-
1
-
-
0028302409
-
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
-
de Sauvage FJ, Hass PE, Spencer SD, et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature. 1994;369:533-538.
-
(1994)
Nature
, vol.369
, pp. 533-538
-
-
De Sauvage, F.J.1
Hass, P.E.2
Spencer, S.D.3
-
2
-
-
0028199208
-
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo
-
Lok S, Kaushansky K, Holly RD, et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature. 1994;369:565-568.
-
(1994)
Nature
, vol.369
, pp. 565-568
-
-
Lok, S.1
Kaushansky, K.2
Holly, R.D.3
-
3
-
-
0028332474
-
Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin
-
Kaushansky K, Lok S, Holly RD, et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature. 1994;369:568-571.
-
(1994)
Nature
, vol.369
, pp. 568-571
-
-
Kaushansky, K.1
Lok, S.2
Holly, R.D.3
-
4
-
-
0028176283
-
cMpl ligand is a humoral regulator of megakaryocytopoiesis
-
Wendling F, Maraskovsky E, Debili N, et al. cMpl ligand is a humoral regulator of megakaryocytopoiesis. Nature. 1994;369:571-574.
-
(1994)
Nature
, vol.369
, pp. 571-574
-
-
Wendling, F.1
Maraskovsky, E.2
Debili, N.3
-
5
-
-
0028343099
-
Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl
-
Bartley TD, Bogenberger J, Hunt P, et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell. 1994;77:1117-1124.
-
(1994)
Cell
, vol.77
, pp. 1117-1124
-
-
Bartley, T.D.1
Bogenberger, J.2
Hunt, P.3
-
6
-
-
0037071389
-
The molecular and cellular biology of thrombopoietin: The primary regulator of platelet production
-
Kaushansky K, Drachman JG. The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene. 2002;21:3359-3367.
-
(2002)
Oncogene
, vol.21
, pp. 3359-3367
-
-
Kaushansky, K.1
Drachman, J.G.2
-
7
-
-
0037111558
-
Recombinant human thrombopoietin: Basic biology and evaluation of clinical studies
-
Kuter DJ, Begley CG. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood. 2002;100:3457-3469.
-
(2002)
Blood
, vol.100
, pp. 3457-3469
-
-
Kuter, D.J.1
Begley, C.G.2
-
8
-
-
0035760892
-
Thrombocytopenia caused by the development of antibodies to thrombopoietin
-
Li J, Yang C, Xia Y, et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood. 2001;98:3241-3248.
-
(2001)
Blood
, vol.98
, pp. 3241-3248
-
-
Li, J.1
Yang, C.2
Xia, Y.3
-
9
-
-
18344410760
-
NOD/SCID/gamma(c)(null) mouse: An excellent recipient mouse model for engraftment of human cells
-
Ito M, Hiramatsu H, Kobayashi K, et al. NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood. 2002;100:3175-3182.
-
(2002)
Blood
, vol.100
, pp. 3175-3182
-
-
Ito, M.1
Hiramatsu, H.2
Kobayashi, K.3
-
10
-
-
22244475160
-
An oral, non-petide, small molecule thrombopoietin receptor agonist increases platelet counts in healthy subjects
-
Abstract 2916
-
Jenkins J, Nicholl R, Williams D, et al. An oral, non-petide, small molecule thrombopoietin receptor agonist increases platelet counts in healthy subjects [abstract]. Blood. 2004;104:797a. Abstract 2916.
-
(2004)
Blood
, vol.104
-
-
Jenkins, J.1
Nicholl, R.2
Williams, D.3
-
11
-
-
0015694434
-
Cholinesterase as a possible marker for early cells of the megakaryocytic series
-
Jackson CW. Cholinesterase as a possible marker for early cells of the megakaryocytic series. Blood. 1973;42:413-421.
-
(1973)
Blood
, vol.42
, pp. 413-421
-
-
Jackson, C.W.1
-
12
-
-
0030956715
-
CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
-
Matsumoto A, Masuhara M, Mitsui K, et al. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood. 1997;89:3148-3154.
-
(1997)
Blood
, vol.89
, pp. 3148-3154
-
-
Matsumoto, A.1
Masuhara, M.2
Mitsui, K.3
-
13
-
-
0038083127
-
Immunocytochemical studies on co-localization of alpha-granule membrane alphaIIbbeta3 integrin and intragranular fibrinogen of human platelets and their cell-surface expression during the thrombin-induced release reaction
-
Tokyo
-
Suzuki H, Yamazaki H, Tanoue K. Immunocytochemical studies on co-localization of alpha-granule membrane alphaIIbbeta3 integrin and intragranular fibrinogen of human platelets and their cell-surface expression during the thrombin-induced release reaction. J Electron Microsc (Tokyo). 2003;52:183-195.
-
(2003)
J Electron Microsc
, vol.52
, pp. 183-195
-
-
Suzuki, H.1
Yamazaki, H.2
Tanoue, K.3
-
14
-
-
0034094923
-
Blood platelet activation evaluated by flow cytometry: Optimised methods for clinical studies
-
Hagberg IA, Lyberg T. Blood platelet activation evaluated by flow cytometry: optimised methods for clinical studies. Platelets. 2000;11:137-150.
-
(2000)
Platelets
, vol.11
, pp. 137-150
-
-
Hagberg, I.A.1
Lyberg, T.2
-
15
-
-
0000228408
-
Guideline for animal experimentation
-
Guideline for animal experimentation. [in japanese]. Exp Anim. 1987;36:285-288.
-
(1987)
Exp Anim
, vol.36
, pp. 285-288
-
-
-
16
-
-
0030043043
-
Establishment and characterization of the thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO
-
Komatsu N, Kunitama M, Yamada M, et al. Establishment and characterization of the thrombopoietin-dependent megakaryocytic cell line, UT-7/TPO. Blood. 1996;87:4552-4560.
-
(1996)
Blood
, vol.87
, pp. 4552-4560
-
-
Komatsu, N.1
Kunitama, M.2
Yamada, M.3
-
17
-
-
0026034133
-
Establishment and characterization of a human leukemic cell line with megakaryocytic features: Dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival
-
Komatsu N, Nakauchi H, Miwa A, et al. Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival. Cancer Res. 1991;51:341-348.
-
(1991)
Cancer Res
, vol.51
, pp. 341-348
-
-
Komatsu, N.1
Nakauchi, H.2
Miwa, A.3
-
18
-
-
0031002465
-
Identification of functional domains of the human thrombopoietin receptor required for growth and differentiation of megakaryocytic cells
-
Takatoku M, Kametaka M, Shimizu R, Miura Y, Komatsu N. Identification of functional domains of the human thrombopoietin receptor required for growth and differentiation of megakaryocytic cells. J Biol Chem. 1997;272:7259-7263.
-
(1997)
J Biol Chem
, vol.272
, pp. 7259-7263
-
-
Takatoku, M.1
Kametaka, M.2
Shimizu, R.3
Miura, Y.4
Komatsu, N.5
-
19
-
-
0027321052
-
Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7
-
Komatsu N, Yamamoto M, Fujita H, et al. Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7. Blood. 1993;82:456-464.
-
(1993)
Blood
, vol.82
, pp. 456-464
-
-
Komatsu, N.1
Yamamoto, M.2
Fujita, H.3
-
20
-
-
0020043243
-
Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: Immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients
-
Vainchenker W, Deschamps JF, Bastin JM, et al. Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients. Blood. 1982;59:514-521.
-
(1982)
Blood
, vol.59
, pp. 514-521
-
-
Vainchenker, W.1
Deschamps, J.F.2
Bastin, J.M.3
-
21
-
-
0033796946
-
Differences in megakaryocyte expansion potential between CD34(+) stem cells derived from cord blood, peripheral blood, and bone marrow from adults and children
-
van den Oudenrijn S, von dem Borne AE, de Haas M. Differences in megakaryocyte expansion potential between CD34(+) stem cells derived from cord blood, peripheral blood, and bone marrow from adults and children. Exp Hematol. 2000;28:1054-1061.
-
(2000)
Exp Hematol
, vol.28
, pp. 1054-1061
-
-
Van Den Oudenrijn, S.1
Von Dem Borne, A.E.2
De Haas, M.3
-
22
-
-
0032577533
-
A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl
-
Kimura T, Kaburaki H, Tsujino T, Ikeda Y, Kato H, Watanabe Y. A non-peptide compound which can mimic the effect of thrombopoietin via c-Mpl. FEBS Lett. 1998;428:250-254.
-
(1998)
FEBS Lett
, vol.428
, pp. 250-254
-
-
Kimura, T.1
Kaburaki, H.2
Tsujino, T.3
Ikeda, Y.4
Kato, H.5
Watanabe, Y.6
-
23
-
-
0037103160
-
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics
-
Duffy KJ, Price AT, Delorme E, et al. Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics. J Med Chem. 2002;45:3576-3578.
-
(2002)
J Med Chem
, vol.45
, pp. 3576-3578
-
-
Duffy, K.J.1
Price, A.T.2
Delorme, E.3
-
24
-
-
0035950101
-
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis
-
Duffy KJ, Darcy MG, Delorme E, et al. Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis. J Med Chem. 2001;44:3730-3745.
-
(2001)
J Med Chem
, vol.44
, pp. 3730-3745
-
-
Duffy, K.J.1
Darcy, M.G.2
Delorme, E.3
-
25
-
-
3042830471
-
Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities
-
Inagaki K, Oda T, Naka Y, Shinkai H, Komatsu N, Iwamura H. Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities. Blood. 2004;104:58-64.
-
(2004)
Blood
, vol.104
, pp. 58-64
-
-
Inagaki, K.1
Oda, T.2
Naka, Y.3
Shinkai, H.4
Komatsu, N.5
Iwamura, H.6
-
26
-
-
27544489860
-
Xanthocillins as thrombopoietin mimetic small molecules
-
Sakai R, Nakamura T, Nishino T, et al. Xanthocillins as thrombopoietin mimetic small molecules. Bioorg Med Chem. 2005;13:6388-6393.
-
(2005)
Bioorg Med Chem
, vol.13
, pp. 6388-6393
-
-
Sakai, R.1
Nakamura, T.2
Nishino, T.3
-
27
-
-
19944432021
-
Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist
-
Erickson-Miller CL, DeLorme E, Tian SS, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005;33:85-93.
-
(2005)
Exp Hematol
, vol.33
, pp. 85-93
-
-
Erickson-Miller, C.L.1
DeLorme, E.2
Tian, S.S.3
-
28
-
-
33744497342
-
Species specificity and receptor domain interaction of a small molecule TPO receptor agonist
-
Erickson-Miller CL, Delorme E, Iskander M, et al. Species specificity and receptor domain interaction of a small molecule TPO receptor agonist [abstract]. Blood. 2004;104:795a.
-
(2004)
Blood
, vol.104
-
-
Erickson-Miller, C.L.1
Delorme, E.2
Iskander, M.3
-
29
-
-
0029794142
-
Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer
-
Onishi M, Mui AL, Morikawa Y, et al. Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer. Blood. 1996;88:1399-1406.
-
(1996)
Blood
, vol.88
, pp. 1399-1406
-
-
Onishi, M.1
Mui, A.L.2
Morikawa, Y.3
-
30
-
-
2542502506
-
Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin
-
Ding J, Komatsu H, Wakita A, et al. Familial essential thrombocythemia associated with a dominant-positive activating mutation of the c-MPL gene, which encodes for the receptor for thrombopoietin. Blood. 2004;103:4198-4200.
-
(2004)
Blood
, vol.103
, pp. 4198-4200
-
-
Ding, J.1
Komatsu, H.2
Wakita, A.3
-
31
-
-
0029151003
-
Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling
-
Jenkins BJ, D'Andrea R, Gonda TJ. Activating point mutations in the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of beta subunit dimerization and cell type-specific molecules in signalling. EMBO J. 1995;14:4276-4287.
-
(1995)
EMBO J
, vol.14
, pp. 4276-4287
-
-
Jenkins, B.J.1
D'Andrea, R.2
Gonda, T.J.3
-
32
-
-
0035836645
-
Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain
-
U S A
-
Constantinescu SN, Keren T, Socolovsky M, Nam H, Henis YI, Lodish HF. Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc Natl Acad Sci U S A. 2001;98:4379-4384.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 4379-4384
-
-
Constantinescu, S.N.1
Keren, T.2
Socolovsky, M.3
Nam, H.4
Henis, Y.I.5
Lodish, H.F.6
-
33
-
-
26944493862
-
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
-
Brown RJ, Adams JJ, Pelekanos RA, et al. Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol. 2005;12:814-821.
-
(2005)
Nat Struct Mol Biol
, vol.12
, pp. 814-821
-
-
Brown, R.J.1
Adams, J.J.2
Pelekanos, R.A.3
-
34
-
-
0035869564
-
Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production
-
Perez LE, Rinder HM, Wang C, Tracey JB, Maun N, Krause DS. Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production. Blood. 2001;97:1635-1643.
-
(2001)
Blood
, vol.97
, pp. 1635-1643
-
-
Perez, L.E.1
Rinder, H.M.2
Wang, C.3
Tracey, J.B.4
Maun, N.5
Krause, D.S.6
-
35
-
-
1542327256
-
Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice
-
Perez LE, Alpdogan O, Shieh JH, et al. Increased plasma levels of stromal-derived factor-1 (SDF-1/CXCL12) enhance human thrombopoiesis and mobilize human colony-forming cells (CFC) in NOD/SCID mice. Exp Hematol. 2004;32:300-307.
-
(2004)
Exp Hematol
, vol.32
, pp. 300-307
-
-
Perez, L.E.1
Alpdogan, O.2
Shieh, J.H.3
-
36
-
-
1842510507
-
A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftment
-
Angelopoulou MK, Rinder H, Wang C, Burtness B, Cooper DL, Krause DS. A preclinical xenotransplantation animal model to assess human hematopoietic stem cell engraftment. Transfusion. 2004;44:555-566.
-
(2004)
Transfusion
, vol.44
, pp. 555-566
-
-
Angelopoulou, M.K.1
Rinder, H.2
Wang, C.3
Burtness, B.4
Cooper, D.L.5
Krause, D.S.6
|