In vitro and in vivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes

Toxicological Sciences

Volumn 96, Issue 1, 2007, Pages 145-153

  Quinn, Anne L ^a   Regan, Jane M ^a   Tobin, Joseph M ^a   Marinik, Brian J ^a   McMahon, Joan M ^a   McNett, Debra A ^a   Sushynski, Christopher M ^a   Crofoot, Steven D ^a   Jean, Paul A ^a   Plotzke, Kathleen P ^a  

^a DOW CORNING CORPORATION   (United States)

Author keywords

Androgen; D4; D5; Decamethylcyclopentasiloxane; Estrogen receptor and ; Estrogenic; Luciferase reporter gene; Octamethylcyclotetrasiloxane; Progesterone; RUA; Silicone; Siloxane

Indexed keywords

DECAMETHYLCYCLOPENTASILOXANE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; LUCIFERASE; OCTAMETHYLCYCLOTETRASILOXANE; PROGESTERONE RECEPTOR A; PROGESTERONE RECEPTOR B; SILOXANE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; CHEMICAL BINDING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EPITHELIUM CELL; ESTROGEN ACTIVITY; FISCHER 344 RAT; GENE ACTIVATION; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; NONHUMAN; PROTEIN DETERMINATION; RAT; RECEPTOR BINDING; REPORTER GENE; SPRAGUE DAWLEY RAT; UTERUS WEIGHT; WEIGHT GAIN;

ANDROGENS; ANIMALS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS; FEMALE; GENITALIA, MALE; HUMANS; INHALATION EXPOSURE; MALE; ORCHIECTOMY; ORGAN SIZE; OVARIECTOMY; PROGESTINS; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REPRODUCTION; SILOXANES; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFECTION; UTERUS;

RATTUS;

EID: 33847331248     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl185     Document Type: Article

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