Cytotoxicity and gene array analysis of alveolar epithelial A549 cells exposed to paraquat

Chemico-Biological Interactions

Volumn 188, Issue 3, 2010, Pages 427-436

  Mitsopoulos, Panagiotis ^a,b   Suntres, Zacharias E ^a,b  

^a NORTHERN ONTARIO SCHOOL OF MEDICINE   (Canada)

^b LAKEHEAD UNIVERSITY   (Canada)

Author keywords

Apoptosis; Cytotoxicity; Gene expression; Inflammation; Paraquat; Reactive oxygen species

Indexed keywords

CASPASE 10; CASPASE 8; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYTOKINE; EARLY GROWTH RESPONSE FACTOR 1; GLUTATHIONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45A; GROWTH DIFFERENTIATION FACTOR 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN 1; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; PARAQUAT; PROTEIN MDM2; REACTIVE OXYGEN METABOLITE; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA SEQUENCE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; MITOCHONDRIAL MEMBRANE POTENTIAL; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION STATE; SEQUENCE ANALYSIS; TOXICOGENETICS; UNINDEXED SEQUENCE;

ANNEXIN A5; CELL SURVIVAL; CYTOKINES; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GLUTATHIONE; HERBICIDES; HUMANS; INTRACELLULAR SPACE; MEMBRANE POTENTIAL, MITOCHONDRIAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARAQUAT; PULMONARY ALVEOLI; REACTIVE OXYGEN SPECIES; TIME FACTORS; TOXICITY TESTS;

ANIMALIA;

EID: 78149465001     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.09.022     Document Type: Article

References (54)

1. Bismuth C., Garnier R., Baud F.J., Muszynski J., Keyes C. Paraquat poisoning. An overview of the current status. Drug Saf. 1990, 5:243-251.
2. Vale J.A., Meredith T.J., Buckley B.M. Paraquat poisoning: clinical features and immediate general management. Hum. Toxicol. 1987, 6:41-47.
3. Smith L.L., Lewis C.P., Wyatt I., Cohen G.M. The importance of epithelial uptake systems in lung toxicity. Environ. Health Perspect. 1990, 85:25-30.
4. Suntres Z.E. Role of antioxidants in paraquat toxicity. Toxicology 2002, 180:65-77.
5. Hoet P.H., Nemery B. Polyamines in the lung: polyamine uptake and polyamine-linked pathological or toxicological conditions. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000, 278:L417-L433.
6. Bus J.S., Gibson J.E. Paraquat: model for oxidant-initiated toxicity. Environ. Health Perspect. 1984, 55:37-46.
7. Franco R., Cidlowski J.A. Apoptosis and glutathione: beyond an antioxidant. Cell Death Differ. 2009, 16:1303-1314.
8. Raff M.C. Social controls on cell survival and cell death. Nature 1992, 356:397-400.
9. Hotchkiss R.S., Strasser A., McDunn J.E., Swanson P.E. Cell death. N. Engl. J. Med. 2009, 361:1570-1583.
10. Circu M.L., Aw T.Y. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic. Biol. Med. 2010, 48:749-762.
11. Majno G., Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol. 1995, 146:3-15.
12. Ciencewicki J., Trivedi S., Kleeberger S.R. Oxidants and the pathogenesis of lung diseases. J. Allergy Clin. Immunol. 2008, 122:456-468. (quiz 469-70).
13. Ishida Y., Takayasu T., Kimura A., Hayashi T., Kakimoto N., Miyashita T., Kondo T. Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice. Leg. Med. (Tokyo) 2006, 8:102-109.
14. Mainwaring G., Lim F.L., Antrobus K., Swain C., Clapp M., Kimber I., Orphanides G., Moggs J.G. Identification of early molecular pathways affected by paraquat in rat lung. Toxicology 2006, 225:157-172.
15. Beyerle A., Irmler M., Beckers J., Kissel T.H., Stoeger T. Toxicity pathway focused gene expression profiling of pei-based polymers for pulmonary applications. Mol. Pharm. 2010, 7:727-737.
16. Chen Z.H., Kim H.P., Ryter S.W., Choi A.M. Identifying targets for COPD treatment through gene expression analyses. Int. J. Chron. Obstruct Pulmon Dis. 2008, 3:359-370.
17. Dandrea T., Hellmold H., Jonsson C., Zhivotovsky B., Hofer T., Warngard L., Cotgreave I. The transcriptosomal response of human A549 lung cells to a hydrogen peroxide-generating system: relationship to DNA damage, cell cycle arrest, and caspase activation. Free Radic. Biol. Med. 2004, 36:881-896.
18. Siddiqui A.Q., Merson-Davies L., Cullis P.M. The synthesis of novel polyamine-nitroimidazole conjugates designed to probe the structural specificities of the polyamine uptake system in A549 lung carcinoma cells. J. Chem. Soc., Perkin Trans. 1999, 1:3243-3252.
19. Gram T.E. Chemically reactive intermediates and pulmonary xenobiotic toxicity. Pharmacol. Rev. 1997, 49:297-341.
20. Keeling P.L., Smith L.L., Aldridge W.N. The formation of mixed disulphides in rat lung following paraquat administration. Correlation with changes in intermediary metabolism. Biochim. Biophys. Acta 1982, 716:249-257.
21. Suntres Z.E., Shek P.N. Alleviation of paraquat-induced lung injury by pretreatment with bifunctional liposomes containing alpha-tocopherol and glutathione. Biochem. Pharmacol. 1996, 52:1515-1520.
22. Lee J., Kwon W., Jo Y., Suh G., Youn Y. Protective effects of ethyl pyruvate treatment on paraquat-intoxicated rats. Hum. Exp. Toxicol. 2008, 27:49-54.
23. Palmeira C.M., Moreno A.J., Madeira V.M. Thiols metabolism is altered by the herbicides paraquat, dinoseb and 2,4-D: a study in isolated hepatocytes. Toxicol. Lett. 1995, 81:115-123.
24. Hirai K., Witschi H., Cote M.G. Mitochondrial injury of pulmonary alveolar epithelial cells in acute paraquat intoxication. Exp. Mol. Pathol. 1985, 43:242-252.
25. Cheng Q., Nguyen T., Song H., Bonanno J. Hypoxia protects human corneal endothelium from tertiary butyl hydroperoxide and paraquat-induced cell death in vitro. Exp. Biol. Med. (Maywood) 2007, 232:445-453.
26. Kang X., Chen J., Xu Z., Li H., Wang B. Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells. Toxicol. In. Vitro 2007, 21:1003-1009.
27. Cocheme H.M., Murphy M.P. Complex I is the major site of mitochondrial superoxide production by paraquat. J. Biol. Chem. 2008, 283:1786-1798.
28. Han J., Goldstein L.A., Hou W., Froelich C.J., Watkins S.C., Rabinowich H. Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. J. Biol. Chem. 2010.
29. Jacotot E., Costantini P., Laboureau E., Zamzami N., Susin S.A., Kroemer G. Mitochondrial membrane permeabilization during the apoptotic process. Ann. N. Y. Acad. Sci. 1999, 887:18-30.
30. Marchetti P., Castedo M., Susin S.A., Zamzami N., Hirsch T., Macho A., Haeffner A., Hirsch F., Geuskens M., Kroemer G. Mitochondrial permeability transition is a central coordinating event of apoptosis. J. Exp. Med. 1996, 184:1155-1160.
31. Cappelletti G., Maggioni M.G., Maci R. Apoptosis in human lung epithelial cells: triggering by paraquat and modulation by antioxidants. Cell Biol. Int. 1998, 22:671-678. 10.1006/cbir.1998.0305.
32. Fabisiak J.P., Kagan V.E., Ritov V.B., Johnson D.E., Lazo J.S. Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis. Am. J. Physiol. 1997, 272:C675-C684.
33. Kazzaz J.A., Xu J., Palaia T.A., Mantell L., Fein A.M., Horowitz S. Cellular oxygen toxicity. Oxidant injury without apoptosis. J. Biol. Chem. 1996, 271:15182-15186.
34. Franek W.R., Horowitz S., Stansberry L., Kazzaz J.A., Koo H.C., Li Y., Arita Y., Davis J.M., Mantell A.S., Scott W., Mantell L.L. Hyperoxia inhibits oxidant-induced apoptosis in lung epithelial cells. J. Biol. Chem. 2001, 276:569-575.
35. Johnson N.F., Carpenter T.R., Jaramillo R.J., Liberati T.A. DNA damage-inducible genes as biomarkers for exposures to environmental agents. Environ. Health Perspect. 1997, 105(Suppl. 4):913-918.
36. Zerbini L.F., Wang Y., Czibere A., Correa R.G., Cho J.Y., Ijiri K., Wei W., Joseph M., Gu X., Grall F., Goldring M.B., Zhou J.R., Libermann T.A. NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:13618-13623.
37. Moran J.M., Gonzalez-Polo R.A., Ortiz-Ortiz M.A., Niso-Santano M., Soler G., Fuentes J.M. Identification of genes associated with paraquat-induced toxicity in SH-SY5Y cells by PCR array focused on apoptotic pathways. J. Toxicol. Environ. Health A 2008, 71:1457-1467.
38. Olesen B.T., Clausen J., Vang O. Characterization of the transcriptional profile in primary astrocytes after oxidative stress induced by Paraquat. Neurotoxicology 2008, 29:13-21.
39. Stoyanova T., Roy N., Kopanja D., Bagchi S., Raychaudhuri P. DDB2 decides cell fate following DNA damage. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:10690-10695.
40. King K.L., Cidlowski J.A. Cell cycle regulation and apoptosis. Annu. Rev. Physiol. 1998, 60:601-617.
41. Ariyama Y., Tanaka Y., Shimizu H., Shimomura K., Okada S., Saito T., Yamada E., Oyadomari S., Mori M., Mori M. The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis. Metabolism 2008, 57:1625-1635.
42. McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., Holbrook N.J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 2001, 21:1249-1259.
43. Chen Y.L., Lin P.C., Chen S.P., Lin C.C., Tsai N.M., Cheng Y.L., Chang W.L., Lin S.Z., Harn H.J. Activation of nonsteroidal anti-inflammatory drug-activated gene-1 via extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase revealed a isochaihulactone-triggered apoptotic pathway in human lung cancer A549 cells. J. Pharmacol. Exp. Ther. 2007, 323:746-756.
44. Sperandio S., Fortin J., Sasik R., Robitaille L., Corbeil J., de Belle I. The transcription factor Egr1 regulates the HIF-1alpha gene during hypoxia. Mol. Carcinog. 2009, 48:38-44.
45. Thiel G., Cibelli G. Regulation of life and death by the zinc finger transcription factor Egr-1. J. Cell. Physiol. 2002, 193:287-292.
46. Dusinska M., Kovacikova Z., Vallova B., Collins A. Responses of alveolar macrophages and epithelial type II cells to oxidative DNA damage caused by paraquat. Carcinogenesis 1998, 19:809-812.
47. Don Porto Carero A., Hoet P.H., Verschaeve L., Schoeters G., Nemery B. Genotoxic effects of carbon black particles, diesel exhaust particles, and urban air particulates and their extracts on a human alveolar epithelial cell line (A549) and a human monocytic cell line (THP-1). Environ. Mol. Mutagen. 2001, 37:155-163.
48. Ali S., Jain S.K., Abdulla M., Athar M. Paraquat induced DNA damage by reactive oxygen species. Biochem. Mol. Biol. Int. 1996, 39:63-67.
49. Ribas G., Surralles J., Carbonell E., Xamena N., Creus A., Marcos R. Genotoxic evaluation of the herbicide paraquat in cultured human lymphocytes. Teratog. Carcinog. Mutagen. 1997, 17:339-347.
50. Ross W.E., Block E.R., Chang R.Y. Paraquat-induced DNA damage in mammalian cells. Biochem. Biophys. Res. Commun. 1979, 91:1302-1308.
51. Senator A., Rachidi W., Lehmann S., Favier A., Benboubetra M. Prion protein protects against DNA damage induced by paraquat in cultured cells. Free Radic. Biol. Med. 2004, 37:1224-1230.
52. Tanaka R. Inhibitory effects of xanthone on paraquat- and NaNO(2)-induced genotoxicity in cultured cells. J. Toxicol. Sci. 2007, 32:571-574.
53. Yamamoto H.A., Mohanan P.V. Effects of melatonin on paraquat or ultraviolet light exposure-induced DNA damage. J. Pineal Res. 2001, 31:308-313.
54. Bianchi M., Fantuzzi G., Bertini R., Perin L., Salmona M., Ghezzi P. The pneumotoxicant paraquat induces IL-8 mRNA in human mononuclear cells and pulmonary epithelial cells. Cytokine 1993, 5:525-530.