Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells

Investigational New Drugs

Volumn 30, Issue 3, 2012, Pages 1248-1256

  Davidson, David ^a   Coulombe, Yannick ^b   Martinez Marignac, Veronica L ^a   Amrein, Lilian ^a   Grenier, Jeremy ^a   Hodkinson, Keira ^a   Masson, Jean Yves ^b   Aloyz, Raquel ^a   Panasci, Lawrence ^a  

^a MCGILL UNIVERSITY   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Anthracyclines; Breast cancer; DNA damage; DNA PK; DNA repair; Drug synergism; Homologous recombination; Non homologous end joining

Indexed keywords

CISPLATIN; DNA DEPENDENT PROTEIN KINASE; FIRTECAN; GREEN FLUORESCENT PROTEIN; HISTONE H2AX; IC 486241; IRINOTECAN; NU 7026; OXALIPLATIN; PROTEIN KINASE INHIBITOR; RAD51 PROTEIN; SULFORHODAMINE B; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL KILLING; CELL STRAIN HCT116; COLON CANCER; COMET ASSAY; DNA DAMAGE; DRUG DETERMINATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; RECOMBINATION REPAIR; UPREGULATION; WESTERN BLOTTING;

ACRIDONES; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL CYCLE CHECKPOINTS; CELL SURVIVAL; CHROMONES; CISPLATIN; COLONIC NEOPLASMS; COMET ASSAY; DNA-ACTIVATED PROTEIN KINASE; DRUG SYNERGISM; HCT116 CELLS; HT29 CELLS; HUMANS; MORPHOLINES; ORGANOPLATINUM COMPOUNDS; PROTEIN KINASE INHIBITORS; PYRIDINES; TOPOISOMERASE I INHIBITORS;

EID: 84864328191     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9626-9     Document Type: Article

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