Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome

International Immunology

Volumn 8, Issue 5, 1996, Pages 651-659

  Wentworth, Peggy A ^a   Sette, Alessandro ^a   Celis, Esteban ^a   Sidney, John ^a   Southwood, Scott ^a   Crimi, Claire ^a   Stitely, Suzette ^a   Keogh, Elissa ^a   Wong, Nanette C ^a   Livingston, Brian ^a   Alazard, David ^a   Vitiello, Antonella ^a,b   Grey, Howard M ^a,c   Chisari, Francis V ^d   Chesnut, Robert W ^a   Fikes, John ^a  

^a CYTEL CORPORATION   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

A2; Cytotoxic T lymphocyte; Epitope; Hepatitis C virus

Indexed keywords

EPITOPE; HLA A1 ANTIGEN; HLA A2 ANTIGEN; HLA A3 ANTIGEN; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CELL CULTURE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; VACCINE PRODUCTION; VIRUS GENOME;

EID: 9344219963     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.5.651     Document Type: Article

References (74)

1. Choo, Q.-L , Kuo, G , Weiner, A J , Overby, L R., Bradley, D W. and Houghton, M 1989. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome Science 244.359
2. Kuo, G , Choo, Q. L., Alter, H. J , Gitnick, G L , Redeker, A G , Purcell, R H., Miyamura, T , Dienstag, J. L., Alter, M J , Stevens, C E , Tegtmeier, G E., Bonino, F , Colombo, M , Lee, W.-S., Kuo, C., Berger, K , Shuster, J R , Overby, L R , Bradley, D W. and Houghton, M. 1989 An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244:362
3. Davis, G L 1989. Interferon treatment of viral hepatitis in immunocompromised patients Semin Liver Dis 9.267.
4. Alter, H. J 1989 Chronic consequences of non-A, non-B hepatitis. In Seeff, L B: and Lewis, J H., eds, Current Perspectives in Hepatology p 83. Plenum, New York.
5. Alter, M J , Margolis, H S , Krawczynski, K , Judson, F N., Mares, A , Alexander, W. J , Hu, P. Y , Miller, J K., Gerber, M A , Sampliner, R E , Meeks, E L and Beach, M. J. 1992. The natural history of community-acquired Hepatitis C in the United States, N Engl J Med 327:1899.
6. Dienstag, J L 1983 Non-A, non-B hepatitis recognition, epidemiology, and clinical features. Gastroenterology 85 430.
7. Davis, G L , Balart, L. A., Schiff, E. R , Lindsay, K., Bodenheimer, H C , Jr. Perrillo, R P , Carey, W., Jocobson, I M., Payne, J , Dienstag, J. L , VanThiel, D. H., Tamburro, C , Lefkowitch, J , Albrecht, J , Meschievitz, C , Ortego, T. J and Gibas, A 1989 Treatment of chronic hepatitis C with recombinant interferon alfa A multi-center randomized, controlled trial. N. Engl J. Med 321 1501
8. Colombo, M G , Kuo, G , Choo, Q.-L , Donato, M F , del Ninno, E Tommasini, M A , Dioguardi, N. and Houghton, M 1989. Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma Lancet II 1007
9. Saito, I , Miyamura, T , Ohbayashi, A , Harada, H , Katayama, T., Kikuchi, S , Watanabe, Y , Koi, S., Onji, M., Ohta, Y., Choo, Q-L., Houghton, M and Kuo, G. 1990 Hepatitis C virus infection is associated with the development of hepatodcellular carcinoma. Proc Natl Acad Sci USA 87 6547.
10. Hoofnagle, J H , Mullen, K D Jones, D. B., Rustgi, V , Dibisceglie, A , Peters, M , Waggoner, J G , Park, Y and Jones, E. A 1986. Treatment of non-A, non-B hepatitis with recombinant human alpha-interferon a preliminary report N Engl J Med 315:1575
11. DiBisceglie, A M , Martin, P , Kassiniedes, C., Lisker-Melman, M , Murray, L , Waggoner, J , Goodman, Z , Banks, S M. and Hoofnagle, J H 1989 Recombinant interferon-alpha therapy for chronic hepatitis C A randomized, double-blind, placebo-control trial N Engl. J Med 321 1506
12. Liang, T J , Rustgi, V , Galun, E. and Blum, H E 1993 HCV RNA in patients with chronic hepatitis C treated with interferon-α. J. Med Virol 40:69
13. Oldstone, M., Blount, P , Southern, P and Lampert, P. 1989. Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature 321:239
14. + T cells and nonspecific bone marrow-derived cells J Virol. 61:3930
15. Yap, K L., Ada, G L. and Mckenzie, I. F C 1978. Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature 273 238
16. Lukacher, A E., Braciale, V L. and Braciale, T J. 1994 In vivo effector function of influenzavirus, specific cytotoxic T lymphocyte clones is highly specific J Exp. Med. 160:814.
17. McMichael, A. J , Gotch, F. M., Noble, G. R. and Beare, P. A. S. 1983 Cytotoxic T-cell immunity to influenza N. Engl J. Med. 309:13
18. Sethi, K. K , Omata, Y. and Schnewer, K E. 1983. Protection of mice from fatal herpes simplex virus type 1 infection by adoptive transfer of virus-specific and H-2 restricted cytotoxic T lymphocytes. J Gen. Virol 64:443.
19. Watari, E., Dietzschold, B , Scokan, G and Heber-Katz, E 1987. Asynthetic peptide induces long-term protection from lethal infection with herpes simplex virus 2 J Exp. Med. 165.459
20. - herpes simplex virus-specific human cytotoxic T cells J Immunol 143.2051
21. + herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens. J Virol. 66.1622.
22. Reddenhase, M. J., Weiland, F., Munch, K., Jonjic, S., Luske, A. and Koszinowski, U. H 1985. Interstitial murine cytomegalovirus pneumonia after irradiation, characterization of cells that limit viral replication during established infection of the lungs. J. Virol 55:264
23. Quinnan, G. V., Kirmeni, N., Rook, A H , Manishevitz, J V., Jackson, L , Moreschi G., Santos, G W., Saral, R. and Burns, W H 1982 Cytotoxic T cells in cytomegalovirus infection HLA-restricted T-lymphocyte cytotoxic response correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients. N. Engl J. Med. 307.6.
24. Koziel, M. J , Dudley, D , Wong, J T., Dienstag, J., Houghton, M , Ralston, R. and Walker, B. D 1992 Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis. J Immunol. 149.3339
25. Koziel, M. J , Dudley, D., Afdhal, N , Choo, Q.-L., Houghton, M , Ralston, R. and Walker, B D 1993. Hepatitis C Virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J. Virol 67.7522
26. Cerny, A., McHutchison, J G., Pasquinelli, C , Brown, M. E , Brothers, M. A., Grabscheid, B., Fowler, P , Houghton, M. and Chisari, F V. 1995. Cytotoxic T lymphocyte response to Hepatitis C Virus-derived peptides containing the HLA A2 1 binding motif. J. Clin. Invest 95.521.
27. Cerny, A , Ferrari, C and Chisari, F V 1994 The class I restricted cytotoxic T lymphocyte response to predetermined epitopes in the hepatitis B and C viruses Curr Topics Microbiol Immunol 189 169.
28. Cerny, A , McHutchison, J G , Pasquinelli, C , Brown, M. E , Brothers, M A , Fowler, P , Houghton, M. and Chisari, F V 1994 Hepatitis C virus specific cytotoxic T cell response Identification of multiple HLA-A2 restricted epitopes In Abstracts of the 2nd International Meeting on Hepatitis C and Related Viruses, La Jolla CA July 31-August 5
29. Battegay, M., Akatsuka, T., DiBisceglie, A. M , Fikes, J , Wentworth, P , Ching, W. M., Berzofsky, J. A , Hoofnagle, J. H and Feinstone, S. M. 1994. HLA-A2 restricted cytotoxic T cells (CTL) recognize hepatitis C virus encoded NS4 and NS5 peptides strongly binding to HLA-A2. In Abstracts of the 2nd International Meeting on Hepatitis C and Related Viruses. La Jolla, CA. July 31-August 5.
30. Shirai, M , Okada, H., Nishioka, M., Akatsuka, T , Wychowski, C , Houghten, R , Pendleton, C D , Feinstone, S M. and Berzofsky, J. A 1994. An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans. J Virol. 68:3334
31. Shirai, M., Arichi, T., Nishhioka, M., Nomura, T., Ikeda, K , Kawanishi, K , Engelhard, V H , Feinstone, S M. and Berzofsky, J A. 1995. CTL responses of HLA-A2 1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2 1. J. Immunol 154:2733.
32. Battegay, M., Fikes, J , Di Bisceglie, A M , Wentworth, P A., Sette, A , Celis, E , Ching, W-M., Grakoui, A., Rice, C M , Kurokohchi, K , Berzofsky, J. A., Hoofnagle, J. H., Feinstone, S. M and Akatsuka, T 1995 Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2 1 molecules J Virol 69 2462
33. Prince, A. 1994. Challenges for development of hepatitis C virus vaccines FEMS Micro Rev. 14273
34. Carbone, F and Bevan, M 1989 Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization J. Exp Med 169.603.
35. Ishioka, G., Colón, S , Miles, C., Grey, H M. and Chesnut, R. W 1989 Induction of class I MHC-restricted, peptide-specific cytolytic T lymphocytes by peptide priming in vivo J Imunol. 143 1094
36. Deres, K , Schild, H , Wiesmüller, K , Jung, G. and Rammensee, H 1989. In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine. Nature 342 561.
37. Aichele, P., Hengartner, H. Zinkernagel, R. and Schulz, M 1990. Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide. J. Exp Med 171 1815
38. Vitiello, A., Ishioka, G , Grey, H M , Rose, R , Farness, P , LaFond, R , Yuan, L , Chisari, F V , Furze, J , Bartholomeuz, R and Chesnut, R. W 1995 Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. J. Clin Invest 95 341
39. - lymphocyte response in acutely infected rhesus monkeys. J Virol. 67:1707.
40. - cytotoxic T-cells in vivo by carrier-free HIV synthetic peptides Proc Natl Acad Sci USA 88 9448
41. Kast, W. M , Roux, L., Curren, J , Blom, H. J J Voordouw, A C., Meloen R H and Melief, C J M 1991 Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide. Proc. Natl Acad Sci. USA 88 2283.
42. - cytotoxic T lymphocytes by a 15-ammo acid unmodified free peptide from the immunodominant V3-loop of GP120. Virology 188:502
43. Schultz, M., Zindernagel, R M and Hengartner, H 1991 Peptide-induced antiviral prosection by cytotoxic T cells Proc Natl Acad Sci USA 88 991
44. Gao, X , Zheng, B , Liew, F Y , Brett S and Tite, J 1991 Priming of influenza virus-specific cytotoxic T lymphocytes in vivo by short synthetic peptides. J Immunol 147:3268
45. + T cell help J Immunol 147:4069.
46. Nardelli, B and Tam, J. P 1993 Cellular immune responses induced by in vivo priming with a lipid-conjugated multimeric antigen peptide. Immunology 79 355
47. + cytotoxic T lymphocytes J. Exp. Med. 176.1739
48. - T cells J. Immunol 150 2346.
49. + cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells Int Immunol 5.849
50. Zhou, X., Berg, L , Motal, U. M A and Jondal, M 1992 In vivo primary induction of virus-specific CTL by immunization with 9-mer synthetic peptides J. Immunol. Methods 153.193
51. Kast, M W , Brandt, R. M. P. and Melief, C J. M. 1993. Strict peptide length is not required for the induction of cytotoxic T lymphocyte-mediated antiviral protection by peptide vaccination. Eur J Immunol. 23 1189.
52. Moore, R L and Fox, B S. 1993. Immunization of mice with Human Immunodeficiency Virus glycoprotein gp160 peptide 315-329 induces both class I- and class II-restricted T cells, not all T cells can respond to whole molecule stimulation. AIDS Res Hum. Retrovir 9.51
53. Widmann, C , Romero, P , Maryanski, J L , Corradin, G and Valmori, D 1992 T helper epitopes enhance the cytotoxtc response of mice immunized with MHC class I-restricted malaria peptides. J. Immunol Methods 155 95.
54. Feltkamp, M C. W , Smits, H L., Vierboom, M P. M , Minnaar, R. P , de Jongh, B. M , Drijfhout, J W , ter Schegget, J , Melief, C J. M and Kast, W M 1993. Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells Eur J Immunol 23 2242.
55. Ogata, N., Alter, H. J., Miller, R. H and R H. Purcell, R H 1991. Nucleotide sequence and mutation rate of the H strain of hepatitis C virus. Proc Natl Acad Sci USA 88:3392
56. Okamoto, H , Kojima, M , Okada, S -I , Yoshizawa, H , Iizuka, H , Tanaka, T , Muchmore, E E , Peterson, D A , Ito, Y and Mishiro, S 1992. Genetic drift of hepatitis C virus during an 8.2 year infection in a chimpanzee variability and stability Virology 190:894
57. Taniguchi, S , Okamoto, H , Sakamoto, M , Kojima, M , Tsuda, F., Tanaka, T , Munekata, E , Muchmore, E E , Peterson, D A. and Mishiro, S 1993 A structurally flexible and antigenicaliy variable N-terminal domain of the hepatitis C virus E2/NS1 protein, implication for an escape from antibody. Virology 195 297
58. Kubo, R T , Sette, A , Grey, H M , Appella, E , Sakaguchi, K , Zhu, N -Z , Arnott, D , Sherman, N , Shabanowitz, J , Michel, H , Bodnar, W M , Davis, T A and Hunt, D. F. 1994 Definition of specific peptide motifs for four major HLA-A alleles J Immunol. 152:3913.
59. Kast, W M , Brandt, R. M P. Sidney, J , Drijfhout, J -W , Kubo, R T , Grey, H M , Melief, C J M and Sette, A. 1994. The role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins J Immunol. 152:3904
60. Faik, K , Rotzschke, O., Stevanovic, S , Jung, G and Rammensee, H-G 1991 Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules Nature 351 290
61. Di Brino M , Tsuchida, T , Turner, R V , Parker, K C , Coligan, J E and Biddison, W E 1993 HLA-A1 and HLA-A3 T-cell epitopes derived from Influenza virus proteins predicted from peptide binding motifs J. Immunol 151.5930
62. Sette, A , Sidney, J , del Guercio, M -F , Southwood, S , Ruppert, J Dahlberg, C , Grey, H M. and Kubo, R T 1994 Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays Mol. Imunol 31 813.
63. Sette, A , Vitiello, A , Reherman, B , Fowler, P., Nayersina, R , Kast, W M., Melief, C. J M., Oseroff, C., Yuan, L., Ruppert, J , Sidney, J , del Guercio, M.-F., Southwood, S., Kubo, R. T , Chesnut, R W., Grey, H M and Chisari, F 1994. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. J. Immunol. 153:5586.
64. O'Sullivan, D., Sidney, J , del Guercio, M.-F., Cólon, S M and Sette, A. 1991 Truncation analysis of several DR binding epitopes J Immunol 146 1240.
65. Ruppert, J., Sidney, J., Celis, E , Kubo, R. T., Grey, H. M. and Sette, A. 1993 Prominent role of secondary anchor residues in peptide binding to HLA A2 1 molecules Cell 74:929.
66. 131I-labeled human growth hormone of high specific radioactivity. Biochem J 89 114.
67. Wentworth, P A , Celis, E , Crimi, C., Stitely, S , Hale, L , Tsai, V., Serra, H M , del Guercio, M -F , Livingston, B , Alazard, D , Fikes, J , Kubo, R T , Grey, H. M., Chesnut, R W., Chisari, F. V and Sette, A 1995 In vitro induction of primary antigen-specific CTL from human peripheral blood mononuclear cells stimulated with synthetic peptides Mol Immunol 32:603
68. Vitiello, A , Marchesini, D , Furze, J , Sherman, L. A and Chesnut, R. W 1991 Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex J Exp Med. 173:1007
69. b-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs Eur J Immunol. 22 2663.
70. Parker, K. C , Bednarke, M. A., Hull, L K., Utz, U., Cunningham, B , Zweerink, H J , Biddison, W. E and Cooligan, J E 1992 Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2 J. Immunol 149:3580.
71. del Guercio, M.-F., Sidney, J , Hermanson, G , Perez, C , Grey, H. M., Kubo, R T and Sette, A 1995 Binding of an antigen peptide to multiple HLA alleles allows definition of an A2-like supermotif J Immunol. 154:685
72. Sidney, J , del Guercio, M-F , Southwood, S , Engelhard, V H., Appella, E , Rammensee, H.-G , Falk, K , Rotzschke, O., Takiguchi, M., Kubo, R T , Grey, H. M. and Sette, A 1995. Identification of broadly reactive peptide epitopes: several distinct HLA alleles recognize the same B7-like supermotif J. Immunol 154 247.
73. Sidney, J., Grey, H M , Southwood, S , Celis E , Wentworth, P A , del Guercio, M-F., Kubo, R T., Chesnut, R W and Sette, A 1996 Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide binding repertoires of common HLA molecules Hum Immunol in press
74. Sidney, J , Grey, H. M., Kubo, R. T and Sette, A 1996 Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs. Immunol. Today in press