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Volumn 15, Issue 4, 2012, Pages

Humanized mouse models in drug discovery research

Author keywords

[No Author keywords available]

Indexed keywords

MARAVIROC; THROMBOPOIETIN;

EID: 84864149297     PISSN: 10998012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (39)
  • 1
    • 0037267313 scopus 로고    scopus 로고
    • Knockouts model the 100 best-selling drugs - Will they model the next 100?
    • DOI 10.1038/nrd987
    • Zambrowicz, B.P. and Sands, A.T. (2003) Knockouts model the 100 best-selling drugs - will they model the next 100? Nat Rev Drug Discov 2 (1), 38-51 (Pubitemid 37361623)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.1 , pp. 38-51
    • Zambrowicz, B.P.1    Sands, A.T.2
  • 2
    • 33846630040 scopus 로고    scopus 로고
    • Humanized mice in translational biomedical research
    • DOI 10.1038/nri2017, PII NRI2017
    • Shultz, L.D. et al. (2007) Humanized mice in translational biomedical research. Nat Rev Immunol 7 (2), 118-130 (Pubitemid 46174859)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.2 , pp. 118-130
    • Shultz, L.D.1    Ishikawa, F.2    Greiner, D.L.3
  • 4
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola, I. and Landis, J. (2004) Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov 3 (8), 711-715 (Pubitemid 39173511)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.8 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 6
    • 0031033221 scopus 로고    scopus 로고
    • Altered myeloid development and acute leukemia in transgenic mice expressing PML-RARalpha under control of cathepsin G regulatory sequences
    • Grisolano, J.L. et al. (1997) Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood 89 (2), 376-387 (Pubitemid 27051671)
    • (1997) Blood , vol.89 , Issue.2 , pp. 376-387
    • Grisolano, J.L.1    Wesselschmidt, R.L.2    Pelicci, P.G.3    Ley, T.J.4
  • 7
    • 0031000207 scopus 로고    scopus 로고
    • Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice
    • He, L.Z. et al. (1997) Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci U S A 94 (10), 5302-5307
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.10 , pp. 5302-5307
    • He, L.Z.1
  • 9
    • 0034730198 scopus 로고    scopus 로고
    • Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins
    • Rego, E.M. et al. (2000) Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins. Proc Natl Acad Sci U S A 97 (18), 10173-10178
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.18 , pp. 10173-10178
    • Rego, E.M.1
  • 10
    • 0035189761 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce remission in transgenic models of therapyresistant acute promyelocytic leukemia
    • He, L.Z. et al. (2001) Histone deacetylase inhibitors induce remission in transgenic models of therapyresistant acute promyelocytic leukemia. J Clin Invest 108 (9), 1321-1330
    • (2001) J Clin Invest , vol.108 , Issue.9 , pp. 1321-1330
    • He, L.Z.1
  • 12
    • 79953299687 scopus 로고    scopus 로고
    • Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression
    • Wartman, L.D. et al. (2011) Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. J Clin Invest 121 (4), 1445-1455
    • (2011) J Clin Invest , vol.121 , Issue.4 , pp. 1445-1455
    • Wartman, L.D.1
  • 13
    • 0026684707 scopus 로고
    • Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
    • Vigon, I. et al. (1992) Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci U S A 89 (12), 5640-5644
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.12 , pp. 5640-5644
    • Vigon, I.1
  • 18
    • 43549086159 scopus 로고    scopus 로고
    • Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor
    • Yamane, N. et al. (2008) Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor. Eur J Pharmacol 586 (1-3), 44-51
    • (2008) Eur J Pharmacol , vol.586 , Issue.1-3 , pp. 44-51
    • Yamane, N.1
  • 19
    • 62549153611 scopus 로고    scopus 로고
    • Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist
    • Erickson-Miller, C.L. et al. (2009) Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells 27 (2), 424-430
    • (2009) Stem Cells , vol.27 , Issue.2 , pp. 424-430
    • Erickson-Miller, C.L.1
  • 20
    • 54349089372 scopus 로고    scopus 로고
    • The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis
    • Nogami, W. et al. (2008) The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica 93 (10), 1495-1504
    • (2008) Haematologica , vol.93 , Issue.10 , pp. 1495-1504
    • Nogami, W.1
  • 21
    • 77953872914 scopus 로고    scopus 로고
    • Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor
    • Antipas, A.S. et al. (2010) Structure-activity relationships and hepatic safety risks of thiazole agonists of the thrombopoietin receptor. Bioorg Med Chem Lett 20 (14), 4069-4072
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.14 , pp. 4069-4072
    • Antipas, A.S.1
  • 24
    • 0030032063 scopus 로고    scopus 로고
    • Hybrid restriction enzymes: Zinc finger fusions to Fok i cleavage domain
    • Kim, Y.G. et al. (1996) Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci U S A 93 (3), 1156-1160
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.3 , pp. 1156-1160
    • Kim, Y.G.1
  • 26
    • 78650735673 scopus 로고    scopus 로고
    • Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    • Holt, N. et al. (2010) Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol 28 (8), 839-847
    • (2010) Nat Biotechnol , vol.28 , Issue.8 , pp. 839-847
    • Holt, N.1
  • 27
    • 52949154301 scopus 로고    scopus 로고
    • Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
    • Rogers, C.S. et al. (2008) Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 321 (5897), 1837-1841
    • (2008) Science , vol.321 , Issue.5897 , pp. 1837-1841
    • Rogers, C.S.1
  • 29
    • 77956524118 scopus 로고    scopus 로고
    • Production of p53 gene knockout rats by homologous recombination in embryonic stem cells
    • Tong, C. et al. (2010) Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature 467 (7312), 211-213
    • (2010) Nature , vol.467 , Issue.7312 , pp. 211-213
    • Tong, C.1
  • 30
    • 67749106611 scopus 로고    scopus 로고
    • Knockout rats via embryo microinjection of zinc-finger nucleases
    • Geurts, A.M. et al. (2009) Knockout rats via embryo microinjection of zinc-finger nucleases. Science 325 (5939), 433
    • (2009) Science , vol.325 , Issue.5939 , pp. 433
    • Geurts, A.M.1
  • 31
    • 79961196358 scopus 로고    scopus 로고
    • Knockout rats generated by embryo microinjection of TALENs
    • Tesson, L. et al. (2011) Knockout rats generated by embryo microinjection of TALENs. Nat Biotechnol 29 (8), 695-696
    • (2011) Nat Biotechnol , vol.29 , Issue.8 , pp. 695-696
    • Tesson, L.1
  • 33
    • 77956304908 scopus 로고    scopus 로고
    • Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells
    • Eastwood, D. et al. (2010) Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells. Br J Pharmacol 161 (3), 512-526
    • (2010) Br J Pharmacol , vol.161 , Issue.3 , pp. 512-526
    • Eastwood, D.1
  • 34
    • 0022389290 scopus 로고
    • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination
    • DOI 10.1038/317230a0
    • Smithies, O. et al. (1985) Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature 317 (6034), 230-234 (Pubitemid 16246494)
    • (1985) Nature , vol.317 , Issue.6034 , pp. 230-234
    • Smithies, O.1    Gregg, R.G.2    Boggs, S.S.3
  • 35
    • 0022542596 scopus 로고
    • High frequency targeting of genes to specific sites in the mammalian genome
    • Thomas, K.R. et al. (1986) High frequency targeting of genes to specific sites in the mammalian genome. Cell 44 (3), 419-428 (Pubitemid 16043333)
    • (1986) Cell , vol.44 , Issue.3 , pp. 419-428
    • Thomas, K.R.1    Folger, K.R.2    Capecchi, M.R.3
  • 36
    • 0023090920 scopus 로고
    • A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice
    • DOI 10.1038/326295a0
    • Kuehn, M.R. et al. (1987) A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 326 (6110), 295-298 (Pubitemid 17053753)
    • (1987) Nature , vol.326 , Issue.6110 , pp. 295-298
    • Kuehn, M.R.1    Bradley, A.2    Robertson, E.J.3    Evans, M.J.4
  • 37
    • 0021755231 scopus 로고
    • Transgenic mice containing growth hormone fusion genes
    • Brinster, R.L. and Palmiter, R.D. (1984) Transgenic mice containing growth hormone fusion genes. Philos Trans R Soc Lond B Biol Sci 307 (1132), 309-312
    • (1984) Philos Trans R Soc Lond B Biol Sci , vol.307 , Issue.1132 , pp. 309-312
    • Brinster, R.L.1    Palmiter, R.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.