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Volumn 86, Issue 13, 2012, Pages 7060-7071

Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

EID: 84864140327     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00164-12     Document Type: Article
Times cited : (37)

References (76)
  • 1
    • 0021225388 scopus 로고
    • Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice Role in suppression of cytotoxic T lymphocyte response and viral persistence
    • Ahmed R, Salmi A, Butler LD, Chiller JM, Oldstone MB. 1984. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160:521-540.
    • (1984) J. Exp. Med. , vol.160 , pp. 521-540
    • Ahmed, R.1    Salmi, A.2    Butler, L.D.3    Chiller, J.M.4    Oldstone, M.B.5
  • 2
    • 0023734872 scopus 로고
    • Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus
    • Ahmed R, et al. 1988. Genetic analysis of in vivo-selected viral variants causing chronic infection: importance of mutation in the L RNA segment of lymphocytic choriomeningitis virus. J. Virol. 62:3301-3308.
    • (1988) J. Virol. , vol.62 , pp. 3301-3308
    • Ahmed, R.1
  • 3
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8 T cells during chronic viral infection
    • Barber DL, et al. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682- 687.
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1
  • 4
    • 79953169475 scopus 로고    scopus 로고
    • Development of tumor-infiltrating CD8+ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-beta blockade during the perioperative period of tumor resection
    • Bellavance EC, et al. 2011. Development of tumor-infiltrating CD8_ T cell memory precursor effector cells and antimelanoma memory responses are the result of vaccination and TGF-beta blockade during the perioperative period of tumor resection. J. Immunol. 186:3309 -3316.
    • (2011) J. Immunol. , vol.186 , pp. 3309-3316
    • Bellavance, E.C.1
  • 5
    • 0034688296 scopus 로고    scopus 로고
    • Defining parameters for successful immunocytotherapy of persistent viral infection
    • Berger DP, Homann D, Oldstone MB. 2000. Defining parameters for successful immunocytotherapy of persistent viral infection. Virology 266: 257-263.
    • (2000) Virology , vol.266 , pp. 257-263
    • Berger, D.P.1    Homann, D.2    Oldstone, M.B.3
  • 6
    • 49649114804 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • Berger R, et al. 2008. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin. Cancer Res. 14:3044 -3051.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3044-3051
    • Berger, R.1
  • 7
    • 78650726071 scopus 로고    scopus 로고
    • Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression
    • Bergthaler A, et al. 2010. Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. Proc. Natl. Acad. Sci. U. S. A. 107:21641-21646.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 21641-21646
    • Bergthaler, A.1
  • 8
    • 57849168934 scopus 로고    scopus 로고
    • Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
    • Blackburn SD, et al. 2009. Coregulation of CD8_ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10:29 -37.
    • (2009) Nat. Immunol. , vol.10 , pp. 29-37
    • Blackburn, S.D.1
  • 9
    • 34047172640 scopus 로고    scopus 로고
    • IL-10 T cell exhaustion and viral persistence
    • Blackburn SD, Wherry EJ. 2007. IL-10, T cell exhaustion and viral persistence. Trends Microbiol. 15:143-146.
    • (2007) Trends Microbiol , vol.15 , pp. 143-146
    • Blackburn, S.D.1    Wherry, E.J.2
  • 10
    • 34247117935 scopus 로고    scopus 로고
    • Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection
    • Boni C, et al. 2007. Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection. J. Virol. 81:4215- 4225.
    • (2007) J. Virol. , vol.81 , pp. 4215-4225
    • Boni, C.1
  • 12
    • 33750499311 scopus 로고    scopus 로고
    • Interleukin-10 determines viral clearance or persistence in vivo
    • Brooks DG, et al. 2006. Interleukin-10 determines viral clearance or persistence in vivo. Nat. Med. 12:1301-1309.
    • (2006) Nat. Med. , vol.12 , pp. 1301-1309
    • Brooks, D.G.1
  • 13
    • 0023270567 scopus 로고
    • A new member of the immunoglobulin superfamily-CTLA-4
    • Brunet JF, et al. 1987. A new member of the immunoglobulin superfamily- CTLA-4. Nature 328:267-270.
    • (1987) . Nature , vol.328 , pp. 267-270
    • Brunet, J.F.1
  • 14
    • 0032509177 scopus 로고    scopus 로고
    • Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus
    • Cao W, et al. 1998. Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science 282: 2079-2081.
    • (1998) Science , vol.282 , pp. 2079-2081
    • Cao, W.1
  • 15
    • 12244285937 scopus 로고    scopus 로고
    • Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo
    • Chen ML, et al. 2005. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc. Natl. Acad. Sci. U. S. A. 102:419-424.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 419-424
    • Chen, M.L.1
  • 16
    • 0024553650 scopus 로고
    • Monoclonal antibodies recognizing transforming growth factor-beta Bioactivity neutralization and transforming growth factor beta 2 affinity purification
    • Dasch JR, Pace DR, Waegell W, Inenaga D, Ellingsworth L. 1989. Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification. J. Immunol. 142:1536 -1541.
    • (1989) J. Immunol. , vol.142 , pp. 1536-1541
    • Dasch, J.R.1    Pace, D.R.2    Waegell, W.3    Inenaga, D.4    Ellingsworth, L.5
  • 17
    • 33748947326 scopus 로고    scopus 로고
    • PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
    • Day CL, et al. 2006. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443:350 -354.
    • (2006) Nature , vol.443 , pp. 350-354
    • Day, C.L.1
  • 18
    • 33750530611 scopus 로고    scopus 로고
    • Resolution of a chronic viral infection after interleukin-10 receptor blockade
    • Ejrnaes M, et al. 2006. Resolution of a chronic viral infection after interleukin-10 receptor blockade. J. Exp. Med. 203:2461-2472.
    • (2006) J. Exp. Med. , vol.203 , pp. 2461-2472
    • Ejrnaes, M.1
  • 19
    • 15444363794 scopus 로고    scopus 로고
    • T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells
    • Fahlen L, et al. 2005. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J. Exp. Med. 201:737-746.
    • (2005) J. Exp. Med. , vol.201 , pp. 737-746
    • Fahlen, L.1
  • 20
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25+ T cells through Foxp3 induction and downregulation of Smad7
    • Fantini MC, et al. 2004. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25+ T cells through Foxp3 induction and downregulation of Smad7. J. Immunol. 172:5149 -5153.
    • (2004) J. Immunol. , vol.172 , pp. 5149-5153
    • Fantini, M.C.1
  • 21
    • 0025785045 scopus 로고
    • High resolution in situ hybridization to determine the cellular distribution of lymphocytic choriomeningitis virusRNAin the tissues of persistently infected mice: relevance to arenavirus disease and mechanisms of viral persistence
    • Fazakerley JK, Southern P, Bloom F, Buchmeier MJ. 1991. High resolution in situ hybridization to determine the cellular distribution of lymphocytic choriomeningitis virusRNAin the tissues of persistently infected mice: relevance to arenavirus disease and mechanisms of viral persistence. J. Gen. Virol. 72(Pt 7):1611-1625.
    • (1991) J. Gen. Virol. , vol.72 , Issue.PART 7 , pp. 1611-1625
    • Fazakerley, J.K.1    Southern, P.2    Bloom, F.3    Buchmeier, M.J.4
  • 23
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. 2010. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 236:219 -242.
    • (2010) Immunol. Rev. , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 24
    • 34548191951 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction
    • Golden-Mason L, et al. 2007. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J. Virol. 81:9249 -9258.
    • (2007) J. Virol. , vol.81 , pp. 9249-9258
    • Golden-Mason, L.1
  • 25
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • Gorelik L, Flavell RA. 2000. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12:171-181.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 26
    • 0036372440 scopus 로고    scopus 로고
    • Transforming growth factor-beta in T-cell biology
    • Gorelik L, Flavell RA. 2002. Transforming growth factor-beta in T-cell biology. Nat. Rev. Immunol. 2:46 -53.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 46-53
    • Gorelik, L.1    Flavell, R.A.2
  • 27
    • 0025790449 scopus 로고
    • Abrogation of tolerance to a chronic viral infection
    • Jamieson BD, Somasundaram T, Ahmed R. 1991. Abrogation of tolerance to a chronic viral infection. J. Immunol. 147:3521-3529.
    • (1991) J. Immunol. , vol.147 , pp. 3521-3529
    • Jamieson, B.D.1    Somasundaram, T.2    Ahmed, R.3
  • 28
    • 77957059176 scopus 로고    scopus 로고
    • Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
    • Jin HT, et al. 2010. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl. Acad. Sci. U. S. A. 107:14733-14738.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 14733-14738
    • Jin, H.T.1
  • 29
    • 0037074012 scopus 로고    scopus 로고
    • Molecular and functional profiling of memory CD8 T cell differentiation
    • Kaech SM, Hemby S, Kersh E, Ahmed R. 2002. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111:837- 851.
    • (2002) Cell , vol.111 , pp. 837-851
    • Kaech, S.M.1    Hemby, S.2    Kersh, E.3    Ahmed, R.4
  • 30
    • 34548680261 scopus 로고    scopus 로고
    • Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction
    • Kaufmann DE, et al. 2007. Upregulation of CTLA-4 by HIV-specific CD4(+) T cells correlates with disease progression and defines a reversible immune dysfunction. Nat. Immunol. 8:1246 -1254.
    • (2007) Nat. Immunol. , vol.8 , pp. 1246-1254
    • Kaufmann, D.E.1
  • 31
    • 0022465625 scopus 로고
    • Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth
    • Kehrl JH, et al. 1986. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163:1037-1050.
    • (1986) J. Exp. Med. , vol.163 , pp. 1037-1050
    • Kehrl, J.H.1
  • 32
    • 77950415363 scopus 로고    scopus 로고
    • IN-1233, an ALK-5 inhibitor: prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model
    • Kim JH, et al. 2010. IN-1233, an ALK-5 inhibitor: prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model. Radiology 255:75- 82.
    • (2010) Radiology , vol.255 , pp. 75-82
    • Kim, J.H.1
  • 33
    • 77951258833 scopus 로고    scopus 로고
    • Features of responding T cells in cancer and chronic infection
    • Kim PS, Ahmed R. 2010. Features of responding T cells in cancer and chronic infection. Curr. Opin. Immunol. 22:223-230.
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 223-230
    • Kim, P.S.1    Ahmed, R.2
  • 34
    • 0032525922 scopus 로고    scopus 로고
    • Chimeric extracellular domain type II transforming growth factor (TGF)-beta receptor fused to the Fc region of human immunoglobulin as a TGF-beta antagonist
    • Komesli S, Vivien D, Dutartre P. 1998. Chimeric extracellular domain type II transforming growth factor (TGF)-beta receptor fused to the Fc region of human immunoglobulin as a TGF-beta antagonist. Eur. J. Biochem. 254:505-513.
    • (1998) Eur. J. Biochem. , vol.254 , pp. 505-513
    • Komesli, S.1    Vivien, D.2    Dutartre, P.3
  • 35
    • 0346244001 scopus 로고    scopus 로고
    • Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events
    • Krutzik PO, Nolan GP. 2003. Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A 55:61-70.
    • (2003) Cytometry A , vol.55 , pp. 61-70
    • Krutzik, P.O.1    Nolan, G.P.2
  • 36
    • 0027531528 scopus 로고
    • Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni AB, et al. 1993. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. U. S. A. 90:770 -774.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 770-774
    • Kulkarni, A.B.1
  • 37
    • 34347348127 scopus 로고    scopus 로고
    • Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification
    • Lauterbach H, Truong P, McGavern DB. 2007. Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification. Virol. J. 4:53.
    • (2007) Virol. J. , vol.4 , pp. 53
    • Lauterbach, H.1    Truong, P.2    McGavern, D.B.3
  • 38
    • 33746905859 scopus 로고    scopus 로고
    • Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection
    • Lauterbach H, Zuniga EI, Truong P, Oldstone MB, McGavern DB. 2006. Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. J. Exp. Med. 203:1963-1975.
    • (2006) J. Exp. Med. , vol.203 , pp. 1963-1975
    • Lauterbach, H.1    Zuniga, E.I.2    Truong, P.3    Oldstone, M.B.4    McGavern, D.B.5
  • 39
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and-independent mechanisms
    • Li MO, Sanjabi S, Flavell RA. 2006. Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 25:455- 471.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell, R.A.3
  • 40
    • 0034600070 scopus 로고    scopus 로고
    • Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor
    • Lucas PJ, Kim SJ, Melby SJ, Gress RE. 2000. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor. J. Exp. Med. 191:1187-1196.
    • (2000) J. Exp. Med. , vol.191 , pp. 1187-1196
    • Lucas, P.J.1    Kim, S.J.2    Melby, S.J.3    Gress, R.E.4
  • 41
    • 17144400393 scopus 로고    scopus 로고
    • TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+regulatory T cells
    • Marie JC, Letterio JJ, Gavin M, Rudensky AY. 2005. TGF-beta1 maintains suppressor function and Foxp3 expression in CD4_CD25_regulatory T cells. J. Exp. Med. 201:1061-1067.
    • (2005) J. Exp. Med. , vol.201 , pp. 1061-1067
    • Marie, J.C.1    Letterio, J.J.2    Gavin, M.3    Rudensky, A.Y.4
  • 42
    • 33748465396 scopus 로고    scopus 로고
    • Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
    • Marie JC, Liggitt D, Rudensky AY. 2006. Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25:441- 454.
    • (2006) Immunity , vol.25 , pp. 441-454
    • Marie, J.C.1    Liggitt, D.2    Rudensky, A.Y.3
  • 43
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague J, Blain SW, Lo RS. 2000. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 44
    • 33745978399 scopus 로고    scopus 로고
    • Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
    • Mempel TR, et al. 2006. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity 25:129- 141.
    • (2006) Immunity , vol.25 , pp. 129-141
    • Mempel, T.R.1
  • 45
    • 0037203867 scopus 로고    scopus 로고
    • Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
    • Monney L, et al. 2002. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415:536 -541.
    • (2002) Nature , vol.415 , pp. 536-541
    • Monney, L.1
  • 46
    • 33748939751 scopus 로고    scopus 로고
    • IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy
    • Moon JA, Kim HT, Cho IS, Sheen YY, Kim DK. 2006. IN-1130, a novel transforming growth factor-beta type I receptor kinase (ALK5) inhibitor, suppresses renal fibrosis in obstructive nephropathy. Kidney Int. 70: 1234-1243.
    • (2006) Kidney Int , vol.70 , pp. 1234-1243
    • Moon, J.A.1    Kim, H.T.2    Cho, I.S.3    Sheen, Y.Y.4    Kim, D.K.5
  • 47
    • 0027158798 scopus 로고
    • Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
    • Moskophidis D, Lechner F, Pircher H, Zinkernagel RM. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362:758 -761.
    • (1993) Nature , vol.362 , pp. 758-761
    • Moskophidis, D.1    Lechner, F.2    Pircher, H.3    Zinkernagel, R.M.4
  • 48
    • 0022508921 scopus 로고
    • Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system
    • Oldstone MB, Blount P, Southern PJ, Lampert PW. 1986. Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature 321:239 -243.
    • (1986) Nature , vol.321 , pp. 239-243
    • Oldstone, M.B.1    Blount, P.2    Southern, P.J.3    Lampert, P.W.4
  • 49
    • 0031975635 scopus 로고    scopus 로고
    • Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection
    • Oxenius A, Bachmann MF, Zinkernagel RM, Hengartner H. 1998. Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur. J. Immunol. 28:390-400.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 390-400
    • Oxenius, A.1    Bachmann, M.F.2    Zinkernagel, R.M.3    Hengartner, H.4
  • 50
    • 33749338938 scopus 로고    scopus 로고
    • PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection
    • Petrovas C, et al. 2006. PD-1 is a regulator of virus-specific CD8_ T cell survival in HIV infection. J. Exp. Med. 203:2281-2292.
    • (2006) J. Exp. Med. , vol.203 , pp. 2281-2292
    • Petrovas, C.1
  • 51
    • 0024307348 scopus 로고
    • Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    • Pircher H, Burki K, Lang R, Hengartner H, Zinkernagel RM. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342:559 -561.
    • (1989) Nature , vol.342 , pp. 559-561
    • Pircher, H.1    Burki, K.2    Lang, R.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 52
    • 77949361177 scopus 로고    scopus 로고
    • On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection
    • Richter K, Agnellini P, Oxenius A. 2010. On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection. Int. Immunol. 22:13-23.
    • (2010) Int. Immunol. , vol.22 , pp. 13-23
    • Richter, K.1    Agnellini, P.2    Oxenius, A.3
  • 53
    • 34249678653 scopus 로고    scopus 로고
    • TGFbeta signalling in control of T-cellmediated self-reactivity
    • Rubtsov YP, Rudensky AY. 2007. TGFbeta signalling in control of T-cellmediated self-reactivity. Nat. Rev. Immunol. 7:443- 453.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 443-453
    • Rubtsov, Y.P.1    Rudensky, A.Y.2
  • 54
    • 77649272306 scopus 로고    scopus 로고
    • Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling
    • Sanjabi S, Flavell RA. 2010. Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling. J. Immunol. Methods 353: 111-114.
    • (2010) J. Immunol. Methods , vol.353 , pp. 111-114
    • Sanjabi, S.1    Flavell, R.A.2
  • 55
    • 0034613731 scopus 로고    scopus 로고
    • Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells
    • Sevilla N, et al. 2000. Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells. J. Exp. Med. 192:1249 -1260.
    • (2000) J. Exp. Med. , vol.192 , pp. 1249-1260
    • Sevilla, N.1
  • 56
    • 34247884612 scopus 로고    scopus 로고
    • The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
    • Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. 2007. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat. Immunol. 8:239 -245.
    • (2007) Nat. Immunol. , vol.8 , pp. 239-245
    • Sharpe, A.H.1    Wherry, E.J.2    Ahmed, R.3    Freeman, G.J.4
  • 57
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull MM, et al. 1992. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359:693- 699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1
  • 58
    • 79952582607 scopus 로고    scopus 로고
    • Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence
    • Sullivan BM, et al. 2011. Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence. Proc. Natl. Acad. Sci. U. S. A. 108:2969 -2974.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 2969-2974
    • Sullivan, B.M.1
  • 59
    • 68249152608 scopus 로고    scopus 로고
    • Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo
    • Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI. 2009. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8_ T cell deletion and viral persistence in vivo. Immunity 31:145-157.
    • (2009) Immunity , vol.31 , pp. 145-157
    • Tinoco, R.1    Alcalde, V.2    Yang, Y.3    Sauer, K.4    Zuniga, E.I.5
  • 60
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol EA, et al. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1
  • 61
    • 85019277983 scopus 로고
    • Factors influencing the persistence of choriomeningitis virus in the blood of mice after clinical recovery
    • Traub E. 1938. Factors influencing the persistence of choriomeningitis virus in the blood of mice after clinical recovery. J. Exp. Med. 68:229 -250.
    • (1938) J. Exp. Med. , vol.68 , pp. 229-250
    • Traub, E.1
  • 62
    • 33749009709 scopus 로고    scopus 로고
    • Upregulation of PD-1 expression on HIVspecific CD8+ T cells leads to reversible immune dysfunction
    • Trautmann L, et al. 2006. Upregulation of PD-1 expression on HIVspecific CD8_ T cells leads to reversible immune dysfunction. Nat. Med. 12:1198 -1202.
    • (2006) Nat. Med. , vol.12 , pp. 1198-1202
    • Trautmann, L.1
  • 63
    • 0025338920 scopus 로고
    • LAG-3, a novel lymphocyte activation gene closely related to CD4
    • Triebel F, et al. 1990. LAG-3, a novel lymphocyte activation gene closely related to CD4. J. Exp. Med. 171:1393-1405.
    • (1990) J. Exp. Med. , vol.171 , pp. 1393-1405
    • Triebel, F.1
  • 64
    • 33750691709 scopus 로고    scopus 로고
    • PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion
    • Urbani S, et al. 2006. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J. Virol. 80: 11398-11403.
    • (2006) J. Virol. , vol.80 , pp. 11398-11403
    • Urbani, S.1
  • 65
    • 62249172189 scopus 로고    scopus 로고
    • Enhancing SIV-specific immunity in vivo by PD-1 blockade
    • Velu V, et al. 2009. Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature 458:206 -210.
    • (2009) Nature , vol.458 , pp. 206-210
    • Velu, V.1
  • 66
    • 0000706211 scopus 로고
    • Studies on immunological tolerance to Lcm virus 2. Treatment of virus carrier mice by adoptive immunization
    • Volkert M. 1963. Studies on immunological tolerance to Lcm virus. 2. Treatment of virus carrier mice by adoptive immunization. Acta Pathol. Microbiol. Scand. 57:465- 487.
    • (1963) Acta Pathol. Microbiol. Scand. , vol.57 , pp. 465-487
    • Volkert, M.1
  • 67
    • 0008558204 scopus 로고
    • Studies on immunological tolerance to LCM virus A preliminary report on adoptive immunization of virus carrier mice
    • Volkert M. 1962. Studies on immunological tolerance to LCM virus. A preliminary report on adoptive immunization of virus carrier mice. Acta Pathol. Microbiol. Scand. 56:305-310.
    • (1962) Acta Pathol. Microbiol. Scand. , vol.56 , pp. 305-310
    • Volkert, M.1
  • 68
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, et al. 1995. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270:985-988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1
  • 69
    • 79956077563 scopus 로고    scopus 로고
    • T cell exhaustion
    • Wherry EJ. 2011. T cell exhaustion. Nat. Immunol. 12:492- 499.
    • (2011) Nat. Immunol. , vol.12 , pp. 492-499
    • Wherry, E.J.1
  • 70
    • 0037383592 scopus 로고    scopus 로고
    • Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment
    • Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R. 2003. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77:4911- 4927.
    • (2003) J. Virol. , vol.77 , pp. 4911-4927
    • Wherry, E.J.1    Blattman, J.N.2    Murali-Krishna, K.3    van der Most, R.4    Ahmed, R.5
  • 71
    • 35349014587 scopus 로고    scopus 로고
    • Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    • Wherry EJ, et al. 2007. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27:670-684.
    • (2007) Immunity , vol.27 , pp. 670-684
    • Wherry, E.J.1
  • 73
    • 0036242557 scopus 로고    scopus 로고
    • Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy
    • Yata Y, Gotwals P, Koteliansky V, Rockey DC. 2002. Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy. Hepatology 35:1022-1030.
    • (2002) Hepatology , vol.35 , pp. 1022-1030
    • Yata, Y.1    Gotwals, P.2    Koteliansky, V.3    Rockey, D.C.4
  • 74
    • 80052028209 scopus 로고    scopus 로고
    • Role of IN-1233 in the prevention of neointimal hyperplasia after stent placement in a rat artery model
    • Yoon HJ, et al. 2011. Role of IN-1233 in the prevention of neointimal hyperplasia after stent placement in a rat artery model. J. Vasc. Interv. Radiol. 22:1321-1328.
    • (2011) J. Vasc. Interv. Radiol. , vol.22 , pp. 1321-1328
    • Yoon, H.J.1
  • 75
    • 77954505672 scopus 로고    scopus 로고
    • Transgenic expression of TGF-beta on thyrocytes inhibits development of spontaneous autoimmune thyroiditis and increases regulatory T cells in thyroids of NOD H-2h4 mice
    • Yu S, Fang Y, Sharp GC, Braley-Mullen H. 2010. Transgenic expression of TGF-beta on thyrocytes inhibits development of spontaneous autoimmune thyroiditis and increases regulatory T cells in thyroids of NOD.H-2h4 mice. J. Immunol. 184:5352-5359.
    • (2010) J. Immunol. , vol.184 , pp. 5352-5359
    • Yu, S.1    Fang, Y.2    Sharp, G.C.3    Braley-Mullen, H.4
  • 76
    • 0032416085 scopus 로고    scopus 로고
    • Viral immune evasion due to persistence of activated T cells without effector function
    • Zajac AJ, et al. 1998. Viral immune evasion due to persistence of activated T cells without effector function. J. Exp. Med. 188:2205-2213.
    • (1998) J. Exp. Med. , vol.188 , pp. 2205-2213
    • Zajac, A.J.1


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