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Volumn 12, Issue , 2012, Pages

Deletion of Foxp3+ regulatory T cells in genetically targeted mice supports development of intestinal inflammation

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; DOCUSATE SODIUM; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; TRANSCRIPTION FACTOR FOXP3;

EID: 84864330113     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-97     Document Type: Article
Times cited : (76)

References (43)
  • 1
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • 10.1016/j.immuni.2009.04.009, 19464984
    • Josefowicz SZ, Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009, 30:616-625. 10.1016/j.immuni.2009.04.009, 19464984.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 2
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • 10.1038/ni1428, 17136045
    • Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007, 8:191-197. 10.1038/ni1428, 17136045.
    • (2007) Nat Immunol , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 3
    • 76249088097 scopus 로고    scopus 로고
    • Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice
    • 10.4049/jimmunol.0804308, 19923467
    • Kim J, Lahl K, Hori S, Loddenkemper C, Chaudhry A, deRoos P, Rudensky A, Sparwasser T. Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 2009, 183:7631-7634. 10.4049/jimmunol.0804308, 19923467.
    • (2009) J Immunol , vol.183 , pp. 7631-7634
    • Kim, J.1    Lahl, K.2    Hori, S.3    Loddenkemper, C.4    Chaudhry, A.5    deRoos, P.6    Rudensky, A.7    Sparwasser, T.8
  • 4
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003, 4:330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 5
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • 10.1126/science.1079490, 12522256
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061. 10.1126/science.1079490, 12522256.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 6
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • Khattri R, Cox T, Yasayko SA, Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003, 4:337-342.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 7
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    • 10.1016/j.immuni.2005.01.016, 15780990
    • Fontenot JD, Rasmussen JP, Williams LM, dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005, 22:329-341. 10.1016/j.immuni.2005.01.016, 15780990.
    • (2005) Immunity , vol.22 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3    dooley, J.L.4    Farr, A.G.5    Rudensky, A.Y.6
  • 9
    • 0036346861 scopus 로고    scopus 로고
    • Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
    • 10.1136/jmg.39.8.537, 1735203, 12161590
    • Wildin RS, Smyk-Pearson S, Filipovich AH. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 2002, 39:537-545. 10.1136/jmg.39.8.537, 1735203, 12161590.
    • (2002) J Med Genet , vol.39 , pp. 537-545
    • Wildin, R.S.1    Smyk-Pearson, S.2    Filipovich, A.H.3
  • 10
    • 65549136983 scopus 로고    scopus 로고
    • Mechanisms of foxp3+ T regulatory cell-mediated suppression
    • 10.1016/j.immuni.2009.04.010, 19464986
    • Shevach EM. Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity 2009, 30:636-645. 10.1016/j.immuni.2009.04.010, 19464986.
    • (2009) Immunity , vol.30 , pp. 636-645
    • Shevach, E.M.1
  • 11
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • 10.1038/nri1132, 12876555
    • Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003, 3:521-533. 10.1038/nri1132, 12876555.
    • (2003) Nat Rev Immunol , vol.3 , pp. 521-533
    • Bouma, G.1    Strober, W.2
  • 12
    • 33746377279 scopus 로고    scopus 로고
    • Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
    • 10.1111/j.0105-2896.2006.00423.x, 16903919
    • Izcue A, Coombes JL, Powrie F. Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation. Immunol Rev 2006, 212:256-271. 10.1111/j.0105-2896.2006.00423.x, 16903919.
    • (2006) Immunol Rev , vol.212 , pp. 256-271
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 13
    • 65749103989 scopus 로고    scopus 로고
    • Regulatory lymphocytes and intestinal inflammation
    • 10.1146/annurev.immunol.021908.132657, 19302043
    • Izcue A, Coombes JL, Powrie F. Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol 2009, 27:313-338. 10.1146/annurev.immunol.021908.132657, 19302043.
    • (2009) Annu Rev Immunol , vol.27 , pp. 313-338
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 14
    • 37149052140 scopus 로고    scopus 로고
    • Special regulatory T-cell review: Regulatory T cells and the intestinal tract-patrolling the frontier
    • 10.1111/j.1365-2567.2007.02778.x, 2433286, 18154611
    • Izcue A, Powrie F. Special regulatory T-cell review: Regulatory T cells and the intestinal tract-patrolling the frontier. Immunology 2008, 123:6-10. 10.1111/j.1365-2567.2007.02778.x, 2433286, 18154611.
    • (2008) Immunology , vol.123 , pp. 6-10
    • Izcue, A.1    Powrie, F.2
  • 15
    • 16244379546 scopus 로고    scopus 로고
    • Regulatory T cells and intestinal homeostasis
    • 10.1111/j.0105-2896.2005.00250.x, 15790359
    • Coombes JL, Robinson NJ, Maloy KJ, Uhlig HH, Powrie F. Regulatory T cells and intestinal homeostasis. Immunol Rev 2005, 204:184-194. 10.1111/j.0105-2896.2005.00250.x, 15790359.
    • (2005) Immunol Rev , vol.204 , pp. 184-194
    • Coombes, J.L.1    Robinson, N.J.2    Maloy, K.J.3    Uhlig, H.H.4    Powrie, F.5
  • 16
    • 0032718352 scopus 로고    scopus 로고
    • Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice
    • 10.1016/S0016-5085(99)70392-6, 10535870
    • Fuss IJ, Marth T, Neurath MF, Pearlstein GR, Jain A, Strober W. Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice. Gastroenterology 1999, 117:1078-1088. 10.1016/S0016-5085(99)70392-6, 10535870.
    • (1999) Gastroenterology , vol.117 , pp. 1078-1088
    • Fuss, I.J.1    Marth, T.2    Neurath, M.F.3    Pearlstein, G.R.4    Jain, A.5    Strober, W.6
  • 17
    • 2142643604 scopus 로고    scopus 로고
    • Control of immune pathology by regulatory T cells
    • discussion 98-105, 106-14
    • Powrie F, Read S, Mottet C, Uhlig H, Maloy K. Control of immune pathology by regulatory T cells. Novartis Found Symp 2003, 252:92-98. discussion 98-105, 106-14.
    • (2003) Novartis Found Symp , vol.252 , pp. 92-98
    • Powrie, F.1    Read, S.2    Mottet, C.3    Uhlig, H.4    Maloy, K.5
  • 18
    • 44649189362 scopus 로고    scopus 로고
    • Induction of inflammatory bowel disease in immunodeficient mice by depletion of regulatory T cells
    • Chapter 15:Unit 15 13
    • Read S, Powrie F. Induction of inflammatory bowel disease in immunodeficient mice by depletion of regulatory T cells. Curr Protoc Immunol 2001, : . Chapter 15:Unit 15 13.
    • (2001) Curr Protoc Immunol
    • Read, S.1    Powrie, F.2
  • 20
    • 44349132270 scopus 로고    scopus 로고
    • Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
    • 10.1038/nri2316, 18469830
    • Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol 2008, 8:411-420. 10.1038/nri2316, 18469830.
    • (2008) Nat Rev Immunol , vol.8 , pp. 411-420
    • Artis, D.1
  • 21
    • 70049098536 scopus 로고    scopus 로고
    • Regulatory T cells reinforce intestinal homeostasis
    • 10.1016/j.immuni.2009.08.011, 19766083
    • Barnes MJ, Powrie F. Regulatory T cells reinforce intestinal homeostasis. Immunity 2009, 31:401-411. 10.1016/j.immuni.2009.08.011, 19766083.
    • (2009) Immunity , vol.31 , pp. 401-411
    • Barnes, M.J.1    Powrie, F.2
  • 22
    • 55749091152 scopus 로고    scopus 로고
    • Regulatory T cells in inflammatory bowel disease
    • 10.1097/MOG.0b013e328311f26e, 19125486
    • Boden EK, Snapper SB. Regulatory T cells in inflammatory bowel disease. Curr Opin Gastroenterol 2008, 24:733-741. 10.1097/MOG.0b013e328311f26e, 19125486.
    • (2008) Curr Opin Gastroenterol , vol.24 , pp. 733-741
    • Boden, E.K.1    Snapper, S.B.2
  • 24
    • 20444434616 scopus 로고    scopus 로고
    • Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease
    • 10.1053/j.gastro.2005.03.043, 15940622
    • Maul J, Loddenkemper C, Mundt P, Berg E, Giese T, Stallmach A, Zeitz M, Duchmann R. Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology 2005, 128:1868-1878. 10.1053/j.gastro.2005.03.043, 15940622.
    • (2005) Gastroenterology , vol.128 , pp. 1868-1878
    • Maul, J.1    Loddenkemper, C.2    Mundt, P.3    Berg, E.4    Giese, T.5    Stallmach, A.6    Zeitz, M.7    Duchmann, R.8
  • 25
    • 33745275219 scopus 로고    scopus 로고
    • Functional CD4+CD25 high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity
    • 10.1097/00054725-200606000-00003, 16775488
    • Holmen N, Lundgren A, Lundin S, Bergin AM, Rudin A, Sjovall H, Ohman L. Functional CD4+CD25 high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity. Inflamm Bowel Dis 2006, 12:447-456. 10.1097/00054725-200606000-00003, 16775488.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 447-456
    • Holmen, N.1    Lundgren, A.2    Lundin, S.3    Bergin, A.M.4    Rudin, A.5    Sjovall, H.6    Ohman, L.7
  • 26
    • 77249137663 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease
    • 10.1007/s10875-009-9345-1, 19936899
    • Eastaff-Leung N, Mabarrack N, Barbour A, Cummins A, Barry S. Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol 2010, 30:80-89. 10.1007/s10875-009-9345-1, 19936899.
    • (2010) J Clin Immunol , vol.30 , pp. 80-89
    • Eastaff-Leung, N.1    Mabarrack, N.2    Barbour, A.3    Cummins, A.4    Barry, S.5
  • 28
    • 37849002328 scopus 로고    scopus 로고
    • Basal lymphoid aggregates in ulcerative colitis colon: a site for regulatory T cell action
    • 10.1111/j.1365-2249.2007.03566.x, 2276944, 18190460
    • Sitohy B, Hammarstrom S, Danielsson A, Hammarstrom ML. Basal lymphoid aggregates in ulcerative colitis colon: a site for regulatory T cell action. Clin Exp Immunol 2008, 151:326-333. 10.1111/j.1365-2249.2007.03566.x, 2276944, 18190460.
    • (2008) Clin Exp Immunol , vol.151 , pp. 326-333
    • Sitohy, B.1    Hammarstrom, S.2    Danielsson, A.3    Hammarstrom, M.L.4
  • 29
    • 34249309861 scopus 로고    scopus 로고
    • Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis
    • 10.1002/ibd.20053, 17206665
    • Yu QT, Saruta M, Avanesyan A, Fleshner PR, Banham AH, Papadakis KA. Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis. Inflamm Bowel Dis 2007, 13:191-199. 10.1002/ibd.20053, 17206665.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 191-199
    • Yu, Q.T.1    Saruta, M.2    Avanesyan, A.3    Fleshner, P.R.4    Banham, A.H.5    Papadakis, K.A.6
  • 30
    • 67049168780 scopus 로고    scopus 로고
    • Plasticity of CD4(+) FoxP3(+) T cells
    • 10.1016/j.coi.2009.05.007, 2733784, 19500966
    • Zhou X, Bailey-Bucktrout S, Jeker LT, Bluestone JA. Plasticity of CD4(+) FoxP3(+) T cells. Curr Opin Immunol 2009, 21:281-285. 10.1016/j.coi.2009.05.007, 2733784, 19500966.
    • (2009) Curr Opin Immunol , vol.21 , pp. 281-285
    • Zhou, X.1    Bailey-Bucktrout, S.2    Jeker, L.T.3    Bluestone, J.A.4
  • 33
    • 33646370647 scopus 로고    scopus 로고
    • TNF down modulates the function of human CD4+CD25hi T-regulatory cells
    • 10.1182/blood-2005-11-4567, 1895836, 16537805
    • Valencia X, Stephens G, Goldbach-Mansky R, Wilson M, Shevach EM, Lipsky PE. TNF down modulates the function of human CD4+CD25hi T-regulatory cells. Blood 2006, 108:253-261. 10.1182/blood-2005-11-4567, 1895836, 16537805.
    • (2006) Blood , vol.108 , pp. 253-261
    • Valencia, X.1    Stephens, G.2    Goldbach-Mansky, R.3    Wilson, M.4    Shevach, E.M.5    Lipsky, P.E.6
  • 34
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
    • 10.1084/jem.20061531, 2118431, 17200409
    • Nadkarni S, Mauri C, Ehrenstein MR. Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J Exp Med 2007, 204:33-39. 10.1084/jem.20061531, 2118431, 17200409.
    • (2007) J Exp Med , vol.204 , pp. 33-39
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.R.3
  • 35
    • 51249084103 scopus 로고    scopus 로고
    • Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease
    • 10.1111/j.1365-2567.2008.02839.x, 2561134, 18422560
    • Ricciardelli I, Lindley KJ, Londei M, Quaratino S. Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease. Immunology 2008, 125:178-183. 10.1111/j.1365-2567.2008.02839.x, 2561134, 18422560.
    • (2008) Immunology , vol.125 , pp. 178-183
    • Ricciardelli, I.1    Lindley, K.J.2    Londei, M.3    Quaratino, S.4
  • 36
    • 44349095801 scopus 로고    scopus 로고
    • Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells
    • 10.1002/ibd.20369, 18240282
    • Pronio A, Montesani C, Butteroni C, Vecchione S, Mumolo G, Vestri A, Vitolo D, Boirivant M. Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells. Inflamm Bowel Dis 2008, 14:662-668. 10.1002/ibd.20369, 18240282.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 662-668
    • Pronio, A.1    Montesani, C.2    Butteroni, C.3    Vecchione, S.4    Mumolo, G.5    Vestri, A.6    Vitolo, D.7    Boirivant, M.8
  • 38
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23drives innate and T cell-mediated intestinal inflammation
    • 10.1084/jem.20061099, 2118132, 17030949
    • Hue S, Ahern P, Buonocore S, Kullberg MC, Cuad J, McKenzie BS, Powrie F, Maloy KJ. Interleukin-23drives innate and T cell-mediated intestinal inflammation. J Exp Med 2006, 203:2473-2483. 10.1084/jem.20061099, 2118132, 17030949.
    • (2006) J Exp Med , vol.203 , pp. 2473-2483
    • Hue, S.1    Ahern, P.2    Buonocore, S.3    Kullberg, M.C.4    Cuad, J.5    McKenzie, B.S.6    Powrie, F.7    Maloy, K.J.8
  • 39
    • 34250026960 scopus 로고    scopus 로고
    • Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
    • 10.1053/j.gastro.2007.03.104, 17570211
    • Elson CO, Cong Y, Weaver CT, Schoeb TR, McClanahan TK, Fick RB, Kastelein RA. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 2007, 132:2359-2370. 10.1053/j.gastro.2007.03.104, 17570211.
    • (2007) Gastroenterology , vol.132 , pp. 2359-2370
    • Elson, C.O.1    Cong, Y.2    Weaver, C.T.3    Schoeb, T.R.4    McClanahan, T.K.5    Fick, R.B.6    Kastelein, R.A.7
  • 42
    • 41549160626 scopus 로고    scopus 로고
    • Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis
    • 10.1016/j.immuni.2008.02.019, 2292821, 18400195
    • Izcue A, Hue S, Buonocore S, Arancibia-Carcamo CV, Ahern PP, Iwakura Y, Maloy KJ, Powrie F. Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis. Immunity 2008, 28:559-570. 10.1016/j.immuni.2008.02.019, 2292821, 18400195.
    • (2008) Immunity , vol.28 , pp. 559-570
    • Izcue, A.1    Hue, S.2    Buonocore, S.3    Arancibia-Carcamo, C.V.4    Ahern, P.P.5    Iwakura, Y.6    Maloy, K.J.7    Powrie, F.8
  • 43
    • 34548598702 scopus 로고    scopus 로고
    • Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells
    • 10.1111/j.1365-2567.2007.02651.x, 2266004, 17848162
    • Liu G, Zhao Y. Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells. Immunology 2007, 122:149-156. 10.1111/j.1365-2567.2007.02651.x, 2266004, 17848162.
    • (2007) Immunology , vol.122 , pp. 149-156
    • Liu, G.1    Zhao, Y.2


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