Wilms tumor 1 (WT1) gene mutations in pediatric T-cell malignancies

Leukemia

Volumn 24, Issue 2, 2010, Pages 476-480

  Renneville, A ^a,b,c,d   Kaltenbach, S ^e   Clappier, E ^e,f   Collette, S ^g   Micol, J B ^a   Nelken, B ^a   Lepelley, P ^a,b,c,d   Dastugue, N ^h   Benot, Y ⁱ   Bertrand, Y ^j   Preudhomme, C ^a,b,c,d   Cave H ^e,f  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b INSERM   (France)

^c UNIV LILLE   (France)

^d Institut de Recherche sur le Cancer de Lille   (France)

^e HÔPITAL ROBERT DEBRÉ   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g EORTC DATA CENTER   (Belgium)

^h CHU PURPAN   (France)

ⁱ GHENT UNIVERSITY HOSPITAL   (Belgium)

^j Institut d'Hematologie et d'Oncologie Pediatrique   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; HOX PROTEIN; PROTEIN AF10; PROTEIN CALM; PROTEIN SIL; PROTEIN TAL; PROTIN TLX1; PROTIN TLX3; TRANSCRIPTION FACTOR HOX 11; TRANSCRIPTION FACTOR HOX 11 L 2; TRANSCRIPTION FACTOR HOXA10; UNCLASSIFIED DRUG; WT1 PROTEIN;

ADOLESCENT; CANCER GROWTH; CANCER RELAPSE; CANCER SURVIVAL; CHILD; CONTROLLED STUDY; EVENT FREE SURVIVAL; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENE DUPLICATION; GENE FREQUENCY; GENE INSERTION; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENETIC SCREENING; HETEROZYGOSITY LOSS; HUMAN; INFANT; KARYOTYPE; LETTER; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T CELL LEUKEMIA;

EID: 76749151326     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.221     Document Type: Letter

References (12)

1. Cilloni D, Renneville A, Hermitte F, Hills RK, Daly S, Jovanovic JV et al. Real-time quantitative PCR detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet Study. J Clin Oncol 2009, e-pub ahead of print 14 September 2009.
2. Paschka P, Marcucci G, Ruppert AS, Whitman SP, Mrozek K, Maharry K et al. Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study. J Clin Oncol 2008; 26: 4595-4602.
3. Renneville A, Boissel N, Zurawski V, Llopis L, Biggio V, Nibourel O et al. Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a Study From the Acute Leukemia French Association. Cancer 2009; 115: 3719-3727.
4. Virappane P, Gale R, Hills R, Kakkas I, Summers K, Stevens J et al. Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party. J Clin Oncol 2008; 26: 5429-5435.
5. King-Underwood L, Pritchard-Jones K. Wilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance. Blood 1998; 91: 2961-2968.
6. Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia 1995; 9: 1783-1786.
7. Cave H, Suciu S, Preudhomme C, Poppe B, Robert A, Uyttebroeck A et al. Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951. Blood 2004; 103: 442-450.
8. Clappier E, Cuccuini W, Kalota A, Crinquette A, Cayuela JM, Dik WA et al. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood 2007; 110: 1251-1261.
9. Thompson BJ, Buonamici S, Sulis ML, Palomero T, Vilimas T, Basso G et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med 2007; 204: 1825-1835.
10. Weng AP, Ferrando AA, Lee W, Morris JPT, Silverman LB, Sanchez-Irizarry C et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306: 269-271.
11. Swiatecka-Urban A, Mokrzycki MH, Kaskel F, Da Silva F, Denamur E. Novel WT1 mutation (C388Y) in a female child with Denys-Drash syndrome. Pediatr Nephrol 2001; 16: 627-630.
12. Tosello V, Mansour MR, Barnes K, Paganin M, Sulis ML, Jenkinson S et al. WT1 mutations in T-ALL. Blood 2009; 114: 1038-1045.