Endocrine disruptors and asthma-associated chemicals in consumer products

Environmental Health Perspectives

Volumn 120, Issue 7, 2012, Pages 935-943

  Dodson, Robin E ^a   Nishioka, Marcia ^b   Standley, Laurel J ^a,c   Perovich, Laura J ^a   Brody, Julia Green ^a   Rudel, Ruthann A ^a  

^a Silent Spring Institute   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

^c Clear Current LLC   (United States)

Author keywords

Alkylphenols; Asthma; Bisphenol A; Consumer products; Cyclosiloxane; Endocrine disruptors; Fragrance compounds; Parabens; Phthalates; UV filters

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; 4, 4' ISOPROPYLIDENEDIPHENOL; ALKYLPHENOL; ANTIINFECTIVE AGENT; COSMETIC; ENDOCRINE DISRUPTOR; ETHANOLAMINE; FRAGRANCE; PHTHALIC ACID; PHTHALIC ACID BIS (2 ETHYLHEXYL) ESTER; SILOXANE; SUNSCREEN; TRICLOSAN; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ASTHMA; CHEMICAL ANALYSIS; DISEASE EXACERBATION; EXPOSURE; HUMAN; LIMIT OF DETECTION; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SAMPLING; TOXICITY TESTING; TOXICOLOGY; ULTRAVIOLET RADIATION;

ASTHMA; CONSUMER PRODUCT SAFETY; DIETHYLHEXYL PHTHALATE; ENDOCRINE DISRUPTORS; ENVIRONMENTAL EXPOSURE; HUMANS; PARABENS; PHENOLS; PHTHALIC ACIDS;

EID: 84864127999     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1104052     Document Type: Review

References (109)

1. Adolfsson-Erici M, Pettersson M, Parkkonen J, Sturve J. 2002. Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden. Chemosphere 46(9-10):1485-1489.
2. Association of Occupational and Environmental Clinics. 2010. Description of the AOEC Exposure Code System. Available: http://www.aoecdata.org/ [accessed 17January 2012].
3. Bickers DR, Calow P, Greim HA, Hanifin JM, Rogers AE, SauratJH, et al. 2003. The safety assessment of fragrance materials. Regul Toxicol Pharmacol 37(2):218-273.
4. Bitsch N, Dudas C, Körner W, Failing K, Biselli S, Rimkus G, et al. 2002. Estrogenic activity of musk fragrances detected by the E-Screen assay using human MCF-7 cells. Arch Environ Contam Toxicol 43:257-264.
5. Boberg J, Christiansen S, Axelstad M, Kledal TS, VinggaardAM, Dalgaard M, et al. 2011. Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats. Reprod Toxicol 31(2):200-209.
6. Bonefeld-Jørgensen EC, Long M, Hofmeister MV, VinggaardAM. 2007. Endocrine-disrupting potential of bisphenolA, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol invitro: new data and a brief review. Environ Health Perspect 115:69-76.
7. Bornehag CG, Nanberg E. 2010. Phthalate exposure and asthma in children. Int J Androl 33:333-345.
8. Bornehag CG, Sundell J, Weschler CJ, Sigsgaard T, LundgrenB, HasselgrenM, et al. 2004. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study. Environ Health Perspect 112:1393-1397.
9. Bridges B. 2002. Fragrance: emerging health and environmental concerns. Flavour Fragr J 17(5):361-371.
10. Brody JG, Morello-Frosch R, Zota A, Brown P, Perez C, RudelRA. 2009. Linking exposure assessment science with policy objectives for environmental justice and breast cancer advocacy: the northern California household exposure study. Am J Public Health 99(suppl 3):S600-S609.
11. Calafat AM, Wong LY, Ye X, Reidy JA, Needham LL. 2008a. Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003-2004. Environ Health Perspect 116:893-897.
12. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. 2008b. Exposure of the U.S. population to bisphenolA and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect 116:39-44.
13. Calafat AM, Ye X, Wong LY, Reidy JA, Needham LL. 2008c. Urinary concentrations of triclosan in the U.S. population: 2003-2004. Environ Health Perspect 116:303-307.
14. CDC (Centers for Disease Control and Prevention). 2009. Fourth National Report on Human Exposure to Environmental Chemicals. Available: http://www.cdc.gov/ExposureReport/pdf/FourthReport.pdf [accessed 10September 2011].
15. Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, et al. 2008. Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology 149(3):1173-1179.
16. Cherry N, Moore H, McNamee R, Pacey A, Burgess G, ClymaJA, et al. 2008. Occupation and male infertility: glycol ethers and other exposures. Occup Environ Med 65(10):708-714.
17. Choi H, Schmidbauer N, Sundell J, Hasselgren M, SpenglerJD, BornehagCG. 2010. Common household chemicals and the allergy risks in pre-school age children. PLoS ONE 5(10):e13423; doi:10.1371/journal.pone.0013423 [Online 18October 2010].
18. Colborn T, vom Saal FS, Soto A. 1993. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 101:378-385.
19. Dodson RE, Levy JI, Spengler JD, Shine JP, Bennett DH. 2008. Influence of basements, garages, and common hallways on indoor residential volatile organic compound concentrations. Atmos Environ 42(7):1569-1581.
20. Douwes J, Pearce N. 2002. Asthma and the westernization 'package.' Int J Epidemiol 31(6):1098-1102.
21. Dunagan SC, Dodson RE, Rudel RA, Brody JG. 2011. Toxics use reduction in the home: lessons learned from household exposure studies. JClean Prod 19:438-444.
22. Duty SM, Singh NP, Silva MJ, Barr DB, Brock JW, Ryan L, et al. 2003. The relationship between environmental exposures to phthalates and DNA damage in human sperm using the neutral comet assay. Environ Health Perspect 111:1164-1169.
23. Engel SM, Miodovnik A, Canfield RL, Zhu C, Silva MJ, CalafatAM, et al. 2010. Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environ Health Perspect 118:565-571.
24. Environmental Working Group. 2011. EWG's Skin Deep Cosmetics Database. Available: http://www.ewg.org/skindeep/ [accessed 7September 2011].
25. European Commission. 2002. European Union Risk Assessment Report: 4-Nonylphenol (Branched) and Nonylphenol. EUR 20387 EN. Luxembourg:Joint Research Centre Institute for Health and Consumer Protection, European Chemicals Bureau. Available: http://www.bfr.bund.de/cm/343/4_nonylphenol_und_nonylphenol.pdf [accessed 15May 2012].
26. European Commission. 2011. CosIng. Available: http://ec.europa.eu/consumers/cosmetics/cosing [accessed 7September 2011].
27. Fair Packaging and Labeling Act. 1967. Public Law 89-755.
28. FDA (Food and Drug Administration). 2009. Cosmetic Labeling Manual. Available: http://www.fda.gov/Cosmetics/CosmeticLabelingLabelClaims/CosmeticLabelin gManual/default.htm [accessed 7September 2011].
29. Federal Food, Drug, and Cosmetic Act. 1938. Public Law 75-717.
30. FIFRA (Federal Insecticide, Fungicide, and Rodenticide Act). 1972. 7USC136.
31. Food and Agriculture Organization of the United Nations/World Health Organization). 2010. Joint FAO/WHO Expert Meeting to Review Toxicological and Health Aspects of Bisphenol A: Summary Report including Report of Stakeholder Meeting on Bisphenol A. Available: http://www.who.int/foodsafety/chem/chemicals/BPA_Summary2010.pdf [accessed 15May 2012].
32. GoodGuide. 2012. GoodGuide Homepage. Available: http://www.goodguide.com [accessed 2February 2012].
33. Hannas BR, Furr J, Lambright CS, Wilson VS, Foster PM, GrayLE, Jr. 2011. Dipentyl phthalate dosing during sexual differentiation disrupts fetal. testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates. Toxicol Sci 120(1):184-193.
34. Hauser R, Calafat AM. 2005. Phthalates and human health. Occup Environ Med 62:806-818.
35. Hauser R, Meeker JD, Duty S, Silva MJ, Calafat AM. 2006. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology 17(6):682-691.
36. Hauser R, Meeker JD, Singh NP, Silva MJ, Ryan L, Duty S, et al. 2007. DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Hum Reprod 22(3):688-695.
37. Heindel JJ, Gulati DK, Mounce RC, Russell SR, LambJCIV. 1989. Reproductive toxicity of three phthalic acid esters in a continuous breeding protocol. Fundam Appl Toxicol 12(3):508-518.
38. Henley DV, Lipson N, Korach KS, Bloch CA. 2007. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med 356(5):479-485.
39. Heudorf U, Mersch-Sundermann V, Angerer E. 2007. Phthalates: toxicology and exposure. Int J Hyg Environ Health 210(5):623-634.
40. Heydorn S, Johansen JD, Andersen KE, Bruze M, SvedmanC, WhiteIR, et al. 2003. Fragrance allergy in patients with hand eczema-a clinical study. Contact Dermatitis 48(6):317-323.
41. Horii Y, Kannan K. 2008. Survey of organosilicone compounds, including cyclic and linear siloxanes, in personal-care and household products. Arch Environ Contam Toxicol 55:701-710.
42. Howdeshell KL, Wilson VS, Furr J, Lambright CR, Rider CV, BlystoneCR, et al. 2008. A mixture of five phthalate esters inhibits fetal. testicular testosterone production in the Sprague-Dawley rat in a cumulative, dose-additive manner. Toxicol Sci 105(1):153-165.
43. Hubinger JC, Havery DC. 2006. Analysis of consumer cosmetic products for phthalate esters. J Cosmet Sci 57:127-137.
44. IARC (International Agency for Research on Cancer). 1999. Some Chemicals that Cause Tumours of the Kidney or Urinary Bladder in Rodents and Some Other Substances. IARC Monogr Eval Carcinog Risk Hum 73:1-641. Available: http://monographs.iarc.fr/ENG/Monographs/vol73/mono73.pdf [accessed 15May 2012].
45. IARC (International Agency for Research on Cancer). 2000. Some Industrial Chemicals. IARC Monogr Eval Carcinog Risk Hum 77:1-529. Available: http://monographs.iarc.fr/ENG/Monographs/vol77/mono77.pdf [accessed 7September 2011].
46. International Fragrance Association. 2010. Ingredients. Available: http://www.ifraorg.org/en-us/Ingredients_2 [accessed 31May 2012].
47. Jie X, Yang W, Jie Y, Hashim JH, Liu XY, Fan QY, et al. 2010. Toxic effect of gestational exposure to nonylphenol on F1 male rats. Birth Defects Res B Dev Reprod Toxicol 89(5):418-428.
48. Kamijo Y, Hayashi I, Ide A, Yoshimura K, Soma K, Majima M. 2009. Effects of inhaled monoethanolamine on bronchoconstriction. J Appl Toxicol 29(1):15-19.
49. Kang KS, Che JH, Ryu DY, Kim TW, Li GX, Lee YS. 2002. Decreased sperm number and motile activity on the F1 offspring maternally exposed to butyl p-hydroxybenzoic acid (butyl paraben). J Vet Med Sci 64(3):227-235.
50. Kimber I, Dearmna RJ. 2010. An assessment of the ability of phthalates to influence immune and allergic responses. Toxicology 271:73-82.
51. Koniecki D, Wang R, Moody RP, Zhu J. 2011. Phthalates in cosmetic and personal care products: concentrations and possible dermal exposure. Environ Res 111(3):329-336.
52. Kumar P, Caradonna-Graham VM, Gupta S, Cai X, Rao PN, Thompson J. 1995. Inhalation challenge effects of perfume scent strips in patients with asthma. Ann Allergy Asthma Immunol 75:429-433.
53. Kunz P, Fent K. 2006. Estrogenic activity of UV filter mixtures. Toxicol Appl Pharmacol 217:86-99.
54. Kwon KD, Jo WK, Lim HJ, Jeong WS. 2008. Volatile pollutants emitted from selected liquid household products. Environ Sci Pollut Res Int 15(6):521-526.
55. López-Carrillo L, Hernández-Ramírez RU, Calafat AM, Torres-SánchezL, Galván-Portillo M, Needham LL, et al. 2010. Exposure to phthalates and breast cancer risk in northern Mexico. Environ Health Perspect 118:539-544.
56. Lorber M. 2008. Exposure of Americans to polybrominated diphenyl ethers. J Expo Sci Environ Epidemiol 18(1):2-19.
57. Lu CS, Toepel K, Irish R, Fenske RA, Barr DB, Bravo R. 2006. Organic diets significantly lower children's dietary exposure to organophosphorus pesticides. Environ Health Perspect 114:260-263.
58. Mäkelä R, Kauppi P, Suuronen K, Tuppurainen M, Hannu T. 2011. Occupational asthma in professional cleaning work: a clinical study. Occup Med (Lond) 61(2):121-126.
59. Meeker JD, Calafat AM, Hauser R. 2009a. Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men. J Androl 30(3):287-297.
60. Meeker JD, Sathyanarayana S, Swan SH. 2009b. Phthalates and other additives in plastics: human exposure and associated health outcomes. Philos Trans R Soc Lond B Biol Sci 364(1526):2097-2113.
61. Mendiola J, Meeker JD, Jorgensen N, Andersson AM, Liu F, CalafatAM, et al. 2011. Urinary concentrations of di(2-ethylhexyl) phthalate metabolites and serum reproductive hormones: Pooled analysis of fertile and infertile men. J Androl; doi:10.2164/jandrol.111.013557 [19May 2011].
62. National Library of Medicine. 2010a. TOXNET. Available: http://toxnet.nlm.nih.gov [accessed 8September 2011].
63. National Library of Medicine. 2010b. Household Products Database. Available: http://householdproducts.nlm.nih.gov [accessed 9September 2011].
64. Nazaroff WW, Weschler CJ. 2004. Cleaning products and air fresheners: exposure to primary and secondary air pollutants. Atmos Environ 38(18):2841-2865.
65. Newton E, Rudel R. 2007. Estimating correlation with multiply censored data arising from the adjustment of singly censored data. Environ Sci Technol 41:221-228.
66. National Research Council. 2008. Phthalates and Cumulative Risk Assessment: The Task Ahead. Washington, DC:National Academies Press.
67. Paul KB, Hedge JM, DeVito MJ, Crofton KM. 2010. Short-term exposure to triclosan decreases thyroxine invivo via upregulation of hepatic catabolism in young Long-Evans rats. Toxicol Sci 113(2):367-379.
68. Perencevich EN, Wong MT, Harris AD. 2001. National and regional assessment of the antibacterial soap market: a step toward determining the impact of prevalent antibacterial soaps. Am J Infect Control 29(5):281-283.
69. Piipari R, Tuppurainen M, Tuomi T, Mäntylä L, Henriks-EckermanML, Keskinen H, et al. 1998. Diethanolamine-induced occupational asthma, a case report. Clin Exp Allergy 28(3):358-362.
70. Plaisance H, Desmettres P, Leonardis T, Pennequin-CardinalA, LocogeN, Galloo JC. 2008. Passive sampling of glycol ethers and their acetates in indoor air. J Environ Monit 10(4):517-526.
71. Quinn AL, Regan JM, Tobin JM, Marinik BJ, McMahon JM, McNettDA, et al. 2007. Invitro and invivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes. Toxicol Sci 96(1):145-153.
72. Rakkestad KE, Dye CJ, Yttri KE, Holme JA, Hongslo JK, SchwarzePE, et al. 2007. Phthalate levels in Norwegian indoor air related to particle size fraction. J Environ Monit 9(12):1419-1425.
73. Rastogi SC. 2002. UV filters in sunscreen products-a survey. Contact Dermatitis 46(6):348-351.
74. Rastogi SC, Heydorn S, Johansen JD, Basketter DA. 2001. Fragrance chemicals in domestic and occupational products. Contact Dermatitis 45(4):221-225.
75. Rastogi SC, Johansen JD, Menné T. 1996. Natural ingredients based cosmetics. Content of selected fragrance sensitizers. Contact Dermatitis 34(6):423-426.
76. Rastogi SC, Schouten A, deKruijf N, Weijland JW. 1995. Contents of methyl-, ethyl-, propyl-, butyl-and benzylparaben in cosmetic products. Contact Dermatitis 32(1):28-30.
77. Ravid U, Elkabetz M, Zamir C, Cohen K, Larkov O, Aly R. 2010. Authenticity assessment of natural fruit flavour compounds in foods and beverages by auto-HS-SPME stereoselective GC-MS. Flavour Fragr J 25:20-27.
78. Reiner JL, Kannan K. 2006. A survey of polycyclic musks in selected household commodities from the United States. Chemosphere 62(6):867-873.
79. Rodríguez PE, Sanchez MS. 2010. Maternal exposure to triclosan impairs thyroid homeostasis and female pubertal development in Wistar rat offspring. J Toxicol Environ Health A 73(24):1678-1688.
80. Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, HouckKA, et al. 2010. Incorporating human dosimetry and exposure into high-throughput invitro toxicity screening. Toxicol Sci 117(2):348-358.
81. Routledge EJ, Parker J, Odum J, Ashby J, Sumpter JP. 1998. Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic. Toxicol Appl Pharmacol 153(1):12-19.
82. Rudel RA, Camann DE, Spengler JD, Korn LR, Brody JG. 2003. Phthalates, alkylphenols, pesticides, polybrominated diphenyl ethers, and other endocrine-disrupting compounds in indoor air and dust. Environ Sci Technol 37(20):4543-4553.
83. Rudel RA, Dodson RE, Perovich LJ, Morello-Frosch R, CamannDE, Zuniga MM, et al. 2010. Semivolatile endocrine-disrupting compounds in paired indoor and outdoor air in two northern California communities. Environ Sci Technol 44:6583-6590.
84. Rudel RA, Gray JM, Engel CL, Rawsthorne TW, Dodson RE, AckermanJM, et al. 2011. Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention. Environ Health Perspect 119:914-920.
85. Rudel RA, Perovich LJ. 2009. Endocrine disrupting chemicals in indoor and outdoor air. Atmos Environ 43(1):170-181.
86. Rudel RA, Seryak LM, Brody JG. 2008. PCB-containing wood floor finish is a likely source of elevated PCBs in residents' blood, household air and dust: a case study of exposure. Environ Health 7:2; doi:10.1186/1476-069X-7-2 [Online 17January 2008].
87. Saillenfait AM, Gallissot F, Sabate JP. 2009. Differential developmental toxicities of di-n-hexyl phthalate and dicyclohexyl phthalate administered orally to rats. J Appl Toxicol 29(6):510-521.
88. Savonius B, Keskinen H, Tuppurainen M, Kanerva L. 1994. Occupational asthma caused by ethanolamines. Allergy 49(10):877-881.
89. Schlumpf M, Schmid P, Durrer S, Conscience M, Maerkel K, HenselerM, et al. 2004. Endocrine activity and develop-mental toxicity of cosmetic UV filters-an update. Toxicology 205(1-2):113-122.
90. Schreurs RH, Sonneveld E, Jansen JH, Seinen W, vanderBurgB. 2005. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci 83(2):264-272.
91. Seinen W, Lemmen JG, Pieters RHH, Verbruggen EMJ, vanderBurg B. 1999. AHTN and HHCB show weak estrogic-but no uterotrophic activity. Toxicol Lett 111:161-168.
92. Shen H-Y, Jiang H-L, Mao H-L, Pan G, Zhou L, Cao Y-F. 2007. Simultaneous determination of seven phthalates and four parabens in cosmetic products using HPLC-DAD and GC-MS methods. J Sep Sci 30:48-54.
93. Silent Spring Institute. 2012. Table: Consumer Products Tested for Endocrine Disruptors and Asthma-Associated Chemicals. Available: http://silentspring.org/table-consumer-products-tested-endocrine-disrupt ors-and-asthma-associated-chemicals [accessed 8March 2012].
94. 5). Available: http://www.sehsc.com/d5.asp [accessed 10September 2011].
95. Singer BC, Coleman BK, Destaillats H, Hodgson AT, LundenMM, Weschler CJ, et al. 2006. Indoor secondary pollutants from cleaning product and air freshener use in the presence of ozone. Atmos Environ 40(35):6696-6710.
96. Smith SW. 2009. Chiral toxicology: it's the same thing only different. Toxicol Sci 110(1):4-30.
97. Soni MG, Burdock GA, Taylor SL, Greenberg NA. 2001. Safety assessment of propyl paraben: a review of the published literature. Food Chem Toxicol 39(6):513-532.
98. Starek A, Szymczak W, Zapor L. 2008. Hematological effects of four ethylene glycol monoalkyl ethers in short-term repeated exposure in rats. Arch Toxicol 82(2):125-136.
99. Steinemann AC. 2009. Fragranced consumer products and undisclosed ingredients. Environ Impact Assess Rev 29(1):32-38.
100. Steinemann AC, MacGregor IC, Gordon SM, Gallagher LG, DavisAL, Ribeiro DS, et al. 2011. Fragranced consumer products: chemicals emitted, ingredients unlisted. Environ Impact Assess Rev 31(3):328-333.
101. Stoker TE, Gibson EK, Zorrilla LM. 2010. Triclosan exposure modulates estrogen-dependent responses in the female Wistar rat. Toxicol Sci 117(1):45-53.
102. Swan SH. 2008. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res 108(2):177-184.
103. Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, et al. 2005. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect 113:1056-1061.
104. van der Burg B, Schreurs R, van der Linden S, SeinenW, BrouwerA, Sonneveld E. 2008. Endocrine effects of poly-cyclic musks: do we smell a rat? Int J Androl 31(2):188-193.
105. Wang R, Moody RP, Koniecki D, Zhu J. 2009. Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canda: implications for dermal exposure. Environ Int 35:900-904.
106. Weschler CJ. 2009. Changes in indoor pollutants since the 1950s. Atmos Environ 43:153-169.
107. Ye X, Bishop AM, Reidy JA, Needham LL, Calafat AM. 2006. Parabens as urinary biomarkers of exposure in humans. Environ Health Perspect 114:1843-1846.
108. Zhang XL, Yao Y, Zeng XY, Qian GR, Guo YW, Wu MH, et al. 2008. Synthetic musks in the aquatic environment and personal care products in Shanghai, China. Chemosphere 72(10):1553-1558.
109. Zota AR, Rudel RA, Morello-Frosch RA, Brody JG. 2008. Elevated house dust and serum concentrations of PBDEs in California: unintended consequences of furniture flammability standards? Environ Sci Technol 42(21):8158-8164.