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Volumn 50, Issue 9, 2012, Pages 3206-3214

Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line

Author keywords

Antioxidant; Nrf2; Paraquat; Reactive oxygen species; Silymarin

Indexed keywords

GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; PARAQUAT; REACTIVE OXYGEN METABOLITE; SILYMARIN;

EID: 84864134568     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.06.007     Document Type: Article
Times cited : (59)

References (51)
  • 1
    • 79954416526 scopus 로고    scopus 로고
    • The cytoprotective role of the Keap1-Nrf2 pathway
    • Baird L., Dinkova-Kostova A.T. The cytoprotective role of the Keap1-Nrf2 pathway. Arch. Toxicol. 2011, 85:241-272.
    • (2011) Arch. Toxicol. , vol.85 , pp. 241-272
    • Baird, L.1    Dinkova-Kostova, A.T.2
  • 2
    • 62549116131 scopus 로고    scopus 로고
    • Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis
    • Basiglio C.L., Sanchez Pozzi E.J., Mottino A.D., Roma M.G. Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis. Chem. Biol. Interact. 2009, 179:297-303.
    • (2009) Chem. Biol. Interact. , vol.179 , pp. 297-303
    • Basiglio, C.L.1    Sanchez Pozzi, E.J.2    Mottino, A.D.3    Roma, M.G.4
  • 3
    • 0042696207 scopus 로고    scopus 로고
    • Effect of Silybum marianum oil and legalon on lipid peroxidation and liver antioxidant systems in rats intoxicated with carbon tetrachloride
    • Batakov E.A. Effect of Silybum marianum oil and legalon on lipid peroxidation and liver antioxidant systems in rats intoxicated with carbon tetrachloride. Eksp. Klin. Farmakol. 2001, 64:53-55.
    • (2001) Eksp. Klin. Farmakol. , vol.64 , pp. 53-55
    • Batakov, E.A.1
  • 5
    • 34347242465 scopus 로고    scopus 로고
    • Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain
    • Castello P.R., Drechsel D.A., Patel M. Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain. J. Biol. Chem. 2007, 282:14186-14193.
    • (2007) J. Biol. Chem. , vol.282 , pp. 14186-14193
    • Castello, P.R.1    Drechsel, D.A.2    Patel, M.3
  • 6
    • 26444594915 scopus 로고    scopus 로고
    • Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia
    • Chen J.C., Ho F.M., Pei-Dawn Lee C., Chen C.P., Jeng K.C., Hsu H.B., Lee S.T., Wen Tung W., Lin W.W. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur. J. Pharmacol. 2005, 521:9-20.
    • (2005) Eur. J. Pharmacol. , vol.521 , pp. 9-20
    • Chen, J.C.1    Ho, F.M.2    Pei-Dawn Lee, C.3    Chen, C.P.4    Jeng, K.C.5    Hsu, H.B.6    Lee, S.T.7    Wen Tung, W.8    Lin, W.W.9
  • 9
    • 84861924529 scopus 로고    scopus 로고
    • Improvement of cerebellum redox states and cholinergic functions contribute to the beneficial effects of silymarin against manganese-induced neurotoxicity
    • Chtourou Y., Fetoui H., Garoui E.M., Boudawara T., Zeghal N. Improvement of cerebellum redox states and cholinergic functions contribute to the beneficial effects of silymarin against manganese-induced neurotoxicity. Neurochem Res. 2012, 37:469-479.
    • (2012) Neurochem Res. , vol.37 , pp. 469-479
    • Chtourou, Y.1    Fetoui, H.2    Garoui, E.M.3    Boudawara, T.4    Zeghal, N.5
  • 10
    • 0029929692 scopus 로고    scopus 로고
    • Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells
    • Dehmlow C., Murawski N., de Groot H. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Life Sci. 1996, 58:1591-1600.
    • (1996) Life Sci. , vol.58 , pp. 1591-1600
    • Dehmlow, C.1    Murawski, N.2    de Groot, H.3
  • 11
    • 64149087422 scopus 로고    scopus 로고
    • Therapeutic strategies by modulating oxygen stress in cancer and inflammation
    • Fang J., Seki T., Maeda H. Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv. Drug Deliv. Rev. 2009, 61:290-302.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 290-302
    • Fang, J.1    Seki, T.2    Maeda, H.3
  • 12
    • 0242575197 scopus 로고    scopus 로고
    • Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases
    • Furukawa M., He Y.J., Borchers C., Xiong Y. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nat. Cell Biol. 2003, 5:1001-1007.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 1001-1007
    • Furukawa, M.1    He, Y.J.2    Borchers, C.3    Xiong, Y.4
  • 15
    • 0035965945 scopus 로고    scopus 로고
    • Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
    • Hayes J.D., McMahon M. Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett. 2001, 174:103-113.
    • (2001) Cancer Lett. , vol.174 , pp. 103-113
    • Hayes, J.D.1    McMahon, M.2
  • 16
    • 77953012365 scopus 로고    scopus 로고
    • Silymarin exacerbates p53-mediated tubular apoptosis in glycerol-induced acute kidney injury in rats
    • Homsi E., de Brito S.M., Janino P. Silymarin exacerbates p53-mediated tubular apoptosis in glycerol-induced acute kidney injury in rats. Ren. Fail. 2010, 32:623-632.
    • (2010) Ren. Fail. , vol.32 , pp. 623-632
    • Homsi, E.1    de Brito, S.M.2    Janino, P.3
  • 17
    • 47749116455 scopus 로고    scopus 로고
    • Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation
    • Jain A.K., Mahajan S., Jaiswal A.K. Phosphorylation and dephosphorylation of tyrosine 141 regulate stability and degradation of INrf2: a novel mechanism in Nrf2 activation. J. Biol. Chem. 2008, 283:17712-17720.
    • (2008) J. Biol. Chem. , vol.283 , pp. 17712-17720
    • Jain, A.K.1    Mahajan, S.2    Jaiswal, A.K.3
  • 18
    • 79959757195 scopus 로고    scopus 로고
    • Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics
    • Jing L., Parker C.E., Seo D., Hines M.W., Dicheva N., Yu Y., Schwinn D., Ginsburg G.S., Chen X. Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics. Proteomics 2011, 11:2763-2776.
    • (2011) Proteomics , vol.11 , pp. 2763-2776
    • Jing, L.1    Parker, C.E.2    Seo, D.3    Hines, M.W.4    Dicheva, N.5    Yu, Y.6    Schwinn, D.7    Ginsburg, G.S.8    Chen, X.9
  • 19
    • 0344687228 scopus 로고    scopus 로고
    • Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1beta and prostaglandin E2 synthesis by silymarin
    • Kang J.S., Jeon Y.J., Park S.K., Yang K.H., Kim H.M. Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1beta and prostaglandin E2 synthesis by silymarin. Biochem. Pharmacol. 2004, 67:175-181.
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 175-181
    • Kang, J.S.1    Jeon, Y.J.2    Park, S.K.3    Yang, K.H.4    Kim, H.M.5
  • 20
    • 0034600766 scopus 로고    scopus 로고
    • Lipid peroxidation, antioxidant enzymes, and benzo[a]pyrene-quinones in the blood of rats treated with benzo[a]pyrene
    • Kim H.S., Kwack S.J., Lee B.M. Lipid peroxidation, antioxidant enzymes, and benzo[a]pyrene-quinones in the blood of rats treated with benzo[a]pyrene. Chem. Biol. Interact. 2000, 127:139-150.
    • (2000) Chem. Biol. Interact. , vol.127 , pp. 139-150
    • Kim, H.S.1    Kwack, S.J.2    Lee, B.M.3
  • 22
    • 79952012742 scopus 로고    scopus 로고
    • Molecular targets of phytochemicals for cancer prevention
    • Lee K.W., Bode A.M., Dong Z. Molecular targets of phytochemicals for cancer prevention. Nat. Rev. Cancer 2011, 11:211-218.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 211-218
    • Lee, K.W.1    Bode, A.M.2    Dong, Z.3
  • 24
    • 78149465001 scopus 로고    scopus 로고
    • Cytotoxicity and gene array analysis of alveolar epithelial A549 cells exposed to paraquat
    • Mitsopoulos P., Suntres Z.E. Cytotoxicity and gene array analysis of alveolar epithelial A549 cells exposed to paraquat. Chem. Biol. Interact. 2010, 188:427-436.
    • (2010) Chem. Biol. Interact. , vol.188 , pp. 427-436
    • Mitsopoulos, P.1    Suntres, Z.E.2
  • 26
    • 77951884080 scopus 로고    scopus 로고
    • Exposure to chrysotile asbestos causes carbonylation of glucose 6-phosphate dehydrogenase through a reaction with lipid peroxidation products in human lung epithelial cells
    • Ogasawara Y., Ishii K. Exposure to chrysotile asbestos causes carbonylation of glucose 6-phosphate dehydrogenase through a reaction with lipid peroxidation products in human lung epithelial cells. Toxicol. Lett. 2010, 195:1-8.
    • (2010) Toxicol. Lett. , vol.195 , pp. 1-8
    • Ogasawara, Y.1    Ishii, K.2
  • 29
    • 34748904643 scopus 로고    scopus 로고
    • Translational control of nrf2 protein in activation of antioxidant response by oxidants
    • Purdom-Dickinson S.E., Sheveleva E.V., Sun H., Chen Q.M. Translational control of nrf2 protein in activation of antioxidant response by oxidants. Mol. Pharmacol. 2007, 72:1074-1081.
    • (2007) Mol. Pharmacol. , vol.72 , pp. 1074-1081
    • Purdom-Dickinson, S.E.1    Sheveleva, E.V.2    Sun, H.3    Chen, Q.M.4
  • 30
    • 47249125362 scopus 로고    scopus 로고
    • Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts
    • Ren J., Privratsky J.R., Yang X., Dong F., Carlson E.C. Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. Crit. Care Med. 2008, 36:2106-2116.
    • (2008) Crit. Care Med. , vol.36 , pp. 2106-2116
    • Ren, J.1    Privratsky, J.R.2    Yang, X.3    Dong, F.4    Carlson, E.C.5
  • 31
    • 84870239325 scopus 로고    scopus 로고
    • Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress
    • Rodriguez-Ramiro I., Ramos S., Bravo L., Goya L., Martin M.A. Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress. Eur. J. Nutr. 2011.
    • (2011) Eur. J. Nutr.
    • Rodriguez-Ramiro, I.1    Ramos, S.2    Bravo, L.3    Goya, L.4    Martin, M.A.5
  • 32
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
    • Ryter S.W., Alam J., Choi A.M. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 2006, 86:583-650.
    • (2006) Physiol. Rev. , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 33
    • 79951634450 scopus 로고    scopus 로고
    • Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse
    • Singhal N.K., Srivastava G., Patel D.K., Jain S.K., Singh M.P. Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. J. Pineal Res. 2011, 50:97-109.
    • (2011) J. Pineal Res. , vol.50 , pp. 97-109
    • Singhal, N.K.1    Srivastava, G.2    Patel, D.K.3    Jain, S.K.4    Singh, M.P.5
  • 35
    • 28844471992 scopus 로고    scopus 로고
    • Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the "one-two" punch
    • Srisook K., Kim C., Cha Y.N. Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the "one-two" punch. Antioxid. Redox Signal. 2005, 7:1674-1687.
    • (2005) Antioxid. Redox Signal. , vol.7 , pp. 1674-1687
    • Srisook, K.1    Kim, C.2    Cha, Y.N.3
  • 36
    • 0037201949 scopus 로고    scopus 로고
    • Role of antioxidants in paraquat toxicity
    • Suntres Z.E. Role of antioxidants in paraquat toxicity. Toxicology 2002, 180:65-77.
    • (2002) Toxicology , vol.180 , pp. 65-77
    • Suntres, Z.E.1
  • 37
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh Y.J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer 2003, 3:768-780.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 38
    • 56249106571 scopus 로고    scopus 로고
    • Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals
    • Surh Y.J., Kundu J.K., Na H.K. Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med. 2008, 74:1526-1539.
    • (2008) Planta Med. , vol.74 , pp. 1526-1539
    • Surh, Y.J.1    Kundu, J.K.2    Na, H.K.3
  • 40
  • 41
  • 42
    • 0028136553 scopus 로고
    • Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin
    • Valenzuela A., Garrido A. Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin. Biol. Res. 1994, 27:105-112.
    • (1994) Biol. Res. , vol.27 , pp. 105-112
    • Valenzuela, A.1    Garrido, A.2
  • 44
    • 58149086400 scopus 로고    scopus 로고
    • Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim
    • Velmurugan K., Alam J., McCord J.M., Pugazhenthi S. Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim. Free Radic. Biol. Med. 2009, 46:430-440.
    • (2009) Free Radic. Biol. Med. , vol.46 , pp. 430-440
    • Velmurugan, K.1    Alam, J.2    McCord, J.M.3    Pugazhenthi, S.4
  • 45
    • 33745265207 scopus 로고    scopus 로고
    • Reactive oxygen species: role in the development of cancer and various chronic conditions
    • Waris G., Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J. Carcinog. 2006, 5:14.
    • (2006) J. Carcinog. , vol.5 , pp. 14
    • Waris, G.1    Ahsan, H.2
  • 46
    • 29344457837 scopus 로고    scopus 로고
    • Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways
    • Wung B.S., Hsu M.C., Wu C.C., Hsieh C.W. Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. Pharmacol. Res. 2006, 53:113-122.
    • (2006) Pharmacol. Res. , vol.53 , pp. 113-122
    • Wung, B.S.1    Hsu, M.C.2    Wu, C.C.3    Hsieh, C.W.4
  • 47
    • 84858619079 scopus 로고    scopus 로고
    • Deprenyl prevents MPP(+)-induced oxidative damage in PC12 cells by the upregulation of Nrf2-mediated NQO1 expression through the activation of PI3K/Akt and Erk
    • Xiao H., Lv F., Xu W., Zhang L., Jing P., Cao X. Deprenyl prevents MPP(+)-induced oxidative damage in PC12 cells by the upregulation of Nrf2-mediated NQO1 expression through the activation of PI3K/Akt and Erk. Toxicology 2011, 290:286-294.
    • (2011) Toxicology , vol.290 , pp. 286-294
    • Xiao, H.1    Lv, F.2    Xu, W.3    Zhang, L.4    Jing, P.5    Cao, X.6
  • 48
    • 0034704079 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism
    • Yu R., Chen C., Mo Y.Y., Hebbar V., Owuor E.D., Tan T.H., Kong A.N. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J. Biol. Chem. 2000, 275:39907-39913.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39907-39913
    • Yu, R.1    Chen, C.2    Mo, Y.Y.3    Hebbar, V.4    Owuor, E.D.5    Tan, T.H.6    Kong, A.N.7
  • 49
    • 81255173544 scopus 로고    scopus 로고
    • Protective effect of methylprednisolone on paraquat-induced A549 cell cytotoxicity via induction of efflux transporter, P-glycoprotein expression
    • Zerin T., Kim Y.S., Hong S.Y., Song H.Y. Protective effect of methylprednisolone on paraquat-induced A549 cell cytotoxicity via induction of efflux transporter, P-glycoprotein expression. Toxicol. Lett. 2012, 208:101-107.
    • (2012) Toxicol. Lett. , vol.208 , pp. 101-107
    • Zerin, T.1    Kim, Y.S.2    Hong, S.Y.3    Song, H.Y.4
  • 50
    • 33845442925 scopus 로고    scopus 로고
    • Mechanistic studies of the Nrf2-Keap1 signaling pathway
    • Zhang D.D. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab. Rev. 2006, 38:769-789.
    • (2006) Drug Metab. Rev. , vol.38 , pp. 769-789
    • Zhang, D.D.1
  • 51
    • 0034006962 scopus 로고    scopus 로고
    • Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin
    • Zhao J., Lahiri-Chatterjee M., Sharma Y., Agarwal R. Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Carcinogenesis 2000, 21:811-816.
    • (2000) Carcinogenesis , vol.21 , pp. 811-816
    • Zhao, J.1    Lahiri-Chatterjee, M.2    Sharma, Y.3    Agarwal, R.4


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