Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative potency than other phthalates

Toxicological Sciences

Volumn 120, Issue 1, 2011, Pages 185-193

  Hannas, Bethany R ^a   Furr, Johnathan ^b   Lambright, Christy S ^b   Wilson, Vickie S ^b   Foster, Paul M D ^c   Earl Gray, Jr ^b  

^a NATIONAL RESEARCH COUNCIL   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Antiandrogen; Dipentyl phthalate; Fetal male rat endocrine; Risk assessment

Indexed keywords

CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); DIPENTYLPHTHALATE; MESSENGER RNA; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID ESTER; TESTOSTERONE; UNCLASSIFIED DRUG; DI-N-PENTYL PHTHALATE; ENDOCRINE DISRUPTOR; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIPENTYL ESTER;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; FETUS DEVELOPMENT; GENE; GENE EXPRESSION; INSL3 GENE; MALE; NONHUMAN; ONTOGENY; POSTNATAL DEVELOPMENT; RAT; RISK ASSESSMENT; SEX DIFFERENTIATION; STAR GENE; TESTIS FUNCTION; TESTOSTERONE RELEASE; ANIMAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GESTATIONAL AGE; GROWTH, DEVELOPMENT AND AGING; METABOLISM; NEWBORN; PREGNANCY; PRENATAL DEVELOPMENT; PRENATAL EXPOSURE; SPRAGUE DAWLEY RAT; TESTIS;

RATTUS;

ANIMALS; ANIMALS, NEWBORN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; MALE; PHTHALIC ACIDS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; SEX DIFFERENTIATION; TESTIS;

EID: 79952083051     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq386     Document Type: Article

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