α-Tocopherol is an effective Phase II enzyme inducer: Protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells

Journal of Nutritional Biochemistry

Volumn 21, Issue 12, 2010, Pages 1222-1231

  Feng, Zhihui ^a,b   Liu, Zhongbo ^a,b   Li, Xuesen ^a,b   Jia, Haiqun ^a,b   Sun, Lijuan ^c   Tian, Chuan ^a,b   Jia, Lihong ^d   Liu, Jiankang ^e  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c EAST CHINA NORMAL UNIVERSITY   (China)

^d CHINA MEDICAL UNIVERSITY   (China)

^e XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Glutamate cysteine ligase (GCL); Glutathione; Mitochondrial complex; NAD(P)H:quinone oxidoreductase 1 (NQO1); Nuclear factor E2 related factor 2 (Nrf2); Protein oxidation

Indexed keywords

ACROLEIN; ALPHA TOCOPHEROL; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL NUCLEUS; CELL PROTECTION; CELL VIABILITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INDUCTION; HUMAN; HUMAN CELL; MITOCHONDRION; OXIDATION; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PROTEIN EXPRESSION;

ACROLEIN; ALPHA-TOCOPHEROL; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE TRANSFERASE; HUMANS; LIPID PEROXIDATION; MITOCHONDRIA; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM; SMOKING; SUPEROXIDE DISMUTASE;

MAMMALIA;

EID: 78249255217     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.10.010     Document Type: Article

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