Silymarin exacerbates p53-mediated tubular apoptosis in glycerol-induced acute kidney injury in rats

Renal Failure

Volumn 32, Issue 5, 2010, Pages 623-632

  Homsi, Eduardo ^a   De Brito, Silvano MacHado ^a   Janino, Patrícia ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Acute kidney injury; Antioxidant; Apoptosis; Caspase 3; P53; Silymarin; Survivin

Indexed keywords

CASPASE 3; GLYCEROL; PROTEIN BCL 2; PROTEIN P53; SILYMARIN; SURVIVIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG ACTIVITY; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY FUNCTION; KIDNEY INJURY; LEUKOCYTE; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PEROXIDATION; PRIORITY JOURNAL; RAT; UPREGULATION;

ANIMALS; APOPTOSIS; GLYCEROL; KIDNEY; LEUKOCYTE COUNT; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; RATS, WISTAR; RENAL INSUFFICIENCY, ACUTE; SILYMARIN; SOLVENTS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953012365     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/08860221003778064     Document Type: Article

References (43)

1. Kroll DJ, Shaw HS, Oberlies NH. Milk thistle nomenclature: Why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther. 2007;6:110-119.
2. Mansour HH, Hafez HF, Fahmy NM. Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats. J Biochem Mol Biol. 2006;39:656-661.
3. Pradeep K, Mohan CV, Gobianand K, Karthikeyan S. Silymarin modulates the oxidant-antioxidant imbalance during diethyonitrosinamine induced oxidative stress in rats. Eur J Pharmacol. 2007;560:110-116.
4. Comelli MC, Mengs U, Schneider C, Prosdomici M. Toward definition of the mechanism of action of silymarin: Activities related to cellular protection from toxic damage induced by chemotherapy. Integr Cancer Ther. 2007;6:120-139.
5. Singh RP, Gu M, Agarwal R. Silibinin inhibits colorectal growth by inhibiting tumor cell proliferation and angiogenesis. Cancer Res. 2008;68:2043-2050.
6. Tyagi A, Singh RP, Agarwal C, Agarwal R. Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: Evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis. 2006;27:2269-2280.
7. Singh RP, Dhanalakshmi S, Agarwal C, Agarwal R. Silibinin strongly inhibits growth of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: Implications for angioprevention and antiangiogenic therapy. Oncogene. 2005;24:1188-1202.
8. Dhanalaklshmi S, Agarwal C, Singh RP, Agarwal R. Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells. J Biol Chem. 2005;280:20375-20383.
9. Mallikarjuna G, Dhanalaklshmi S, Singh RP, Agarwal C, Agarwal R. Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res. 2004;64:6349-6356.
10. Paller MS. Hemoglobin and myoglobin induced acute renal failure in rats: Role of iron in nephrotoxicity. Am J Physiol. 1988; 255: F539-F544.
11. Moore KP, Holt GS, Patel RP, et al. A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. J Biol Chem. 1998;273:31731-31737.
12. Zager RA, Burkhart KM, Conrad DS, Gmur DJ. Iron, heme oxygenase and glutathione: Effects on myohemoglobinuric proximal tubular injury. Kidney Int. 1995;48:1624-1634.
13. Shah SV, Walker PD. Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol. 1988; 255: F438-F443.
14. 2 generation by rat kidney in glycerol-induced renal failure. Am J Physiol. 1989; 257: F440-F445.
15. Homsi E, Janino P, de Faria JB. Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure. Kidney Int. 2006;69:1385-1392.
16. Shulman LM, Yuhas Y, Folkis I, Gavendo S, Knecht A, Eliahou HE. Glycerol-induced acute renal failure is mediated by tumor necrosis factor. Kidney Int. 1993;43:1397-1401.
17. Wolfert AI, Oken DE. Glomerular hemodynamics in established glycerol-induced acute renal failure in the rat. J Clin Invest. 1989;84:1967-1973.
18. Turgut F, Bayrak O, Catal F, et al. Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney of rats. Int Urol Nephrol. 2008;40:453-460.
19. Senturk H, Kabay S, Bayramoglu G, et al. Silymarin attenuates the renal ischemia/reperfusion injury-induced morphological changes in the rat kidney. World J Urol. 2008;26:401-407.
20. Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun. N-terminal kinase, and apoptosis. J Immunol. 1999;163:6800-6809.
21. Mansour HH, Hafez HF, Fahmy HM. Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats. J Biochem Mol Biol. 2006;39:656-661.
22. Schuman J, Prockl J, Kiemer AK, Vollmar AM, Bang R, Tiegs G. Silibilin protects mice fom T cell-dependent liver injury. J Hepatol. 2003;39:333-340.
23. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1079;95:351-358.
24. Krajewska M, Smith LH, Rong J, et al. Image analysis algorithms for immunohistochemical assessment of cell death events and fibrosis in tissue sections. J Histochem Cytochem. 2009;57:649-663.
25. Gupta A, Berg DT, Gerlitz B, et al. Role of protein C in renal dysfunction after polymicrobial sepsis. J Am Soc Nephrol. 2007;18:860-867.
26. Duan WR, Garner DS, Williams SD, Funckes-Shippy CL, Spath IS, Blomme EA. Comparison of immunohistochemistry for activated caspase-3 and cleaved cytokeratin 18 with TUNEL method for quantification of apoptosis in histological sections of PC-3 subcutaneous xenografts. J Pathol. 2003;199:221-228.
27. Homsi E, Janino P, Amano M, Camara N O S. Endogenous hepatocyte growth factor attenuates inflammatory response in glycerol-induced acute kidney injury. Am J Nephrol. 2009;29:283-290.
28. Bulavin DV, Saito S, Hollander MC, et al. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J. 1999;18:6845-6854.
29. Xie S, Wang Q, Wu H, et al. Reactive oxygen species inducedphosphorylation of p53 on serine 20 is mediated in part by PIk3. J Biol Chem. 2001;276:36194-36199.
30. Hirao A, Kong YY, Matsuoka S, et al. DNA damage-induced activation of p53 by the checkpoint kinase (Chk2). Science. 2000;287:1824-1827.
31. Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem. 2000;275:8945-8951.
32. Martindale JL, Holbrook NJ. Cellular response to oxidative stress: Signaling for suicide and survival. J Cell Physiol. 2002;192:1-5.
33. Miyashita T, Krajewski S, Krajewska M, et al. Tumor suppressor 53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994;9:1799-1805.
34. Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001;7:683-694.
35. Oda E, Ohki R, Murasawa H, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science. 2000;288:1053-1058.
36. Oda K, Arakawa H, Tanaka T, et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell. 2000;102:849-862.
37. Mirza A, McGuirk TN, Hockenberry Q, Wu H, Ashar S, Black S. Human survivin is negatively regulated by wild type p53 and participate in p53-dependent apoptotic pathway. Oncogene. 2002;2:2613-2622.
38. Hoffman WH, Biade JT, Zilfou J, Chen J, Murphy M. Transcription repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem. 2002;277:3247-3257.
39. Katiyar SK, Roy AM, Baliga MS. Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation. Mol Cancer Ther. 2005;4:207-216.
40. Lechler P, Wu X, Bernhardt W, Campean V, et al. The tumor gene survivin is highly expressed in adult tubular cells. Implications for a pathophysiological role in the kidney. Am J Pathol. 2007;171:1483-1489.
41. Rao PR, Viswanath RK. Cardioprotective activity of silymarin in ischemia-reperfusion-induced myocardial infarction in albino rats. Exp Clin Cardiol. 2007;12:179-187.
42. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature. 1997;389:300-395.
43. Drane P, Bravard A, Bouvard V, May E. Reciprocal downregulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis. Oncogene. 2001;20:430-439.