메뉴 건너뛰기




Volumn 24, Issue 4, 2012, Pages 204-211

Obesity and metabolic syndrome: Future therapeutics based on novel molecular pathways

Author keywords

Antiobesity therapies; Flavonoids; Metabolic syndrome; Mitochondrial dysfunction; Obesity

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIBUTRAMINE; SIRTUIN 1; TETRAHYDROLIPSTATIN;

EID: 84864301605     PISSN: 02149168     EISSN: 15781879     Source Type: Journal    
DOI: 10.1016/j.arteri.2011.11.002     Document Type: Short Survey
Times cited : (6)

References (101)
  • 1
    • 84864303115 scopus 로고    scopus 로고
    • National Heart, Lung and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases. Clinical guidelines on the identification, evaluation and treatment of overweight and obesity in adults: the evidence report. [On line] cited June [2011 April]. Available at: URL:
    • National Heart, Lung and Blood Institute/National Institute of Diabetes and Digestive and Kidney Diseases. Clinical guidelines on the identification, evaluation and treatment of overweight and obesity in adults: the evidence report. [On line] cited 2011 June [2011 April]. Available at: URL: http://www.nhlbi.nih.gov/guidelines/obesity/index.htm.
    • (2011)
  • 2
    • 84864315955 scopus 로고    scopus 로고
    • World Health Organization (WHO). Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity. Ginebra;
    • World Health Organization (WHO). Obesity: preventing and managing the global epidemic. Report of a WHO consultation on obesity. Ginebra; 1999.
    • (1999)
  • 3
    • 0242383401 scopus 로고    scopus 로고
    • Obesity: is it a genetic disorder?
    • Loos R.J., Bouchard C. Obesity: is it a genetic disorder?. J Intern Med 2003, 254:401-425.
    • (2003) J Intern Med , vol.254 , pp. 401-425
    • Loos, R.J.1    Bouchard, C.2
  • 7
    • 23844479290 scopus 로고    scopus 로고
    • Genetics of common forms of obesity: a brief overview
    • Lyon H.N., Hirschhorn J.N. Genetics of common forms of obesity: a brief overview. Am J Clin Nutr 2005, 82(Suppl):215S-217S.
    • (2005) Am J Clin Nutr , vol.82 , Issue.SUPPL
    • Lyon, H.N.1    Hirschhorn, J.N.2
  • 8
    • 34247871303 scopus 로고    scopus 로고
    • Addressing the obesity epidemic: a genomics perspective
    • Newell A., Zlot A., Silvey K., Arail K. Addressing the obesity epidemic: a genomics perspective. Prev Chronic Dis 2007, 4:1-6.
    • (2007) Prev Chronic Dis , vol.4 , pp. 1-6
    • Newell, A.1    Zlot, A.2    Silvey, K.3    Arail, K.4
  • 9
    • 0042484813 scopus 로고    scopus 로고
    • The obesity epidemic: pathophysiology and consequences of obesity
    • Pi-Sunyer F.X. The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 2002, 10(Suppl 2):97S-104S.
    • (2002) Obes Res , vol.10 , Issue.SUPPL. 2
    • Pi-Sunyer, F.X.1
  • 10
    • 34247562702 scopus 로고    scopus 로고
    • Prevalence and etiology of obesity: an overview
    • Afridi A, Khan A. Prevalence and etiology of obesity: an overview. Pak J Nutr 2204;3:14-25.
    • Pak J Nutr 2204 , vol.3 , pp. 14-25
    • Afridi, A.1    Khan, A.2
  • 11
    • 84864300092 scopus 로고    scopus 로고
    • Obesiad y sus complicaciones
    • Luengo-Pérez L.M., Beato-Víbora P. Obesiad y sus complicaciones. Nutr Hosp 2010, 3(Suppl 1):51-61.
    • (2010) Nutr Hosp , vol.3 , Issue.SUPPL. 1 , pp. 51-61
    • Luengo-Pérez, L.M.1    Beato-Víbora, P.2
  • 13
    • 2342520098 scopus 로고    scopus 로고
    • Genetic studies of the etiology of type 2 diabetes in Pima Indians: hunting for the pieces to a complicated puzzle
    • Baier L.J., Hanson R.L. Genetic studies of the etiology of type 2 diabetes in Pima Indians: hunting for the pieces to a complicated puzzle. Diabetes 2004, 53:1181-1186.
    • (2004) Diabetes , vol.53 , pp. 1181-1186
    • Baier, L.J.1    Hanson, R.L.2
  • 14
    • 0033978361 scopus 로고    scopus 로고
    • Daily energy expenditure in Mexican and USA Pima Indians: low physical activity as a possible cause of obesity
    • Esparza J., Fox C., Harper I.T., Bennett P.H., Schulz L.O., Valencia M.E., et al. Daily energy expenditure in Mexican and USA Pima Indians: low physical activity as a possible cause of obesity. Int J Obes Relat Metab Disord 2000, 24:55-59.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 55-59
    • Esparza, J.1    Fox, C.2    Harper, I.T.3    Bennett, P.H.4    Schulz, L.O.5    Valencia, M.E.6
  • 15
    • 33746607619 scopus 로고    scopus 로고
    • Effects of a traditional and western environment on prevalence of type 2 diabetes in Pima Indians in Mexico and the U.S.
    • Schultz L.O., Bennett P.H., Ravussin E., Kidd J.R., Kidd K.K., Esparza J., et al. Effects of a traditional and western environment on prevalence of type 2 diabetes in Pima Indians in Mexico and the U.S. Diabetes Care 2006, 29:1866-1871.
    • (2006) Diabetes Care , vol.29 , pp. 1866-1871
    • Schultz, L.O.1    Bennett, P.H.2    Ravussin, E.3    Kidd, J.R.4    Kidd, K.K.5    Esparza, J.6
  • 16
    • 4344592422 scopus 로고    scopus 로고
    • Prevalence of overweight and obesity among young people in Great Britain
    • Jebb S.A., Rennie K.L., Cole T.J. Prevalence of overweight and obesity among young people in Great Britain. Public Health Nutr 2004, 7:461-465.
    • (2004) Public Health Nutr , vol.7 , pp. 461-465
    • Jebb, S.A.1    Rennie, K.L.2    Cole, T.J.3
  • 17
    • 84864303113 scopus 로고    scopus 로고
    • World Health Organization Obesity and overweight: fact sheet 311. [On line] February [cited 2011 February]. Available at: URL:
    • World Health Organization Obesity and overweight: fact sheet 311. [On line] 2011 February [cited 2011 February]. Available at: URL: http://www.who.int/mediacentre/factsheets/fs311/en/.
    • (2011)
  • 18
    • 84881701126 scopus 로고    scopus 로고
    • Organization for Economic Cooperation and Development (OECD). Obesity and the economics of prevention: fit not fat. [On line] September 23 [cited 2010 October]. Available at: URL:
    • Organization for Economic Cooperation and Development (OECD). Obesity and the economics of prevention: fit not fat. [On line] 2010 September 23 [cited 2010 October]. Available at: URL: http://www.oecd.org/document/31/.
    • (2010)
  • 19
    • 64649083354 scopus 로고    scopus 로고
    • The incidence of comorbidities related to obesity and overweight: a systematic review and meta-analysis
    • Guh D.P., Zhang W., Bansback N., Amarsi Z., Birmingham C.L., Anis A.H. The incidence of comorbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009, 9:88.
    • (2009) BMC Public Health , vol.9 , pp. 88
    • Guh, D.P.1    Zhang, W.2    Bansback, N.3    Amarsi, Z.4    Birmingham, C.L.5    Anis, A.H.6
  • 20
    • 67650333178 scopus 로고    scopus 로고
    • A comprehensive definition for metabolic syndrome
    • Huang P.L. A comprehensive definition for metabolic syndrome. Dis Model Mech 2009, 2:231-237.
    • (2009) Dis Model Mech , vol.2 , pp. 231-237
    • Huang, P.L.1
  • 21
    • 33846970555 scopus 로고    scopus 로고
    • Metabolic syndrome: a multiplex cardiovascular risk factor
    • Grundy S.M. Metabolic syndrome: a multiplex cardiovascular risk factor. J Clin Endocrinol Metabol 2007, 92:399-404.
    • (2007) J Clin Endocrinol Metabol , vol.92 , pp. 399-404
    • Grundy, S.M.1
  • 22
    • 1842590296 scopus 로고    scopus 로고
    • Insulin resistance, cardiovascular disease, and the metabolic syndrome: how well do the emperor's clothes fit
    • Reaven G.M. Insulin resistance, cardiovascular disease, and the metabolic syndrome: how well do the emperor's clothes fit. Diabetes Care 2004, 27:1011-1012.
    • (2004) Diabetes Care , vol.27 , pp. 1011-1012
    • Reaven, G.M.1
  • 23
    • 1542720650 scopus 로고    scopus 로고
    • Obesity as the core of the metabolic syndrome and the management of coronary heart disease
    • Shirai K. Obesity as the core of the metabolic syndrome and the management of coronary heart disease. Curr Med Res Opin 2004, 20:295-304.
    • (2004) Curr Med Res Opin , vol.20 , pp. 295-304
    • Shirai, K.1
  • 25
    • 52049097577 scopus 로고    scopus 로고
    • The link between abdominal obesity and the metabolic syndrome
    • Phillips L.K., Prins J.B. The link between abdominal obesity and the metabolic syndrome. Curr Hypertens Rep 2008, 10:156-164.
    • (2008) Curr Hypertens Rep , vol.10 , pp. 156-164
    • Phillips, L.K.1    Prins, J.B.2
  • 26
    • 31744443753 scopus 로고    scopus 로고
    • Is visceral obesity the cause of the metabolic syndrome
    • Despres J.P. Is visceral obesity the cause of the metabolic syndrome. Ann Med 2006, 38:52-63.
    • (2006) Ann Med , vol.38 , pp. 52-63
    • Despres, J.P.1
  • 27
    • 0035168093 scopus 로고    scopus 로고
    • Health consequences of visceral adiposity
    • Despres J.P. Health consequences of visceral adiposity. Ann Med 2001, 33:534-541.
    • (2001) Ann Med , vol.33 , pp. 534-541
    • Despres, J.P.1
  • 28
    • 2442647863 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in non-diabetic European men and women
    • DECODE Study Group
    • Hu G., Qiao Q., Tuomilehto J., Balkau B., Borch-Johnsen K., Pyorala K. Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in non-diabetic European men and women. Arch Intern Med 2004, 164:1066-1076. DECODE Study Group.
    • (2004) Arch Intern Med , vol.164 , pp. 1066-1076
    • Hu, G.1    Qiao, Q.2    Tuomilehto, J.3    Balkau, B.4    Borch-Johnsen, K.5    Pyorala, K.6
  • 29
    • 0041374029 scopus 로고    scopus 로고
    • Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha
    • Ruan H., Lodish H.F. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. Cytokine Growth Factor Rev 2003, 14:447-455.
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 447-455
    • Ruan, H.1    Lodish, H.F.2
  • 30
    • 37349065793 scopus 로고    scopus 로고
    • The pathophysiology of obesity and its clinical manifestations
    • Redinger R.N. The pathophysiology of obesity and its clinical manifestations. Gastroenterol Hepatol 2007, 3:856-863.
    • (2007) Gastroenterol Hepatol , vol.3 , pp. 856-863
    • Redinger, R.N.1
  • 31
    • 34047266814 scopus 로고    scopus 로고
    • The link between abdominal obesity, metabolic syndrome and cardiovascular disease
    • Ritchie S.A., Connell J.M.C. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metabol Cardiovasc Dis 2007, 17:319-326.
    • (2007) Nutr Metabol Cardiovasc Dis , vol.17 , pp. 319-326
    • Ritchie, S.A.1    Connell, J.M.C.2
  • 33
    • 55849114349 scopus 로고    scopus 로고
    • Adipocytokines and the metabolic complications of obesity
    • Rasouli N., Kern P.A. Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008, 93:s64-s73.
    • (2008) J Clin Endocrinol Metab , vol.93
    • Rasouli, N.1    Kern, P.A.2
  • 35
    • 11244302456 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 is produced in isolated adipocytes: associated with adiposity and reduced after weight loss in morbid obese subjects
    • Christiansen T., Richelsen B., Bruun J.M. Monocyte chemoattractant protein-1 is produced in isolated adipocytes: associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes 2005, 29:146-150.
    • (2005) Int J Obes , vol.29 , pp. 146-150
    • Christiansen, T.1    Richelsen, B.2    Bruun, J.M.3
  • 36
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity: inflammation, and insulin resistance
    • Bastard J.P., Maachi M., Lagathu C., Kim M.J., Caron M., Vidal H., et al. Recent advances in the relationship between obesity: inflammation, and insulin resistance. Eur Cytokine Netw 2006, 17:4-12.
    • (2006) Eur Cytokine Netw , vol.17 , pp. 4-12
    • Bastard, J.P.1    Maachi, M.2    Lagathu, C.3    Kim, M.J.4    Caron, M.5    Vidal, H.6
  • 37
    • 0035405847 scopus 로고    scopus 로고
    • Effects of acute changes in plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects
    • Boden G., Lebed B., Schatz M., Homko C., Lemieux S. Effects of acute changes in plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 2001, 50:1612-1617.
    • (2001) Diabetes , vol.50 , pp. 1612-1617
    • Boden, G.1    Lebed, B.2    Schatz, M.3    Homko, C.4    Lemieux, S.5
  • 38
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani S.I., Ruderman N.B., Schmieder F., Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes 2002, 51:2005-2011.
    • (2002) Diabetes , vol.51 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 39
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM
    • Unger R.H. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Diabetes 1995, 44:863-870.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 40
    • 77955899564 scopus 로고    scopus 로고
    • The metabolic syndrome: an ongoing story
    • Duvnjak L., Duvnjak M. The metabolic syndrome: an ongoing story. J Physiol Pharmacol 2009, 60(Suppl 7):19-24.
    • (2009) J Physiol Pharmacol , vol.60 , Issue.SUPPL. 7 , pp. 19-24
    • Duvnjak, L.1    Duvnjak, M.2
  • 41
    • 7044278046 scopus 로고    scopus 로고
    • Insulin resistance and its consequences
    • Lippincott, Williams and Wilkins, USA, D. LeRoith, S.I. Taylor, J.M. Olefsky (Eds.)
    • Reaven J.M. Insulin resistance and its consequences. Diabetes mellitus: a fundamental and clinical text 2004, Lippincott, Williams and Wilkins, USA. D. LeRoith, S.I. Taylor, J.M. Olefsky (Eds.).
    • (2004) Diabetes mellitus: a fundamental and clinical text
    • Reaven, J.M.1
  • 42
    • 0034527580 scopus 로고    scopus 로고
    • Insulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension
    • Montagnani M., Quon M.J. Insulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension. Diabetes Obes Metab 2000, 2:285-292.
    • (2000) Diabetes Obes Metab , vol.2 , pp. 285-292
    • Montagnani, M.1    Quon, M.J.2
  • 43
    • 33646178955 scopus 로고    scopus 로고
    • Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms
    • Kim J.A., Montagnani M., Koh K.K., Quon M.J. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006, 113:1888-1904.
    • (2006) Circulation , vol.113 , pp. 1888-1904
    • Kim, J.A.1    Montagnani, M.2    Koh, K.K.3    Quon, M.J.4
  • 44
    • 34447116875 scopus 로고    scopus 로고
    • The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia
    • Atochin D.N., Wang A., Liu V.W., Critchlow J.D., Dantas A.P., Looft-Wilson R., et al. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia. J Clin Invest 2007, 117:1961-1967.
    • (2007) J Clin Invest , vol.117 , pp. 1961-1967
    • Atochin, D.N.1    Wang, A.2    Liu, V.W.3    Critchlow, J.D.4    Dantas, A.P.5    Looft-Wilson, R.6
  • 46
    • 20444505177 scopus 로고    scopus 로고
    • Unraveling the links between diabetes, obesity and cardiovascular disease
    • Huang P.L. Unraveling the links between diabetes, obesity and cardiovascular disease. Circ Res 2005, 96:1129-1131.
    • (2005) Circ Res , vol.96 , pp. 1129-1131
    • Huang, P.L.1
  • 47
    • 0037339931 scopus 로고    scopus 로고
    • Is oxidative stress a connection between obesity and atherosclerosis
    • Morrow J. Is oxidative stress a connection between obesity and atherosclerosis. Arterioscler Tromb Vasc Boil 2003, 23:368-370.
    • (2003) Arterioscler Tromb Vasc Boil , vol.23 , pp. 368-370
    • Morrow, J.1
  • 49
    • 33745828640 scopus 로고    scopus 로고
    • Insulin resistance and atherosclerosis
    • Semenkovich C.F. Insulin resistance and atherosclerosis. J Clin Invest 2006, 116:1813-1822.
    • (2006) J Clin Invest , vol.116 , pp. 1813-1822
    • Semenkovich, C.F.1
  • 50
    • 67149086828 scopus 로고    scopus 로고
    • Insulin resistance and lipid disorders: dysregulation of lipid metabolism
    • Miccoli R., Bianchi C., Penno G., Del Prato S. Insulin resistance and lipid disorders: dysregulation of lipid metabolism. Future Lipidol 2008, 3:651-664.
    • (2008) Future Lipidol , vol.3 , pp. 651-664
    • Miccoli, R.1    Bianchi, C.2    Penno, G.3    Del Prato, S.4
  • 51
    • 0033536189 scopus 로고    scopus 로고
    • Insulin resistance and lipid metabolism
    • Howard B.V. Insulin resistance and lipid metabolism. Am J Cardiol 1999, 84:28J-32J.
    • (1999) Am J Cardiol , vol.84
    • Howard, B.V.1
  • 52
    • 12744279669 scopus 로고    scopus 로고
    • Diabetes: insulin resistance and derangements in lipid metabolism
    • Raz I., Eldor R., Cernea S., Shafrir E. Diabetes: insulin resistance and derangements in lipid metabolism. Diabetes Metab Res Rev 2005, 21:3-14.
    • (2005) Diabetes Metab Res Rev , vol.21 , pp. 3-14
    • Raz, I.1    Eldor, R.2    Cernea, S.3    Shafrir, E.4
  • 53
    • 68849099874 scopus 로고    scopus 로고
    • Could mitochondrial efficiency explain the susceptibility to adiposity, metabolic syndrome, diabetes and cardiovascular diseases in South Asian populations
    • Bhopal R.S., Rafnsson S.B. Could mitochondrial efficiency explain the susceptibility to adiposity, metabolic syndrome, diabetes and cardiovascular diseases in South Asian populations. Int J Epidemiol 2009, 38:1072-1081.
    • (2009) Int J Epidemiol , vol.38 , pp. 1072-1081
    • Bhopal, R.S.1    Rafnsson, S.B.2
  • 55
    • 79955575803 scopus 로고    scopus 로고
    • Regulation of mitochondrial biogenesis in metabolic syndrome
    • Rolo A.P., Gomez A.P., Palmeira C.M. Regulation of mitochondrial biogenesis in metabolic syndrome. Curr Drug Targets 2011, 12:872-878.
    • (2011) Curr Drug Targets , vol.12 , pp. 872-878
    • Rolo, A.P.1    Gomez, A.P.2    Palmeira, C.M.3
  • 56
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
    • Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 2006, 127:1109-1122.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3    Meziane, H.4    Lerin, C.5    Daussin, F.6
  • 57
    • 11144310564 scopus 로고    scopus 로고
    • An overview on biological mechanisms of PPARs
    • Kota B.P., Huang T.H., Roufogalis B.D. An overview on biological mechanisms of PPARs. Pharmacol Res 2005, 51:85-94.
    • (2005) Pharmacol Res , vol.51 , pp. 85-94
    • Kota, B.P.1    Huang, T.H.2    Roufogalis, B.D.3
  • 58
    • 84856008795 scopus 로고    scopus 로고
    • Multifaceted roles or peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels
    • Yessoufou A., Wahli W. Multifaceted roles or peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels. Swiss Med Wkly 2010, 140:E1-E10.
    • (2010) Swiss Med Wkly , vol.140
    • Yessoufou, A.1    Wahli, W.2
  • 59
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptors: nuclear control of metabolism
    • Desvergne B., Wahli W. Peroxisome proliferator activated receptors: nuclear control of metabolism. Endocrinol Rev 1999, 20:649-688.
    • (1999) Endocrinol Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 61
    • 39649101196 scopus 로고    scopus 로고
    • Activation of PPARα promotes reversal of multiple metabolic abnormalities: reduces oxidative stress and increases fatty acid oxidation in moderately obese men
    • Risérus U., Sprecher D., Johnson T., Olson E., Hirschberg S., Liu A., et al. Activation of PPARα promotes reversal of multiple metabolic abnormalities: reduces oxidative stress and increases fatty acid oxidation in moderately obese men. Diabetes 2008, 57:332-339.
    • (2008) Diabetes , vol.57 , pp. 332-339
    • Risérus, U.1    Sprecher, D.2    Johnson, T.3    Olson, E.4    Hirschberg, S.5    Liu, A.6
  • 62
    • 33644645013 scopus 로고    scopus 로고
    • PPAR delta: a dagger in the heart of metabolic syndrome
    • Barish G.D., Narkar V.A., Evans R.M. PPAR delta: a dagger in the heart of metabolic syndrome. J Clin Invest 2006, 116:590-597.
    • (2006) J Clin Invest , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 63
    • 44149120984 scopus 로고    scopus 로고
    • Molecular determinants of brown adipocyte formation and function
    • Farmer S.R. Molecular determinants of brown adipocyte formation and function. Genes Dev 2008, 22:1397-1409.
    • (2008) Genes Dev , vol.22 , pp. 1397-1409
    • Farmer, S.R.1
  • 64
    • 0037304599 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone
    • Wilson-Fritch L., Burkart A., Bell G., Mendelson K., Leszyk J., Nicoloro S., et al. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol 2003, 23:1085-1094.
    • (2003) Mol Cell Biol , vol.23 , pp. 1085-1094
    • Wilson-Fritch, L.1    Burkart, A.2    Bell, G.3    Mendelson, K.4    Leszyk, J.5    Nicoloro, S.6
  • 65
    • 85047689659 scopus 로고    scopus 로고
    • Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
    • Wilson-Fritch L., Nicoloro S., Chouinard M., Lazar M.A., Chui P.C., Leszyk J., et al. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest 2004, 114:1281-1289.
    • (2004) J Clin Invest , vol.114 , pp. 1281-1289
    • Wilson-Fritch, L.1    Nicoloro, S.2    Chouinard, M.3    Lazar, M.A.4    Chui, P.C.5    Leszyk, J.6
  • 66
    • 50949105881 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor β/δ inhibits lipopolisacharide-induced cytokine production in adipocytes
    • Rodríguez-Calvo R., Serrano L., Coll T., Moullan N., Sánchez R.M., Merlos M., et al. Activation of the peroxisome proliferator-activated receptor β/δ inhibits lipopolisacharide-induced cytokine production in adipocytes. Diabetes 2008, 57:2149-2157.
    • (2008) Diabetes , vol.57 , pp. 2149-2157
    • Rodríguez-Calvo, R.1    Serrano, L.2    Coll, T.3    Moullan, N.4    Sánchez, R.M.5    Merlos, M.6
  • 67
    • 77956824021 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptors β/δ on the inflammatory basis of metabolic disease
    • Coll T., Barrosso E., Álvarez-Guardia D., Serrano L., Salvadó L., Merlos M., et al. The role of peroxisome proliferator-activated receptors β/δ on the inflammatory basis of metabolic disease. PPAR Res 2010, 10.1155/2010/368467.
    • (2010) PPAR Res
    • Coll, T.1    Barrosso, E.2    Álvarez-Guardia, D.3    Serrano, L.4    Salvadó, L.5    Merlos, M.6
  • 68
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003, 3:23-25.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-25
    • Gordon, S.1
  • 69
    • 36049034344 scopus 로고    scopus 로고
    • Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
    • Straus D.S., Glass C.K. Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends Immunol 2007, 28:551-558.
    • (2007) Trends Immunol , vol.28 , pp. 551-558
    • Straus, D.S.1    Glass, C.K.2
  • 70
    • 77953493182 scopus 로고    scopus 로고
    • Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages
    • Fuentes L., Rószer T., Ricote M. Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages. Mediat Inflamm 2010, 10.1155/2010/219583.
    • (2010) Mediat Inflamm
    • Fuentes, L.1    Rószer, T.2    Ricote, M.3
  • 71
    • 0031813989 scopus 로고    scopus 로고
    • Effects of fenofibrate on plasma cytokine concentrations in patients with atherosclerosis and hyperlipoproteinemia IIb
    • Madej A., Okopien B., Kowalski J., Zielinski M., Wysocki J., Szygula B., et al. Effects of fenofibrate on plasma cytokine concentrations in patients with atherosclerosis and hyperlipoproteinemia IIb. Int J Clin Pharmacol Ther 1998, 36:345-349.
    • (1998) Int J Clin Pharmacol Ther , vol.36 , pp. 345-349
    • Madej, A.1    Okopien, B.2    Kowalski, J.3    Zielinski, M.4    Wysocki, J.5    Szygula, B.6
  • 72
    • 79954593739 scopus 로고    scopus 로고
    • Treatment of obesity related complications with novel classes of naturally occurring PPAR agonists
    • Bassaganya J., Guri A.J., Hontecillas R. Treatment of obesity related complications with novel classes of naturally occurring PPAR agonists. J Obes 2011, 10.1155/2011/897894.
    • (2011) J Obes
    • Bassaganya, J.1    Guri, A.J.2    Hontecillas, R.3
  • 73
    • 33751011308 scopus 로고    scopus 로고
    • PGC-1α: a key regulator of energy metabolism
    • Liang H., Ward W.F. PGC-1α: a key regulator of energy metabolism. Adv Physiol Educ 2006, 30:145-151.
    • (2006) Adv Physiol Educ , vol.30 , pp. 145-151
    • Liang, H.1    Ward, W.F.2
  • 74
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
    • Finck B.N., Kelly D.P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 2006, 116:615-622.
    • (2006) J Clin Invest , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 75
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptative thermogenesis
    • Puigserver P., Wu Z., Park C.W., Graves R., Wright M., Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptative thermogenesis. Cell 1998, 92:829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 76
    • 0037036115 scopus 로고    scopus 로고
    • Nuclear activators and coactivators in mammalian mitochondrial biogenesis
    • Scarpulla R.C. Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim Biophys Acta 2002, 1576:1-14.
    • (2002) Biochim Biophys Acta , vol.1576 , pp. 1-14
    • Scarpulla, R.C.1
  • 77
    • 0037029049 scopus 로고    scopus 로고
    • Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammal cells
    • Scarpulla R.C. Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammal cells. Gene 2002, 286:81-89.
    • (2002) Gene , vol.286 , pp. 81-89
    • Scarpulla, R.C.1
  • 78
    • 10744228606 scopus 로고    scopus 로고
    • Endurance in training humans lead to fiber type-specific increases in levels of PGC-1alpha and PPARalpha in skeletal muscle
    • Russel A.P., Feilchenfeldt J., Schreiber S., Praz M., Crettenand A., Gobelet C., et al. Endurance in training humans lead to fiber type-specific increases in levels of PGC-1alpha and PPARalpha in skeletal muscle. Diabetes 2003, 52:2874-2881.
    • (2003) Diabetes , vol.52 , pp. 2874-2881
    • Russel, A.P.1    Feilchenfeldt, J.2    Schreiber, S.3    Praz, M.4    Crettenand, A.5    Gobelet, C.6
  • 79
    • 33751011308 scopus 로고    scopus 로고
    • PGC-1α: a key regulator of energy metabolism
    • Liang H., Ward W.F. PGC-1α: a key regulator of energy metabolism. Adv Physiol Edu 2006, 30:145-151.
    • (2006) Adv Physiol Edu , vol.30 , pp. 145-151
    • Liang, H.1    Ward, W.F.2
  • 80
    • 73249117395 scopus 로고    scopus 로고
    • Skeletal muscle characteristics of rats with obesity, diabetes, hypertension and hyperlipidemia
    • Nagamoto F., Gu N., Fujino H., Takeda I., Tsuda K., Ishihara A. Skeletal muscle characteristics of rats with obesity, diabetes, hypertension and hyperlipidemia. J Atheroscler Thromb 2009, 16:576-585.
    • (2009) J Atheroscler Thromb , vol.16 , pp. 576-585
    • Nagamoto, F.1    Gu, N.2    Fujino, H.3    Takeda, I.4    Tsuda, K.5    Ishihara, A.6
  • 81
    • 79953210362 scopus 로고    scopus 로고
    • Regulation of PGC-1α: a nodal regulator of mitochondrial biogenesis
    • Fernández-Marcos P.J., Auwerx J. Regulation of PGC-1α: a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 2011, 93:884S-890S.
    • (2011) Am J Clin Nutr , vol.93
    • Fernández-Marcos, P.J.1    Auwerx, J.2
  • 82
    • 33750445309 scopus 로고    scopus 로고
    • NAD metabolism and sirtuins: metabolic regulation of protein deacetylase in stress and toxicity
    • Yang T., Sauve A.A. NAD metabolism and sirtuins: metabolic regulation of protein deacetylase in stress and toxicity. AAPS J 2006, E632-E643.
    • (2006) AAPS J
    • Yang, T.1    Sauve, A.A.2
  • 84
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic diseases by activating SIRT1 and PGC-1alpha
    • Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., et al. Resveratrol improves mitochondrial function and protects against metabolic diseases by activating SIRT1 and PGC-1alpha. Cell 2006, 127:1109-1122.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3    Meziane, H.4    Lerin, C.5    Daussin, F.6
  • 85
    • 34247259630 scopus 로고    scopus 로고
    • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha
    • Gerhart-Hines Z., Rodgers J.T., Bare O., Lerin C., Kim S.H., Mostoslavsky R., et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J 2007, 26:1913-1923.
    • (2007) EMBO J , vol.26 , pp. 1913-1923
    • Gerhart-Hines, Z.1    Rodgers, J.T.2    Bare, O.3    Lerin, C.4    Kim, S.H.5    Mostoslavsky, R.6
  • 86
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1 alpha and SIRT1
    • Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1 alpha and SIRT1. Nature 2005, 434:113-118.
    • (2005) Nature , vol.434 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 89
    • 84864316182 scopus 로고    scopus 로고
    • Tratamiento de la obesidad
    • Intersistemas Editores, México, A. González, F.J. Lavalle, J.J. Ríos (Eds.)
    • Campos B.S.I., Hernández M.L. Tratamiento de la obesidad. Síndrome metabólico y enfermedad cardiovascular 2009, Intersistemas Editores, México. 3a ed. A. González, F.J. Lavalle, J.J. Ríos (Eds.).
    • (2009) Síndrome metabólico y enfermedad cardiovascular
    • Campos, B.S.I.1    Hernández, M.L.2
  • 90
  • 91
    • 84864313270 scopus 로고    scopus 로고
    • Nutrigenomics and nutrigenetics: the emerging faces of nutrition
    • Mutch D.M., Wahli W., Williamson G. Nutrigenomics and nutrigenetics: the emerging faces of nutrition. FASEB J 2005, 160:2-16.
    • (2005) FASEB J , vol.160 , pp. 2-16
    • Mutch, D.M.1    Wahli, W.2    Williamson, G.3
  • 92
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur J.A., Pearson K.J., Price N.L., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 96
    • 54849425547 scopus 로고    scopus 로고
    • Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
    • Feige J.N., Lagouge M., Canto C., Strehle A., Houten S.M., Milne J.C., et al. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 2008, 8:347-358.
    • (2008) Cell Metab , vol.8 , pp. 347-358
    • Feige, J.N.1    Lagouge, M.2    Canto, C.3    Strehle, A.4    Houten, S.M.5    Milne, J.C.6
  • 97
    • 52649144703 scopus 로고    scopus 로고
    • The effects of soy isoflavones on obesity
    • Orggard A., Jensen L. The effects of soy isoflavones on obesity. Exp Biol Med 2008, 233:1066-1080.
    • (2008) Exp Biol Med , vol.233 , pp. 1066-1080
    • Orggard, A.1    Jensen, L.2
  • 98
    • 70349651441 scopus 로고    scopus 로고
    • Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptornull mice with diet-induced insulin resistance
    • Mulvihill E.E., Allister E.M., Sutherland B.G., Telford D.E., Sawyez C.G., Edwards J.Y., et al. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptornull mice with diet-induced insulin resistance. Diabetes 2009, 58:2198-2210.
    • (2009) Diabetes , vol.58 , pp. 2198-2210
    • Mulvihill, E.E.1    Allister, E.M.2    Sutherland, B.G.3    Telford, D.E.4    Sawyez, C.G.5    Edwards, J.Y.6
  • 100
    • 58149092376 scopus 로고    scopus 로고
    • Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats
    • Kamiyosama H., Honda K., Tominaga Y., Yokota S., Hasegawa S. Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats. Biosci Biotechnol Biochem 2008, 72:3225-3231.
    • (2008) Biosci Biotechnol Biochem , vol.72 , pp. 3225-3231
    • Kamiyosama, H.1    Honda, K.2    Tominaga, Y.3    Yokota, S.4    Hasegawa, S.5
  • 101
    • 78649658091 scopus 로고    scopus 로고
    • Targeting metabolic syndrome: candidate natural agents
    • Xia X., Weng J. Targeting metabolic syndrome: candidate natural agents. J Diabetes 2010, 2:243-249.
    • (2010) J Diabetes , vol.2 , pp. 243-249
    • Xia, X.1    Weng, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.