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Volumn 2, Issue 1, 2012, Pages

Clinical and molecular characterization of early T-cell precursor leukemia: A high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations

Author keywords

Acute lymphoblastic leukemia; ETP ALL; FLT3; Molecular characteristics; NOTCH1; T ALL

Indexed keywords

ANTINEOPLASTIC AGENT; BAALC PROTEIN; CD135 ANTIGEN; FBXW7 PROTEIN; INSULIN LIKE GROWTH FACTOR BINDING PROTEIN 7; NOTCH1 RECEPTOR; PROTEIN; SOMATOMEDIN BINDING PROTEIN; SURVIVAL MOTOR NEURON PROTEIN 1; UNCLASSIFIED DRUG; WT1 PROTEIN;

EID: 84863966948     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2011.49     Document Type: Article
Times cited : (105)

References (65)
  • 1
    • 37549010335 scopus 로고    scopus 로고
    • Launching the T-cell-lineage developmental programme
    • Rothenberg EV, Moore JE, Yui MA. Launching the T-cell-lineage developmental programme. Nat Rev Immunol 2008; 8: 9-21.
    • (2008) Nat Rev Immunol , vol.8 , pp. 9-21
    • Rothenberg, E.V.1    Moore, J.E.2    Yui, M.A.3
  • 2
    • 77958124683 scopus 로고    scopus 로고
    • Early T cell differentiation lessons from T-cell acute lymphoblastic leukemia
    • Tremblay CS, Hoang T, Hoang T. Early T cell differentiation lessons from T-cell acute lymphoblastic leukemia. Prog Mol Biol Transl Sci 2010; 92: 121-156.
    • (2010) Prog Mol Biol Transl Sci , vol.92 , pp. 121-156
    • Tremblay, C.S.1    Hoang, T.2    Hoang, T.3
  • 3
    • 42049087865 scopus 로고    scopus 로고
    • The earliest thymic progenitors for T cells possess myeloid lineage potential
    • DOI 10.1038/nature06840, PII NATURE06840
    • Bell JJ, Bhandoola A. The earliest thymic progenitors for T cells possess myeloid lineage potential. Nature 2008; 452: 764-767. (Pubitemid 351521083)
    • (2008) Nature , vol.452 , Issue.7188 , pp. 764-767
    • Bell, J.J.1    Bhandoola, A.2
  • 4
    • 58749095816 scopus 로고    scopus 로고
    • Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia
    • Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D et al. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol 2009; 10: 147-156.
    • (2009) Lancet Oncol , vol.10 , pp. 147-156
    • Coustan-Smith, E.1    Mullighan, C.G.2    Onciu, M.3    Behm, F.G.4    Raimondi, S.C.5    Pei, D.6
  • 5
    • 78649516513 scopus 로고    scopus 로고
    • Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia
    • Meijerink JP. Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia. Best Pract Res Clin Haematol 2010; 23: 307-318.
    • (2010) Best Pract Res Clin Haematol , vol.23 , pp. 307-318
    • Meijerink, J.P.1
  • 6
    • 59449106454 scopus 로고    scopus 로고
    • T-cell acute lymphoblastic leukemia
    • Chiaretti S, Foa R. T-cell acute lymphoblastic leukemia. Haematologica 2009; 94: 160-162.
    • (2009) Haematologica , vol.94 , pp. 160-162
    • Chiaretti, S.1    Foa, R.2
  • 7
    • 80053340687 scopus 로고    scopus 로고
    • Sucessful subtype oriented treatment strategies in adult T-ALL: Results of 744 patients treated in three consecutive GMALL studies
    • Hoelzer D, Thiel E, Arnold R, Beck J, Beelen D, Bornhäuser M et al. Sucessful subtype oriented treatment strategies in adult T-ALL: results of 744 patients treated in three consecutive GMALL studies. Blood 2009; 144: 324.
    • (2009) Blood , vol.144 , pp. 324
    • Hoelzer, D.1    Thiel, E.2    Arnold, R.3    Beck, J.4    Beelen, D.5    Bornhäuser, M.6
  • 8
    • 79551699535 scopus 로고    scopus 로고
    • New strategies in acute lymphoblastic leukemia: Translating advances in genomics into clinical practice
    • Mullighan CG. New strategies in acute lymphoblastic leukemia: translating advances in genomics into clinical practice. Clin Cancer Res 2011; 17: 396-400.
    • (2011) Clin Cancer Res , vol.17 , pp. 396-400
    • Mullighan, C.G.1
  • 12
    • 0042527713 scopus 로고    scopus 로고
    • + B-cell phenotype
    • DOI 10.1038/sj.leu.2402989
    • Schwartz S, Rieder H, Schlager B, Burmeister T, Fischer L, Thiel E. Expression of the human homologue of rat NG2 in adult acute lymphoblastic leukemia: close association with MLL rearrangement and a CD10(-)/CD24(-)/ CD65s(+)/CD15(+) B-cell phenotype. Leukemia 2003; 17: 1589-1595. (Pubitemid 36986961)
    • (2003) Leukemia , vol.17 , Issue.8 , pp. 1589-1595
    • Schwartz, S.1    Rieder, H.2    Schlager, B.3    Burmeister, T.4    Fischer, L.5    Thiel, E.6
  • 14
    • 77953219717 scopus 로고    scopus 로고
    • Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia
    • Heesch S, Goekbuget N, Stroux A, Tanchez JO, Schlee C, Burmeister T et al. Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia. Haematologica 2010; 95: 942-949.
    • (2010) Haematologica , vol.95 , pp. 942-949
    • Heesch, S.1    Goekbuget, N.2    Stroux, A.3    Tanchez, J.O.4    Schlee, C.5    Burmeister, T.6
  • 15
    • 33845263501 scopus 로고    scopus 로고
    • High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics
    • DOI 10.1182/blood-2006-04-014845
    • Heuser M, Beutel G, Krauter J, Döhner K, von Neuhoff N, Schlegelberger B et al. High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogenetics. Blood 2006; 108: 3898-3905. (Pubitemid 44864574)
    • (2006) Blood , vol.108 , Issue.12 , pp. 3898-3905
    • Heuser, M.1    Beutel, G.2    Krauter, J.3    Dohner, K.4    Von Neuhoff, N.5    Schlegelberger, B.6    Ganser, A.7
  • 17
    • 70349642839 scopus 로고    scopus 로고
    • Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia
    • Baldus CD, Thibaut J, Goekbuget N, Stroux A, Schlee C, Mossner M et al. Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia. Haematologica 2009; 94: 1383-1390.
    • (2009) Haematologica , vol.94 , pp. 1383-1390
    • Baldus, C.D.1    Thibaut, J.2    Goekbuget, N.3    Stroux, A.4    Schlee, C.5    Mossner, M.6
  • 19
    • 77955711085 scopus 로고    scopus 로고
    • BAALCassociated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia
    • Heesch S, Schlee C, Neumann M, Stroux A, Kühnl A, Schwartz S et al. BAALCassociated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia. Leukemia 2010; 24: 1429-1436.
    • (2010) Leukemia , vol.24 , pp. 1429-1436
    • Heesch, S.1    Schlee, C.2    Neumann, M.3    Stroux, A.4    Kühnl, A.5    Schwartz, S.6
  • 20
    • 0029069227 scopus 로고
    • Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias
    • Menssen HD, Renkl HJ, Rodeck U, Maurer J, Notter M, Schwartz S et al. Presence of Wilms' tumor gene (wt1) transcripts and the WT1 nuclear protein in the majority of human acute leukemias. Leukemia 1995; 9: 1060-1067.
    • (1995) Leukemia , vol.9 , pp. 1060-1067
    • Menssen, H.D.1    Renkl, H.J.2    Rodeck, U.3    Maurer, J.4    Notter, M.5    Schwartz, S.6
  • 21
    • 34748824109 scopus 로고    scopus 로고
    • MN1, a novel player in human AML
    • DOI 10.1016/j.bcmd.2007.06.009, PII S1079979607001258
    • Grosveld GC. MN1, a novel player in human AML. Blood Cells Mol Dis 2007; 39: 336-339. (Pubitemid 47484474)
    • (2007) Blood Cells, Molecules, and Diseases , vol.39 , Issue.3 , pp. 336-339
    • Grosveld, G.C.1
  • 22
    • 34250837539 scopus 로고    scopus 로고
    • The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for notch signaling
    • DOI 10.1158/0008-5472.CAN-06-4381
    • Malyukova A, Dohda T, von der LN, Akhoondi S, Corcoran M, Heyman M et al. The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling. Cancer Res 2007; 67: 5611-5616. (Pubitemid 46984990)
    • (2007) Cancer Research , vol.67 , Issue.12 , pp. 5611-5616
    • Malyukova, A.1    Dohda, T.2    Von Der Lehr, N.3    Akhondi, S.4    Corcoran, M.5    Heyman, M.6    Spruck, C.7    Grander, D.8    Lendahl, U.9    Sangfelt, O.10
  • 25
    • 78650305754 scopus 로고    scopus 로고
    • The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function
    • Kox C, Zimmermann M, Stanulla M, Schrappe M, Ludwig WD, Koehler R. The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function. Leukemia 2010; 24: 2005-2013.
    • (2010) Leukemia , vol.24 , pp. 2005-2013
    • Kox, C.1    Zimmermann, M.2    Stanulla, M.3    Schrappe, M.4    Ludwig, W.D.5    Koehler, R.6
  • 26
    • 78650311120 scopus 로고    scopus 로고
    • NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951
    • Clappier E, Collette S, Grardel N, Suarez L, Brunie G, Kaltenbach S et al. NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951. Leukemia 2010; 24: 2023-2031.
    • (2010) Leukemia , vol.24 , pp. 2023-2031
    • Clappier, E.1    Collette, S.2    Grardel, N.3    Suarez, L.4    Brunie, G.5    Kaltenbach, S.6
  • 27
    • 78650307928 scopus 로고    scopus 로고
    • NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols
    • Zuurbier L, Homminga I, Calvert V, te Winkel ML, Buijs-Gladdines JG, Kooi C et al. NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols. Leukemia 2010; 24: 2014-2022.
    • (2010) Leukemia , vol.24 , pp. 2014-2022
    • Zuurbier, L.1    Homminga, I.2    Calvert, V.3    Te Winkel, M.L.4    Buijs-Gladdines, J.G.5    Kooi, C.6
  • 28
    • 78650333573 scopus 로고    scopus 로고
    • NOTCH mutations as prognostic markers in T-ALL
    • Ferrando A. NOTCH mutations as prognostic markers in T-ALL. Leukemia 2010; 24: 2003-2004.
    • (2010) Leukemia , vol.24 , pp. 2003-2004
    • Ferrando, A.1
  • 29
    • 33747155025 scopus 로고    scopus 로고
    • Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
    • DOI 10.1182/blood-2005-12-4956
    • Breit S, Stanulla M, Flohr T, Schrappe M, Ludwig WD, Tolle G et al. Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood 2006; 108: 1151-1157. (Pubitemid 44232009)
    • (2006) Blood , vol.108 , Issue.4 , pp. 1151-1157
    • Breit, S.1    Stanulla, M.2    Flohr, T.3    Schrappe, M.4    Ludwig, W.-D.5    Tolle, G.6    Happich, M.7    Muckenthaler, M.U.8    Kulozik, A.E.9
  • 30
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • DOI 10.1182/blood-2002-02-0492
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood 2002; 100: 1532-1542. (Pubitemid 34925124)
    • (2002) Blood , vol.100 , Issue.5 , pp. 1532-1542
    • Gary Gilliland, D.1    Griffin, J.D.2
  • 31
    • 38049016563 scopus 로고    scopus 로고
    • Detection of FLT3 gene and FLT3/ITD mutation by polymerase chain reaction-single-strand conformation polymorphism in patients with acute lymphoblastic leukemia
    • Xu B, Li L, Tang JH, Zhou SY. Detection of FLT3 gene and FLT3/ITD mutation by polymerase chain reaction-single-strand conformation polymorphism in patients with acute lymphoblastic leukemia. Di Yi Jun Yi Da Xue Xue Bao 2005; 25: 1207-1210.
    • (2005) Di Yi Jun Yi da Xue Xue Bao , vol.25 , pp. 1207-1210
    • Xu, B.1    Li, L.2    Tang, J.H.3    Zhou, S.Y.4
  • 33
    • 73949110789 scopus 로고    scopus 로고
    • T-cell acute lymphoblastic leukemia in adults: Clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)
    • Marks DI, Paietta EM, Moorman AV, Richards SM, Buck G, DeWald G et al. T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993). Blood 2009; 114: 5136-5145.
    • (2009) Blood , vol.114 , pp. 5136-5145
    • Marks, D.I.1    Paietta, E.M.2    Moorman, A.V.3    Richards, S.M.4    Buck, G.5    Dewald, G.6
  • 34
    • 57649126380 scopus 로고    scopus 로고
    • Treatment of adult acute lymphoblastic leukemia
    • Gokbuget N, Hoelzer D. Treatment of adult acute lymphoblastic leukemia. Semin Hematol 2009; 46: 64-75.
    • (2009) Semin Hematol , vol.46 , pp. 64-75
    • Gokbuget, N.1    Hoelzer, D.2
  • 35
    • 79551693621 scopus 로고    scopus 로고
    • Patients with early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) have high levels of minimal residual disease (MRD) at the end of induction-A Children's Oncology Group (COG) Study
    • Wood B, Winter S, Dunsmore K, Raetz E, Borowitz M, Devidas M et al. Patients with early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) have high levels of minimal residual disease (MRD) at the end of induction-a Children's Oncology Group (COG) Study. Blood 2009; 114: 9.
    • (2009) Blood , vol.114 , pp. 9
    • Wood, B.1    Winter, S.2    Dunsmore, K.3    Raetz, E.4    Borowitz, M.5    Devidas, M.6
  • 36
    • 76749102418 scopus 로고    scopus 로고
    • Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000
    • Moricke A, Zimmermann M, Reiter A, Henze G, Schrauder A, Gadner H et al. Long-term results of five consecutive trials in childhood acute lymphoblastic leukemia performed by the ALL-BFM study group from 1981 to 2000. Leukemia 2010; 24: 265-284.
    • (2010) Leukemia , vol.24 , pp. 265-284
    • Moricke, A.1    Zimmermann, M.2    Reiter, A.3    Henze, G.4    Schrauder, A.5    Gadner, H.6
  • 37
    • 76749138468 scopus 로고    scopus 로고
    • Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia
    • Pui CH, Pei D, Sandlund JT, Ribeiro RC, Rubnitz JE, Raimondi SC et al. Long-term results of St Jude Total Therapy Studies 11, 12, 13A, 13B, and 14 for childhood acute lymphoblastic leukemia. Leukemia 2010; 24: 371-382.
    • (2010) Leukemia , vol.24 , pp. 371-382
    • Pui, C.H.1    Pei, D.2    Sandlund, J.T.3    Ribeiro, R.C.4    Rubnitz, J.E.5    Raimondi, S.C.6
  • 38
    • 79952095577 scopus 로고    scopus 로고
    • Modern therapy of acute lymphoblastic leukemia
    • Bassan R, Hoelzer D. Modern therapy of acute lymphoblastic leukemia. J Clin Oncol 2011; 29: 532-543.
    • (2011) J Clin Oncol , vol.29 , pp. 532-543
    • Bassan, R.1    Hoelzer, D.2
  • 43
    • 77952566819 scopus 로고    scopus 로고
    • High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia
    • Kuhnl A, Gokbuget N, Stroux A, Burmeister T, Neumann M, Heesch S et al. High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia. Blood 2010; 115: 3737-3744.
    • (2010) Blood , vol.115 , pp. 3737-3744
    • Kuhnl, A.1    Gokbuget, N.2    Stroux, A.3    Burmeister, T.4    Neumann, M.5    Heesch, S.6
  • 44
    • 84863950111 scopus 로고    scopus 로고
    • Gene expression profiling identifies IGFBP-7 as a BAALC co-expressed gene with a functional role in acute leukemia
    • Heesch S, Schlee C, Neumann M, Stroux A, Kuehnl A, Schwartz S et al. Gene expression profiling identifies IGFBP-7 as a BAALC co-expressed gene with a functional role in acute leukemia. Blood 2009; 114: 2629.
    • (2009) Blood , vol.114 , pp. 2629
    • Heesch, S.1    Schlee, C.2    Neumann, M.3    Stroux, A.4    Kuehnl, A.5    Schwartz, S.6
  • 45
    • 79953735093 scopus 로고    scopus 로고
    • Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia
    • Homminga I, Pieters R, Langerak AW, de Rooi JJ, Stubbs A, Verstegen M et al. Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. Cancer Cell 2011; 19: 484-497.
    • (2011) Cancer Cell , vol.19 , pp. 484-497
    • Homminga, I.1    Pieters, R.2    Langerak, A.W.3    De Rooi, J.J.4    Stubbs, A.5    Verstegen, M.6
  • 47
    • 53749101166 scopus 로고    scopus 로고
    • Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: A cancer and leukemia group B study
    • Paschka P, Marcucci G, Ruppert AS, Whitman SP, Mrózek K, Maharry K et al. Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 2008; 26: 4595-4602.
    • (2008) J Clin Oncol , vol.26 , pp. 4595-4602
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3    Whitman, S.P.4    Mrózek, K.5    Maharry, K.6
  • 50
    • 56749098118 scopus 로고    scopus 로고
    • Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: The United Kingdom Medical Research Council Adult Leukaemia Working Party
    • Virappane P, Gale R, Hills R, Kakkas I, Summers K, Stevens J et al. Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party. J Clin Oncol 2008; 26: 5429-5435.
    • (2008) J Clin Oncol , vol.26 , pp. 5429-5435
    • Virappane, P.1    Gale, R.2    Hills, R.3    Kakkas, I.4    Summers, K.5    Stevens, J.6
  • 51
    • 77954522198 scopus 로고    scopus 로고
    • Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223
    • Chiaretti S, Messina M, Tavolaro S, Zardo G, Elia L, Vitale A et al. Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223. Haematologica 2010; 95: 1114-1121.
    • (2010) Haematologica , vol.95 , pp. 1114-1121
    • Chiaretti, S.1    Messina, M.2    Tavolaro, S.3    Zardo, G.4    Elia, L.5    Vitale, A.6
  • 53
    • 33646366173 scopus 로고    scopus 로고
    • Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
    • Grabher C, von Boehmer H, Look AT. Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 2006; 6: 347-359.
    • (2006) Nat Rev Cancer , vol.6 , pp. 347-359
    • Grabher, C.1    Von Boehmer, H.2    Look, A.T.3
  • 54
    • 79951516547 scopus 로고    scopus 로고
    • Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia
    • Paganin M, Ferrando A. Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia. Blood Rev 2010.
    • Blood Rev , vol.2010
    • Paganin, M.1    Ferrando, A.2
  • 55
    • 74049145806 scopus 로고    scopus 로고
    • Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia
    • Palomero T, Ferrando A. Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia. Clin Lymphoma Myeloma 2009; 9(Suppl 3): S205-S210.
    • (2009) Clin Lymphoma Myeloma , vol.9 , Issue.SUPPL. 3
    • Palomero, T.1    Ferrando, A.2
  • 57
    • 51349169034 scopus 로고    scopus 로고
    • Leukemiaassociated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
    • Chiang MY, Xu L, Shestova O, Histen G, L'heureux S, Romany C et al. Leukemiaassociated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. J Clin Invest 2008; 118: 3181-3194.
    • (2008) J Clin Invest , vol.118 , pp. 3181-3194
    • Chiang, M.Y.1    Xu, L.2    Shestova, O.3    Histen, G.4    L'Heureux, S.5    Romany, C.6
  • 60
    • 78650379575 scopus 로고    scopus 로고
    • Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL
    • Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS et al. Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. Blood 2010; 116: 5443-5454.
    • (2010) Blood , vol.116 , pp. 5443-5454
    • Jeannet, R.1    Mastio, J.2    MacIas-Garcia, A.3    Oravecz, A.4    Ashworth, T.5    Geimer Le Lay, A.S.6
  • 61
    • 78650335900 scopus 로고    scopus 로고
    • Deletionbased mechanisms of Notch1 activation in T-ALL: Key roles for RAG recombinase and a conserved internal translational start site in Notch1
    • Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L et al. Deletionbased mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood 2010; 116: 5455-5464.
    • (2010) Blood , vol.116 , pp. 5455-5464
    • Ashworth, T.D.1    Pear, W.S.2    Chiang, M.Y.3    Blacklow, S.C.4    Mastio, J.5    Xu, L.6
  • 63
    • 80052669473 scopus 로고    scopus 로고
    • Identification of Flt3+CD150- myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential
    • Chi AW, Chavez A, Xu L, Weber BN, Shestova O, Schaffer A et al. Identification of Flt3+CD150- myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential. Blood 2011; 118: 2723-2732.
    • (2011) Blood , vol.118 , pp. 2723-2732
    • Chi, A.W.1    Chavez, A.2    Xu, L.3    Weber, B.N.4    Shestova, O.5    Schaffer, A.6
  • 64
    • 28844477601 scopus 로고    scopus 로고
    • Mutation of FLT3 is not a general phenomenon in CD117-positive T-ALL [4]
    • DOI 10.1016/j.leukres.2005.06.018, PII S0145212605002596
    • Scharnhorst V, Wals J, Beverloo HB, Langerak AW, van der Velden VH. Mutation of FLT3 is not a general phenomenon in CD117-positive T-ALL. Leuk Res 2006; 30: 245-246. (Pubitemid 41773349)
    • (2006) Leukemia Research , vol.30 , Issue.2 , pp. 245-246
    • Scharnhorst, V.1    Wals, J.2    Beverloo, H.B.3    Langerak, A.W.4    Van Der Velden, V.H.J.5
  • 65
    • 74049141397 scopus 로고    scopus 로고
    • FLT3 inhibition as a targeted therapy for acute myeloid leukemia
    • Sanz M, Burnett A, Lo-Coco F, Lowenberg B. FLT3 inhibition as a targeted therapy for acute myeloid leukemia. Curr Opin Oncol 2009; 21: 594-600.
    • (2009) Curr Opin Oncol , vol.21 , pp. 594-600
    • Sanz, M.1    Burnett, A.2    Lo-Coco, F.3    Lowenberg, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.