138
    • Zhou, G.1    Lee, S.C.2    Yao, Z.3    Tan, T.H.4
  • 104
    • 0029560348 scopus 로고
    • Relationship between tamoxifen-induced transforming growth factor beta 1 expression, cytostasis and apoptosis in human breast cancer cells
    • (1995) Br J Cancer , vol.72 , pp. 1441-1446
    • Perry, R.R.1    Kang, Y.2    Greaves, B.R.3
  • 111
    • 0030849605 scopus 로고    scopus 로고
    • Tamoxifen interferes with the insulin-like growth factor I receptor (IGF-IR) signaling pathway in breast cancer cells
    • (1997) Cancer Res , vol.57 , pp. 2606-2610
    • Guvakova, M.A.1    Surmacz, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.