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Volumn 33, Issue 3, 2012, Pages 488-498

Urinary concentrations of Di(2-ethylhexyl) phthalate metabolites and serum reproductive hormones: Pooled analysis of fertile and infertile men

(12)  Mendiola, Jaime a,l   Meeker, John D b   Jørgensen, Niels c   Andersson, Anna Maria c   Liu, Fan a   Calafat, Antonia M d   Redmon, J Bruce e   Drobnis, Erma Z f   Sparks, Amy E g   Wang, Christina h   Hauser, Russ a,i,j   Swan, Shanna H k  


Author keywords

Anti androgens; DEHP metabolites; Endocrine disruptor; Male hormones

Indexed keywords

DI(2 ETHYLHEXYL)PHTHALATE METABOLITE; ESTRADIOL; FOLLITROPIN; INHIBIN B; LUTEINIZING HORMONE; MONO(2 ETHYL 5 HYDROXYHEXYL)PHTHALATE; MONO(2 ETHYL 5 OXOHEXYL)PHTHALATE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 84862524928     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.111.013557     Document Type: Article
Times cited : (66)

References (52)
  • 1
    • 0041304143 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry. Atlanta, GA: Agency for Toxic Substances and Disease Registry
    • Agency for Toxic Substances and Disease Registry. Toxicological Profile for Di(2-ethylhexyl)phthalate (DEHP). Atlanta, GA: Agency for Toxic Substances and Disease Registry; 2002.
    • (2002) Toxicological Profile for Di(2-ethylhexyl)phthalate (DEHP)
  • 3
    • 33748945160 scopus 로고    scopus 로고
    • A doseresponse study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activity
    • Andrade A, Grande SW, Talsness CE, Grote K, Chahoud I. A doseresponse study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activity. Toxicology. 2006;227:185-192.
    • (2006) Toxicology , vol.227 , pp. 185-192
    • Andrade, A.1    Grande, S.W.2    Talsness, C.E.3    Grote, K.4    Chahoud, I.5
  • 4
    • 34548752809 scopus 로고    scopus 로고
    • Increased frequency of reproductive health problems among fathers of boys with hypospadias
    • Asklund C, Jørgensen N, Skakkebaek NE, Jensen TK. Increased frequency of reproductive health problems among fathers of boys with hypospadias. Hum Reprod. 2007;22:2639-2646.
    • (2007) Hum Reprod , vol.22 , pp. 2639-2646
    • Asklund, C.1    Jørgensen, N.2    Skakkebaek, N.E.3    Jensen, T.K.4
  • 5
    • 27944503563 scopus 로고    scopus 로고
    • A study of finger lengths, semen quality and sex hormones in 360 young men from the general Danish population
    • Bang AK, Carlsen E, Holm M, Petersen JH, Skakkebaek NE, Jørgensen N. A study of finger lengths, semen quality and sex hormones in 360 young men from the general Danish population. Hum Reprod. 2005;20:3109-3113.
    • (2005) Hum Reprod , vol.20 , pp. 3109-3113
    • Bang, A.K.1    Carlsen, E.2    Holm, M.3    Petersen, J.H.4    Skakkebaek, N.E.5    Jørgensen, N.6
  • 6
    • 33749540083 scopus 로고    scopus 로고
    • Seasonal variation of estradiol, follicle stimulating hormone, and dehydroepiandrosterone sulfate in women and men
    • Bjornerem A, Straume B, Oian P, Berntsen GK. Seasonal variation of estradiol, follicle stimulating hormone, and dehydroepiandrosterone sulfate in women and men. J Clin Endocrinol Metab. 2006;91: 3798-3802.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3798-3802
    • Bjornerem, A.1    Straume, B.2    Oian, P.3    Berntsen, G.K.4
  • 7
    • 33646584544 scopus 로고    scopus 로고
    • Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis
    • Borch J, Metzdorff SB, Vinggaard AM, Brokken L, Dalgaard M. Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis. Toxicology. 2006;223:144-155.
    • (2006) Toxicology , vol.223 , pp. 144-155
    • Borch, J.1    Metzdorff, S.B.2    Vinggaard, A.M.3    Brokken, L.4    Dalgaard, M.5
  • 8
    • 84946640223 scopus 로고
    • Transformation of the independent variables
    • Box GEP, Tidwell PW. Transformation of the independent variables. Technometrics. 1962;5:531-550.
    • (1962) Technometrics , vol.5 , pp. 531-550
    • Box, G.E.P.1    Tidwell, P.W.2
  • 9
    • 0026657024 scopus 로고
    • Evidence for decreasing quality of semen during the past 50 years
    • Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during the past 50 years. BMJ. 1992;305:609-613.
    • (1992) BMJ , vol.305 , pp. 609-613
    • Carlsen, E.1    Giwercman, A.2    Keiding, N.3    Skakkebaek, N.E.4
  • 10
    • 77954173954 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention (CDC). Atlanta, GA: Centers for Disease Control and Prevention, National Center for Environmental Health, Accessed February 1, 2011
    • Centers for Disease Control and Prevention (CDC). Fourth National Report on Human Exposure to Environmental Chemicals. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Environmental Health; 2011. http://www.cdc.gov/exposurereport/ pdf/Updated_Tables.pdf. Accessed February 1, 2011.
    • (2011) Fourth National Report on Human Exposure to Environmental Chemicals
  • 11
    • 0027974225 scopus 로고
    • Mono-(2-ethylhexyl) phthalate suppresses estradiol production independent of FSHcAMP stimulation in rat granulosa cells
    • Davis BJ, Weaver R, Gaines LJ, Heindel JJ. Mono-(2-ethylhexyl) phthalate suppresses estradiol production independent of FSHcAMP stimulation in rat granulosa cells. Toxicol Appl Pharmacol. 1994;128:224-228.
    • (1994) Toxicol Appl Pharmacol , vol.128 , pp. 224-228
    • Davis, B.J.1    Weaver, R.2    Gaines, L.J.3    Heindel, J.J.4
  • 12
    • 0023751785 scopus 로고
    • Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults
    • Dostal LA, Chapin RE, Stefanski SA, Harris MW, Schwetz BA. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults. Toxicol Appl Pharmacol. 1988;95:104-121.
    • (1988) Toxicol Appl Pharmacol , vol.95 , pp. 104-121
    • Dostal, L.A.1    Chapin, R.E.2    Stefanski, S.A.3    Harris, M.W.4    Schwetz, B.A.5
  • 14
    • 0034523473 scopus 로고    scopus 로고
    • Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    • Gray LE Jr, Ostby J, Furr J, Price M, Veeramachaneni DN, Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol Sci. 2000;58:350-365.
    • (2000) Toxicol Sci , vol.58 , pp. 350-365
    • Gray Jr., L.E.1    Ostby, J.2    Furr, J.3    Price, M.4    Veeramachaneni, D.N.5    Parks, L.6
  • 16
    • 33750482232 scopus 로고    scopus 로고
    • Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites
    • Hauser R, Meeker JD, Duty S, Silva MJ, Calafat AM. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology. 2006;17:682-691.
    • (2006) Epidemiology , vol.17 , pp. 682-691
    • Hauser, R.1    Meeker, J.D.2    Duty, S.3    Silva, M.J.4    Calafat, A.M.5
  • 17
    • 10944238528 scopus 로고    scopus 로고
    • Temporal variability of urinary phthalate metabolite levels in men of reproductive age
    • Hauser R, Meeker JD, Park S, Silva MJ, Calafat AM. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ Health Perspect. 2004;112:1734-1740.
    • (2004) Environ Health Perspect , vol.112 , pp. 1734-1740
    • Hauser, R.1    Meeker, J.D.2    Park, S.3    Silva, M.J.4    Calafat, A.M.5
  • 19
    • 0037387906 scopus 로고    scopus 로고
    • Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure
    • Higuchi TT, Palmer JS, Gray LE Jr, Veeramachaneni DN. Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or postpubertal exposure. Toxicol Sci. 2003;72:301-313.
    • (2003) Toxicol Sci , vol.72 , pp. 301-313
    • Higuchi, T.T.1    Palmer, J.S.2    Gray Jr., L.E.3    Veeramachaneni, D.N.4
  • 20
    • 0036105250 scopus 로고    scopus 로고
    • Reproducibility of urinary phthalate metabolites in first morning urine samples
    • Hoppin JA, Brock JW, Davis BJ, Baird DD. Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ Health Perspect. 2002;110:515-518.
    • (2002) Environ Health Perspect , vol.110 , pp. 515-518
    • Hoppin, J.A.1    Brock, J.W.2    Davis, B.J.3    Baird, D.D.4
  • 21
    • 0025261744 scopus 로고
    • Estimation of average concentration in the presence of non-detectable values
    • Hornung RW, Reed LD. Estimation of average concentration in the presence of non-detectable values. Appl Occup Environ Hyg. 1990; 5:48-51.
    • (1990) Appl Occup Environ Hyg , vol.5 , pp. 48-51
    • Hornung, R.W.1    Reed, L.D.2
  • 22
    • 20544448920 scopus 로고    scopus 로고
    • Urinary phthalate metabolites and biomarkers of reproductive function in young men
    • Jönsson BA, Richthoff J, Rylander L, Giwercman A, Hagmar L. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology. 2005;16:487-493.
    • (2005) Epidemiology , vol.16 , pp. 487-493
    • Jönsson, B.A.1    Richthoff, J.2    Rylander, L.3    Giwercman, A.4    Hagmar, L.5
  • 23
    • 77949621617 scopus 로고    scopus 로고
    • Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis
    • Jørgensen N, Rajpert-De Meyts E, Main KM, Skakkebæk NE. Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis. Int J Androl. 2010; 33:298-303.
    • (2010) Int J Androl , vol.33 , pp. 298-303
    • Jørgensen, N.1    Rajpert-De Meyts, E.2    Main, K.M.3    Skakkebæk, N.E.4
  • 24
    • 0033870871 scopus 로고    scopus 로고
    • A single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces sertoli cell proliferation, and decreases cyclin D2 expression
    • Li LH, Jester WF Jr, Laslett AL, Orth JM. A single dose of di-(2-ethylhexyl) phthalate in neonatal rats alters gonocytes, reduces sertoli cell proliferation, and decreases cyclin D2 expression. Toxicol Appl Pharmacol. 2000;166:222-229.
    • (2000) Toxicol Appl Pharmacol , vol.166 , pp. 222-229
    • Li, L.H.1    Jester Jr., W.F.2    Laslett, A.L.3    Orth, J.M.4
  • 25
    • 0032423198 scopus 로고    scopus 로고
    • Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats
    • Li LH, Jester WF Jr, Orth JM. Effects of relatively low levels of mono-(2-ethylhexyl) phthalate on cocultured Sertoli cells and gonocytes from neonatal rats. Toxicol Appl Pharmacol. 1998;153:258-265.
    • (1998) Toxicol Appl Pharmacol , vol.153 , pp. 258-265
    • Li, L.H.1    Jester Jr., W.F.2    Orth, J.M.3
  • 26
    • 0035341453 scopus 로고    scopus 로고
    • Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells
    • Lovekamp TN, Davis BJ. Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. Toxicol Appl Pharmacol. 2001;172:217-224.
    • (2001) Toxicol Appl Pharmacol , vol.172 , pp. 217-224
    • Lovekamp, T.N.1    Davis, B.J.2
  • 28
    • 65549095014 scopus 로고    scopus 로고
    • Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men
    • Meeker JD, Calafat AM, Hauser R. Urinary metabolites of di(2-ethylhexyl) phthalate are associated with decreased steroid hormone levels in adult men. J Androl. 2009;30:287-297.
    • (2009) J Androl , vol.30 , pp. 287-297
    • Meeker, J.D.1    Calafat, A.M.2    Hauser, R.3
  • 30
    • 0003637272 scopus 로고    scopus 로고
    • National Research Council. Washington, DC: National Research Council, National Academies Press
    • National Research Council. Hormonally Active Agents in the Environment. Washington, DC: National Research Council, National Academies Press; 1999.
    • (1999) Hormonally Active Agents in the Environment
  • 31
    • 34547142615 scopus 로고    scopus 로고
    • Mono-(2-ethylhexyl) phthalate (MEHP) induces nuclear receptor 4A subfamily in NCI-H295R cells: a possible mechanism of aromatase suppression by MEHP
    • Noda M, Ohno S, Nakajin S. Mono-(2-ethylhexyl) phthalate (MEHP) induces nuclear receptor 4A subfamily in NCI-H295R cells: a possible mechanism of aromatase suppression by MEHP. Mol Cell Endocrinol. 2007;274:8-18.
    • (2007) Mol Cell Endocrinol , vol.274 , pp. 8-18
    • Noda, M.1    Ohno, S.2    Nakajin, S.3
  • 32
    • 33750877092 scopus 로고    scopus 로고
    • Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a crosssectional study in China
    • Pan G, Hanaoka T, Yoshimura M, Zhang S, Wang P, Tsukino H, Inoue K, Nakazawa H, Tsugane S, Takahashi K. Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a crosssectional study in China. Environ Health Perspect. 2006;114: 1643-1648.
    • (2006) Environ Health Perspect , vol.114 , pp. 1643-1648
    • Pan, G.1    Hanaoka, T.2    Yoshimura, M.3    Zhang, S.4    Wang, P.5    Tsukino, H.6    Inoue, K.7    Nakazawa, H.8    Tsugane, S.9    Takahashi, K.10
  • 33
    • 0034521058 scopus 로고    scopus 로고
    • The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
    • Parks LG, Ostby JS, Lambright CR, Abbott BD, Klinefelter GR, Barlow NJ, Gray LE Jr. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol Sci. 2000;58:339-349.
    • (2000) Toxicol Sci , vol.58 , pp. 339-349
    • Parks, L.G.1    Ostby, J.S.2    Lambright, C.R.3    Abbott, B.D.4    Klinefelter, G.R.5    Barlow, N.J.6    Gray Jr., L.E.7
  • 34
    • 0022973652 scopus 로고
    • Effect of di(2-ethylhexyl) phthalate (DEHP) on spermatogenesis in adult rats
    • Parmar D, Srivastava SP, Seth PK. Effect of di(2-ethylhexyl) phthalate (DEHP) on spermatogenesis in adult rats. Toxicology. 1986;42:47-55.
    • (1986) Toxicology , vol.42 , pp. 47-55
    • Parmar, D.1    Srivastava, S.P.2    Seth, P.K.3
  • 36
    • 47549111535 scopus 로고    scopus 로고
    • The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men
    • Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF Jr, Hayes FJ. The relative role of gonadal sex steroids and gonadotropin-releasing hormone pulse frequency in the regulation of follicle-stimulating hormone secretion in men. J Clin Endocrinol Metab. 2008;93:2686-2692.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2686-2692
    • Pitteloud, N.1    Dwyer, A.A.2    DeCruz, S.3    Lee, H.4    Boepple, P.A.5    Crowley Jr., W.F.6    Hayes, F.J.7
  • 37
    • 33846991956 scopus 로고    scopus 로고
    • Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement
    • Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H. Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. J Clin Endocrinol Metab. 2007;92:405-413.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 405-413
    • Rosner, W.1    Auchus, R.J.2    Azziz, R.3    Sluss, P.M.4    Raff, H.5
  • 38
    • 41749092093 scopus 로고    scopus 로고
    • Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects
    • Sharpe RM, Skakkebæk NE. Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. Fertil Steril. 2008;89(2 suppl):33-38.
    • (2008) Fertil Steril , vol.89 , Issue.2 SUPPL. , pp. 33-38
    • Sharpe, R.M.1    Skakkebæk, N.E.2
  • 41
    • 0025354898 scopus 로고
    • Testicular effects of di-n-butyl phthalate (DBP): biochemical and histopathological alterations
    • Srivastava SP, Srivastava S, Saxena DK, Chandra SV, Seth PK. Testicular effects of di-n-butyl phthalate (DBP): biochemical and histopathological alterations. Arch Toxicol. 1990;64:148-152.
    • (1990) Arch Toxicol , vol.64 , pp. 148-152
    • Srivastava, S.P.1    Srivastava, S.2    Saxena, D.K.3    Chandra, S.V.4    Seth, P.K.5
  • 42
    • 52949101044 scopus 로고    scopus 로고
    • Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans
    • Swan SH. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res. 2008;108:177-184.
    • (2008) Environ Res , vol.108 , pp. 177-184
    • Swan, S.H.1
  • 44
    • 0031455688 scopus 로고    scopus 로고
    • Have sperm densities declined? A reanalysis of global trend data
    • Swan SH, Elkin EP, Fenster L. Have sperm densities declined? A reanalysis of global trend data. Environ Health Perspect. 1997; 105:1228-1232.
    • (1997) Environ Health Perspect , vol.105 , pp. 1228-1232
    • Swan, S.H.1    Elkin, E.P.2    Fenster, L.3
  • 46
    • 0042868816 scopus 로고    scopus 로고
    • Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography-mass spectrometry in sera from 116 men, women, and children
    • Taieb J, Mathian B, Millot F, Patricot MC, Mathieu E, Queyrel N, Lacroix I, Somma-Delpero C, Boudou P. Testosterone measured by 10 immunoassays and by isotope-dilution gas chromatography- mass spectrometry in sera from 116 men, women, and children. Clin Chem. 2003;49:1381-1395.
    • (2003) Clin Chem , vol.49 , pp. 1381-1395
    • Taieb, J.1    Mathian, B.2    Millot, F.3    Patricot, M.C.4    Mathieu, E.5    Queyrel, N.6    Lacroix, I.7    Somma-Delpero, C.8    Boudou, P.9
  • 48
    • 38549160115 scopus 로고    scopus 로고
    • Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States
    • Teitelbaum SL, Britton JA, Calafat AM, Ye X, Silva MJ, Reidy JA, Galvez MP, Brenner BL, Wolff MS. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res. 2008;106:257-269.
    • (2008) Environ Res , vol.106 , pp. 257-269
    • Teitelbaum, S.L.1    Britton, J.A.2    Calafat, A.M.3    Ye, X.4    Silva, M.J.5    Reidy, J.A.6    Galvez, M.P.7    Brenner, B.L.8    Wolff, M.S.9
  • 51
    • 0033305020 scopus 로고    scopus 로고
    • A critical evaluation of simple methods for the estimation of free testosterone in serum
    • Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab. 1999;84:3666-3672.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3666-3672
    • Vermeulen, A.1    Verdonck, L.2    Kaufman, J.M.3
  • 52
    • 1442327856 scopus 로고    scopus 로고
    • Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry
    • Wang C, Catlin DH, Demers LM, Starcevic B, Swerdloff RS. Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography- tandem mass spectrometry. J Clin Endocrinol Metab. 2004;89: 534-543.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 534-543
    • Wang, C.1    Catlin, D.H.2    Demers, L.M.3    Starcevic, B.4    Swerdloff, R.S.5


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