Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated cdt1 proteolysis during S phase and following UV irradiation

Molecular and Cellular Biology

Volumn 32, Issue 12, 2012, Pages 2279-2288

  Shiomi, Yasushi ^a   Hayashi, Akiyo ^a   Ishii, Takashi ^a   Shinmyozu, Kaori ^b   Nakayama, Jun ichi ^b   Sugasawa, Kaoru ^c   Nishitani, Hideo ^a  

^a UNIVERSITY OF HYOGO   (Japan)

^b RIKEN Center for Biosystems Dynamics Research   (Japan)

^c KOBE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CRL4 ENZYME; CYCLINE; REPLICATION FACTOR C; REPLICATION FACTOR CTF18; REPLICATION FACTOR RFC1; S PHASE KINASE ASSOCIATED PROTEIN 2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL CYCLE S PHASE; CHROMATIN; DNA REPAIR; DNA REPLICATION; EXCISION REPAIR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; SEQUENCE ANALYSIS; UBIQUITINATION; ULTRAVIOLET IRRADIATION;

CARRIER PROTEINS; CELL CYCLE PROTEINS; HELA CELLS; HUMANS; NUCLEAR PROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEOLYSIS; REPLICATION PROTEIN C; S PHASE; UBIQUITIN-PROTEIN LIGASES; ULTRAVIOLET RAYS;

EID: 84864007900     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.06506-11     Document Type: Article

References (58)

1. Abbas T, et al. 2010. CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Mol. Cell 40: 9-21.
2. Abbas T, et al. 2008. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev. 22:2496-2506.
3. Ansbach AB, et al. 2008. RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe. Mol. Biol. Cell 19:595-607.
4. Arias EE, Walter JC. 2006. PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. Nat. Cell Biol. 8:84-90.
5. Arias EE, Walter JC. 2007. Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev. 21:497-518.
6. Aroya SB, Kupiec M. 2005. The Elg1 replication factor C-like complex: a novel guardian of genome stability. DNA Repair (Amst.) 4:409-417.
7. Blow JJ, Dutta A. 2005. Preventing re-replication of chromosomal DNA. Nat. Rev. Mol. Cell Biol. 6:476-486.
8. Bravo R, Macdonald-Bravo H. 1987. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J. Cell Biol. 105:1549-1554.
9. Centore RC, et al. 2010. CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol. Cell 40:22-33.
10. Dinant C, Houtsmuller AB, Vermeulen W. 2008. Chromatin structure and DNA damage repair. Epigenetics Chromatin 1:9. doi:10.1186/1756-8935-1-9.
11. Friedberg EC, et al. 2006. DNA repair: from molecular mechanism to human disease. DNA Repair (Amst.) 5:986-996.
12. Gillet LC, Scharer OD. 2006. Molecular mechanisms of mammalian global genome nucleotide excision repair. Chem. Rev. 106:253-276.
13. Guarino E, et al. 2011. Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation. Nucleic Acids Res. 39:5978-5990.
14. Hanna JS, Kroll ES, Lundblad V, Spencer FA. 2001. Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. Mol. Cell. Biol. 21:3144-3158.
15. Havens CG, Walter JC. 2009. Docking of a specialized PIP box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2. Mol. Cell 35:93-104.
16. Havens CG, Walter JC. 2011. Mechanism of CRL4Cdt2, a PCNAdependent E3 ubiquitin ligase. Genes Dev. 25:1568-1582.
17. He YJ, McCall CM, Hu J, Zeng Y, Xiong Y. 2006. DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev. 20:2949-2954.
18. Higa LA, et al. 2006. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat. Cell Biol. 8:1277-1283.
19. Ishii T, et al. 2010. Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells. J. Biol. Chem. 285:41993-42000.
20. Jin J, Arias EE, Chen J, Harper JW, Walter JC. 2006. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol. Cell 23:709-721.
21. Jorgensen S, et al. 2011. SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J. Cell Biol. 192:43-54.
22. Kanellis P, Agyei R, Durocher D. 2003. Elg1 forms an alternative PCNAinteracting RFC complex required to maintain genome stability. Curr. Biol. 13:1583-1595.
23. Katayama T, Kubota T, Kurokawa K, Crooke E, Sekimizu K. 1998. The initiator function of DnaA protein is negatively regulated by the sliding clamp of the E. coli chromosomal replicase. Cell 94:61-71.
24. Kim DH, et al. 2010. The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA. Mol. Cell. Biol. 30:4120-4133.
25. Kim J, MacNeill SA. 2003. Genome stability: a new member of the RFC family. Curr. Biol. 13:R873-R875.
26. Kim Y, Starostina NG, Kipreos ET. 2008. The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing. Genes Dev. 22:2507-2519.
27. Lengronne A, et al. 2006. Establishment of sister chromatid cohesion at the S. cerevisiae replication fork. Mol. Cell 23:787-799.
28. Liu E, Li X, Yan F, Zhao Q, Wu X. 2004. Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation. J. Biol. Chem. 279:17283-17288.
29. Majka J, Burgers PM. 2004. The PCNA-RFC families of DNA clamps and clamp loaders. Prog. Nucleic Acid Res. Mol. Biol. 78:227-260.
30. Mayer ML, Gygi SP, Aebersold R, Hieter P. 2001. Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol. Cell 7:959-970.
31. Melixetian M, et al. 2004. Loss of geminin induces rereplication in the presence of functional p53. J. Cell Biol. 165:473-482.
32. Michishita M, et al. 2011. Positively charged residues located downstream of PIP box, together with TD amino acids within PIP box, are important for CRL4(Cdt2)-mediated proteolysis. Genes Cells 16:12-22.
33. Moldovan GL, Pfander B, Jentsch S. 2006. PCNA controls establishment of sister chromatid cohesion during S phase. Mol. Cell 23:723-732.
34. Nichols AF, Sancar A. 1992. Purification of PCNA as a nucleotide excision repair protein. Nucleic Acids Res. 20:2441-2446.
35. Nishitani H, et al. 1991. Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J. 10:1555-1564.
36. Nishitani H, et al. 2008. CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation. J. Biol. Chem. 283:29045-29052.
37. Nishitani H, et al. 2006. Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J. 25:1126-1136.
38. Nishitani H, Taraviras S, Lygerou Z, Nishimoto T. 2001. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 276:44905-44911.
39. Nurse P. 1994. Ordering S phase and M phase in the cell cycle. Cell 79:547-550.
40. Oda H, et al. 2010. Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol. Cell 40:364-376.
41. Ogi T, et al. 2010. Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells. Mol. Cell 37:714-727.
42. Overmeer RM, et al. 2010. Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment. Mol. Cell. Biol. 30:4828-4839.
43. Roukos V, et al. 2011. Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage. J. Cell Sci. 124:422-434.
44. Sansam CL, et al. 2006. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes Dev. 20:3117-3129.
45. Senga T, et al. 2006. PCNA is a cofactor for Cdt1 degradation by CUL4/ DDB1-mediated N-terminal ubiquitination. J. Biol. Chem. 281:6246-6252.
46. Sherwood R, Takahashi TS, Jallepalli PV. 2010. Sister acts: coordinating DNA replication and cohesion establishment. Genes Dev. 24:2723-2731.
47. Shibata E, Abbas T, Huang X, Wohlschlegel JA, Dutta A. 2011. Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex. Mol. Cell. Biol. 31:3136-3145.
48. Shiomi Y, Masutani C, Hanaoka F, Kimura H, Tsurimoto T. 2007. A second proliferating cell nuclear antigen loader complex, Ctf18-replication factor C, stimulates DNA polymerase eta activity. J. Biol. Chem. 282:20906-20914.
49. Shiomi Y, et al. 2004. The reconstituted human Chl12-RFC complex functions as a second PCNA loader. Genes Cells 9:279-290.
50. Shivji KK, Kenny MK, Wood RD. 1992. Proliferating cell nuclear antigen is required for DNA excision repair. Cell 69:367-374.
51. Sugimoto N, et al. 2004. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. J. Biol. Chem. 279:19691-19697.
52. Tardat M, et al. 2010. The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells. Nat. Cell Biol. 12:1086-1093.
53. Terret ME, Sherwood R, Rahman S, Qin J, Jallepalli PV. 2009. Cohesin acetylation speeds the replication fork. Nature 462:231-234.
54. Vaziri C, et al. 2003. A p53-dependent checkpoint pathway prevents rereplication. Mol. Cell 11:997-1008.
55. Waga S, Stillman B. 1998. The DNA replication fork in eukaryotic cells. Annu. Rev. Biochem. 67:721-751.
56. Wang SC, et al. 2006. Tyrosine phosphorylation controls PCNA function through protein stability. Nat. Cell Biol. 8:1359-1368.
57. Zhu W, Chen Y, Dutta A. 2004. Rereplication by depletion of geminin is seen regardless of p53 status and activates a G2/M checkpoint. Mol. Cell. Biol. 24:7140-7150.
58. Zou L, Cortez D, Elledge SJ. 2002. Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16:198-208.