Characterization of novel non-peptide thrombopoietin mimetics, their species specificity and the activation mechanism of the thrombopoietin receptor

European Journal of Pharmacology

Volumn 586, Issue 1-3, 2008, Pages 44-51

  Yamane, Noriko ^a   Tanaka, Yoshikazu ^a   Ohyabu, Naoki ^a   Yamane, Shoji ^a   Maekawa, Kazuhiko ^a   Ishizaki, Jun ^a   Suzuki, Ryuji ^b   Itoh, Tsunetoshi ^c   Takemoto, Hiroshi ^a  

^a SHIONOGI AND CO LTD   (Japan)

^b SAGAMIHARA NATIONAL HOSPITAL   (Japan)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Chimera mutant receptor; Human thrombopoietin mimetics; Loss gain of function; Megakaryocytosis; Species specificity; Thrombopoietin

Indexed keywords

AMINO ACID; CYTOKINE RECEPTOR AGONIST; HISTIDINE; MEMBRANE PROTEIN; N [4 (3,4 DIFLUORO PHENYL)THIAZOL 2 YL] 4 [2,4 DIOXO THIAZOLIDIN(5)YLIDENEMETHYL]BENZAMIDE; RNA; THROMBOPOIETIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVATION; DRUG ACTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GUINEA PIG; HUMAN; HUMAN CELL; MONKEY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA TRANSLATION; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD34; BIOTRANSFORMATION; CELL LINE; CELL PROLIFERATION; GUINEA PIGS; HUMANS; INDICATORS AND REAGENTS; MACACA FASCICULARIS; MEGAKARYOCYTES; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MUTANT CHIMERIC PROTEINS; MUTATION; PLASMIDS; RECEPTORS, THROMBOPOIETIN; SPECIES SPECIFICITY; THROMBOPOIETIN; TUMOR STEM CELL ASSAY;

EID: 43549086159     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.02.060     Document Type: Article

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