Toll-like receptors and immune regulation: Their direct and indirect modulation on regulatory CD4+ CD25+ T cells

Immunology

Volumn 122, Issue 2, 2007, Pages 149-156

  Liu, Guangwei ^a   Zhao, Yong ^a  

^a INSTITUTE OF ZOOLOGY   (China)

Author keywords

Autoimmune disease; Immune response; Immune tolerance; Regulatory CD4+ CD25+ T cells; Toll like receptors

Indexed keywords

HEAT SHOCK PROTEIN; IMMUNOGLOBULIN G; TOLL LIKE RECEPTOR;

ANTIGEN PRESENTING CELL; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INFECTION; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW;

AUTOIMMUNE DISEASES; AUTOIMMUNITY; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LIGANDS; T-LYMPHOCYTES, REGULATORY; TOLL-LIKE RECEPTORS;

EID: 34548598702     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2007.02651.x     Document Type: Review

References (79)

1. Ausubel FM. Are innate immune signaling pathways in plants and animals conserved? Nat Immunol 2005 6 : 973 9.
2. Powrie F, Maloy KJ. Immunology. Regulating the regulators. Science 2003 299 : 1030 1.
3. Pasare C, Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004 21 : 733 41.
4. Liu G, Wu Y, Gong S, Zhao Y. Toll-like receptors and graft rejection. Transpl Immunol 2006 16 : 25 31.
5. Liu H, Komai-Koma M, Xu D, Liew FY. Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci USA 2006 103 : 7048 53.
6. Jefferies CA, Fitzgerald KA. Interferon gene regulation: not all roads lead to Tolls. Trends Mol Med 2005 11 : 403 11.
7. Uematsu S, Sato S, Yamamoto M et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR) 7- and TLR9-mediated interferon-α induction. J Exp Med 2005 201 : 915 23.
8. Andrade CF, Waddell TK, Keshavjee S, Liu M. Innate immunity and organ transplantation: the potential role of toll-like receptors. Am J Transplant 2005 5 : 969 75.
9. Blanco P, Viallard JF, Pellegrin JL, Moreau JF. Cytotoxic T lymphocytes and autoimmunity. Curr Opin Rheumatol 2005 17 : 731 4.
10. Sibilia J. Novel concepts and treatments for autoimmune disease: ten focal points. Joint Bone Spine 2004 71 : 511 7.
11. Bach JF. Regulatory T cells under scrutiny. Nat Rev Immunol 2003 3 : 189 98.
12. Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006 6 : 295 307.
13. Yi H, Zhen Y, Jiang L, Zheng J, Zhao Y. The phenotypic characterization of naturally occurring regulatory CD4+CD25+ T cells. Cell Mol Immunol 2006 3 : 189 95.
14. Caproni M, Torchia D, Antiga E, Volpi W, Bianco ED, Fabbri P. The effects of tacrolimus ointment on regulatory T lymphocytes in atopic dermatitis. J Clin Immunol 2006 26 : 370 5.
15. Yang Y, Huang CT, Huang X, Pardoll DM. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol 2004 5 : 508 15.
16. Pasare C, Medzhitov R. Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol 2003 15 : 677 82.
17. Houot R, Perrot I, Garcia E, Durand I, Lebecque S. Human CD4+CD25high regulatory T cells modulate myeloid but not plasmacytoid dendritic cells activation. J Immunol 2006 176 : 5293 8.
18. Chaperot L, Blum A, Manches O, Lui G, Angel J, Molens JP, Plumas J. Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. J Immunol 2006 176 : 248 55.
19. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006 441 : 235 8.
20. Bellocchio S, Moretti S, Perruccio K et al. TLRs govern neutrophil activity in aspergillosis. J Immunol 2004 173 : 7406 15.
21. Sutmuller RP, den Brok MH, Kramer M et al. Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest 2006 116 : 485 94.
22. Kawai T, Akira S. TLR signaling. Cell Death Differ 2006 13 : 816 25.
23. Warger T, Osterloh P, Rechtsteiner G et al. Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo. Blood 2006 108 : 544 50.
24. Gautier G, Humbert M, Deauvieau F et al. A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. J Exp Med 2005 201 : 1435 46.
25. Lee J, Wu CC, Lee KJ et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci USA 2006 103 : 1828 33.
26. Sun CM, Deriaud E, Leclerc C, Lo-Man R. Upon TLR9 signaling, CD5+ B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs. Immunity 2005 22 : 467 77.
27. Wang RF, Peng G, Wang HY. Regulatory T cells and Toll-like receptors in tumor immunity. Semin Immunol 2006 18 : 136 42.
28. Hoshino K, Sugiyama T, Matsumoto M et al. IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 2006 440 : 949 53.
29. Patel M, Xu D, Kewin P, Choo-Kang B, McSharry C, Thomson NC, Liew FY. TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells. J Immunol 2005 174 : 7558 63.
30. Murphy TJ, Choileain NN, Zang Y, Mannick JA, Lederer JA. CD4+CD25+ regulatory T cells control innate immune reactivity after injury. J Immunol 2005 174 : 2957 63.
31. Fitzgerald KA, McWhirter SM, Faia KL et al. IKKη and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 2003 4 : 491 6.
32. Liew FY, Xu D, Brint EK, O'Neill LA. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005 5 : 446 58.
33. Honda K, Yanai H, Negishi H et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 2005 434 : 772 7.
34. Oganesyan G, Saha SK, Guo B, He JQ, Shahangian A, Zarnegar B, Perry A, Cheng G. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature 2006 439 : 208 11.
35. Johnson BJ, Le TT, Dobbin CA et al. Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. J Biol Chem 2005 280 : 4037 47.
36. Fitzgerald KA, Rowe DC, Barnes BJ et al. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med 2003 198 : 1043 55.
37. Jung DY, Lee H, Jung BY, Ock J, Lee MS, Lee WH, Suk K. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol 2005 174 : 6467 76.
38. Nishiya T, Kajita E, Miwa S, Defranco AL. TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem 2005 280 : 37107 17.
39. Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003 299 : 1033 6.
40. Yasutomi M, Ohshima Y, Omata N, Yamada A, Iwasaki H, Urasaki Y, Mayumi M. Erythromycin differentially inhibits lipopolysaccharide- or poly (I:C)-induced but not peptidoglycan-induced activation of human monocyte-derived dendritic cells. J Immunol 2005 175 : 8069 76.
41. Crellin NK, Garcia RV, Hadisfar O, Allan SE, Steiner TS, Levings MK. Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. J Immunol 2005 175 : 8051 9.
42. Mazzoni A, Segal DM. Controlling the Toll road to dendritic cell polarization. J Leukoc Biol 2004 75 : 721 30.
43. Babu S, Blauvelt CP, Kumaraswami V, Nutman TB. Cutting edge: Diminished T cell TLR expression and function modulates the immune response in human filarial infection. J Immunol 2006 176 : 3885 9.
44. Kabelitz D. Expression and function of Toll-like receptors in T lymphocytes. Curr Opin Immunol 2007 19 : 39 45.
45. Komai-Koma M, Jones L, Ogg GS, Xu D, Liew FY. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci USA 2004 101 : 3029 34.
46. Sutmuller RP, Morgan ME, Netea MG, Grauer O, Adema GJ. Toll-like receptors on regulatory T cells: expanding immune regulation. Trends Immunol 2006 27 : 387 93.
47. Caron G, Duluc D, Fremaux I, Jeannin P, David C, Gascan H, Delneste Y. Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-γ production by memory CD4+ T cells. J Immunol 2005 175 : 1551 7.
48. Gelman AE, LaRosa DF, Zhang J, Walsh PT, Choi Y, Sunyer JO, Turka LA. The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity 2006 25 : 783 93.
49. Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003 197 : 403 11.
50. Zelenay S, Lopes-Carvalho T, Caramalho I, Moraes-Fontes MF, Rebelo M, Demengeot J. Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci USA 2005 102 : 4091 6.
51. Zhang L, Yi H, Xia XP, Zhao Y. Transforming growth factor-beta: an important role in CD4+CD25+ regulatory T cells and immune tolerance. Autoimmunity 2006 39 : 269 76.
52. Peng G, Guo Z, Kiniwa Y et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 2005 309 : 1380 4.
53. Kato H, Sato S, Yoneyama M et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005 23 : 19 28.
54. Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006 25 : 417 28.
55. Mansson A, Adner M, Cardell LO. Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Respir Res 2006 7 : 36.
56. Dolganiuc A, Garcia C, Kodys K, Szabo G. Distinct Toll-like receptor expression in monocytes and T cells in chronic HCV infection. World J Gastroenterol 2006 12 : 1198 204.
57. Kaiser WJ, Offermann MK. Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif. J Immunol 2005 174 : 4942 52.
58. Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR. Heat shock protein 60 enhances CD4CD25 regulatory T cell function via innate TLR2 signaling. J Clin Invest 2006 116 : 2022 32.
59. Kubo T, Hatton RD, Oliver J, Liu X, Elson CO, Weaver CT. Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J Immunol 2004 173 : 7249 58.
60. Martin M, Rehani K, Jope RS, Michalek SM. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 2005 6 : 777 84.
61. Rehli M. Of mice and men: species variations of Toll-like receptor expression. Trends Immunol 2002 23 : 375 8.
62. Sfondrini L, Rossini A, Besusso D, Merlo A, Tagliabue E, Menard S, Balsari A. Antitumor activity of the TLR-5 ligand flagellin in mouse models of cancer. J Immunol 2006 176 : 6624 30.
63. Wang RF. Regulatory T cells and toll-like receptors in cancer therapy. Cancer Res 2006 66 : 4987 90.
64. Heil F, Hemmi H, Hochrein H et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004 303 : 1526 9.
65. Chiffoleau E, Heslan JM, Heslan M, Louvet C, Condamine T, Cuturi MC. TLR9 ligand enhances proliferation of rat CD4+ T cell and modulates suppressive activity mediated by CD4+ CD25+ T cell. Int Immunol 2007 19 : 193 201.
66. Li X, Shen S, Urso D, Kalique S, Park SH, Sharafieh R, O'Rourke J, Cone RE. Phenotypic and immunoregulatory characteristics of monocytic iris cells. Immunology 2006 117 : 566 75.
67. Liu G, Xia XP, Gong SL, Zhao Y. The macrophage heterogeneity: difference between mouse peritoneal exudate and splenic F4/80+ macrophages. J Cell Physiol 2006 209 : 341 52.
68. Aksoy E, Vanden Berghe W, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M, Willems F. Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4. Eur J Immunol 2005 35 : 2200 9.
69. Aksoy E, Zouain CS, Vanhoutte F et al. Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. J Biol Chem 2005 280 : 277 83.
70. Naik SH, Proietto AI, Wilson NS et al. Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures. J Immunol 2005 174 : 6592 7.
71. Saemann MD, Weichhart T, Zeyda M et al. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 2005 115 : 468 75.
72. O'Neill LA. Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal? Trends Immunol 2002 23 : 296 300.
73. Duez C, Gosset P, Tonnel AB. Dendritic cells and toll-like receptors in allergy and asthma. Eur J Dermatol 2006 16 : 12 6.
74. Barchet W, Price JD, Cella M et al. Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood 2006 107 : 1497 504.
75. Zhao J, Kong HJ, Li H et al. IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-γ signaling pathways. J Biol Chem 2006 281 : 10073 80.
76. Honma K, Udono H, Kohno T et al. Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS. Proc Natl Acad Sci USA 2005 102 : 16001 6.
77. Romani L, Bistoni F, Perruccio K et al. Thymosin alpha 1 activates dendritic cell tryptophan catabolism and establishes a regulatory environment for balance of inflammation and tolerance. Blood 2006 108 : 2265 74.
78. Higgins SC, Lavelle EC, McCann C et al. Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J Immunol 2003 171 : 3119 27.
79. Rutella S, Danese S, Leone G. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 2006 108 : 1435 40.