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Volumn 40, Issue 15, 2012, Pages 7123-7131

Linear motifs confer functional diversity onto splice variants

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; PDZ PROTEIN; PROTEIN; PROTEIN PTB; PROTEIN SH2; PROTEIN WW; UNCLASSIFIED DRUG;

EID: 84863928687     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks442     Document Type: Article
Times cited : (68)

References (65)
  • 2
    • 41149149041 scopus 로고    scopus 로고
    • The functional consequences of alternative promoter use in mammalian genomes
    • Davuluri, R. V., Suzuki, Y., Sugano, S., Plass, C. and Huang, T. H. (2008) The functional consequences of alternative promoter use in mammalian genomes. Trends Genet., 24, 167-177.
    • (2008) Trends Genet. , vol.24 , pp. 167-177
    • Davuluri, R.V.1    Suzuki, Y.2    Sugano, S.3    Plass, C.4    Huang, T.H.5
  • 3
    • 66349122954 scopus 로고    scopus 로고
    • Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing
    • Li, J. B., Levanon, E. Y., Yoon, J. K., Aach, J., Xie, B., Leproust, E., Zhang, K., Gao, Y. and Church, G. M. (2009) Genome-wide identification of human RNA editing sites by parallel DNA capturing and sequencing. Science, 324, 1210-1213.
    • (2009) Science , vol.324 , pp. 1210-1213
    • Li, J.B.1    Levanon, E.Y.2    Yoon, J.K.3    Aach, J.4    Xie, B.5    Leproust, E.6    Zhang, K.7    Gao, Y.8    Church, G.M.9
  • 5
    • 1242352406 scopus 로고    scopus 로고
    • Assessing the impact of alternative splicing on domain interactions in the human proteome
    • Resch, A., Xing, Y., Modrek, B., Gorlick, M., Riley, R. and Lee, C. (2004) Assessing the impact of alternative splicing on domain interactions in the human proteome. J. Proteome. Res., 3, 76-83.
    • (2004) J. Proteome. Res. , vol.3 , pp. 76-83
    • Resch, A.1    Xing, Y.2    Modrek, B.3    Gorlick, M.4    Riley, R.5    Lee, C.6
  • 9
    • 79952351014 scopus 로고    scopus 로고
    • Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder
    • Hegyi, H., Kalmar, L., Horvath, T. and Tompa, P. (2011) Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder. Nucleic Acids Res., 39, 1208-1219.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 1208-1219
    • Hegyi, H.1    Kalmar, L.2    Horvath, T.3    Tompa, P.4
  • 10
    • 84864311086 scopus 로고    scopus 로고
    • Linear motifs: Lost in (pre) translation
    • Weatheritt, R. J. and Gibson, T. J. (2012) Linear motifs: lost in (pre) translation. Trends Biochem. Sci., 37, 333-341.
    • (2012) Trends Biochem. Sci. , vol.37 , pp. 333-341
    • Weatheritt, R.J.1    Gibson, T.J.2
  • 12
    • 34249695447 scopus 로고    scopus 로고
    • Local structural disorder imparts plasticity on linear motifs
    • Fuxreiter, M., Tompa, P. and Simon, I. (2007) Local structural disorder imparts plasticity on linear motifs. Bioinformatics, 23, 950-956.
    • (2007) Bioinformatics , vol.23 , pp. 950-956
    • Fuxreiter, M.1    Tompa, P.2    Simon, I.3
  • 15
    • 49749117432 scopus 로고    scopus 로고
    • Contextual specificity in peptide-mediated protein interactions
    • Stein, A. and Aloy, P. (2008) Contextual specificity in peptide-mediated protein interactions. PLoS One, 3, e2524.
    • (2008) PLoS One , vol.3
    • Stein, A.1    Aloy, P.2
  • 16
    • 0035958082 scopus 로고    scopus 로고
    • The 8-kDa dynein light chain binds to its targets via a conserved (K/R) XTQT motif
    • Lo, K. W., Naisbitt, S., Fan, J. S., Sheng, M. and Zhang, M. (2001) The 8-kDa dynein light chain binds to its targets via a conserved (K/R) XTQT motif. J Biol Chem, 276, 14059-14066.
    • (2001) J Biol Chem , vol.276 , pp. 14059-14066
    • Lo, K.W.1    Naisbitt, S.2    Fan, J.S.3    Sheng, M.4    Zhang, M.5
  • 17
    • 0036803243 scopus 로고    scopus 로고
    • Intrinsically unstructured proteins
    • Tompa, P. (2002) Intrinsically unstructured proteins. Trends Biochem. Sci., 27, 527-533.
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 527-533
    • Tompa, P.1
  • 18
    • 33244483948 scopus 로고    scopus 로고
    • Alternatively and constitutively spliced exons are subject to different evolutionary forces
    • Chen, F. C., Wang, S. S., Chen, C. J., Li, W. H. and Chuang, T. J. (2006) Alternatively and constitutively spliced exons are subject to different evolutionary forces. Mol. Biol. Evol., 23, 675-682.
    • (2006) Mol. Biol. Evol. , vol.23 , pp. 675-682
    • Chen, F.C.1    Wang, S.S.2    Chen, C.J.3    Li, W.H.4    Chuang, T.J.5
  • 19
    • 33749012287 scopus 로고    scopus 로고
    • The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain
    • Wagner, W., Fodor, E., Ginsburg, A. and Hammer, J. A.r. (2006) The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain. Biochemistry, 45, 11564-11577.
    • (2006) Biochemistry , vol.45 , pp. 11564-11577
    • Wagner, W.1    Fodor, E.2    Ginsburg, A.3    Hammer, J.A.4
  • 20
    • 0032945268 scopus 로고    scopus 로고
    • Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs
    • Nishioka, K., Ohtsubo, T., Oda, H., Fujiwara, T., Kang, D., Sugimachi, K. and Nakabeppu, Y. (1999) Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs. Mol. Biol. Cell., 10, 1637-1652.
    • (1999) Mol. Biol. Cell. , vol.10 , pp. 1637-1652
    • Nishioka, K.1    Ohtsubo, T.2    Oda, H.3    Fujiwara, T.4    Kang, D.5    Sugimachi, K.6    Nakabeppu, Y.7
  • 22
    • 84859225975 scopus 로고    scopus 로고
    • The identification of short linear motif-mediated interfaces within the human interactome
    • Weatheritt, R. J., Luck, K., Petsalaki, E., Davey, N. E. and Gibson, T. J. (2012) The identification of short linear motif-mediated interfaces within the human interactome. Bioinformatics, 28, 976-982.
    • (2012) Bioinformatics , vol.28 , pp. 976-982
    • Weatheritt, R.J.1    Luck, K.2    Petsalaki, E.3    Davey, N.E.4    Gibson, T.J.5
  • 24
    • 33750987920 scopus 로고    scopus 로고
    • Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays
    • Smith, M. J., Hardy, W. R., Murphy, J. M., Jones, N. and Pawson, T. (2006) Screening for PTB domain binding partners and ligand specificity using proteome-derived NPXY peptide arrays. Mol. Cell. Biol., 26, 8461-8474.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 8461-8474
    • Smith, M.J.1    Hardy, W.R.2    Murphy, J.M.3    Jones, N.4    Pawson, T.5
  • 26
    • 34250379613 scopus 로고    scopus 로고
    • Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
    • Wu, C., Ma, M. H., Brown, K. R., Geisler, M., Li, L., Tzeng, E., Jia, C. Y., Jurisica, I. and Li, S. S. (2007) Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. Proteomics, 7, 1775-1785.
    • (2007) Proteomics , vol.7 , pp. 1775-1785
    • Wu, C.1    Ma, M.H.2    Brown, K.R.3    Geisler, M.4    Li, L.5    Tzeng, E.6    Jia, C.Y.7    Jurisica, I.8    Li, S.S.9
  • 27
    • 80053299231 scopus 로고    scopus 로고
    • Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins
    • Liou, Y. C., Zhou, X. Z. and Lu, K. P. (2011) Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem. Sci., 36, 501-514.
    • (2011) Trends Biochem. Sci. , vol.36 , pp. 501-514
    • Liou, Y.C.1    Zhou, X.Z.2    Lu, K.P.3
  • 30
    • 75849153303 scopus 로고    scopus 로고
    • The universal protein resource (UniProt) in 2010
    • UniProt Consortium
    • UniProt Consortium (2010) The universal protein resource (UniProt) in 2010. Nucleic Acids Res., 38, D142-D148.
    • (2010) Nucleic Acids Res. , vol.38
  • 31
    • 0035072551 scopus 로고    scopus 로고
    • Clustering of highly homologous sequences to reduce the size of large protein databases
    • Li, W., Jaroszewski, L. and Godzik, A. (2001) Clustering of highly homologous sequences to reduce the size of large protein databases. Bioinformatics, 17, 282-283.
    • (2001) Bioinformatics , vol.17 , pp. 282-283
    • Li, W.1    Jaroszewski, L.2    Godzik, A.3
  • 32
    • 24044538903 scopus 로고    scopus 로고
    • IUPred: Web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
    • Dosztanyi, Z., Csizmok, V., Tompa, P. and Simon, I. (2005) IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content. Bioinformatics, 21, 3433-3434.
    • (2005) Bioinformatics , vol.21 , pp. 3433-3434
    • Dosztanyi, Z.1    Csizmok, V.2    Tompa, P.3    Simon, I.4
  • 34
    • 84857047339 scopus 로고    scopus 로고
    • PhosphoSitePlus: A comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse
    • Hornbeck, P. V., Kornhauser, J. M., Tkachev, S., Zhang, B., Skrzypek, E., Murray, B., Latham, V. and Sullivan, M. (2012) PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse. Nucleic Acids Res., 40, D261-D270.
    • (2012) Nucleic Acids Res. , vol.40
    • Hornbeck, P.V.1    Kornhauser, J.M.2    Tkachev, S.3    Zhang, B.4    Skrzypek, E.5    Murray, B.6    Latham, V.7    Sullivan, M.8
  • 35
    • 70349308508 scopus 로고    scopus 로고
    • Cell regulation: Determined to signal discrete cooperation
    • Gibson, T. J. (2009) Cell regulation: determined to signal discrete cooperation. Trends Biochem. Sci., 34, 471-482.
    • (2009) Trends Biochem. Sci. , vol.34 , pp. 471-482
    • Gibson, T.J.1
  • 36
    • 78650316134 scopus 로고    scopus 로고
    • P53 Research: The past thirty years and the next thirty years
    • Lane, D. and Levine, A. (2010) p53 Research: the past thirty years and the next thirty years. Cold Spring Harb. Perspect. Biol., 2, a000893.
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2
    • Lane, D.1    Levine, A.2
  • 37
    • 80053015725 scopus 로고    scopus 로고
    • P53 Isoforms: An intracellular microprocessor?
    • Khoury, M. P. and Bourdon, J. C. (2011) p53 Isoforms: an intracellular microprocessor? Genes Cancer, 2, 453-465.
    • (2011) Genes Cancer , vol.2 , pp. 453-465
    • Khoury, M.P.1    Bourdon, J.C.2
  • 38
    • 59349099726 scopus 로고    scopus 로고
    • P53 isoforms-a conspiracy to kidnap p53 tumor suppressor activity?
    • Marcel, V. and Hainaut, P. (2009) p53 isoforms-a conspiracy to kidnap p53 tumor suppressor activity? Cell. Mol. Life Sci., 66, 391-406.
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 391-406
    • Marcel, V.1    Hainaut, P.2
  • 39
    • 0037015397 scopus 로고    scopus 로고
    • DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53
    • Courtois, S., Verhaegh, G., North, S., Luciani, M. G., Lassus, P., Hibner, U., Oren, M. and Hainaut, P. (2002) DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. Oncogene, 21, 6722-6728.
    • (2002) Oncogene , vol.21 , pp. 6722-6728
    • Courtois, S.1    Verhaegh, G.2    North, S.3    Luciani, M.G.4    Lassus, P.5    Hibner, U.6    Oren, M.7    Hainaut, P.8
  • 40
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    • Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J. and Pavletich, N. P. (1996) Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science, 274, 948-953.
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1    Gorina, S.2    Marechal, V.3    Elenbaas, B.4    Moreau, J.5    Levine, A.J.6    Pavletich, N.P.7
  • 42
    • 77951296388 scopus 로고    scopus 로고
    • Structure of the p53 C-terminus bound to 14-3-3: Implications for stabilization of the p53 tetramer
    • Schumacher, B., Mondry, J., Thiel, P., Weyand, M. and Ottmann, C. (2010) Structure of the p53 C-terminus bound to 14-3-3: implications for stabilization of the p53 tetramer. FEBS Lett., 584, 1443-1448.
    • (2010) FEBS Lett. , vol.584 , pp. 1443-1448
    • Schumacher, B.1    Mondry, J.2    Thiel, P.3    Weyand, M.4    Ottmann, C.5
  • 43
    • 34447539875 scopus 로고    scopus 로고
    • The impact of alternative splicing in vivo: Mouse models show the way
    • Moroy, T. and Heyd, F. (2007) The impact of alternative splicing in vivo: mouse models show the way. RNA, 13, 1155-1171.
    • (2007) RNA , vol.13 , pp. 1155-1171
    • Moroy, T.1    Heyd, F.2
  • 44
    • 77955662560 scopus 로고    scopus 로고
    • An alternative splicing network links cell-cycle control to apoptosis
    • Moore, M. J., Wang, Q., Kennedy, C. J. and Silver, P. A. (2010) An alternative splicing network links cell-cycle control to apoptosis. Cell, 142, 625-636.
    • (2010) Cell , vol.142 , pp. 625-636
    • Moore, M.J.1    Wang, Q.2    Kennedy, C.J.3    Silver, P.A.4
  • 46
    • 37349094048 scopus 로고    scopus 로고
    • BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae
    • Chiaruttini, C., Sonego, M., Baj, G., Simonato, M. and Tongiorgi, E. (2008) BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae. Mol. Cell. Neurosci., 37, 11-19.
    • (2008) Mol. Cell. Neurosci. , vol.37 , pp. 11-19
    • Chiaruttini, C.1    Sonego, M.2    Baj, G.3    Simonato, M.4    Tongiorgi, E.5
  • 47
    • 33344471142 scopus 로고    scopus 로고
    • Regulation of gene expression by alternative untranslated regions
    • Hughes, T. A. (2006) Regulation of gene expression by alternative untranslated regions. Trends Genet., 22, 119-122.
    • (2006) Trends Genet. , vol.22 , pp. 119-122
    • Hughes, T.A.1
  • 48
    • 0442307867 scopus 로고    scopus 로고
    • Alternative spliced variants of the alpha-methylacyl-CoA racemase gene and their expression in prostate cancer
    • Mubiru, J. N., Shen-Ong, G. L., Valente, A. J. and Troyer, D. A. (2004) Alternative spliced variants of the alpha-methylacyl-CoA racemase gene and their expression in prostate cancer. Gene, 327, 89-98.
    • (2004) Gene , vol.327 , pp. 89-98
    • Mubiru, J.N.1    Shen-Ong, G.L.2    Valente, A.J.3    Troyer, D.A.4
  • 49
    • 9644302736 scopus 로고    scopus 로고
    • PDZ-containing proteins: Alternative splicing as a source of functional diversity
    • Sierralta, J. and Mendoza, C. (2004) PDZ-containing proteins: alternative splicing as a source of functional diversity. Brain Res. Brain Res. Rev., 47, 105-115.
    • (2004) Brain Res. Brain Res. Rev. , vol.47 , pp. 105-115
    • Sierralta, J.1    Mendoza, C.2
  • 51
    • 77956629294 scopus 로고    scopus 로고
    • The early isoform of disabled-1 functions independently of Reelin-mediated tyrosine phosphorylation in chick retina
    • Gao, Z., Monckton, E. A., Glubrecht, D. D., Logan, C. and Godbout, R. (2010) The early isoform of disabled-1 functions independently of Reelin-mediated tyrosine phosphorylation in chick retina. Mol. Cell. Biol., 30, 4339-4353.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 4339-4353
    • Gao, Z.1    Monckton, E.A.2    Glubrecht, D.D.3    Logan, C.4    Godbout, R.5
  • 52
    • 33746606004 scopus 로고    scopus 로고
    • Ligand-independent homo-and heterodimerization of human prolactin receptor variants: Inhibitory action of the short forms by heterodimerization
    • Qazi, A. M., Tsai-Morris, C. H. and Dufau, M. L. (2006) Ligand-independent homo-and heterodimerization of human prolactin receptor variants: inhibitory action of the short forms by heterodimerization. Mol. Endocrinol., 20, 1912-1923.
    • (2006) Mol. Endocrinol. , vol.20 , pp. 1912-1923
    • Qazi, A.M.1    Tsai-Morris, C.H.2    Dufau, M.L.3
  • 56
    • 0031038795 scopus 로고    scopus 로고
    • RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2
    • Lorenzo, M. J., Gish, G. D., Houghton, C., Stonehouse, T. J., Pawson, T., Ponder, B. A. and Smith, D. P. (1997) RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2. Oncogene, 14, 763-771.
    • (1997) Oncogene , vol.14 , pp. 763-771
    • Lorenzo, M.J.1    Gish, G.D.2    Houghton, C.3    Stonehouse, T.J.4    Pawson, T.5    Ponder, B.A.6    Smith, D.P.7
  • 57
    • 27144467717 scopus 로고    scopus 로고
    • Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform
    • Wong, A., Bogni, S., Kotka, P., de Graaff, E., D'Agati, V., Costantini, F. and Pachnis, V. (2005) Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Mol. Cell. Biol., 25, 9661-9673.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 9661-9673
    • Wong, A.1    Bogni, S.2    Kotka, P.3    De Graaff, E.4    D'Agati, V.5    Costantini, F.6    Pachnis, V.7
  • 58
    • 15544379277 scopus 로고    scopus 로고
    • Are splicing mutations the most frequent cause of hereditary disease?
    • Lopez-Bigas, N., Audit, B., Ouzounis, C., Parra, G. and Guigo, R. (2005) Are splicing mutations the most frequent cause of hereditary disease? FEBS Lett., 579, 1900-1903.
    • (2005) FEBS Lett. , vol.579 , pp. 1900-1903
    • Lopez-Bigas, N.1    Audit, B.2    Ouzounis, C.3    Parra, G.4    Guigo, R.5
  • 63
    • 80051690306 scopus 로고    scopus 로고
    • Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: An open-label, phase 2, dose-escalation study
    • Cirak, S., Arechavala-Gomeza, V., Guglieri, M., Feng, L., Torelli, S., Anthony, K., Abbs, S., Garralda, M. E., Bourke, J., Wells, D. J. et al. (2011) Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study. Lancet, 378, 595-605.
    • (2011) Lancet , vol.378 , pp. 595-605
    • Cirak, S.1    Arechavala-Gomeza, V.2    Guglieri, M.3    Feng, L.4    Torelli, S.5    Anthony, K.6    Abbs, S.7    Garralda, M.E.8    Bourke, J.9    Wells, D.J.10
  • 64
    • 78650440393 scopus 로고    scopus 로고
    • Anti-tumor activity of splice-switching oligonucleotides
    • Bauman, J. A., Li, S. D., Yang, A., Huang, L. and Kole, R. (2010) Anti-tumor activity of splice-switching oligonucleotides. Nucleic Acids Res., 38, 8348-8356.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 8348-8356
    • Bauman, J.A.1    Li, S.D.2    Yang, A.3    Huang, L.4    Kole, R.5


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