Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3 withdrawal: Relationship to caspase activity and the loss of glutathione

Cell Death and Differentiation

Volumn 6, Issue 1, 1999, Pages 61-70

  Bojes, Heidi K ^a   Feng, Xiang ^a   Kehrer, James P ^a   Cohen, Gerald M ^b  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Apoptosis; Caspases; FL5.12 cells; Glutathione; Interleukin 3

Indexed keywords

ACRIDINE ORANGE; BUTHIONINE SULFOXIMINE; CASPASE; ETHIDIUM BROMIDE; GLUTATHIONE; INTERLEUKIN 3; KETONE; LAMIN B; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HEMATOPOIETIC CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING;

ANIMALIA; MURINAE;

EID: 0032919769     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400452     Document Type: Article

References (58)

1. Arends MJ and Wyllie AH (1991) Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 32: 223-254
2. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of diseases. Science 267: 1456-1462
3. Earnshaw WC (1995) Nuclear changes in apoptosis. Curr. Opin. Cell Biol. 7: 337-343
4. Kumar S and Harvey NL (1995) Role of multiple cellular proteases in the execution of programmed cell death. FEBS Lett. 375: 169-173
5. Patel T, Gores GJ and Kaufmann SH (1996) The role of proteases during apoptosis. FASEB J. 10: 587-597
6. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem. J. 326: 1-16
7. Thornberry NA and Molineaux SM (1995) Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell death. Protein Sci. 4: 3-12
8. Henkart PA (1996) ICE family proteases: mediators of all apoptotic cell death? Immunity 4: 195-201
9. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG and Earnshaw WC (1994) Cleavage of poly(ADP-ribose)polymerase by a proteinase with properties like ICE. Nature 371: 346-347
10. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE and Poirier GG (1993) Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res. 53: 3976-3985
11. Song Q, Lees-Miller SP, Kumar S, Zhang Z, Chan DW, Smith GCM, Jackson SP, Alnemri ES, Litwack G, Khanna KK and Lavin MF (1996) DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J. 15: 3238-3246
12. Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yamin TT, Yu VL and Miller DK (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43
13. Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G, Earnshaw WC, Litweck G and Alnemri ES (1995) Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res. 55: 6045-6052
14. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, Towne E, Tracey D, Wardwell S, Wai F-Y, Wong W, Kamen R and Seshadri T (1995) Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80 401-411
15. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS and Flavell RA (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267: 2000-2003
16. Sandstrom PA, Mannie MD and Buttke TM (1994) Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: oxidative stress as a mediator of apoptosis. J. Leukoc. Biol. 55: 221-226
17. Sarafian TA and Bredesen DE (1994) Is apoptosis mediated by reactive oxygen species? Free Rad. Res. 21: 1-8
18. Payne CM, Bernstein C and Bernstein H (1995) Apoptosis overview emphasizing the role of oxidative stress, DNA damage and signal-transducing pathways. Leuk. Lymphoma 19: 43-93
19. Slater AF, Nobel CS, Maellaro E, Bustamante J, Kimland M and Orrenius S (1995) Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. Biochem. J. 306: 771-778
20. Satoh T, Sakai N, Enokido Y, Uchiyama Y and Hatanaka H (1996) Survival factor-insensitive generation of reactive oxygen species induced by serum deprivation. Brain Res. 733: 9-14
21. Watson RW, Rotstein OD, Nathens AB, Dachiw AP and Marshall JC (1996) Thiol-mediated redox regulation of neutrophil apoptosis. Surgery 120: 150-157
22. Bojes HK, Datta K, Xu J, Chin A, Simonian P, Nunez G and Kehrer JP (1997) Bcl-xL overexpression attenuates glutathione depletion in FL5. 12 cells following IL-3 withdrawal. Biochem. J. 325: 315-319
23. Beaver JP and Waring P (1995) A decrease in intracellular glutathione concentration precedes the onset of apoptosis in murine thymocytes. Eur. J. Cell Biol. 68: 47-54
24. van den Dobblesteen DJ, Nobel CS, Schlegel J, Cotgreave IA, Orrenius S and Slater AF (1996) Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J. Biol. Chem. 271: 15420-15427
25. Ghibelli L, Fanelli C, Rotilio G, Lafavia E, Coppola S, Colussi C, Civitareale P and Ciriolo MR (1998) Rescue of cells from apoptosis by inhibition of active GSH extrusion. FASEB J 12: 479-486
26. Zhu H, Fearnhead HO and Cohen GM (1995) An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells. FEBS Lett. 374: 303-308
27. MacFarlane M, Cane K, Sun X-M, Alnemri ES and Cohen GM (1997) Processing/activation of at least four interleukin-1β converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells. J. Cell Biol. 137: 469-479
28. Armstrong RC, Aja T, Xiang J, Gaur S, Krebs JF, Hoang K, Bai X, Korsmeyer SJ, Karanewsky DS, Fritz LC and Tomaselli KJ (1996) Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors. J. Biol. Chem. 271: 16850-16855
29. Duke RC and Cohen JJ (1992) In: Current Protocols in Imunology; Colligan JE and Kruisbeak AM, eds. John Wiley and Sons: New York pp. 3.17.1-3.17.6
30. Deshmunk M, Vasilakos J, Deckwerth TL, Lampe PA, Shivers BD and Johnson Jr EM (1996) Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. J. Cell Biol. 135: 1341-1354
31. Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssiere J-L, Petit PX and Kroemer G (1995) Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181: 1661-1672
32. Petit PX, Lecouer H, Zorn E, Dauguet C, Mignotte B and Gougeon ML (1995) Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J. Cell Biol. 130: 157-167
33. Kroemer G, Petit PX, Zamzami N, Vayssiere J-L and Mignotte B (1995) The biochemistry of programmed cell death. FASEB J 9: 1277-1287
34. Fernandes-Alnemri T, Litwack G and Alnemri ES (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzymes. J. Biol. Chem. 269: 30761-30764
35. Orth K, Chinnaiyan AM, Garg M, Froelich CJ and Dixit VM (1996) The CED-3/ ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J. Biol. Chem. 271: 16443-16446
36. Takahashi A, Alnemri ES, Lazebnik YA, Fernandes-Alnemri T, Litwack G, Moir RD, Golman RD, Poirier GG, Kaufman SH and Earnshaw WC (1996) Cleavage of lamin A by Mch2α but not CPP32: multiple interleukin 1β-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc. Natl. Acad. Sci. 93: 8395-8400
37. Ohta T, Kinoshita T, Naito M, Nozaki T, Masutani M, Tsuruo T and Miyajima A (1997) Requirement of the caspase-3/CPP32 protease cascade for apoptotic death following cytokine deprivation in hematopoietic cells. J. Biol. Chem. 272: 23111-23116
38. Vasilakos JP, Lynch T, Ghayur T, Giegel DA, Santoro M and Shivers BD (1997) Caspase-3/CPP32-like activity is not sufficient to mediate apoptosis in an L-2 dependent T cell line. Apoptosis 2: 289-303
39. Xiang J, Chao DT and Korsmeyer SJ (1996) BAX-induced ce l death may not require interleukin-1 beta-converting enzyme-like proteases. Proc. Natl. Acad. Sci. 93: 14559-14563
40. McCarthy NJ, Whyte MKB, Gilbert CS and Evan GI (1997) Inhibition of Ced-3/ ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J. Cell Biol. 136: 215-227
41. Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmunk M, Korsmeyer SJ and Johnson Jr EM (1997) Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J. Cell Biol. 139: 205-217
42. Liu X, Kim CN, Yang J, Jemmerson R and Wang X (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147-157
43. Benson RSP, Dive C and Watson AJM (1998) Comparative effects of Bcl-2 overexpression and ZVAD.FMK treatment on dexamethason and VP16-induced apoptosis in CEM cells. Cell Death Differ. 5: 432-439
44. Brunet CL, Gunby RH, Benson RSP, Hickman JA, Watson AJM and Brady G (1998) Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers. Cell Death Differ. 5: 107-115
45. Hirsch T, Marchetti P, Susin SA, Dallaporta B, Zamzami N, Marzo I, Geuskens M and Kroemer G (1997) The apoptosis-necrosis paradox, Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene 15: 1573-1581
46. Vasilakos JP, Ghayur T, Carroll RT, Giegel DA, Saunders JM, Quintal L, Keane KM and Shivers BD (1995) IL-1 beta converting enzyme (ICE) is not required for apoptosis induced by lymphokine deprivation in an IL-2-dependent T cell line. J. Immunol. 155: 3433-3442
47. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bertz JD, Zhang M, Getz R, Mann M, Krammer PH, Peter ME, Dixit VM (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827
48. Boldin MP, Goncharov TM, Goltsev YV and Wallach D (1996) Involvement of MACH, a novel MORT/FADD-interacting protease, in Fas/APO-1 and TNF receptor-induced cell death. Cell 85: 803-815
49. Voehringer DW, McConkey DJ, McDonnell TJ, Brisbay S and Meyn RE (1998) Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc. Natl. Acad. Sci. USA 94: 2956-2960
50. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T and Bredesen DE (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262: 1274-1277
51. Mirkovic N, Voehringer DW, Story MD, McConkey DJ, McDonnell TJ and Meyn RE (1997) Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols. Oncogene 15: 1461-1470
52. Sato N, Iwata S, Nakamura K, Hori T, Mori K and Yodoi J (1995) Thiol-mediated redox regulation of apoptosis. Possible roles of cellular th ols other than glutathione in T cell apoptosis. J. Immunol. 154: 3194-3203
53. Hampton MB and Orrenius S (1997) Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett. 414: 552-556
54. Lee JC, Hapel AJ and Ihle JN (1982) Constitutive production of a unique lymphokine (IL-3) by WEHI-3 cell line. J Immunol 128: 2393-2398
55. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST and van Oers MH (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84: 1415-1420
56. Vermes I, Haanen C, Steffens-Nakken H and Reutelingsperger C (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods 184: 39-51
57. Martin J and White IN (1991) Fluorimetric determination of oxidised and reduced glutathione in cells and tissues by high-performance liquid chromatography following dervatization with dansyl chloride. J. Chromatogr. 568: 219-225
58. Mizushima N, Koike R, Kohsaka H, Kushi Y, Handa S, Yagita H and Miyasaka N (1996) Ceramide incudes apoptosis via CPP32 activation. FEBS Lett. 395: 267-271